DK0707006T3 - Aroyl-piperidin-derivater - Google Patents

Aroyl-piperidin-derivater

Info

Publication number: DK0707006T3
Authority: DK; Denmark
Prior art keywords: aroyl; piperidine derivatives; substd; opt; halo
Prior art date: 1994-10-14

Application number

DK95810628T

Other languages

English (en)

Inventor

Silvio Dr Ofner

Siem Jacob Dr Veenstra

Walter Dr Schilling

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-14

Filing date

1995-10-05

Publication date

1999-10-18

1995-10-05 Application filed by Novartis Ag filed Critical Novartis Ag

1999-10-18 Application granted granted Critical

1999-10-18 Publication of DK0707006T3 publication Critical patent/DK0707006T3/da

Links

KIQKBYDBEUNWEM-UHFFFAOYSA-N (4-amino-2-benzylpiperidin-1-yl)-[2,3-bis(trifluoromethyl)phenyl]methanone Chemical compound C1C(N)CCN(C(=O)C=2C(=C(C=CC=2)C(F)(F)F)C(F)(F)F)C1CC1=CC=CC=C1 KIQKBYDBEUNWEM-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DK95810628T 1994-10-14 1995-10-05 Aroyl-piperidin-derivater DK0707006T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH309194		1994-10-14

Publications (1)

Publication Number	Publication Date
DK0707006T3 true DK0707006T3 (da)	1999-10-18

Family

ID=4248427

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95810628T DK0707006T3 (da)	1994-10-14	1995-10-05	Aroyl-piperidin-derivater

Country Status (23)

Country	Link
US (1)	US5965562A (da)
EP (1)	EP0707006B1 (da)
JP (1)	JP3022951B2 (da)
KR (1)	KR100413985B1 (da)
CN (1)	CN1066445C (da)
AT (1)	ATE178602T1 (da)
AU (1)	AU705851B2 (da)
CA (1)	CA2160444C (da)
DE (1)	DE59505575D1 (da)
DK (1)	DK0707006T3 (da)
ES (1)	ES2132580T3 (da)
FI (1)	FI114795B (da)
GR (1)	GR3030515T3 (da)
HU (1)	HUT74103A (da)
IL (1)	IL115572A (da)
MX (1)	MX9504349A (da)
MY (1)	MY114679A (da)
NO (1)	NO308034B1 (da)
NZ (1)	NZ280212A (da)
RU (1)	RU2158731C2 (da)
SA (1)	SA96160637B1 (da)
TW (1)	TW397825B (da)
ZA (1)	ZA958647B (da)

Families Citing this family (50)

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TW397825B (en) *	1994-10-14	2000-07-11	Novartis Ag	Aroyl-piperidine derivatives
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JP2001294582A (ja) *	2000-04-12	2001-10-23	Fuji Chemical Industries Ltd	光学活性アミノブチロラクトンの製造法
MXPA03000275A (es)	2000-07-11	2004-12-13	Albany Molecular Res Inc	Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
CN100369898C (zh) *	2002-02-12	2008-02-20	史密丝克莱恩比彻姆公司	用作p38抑制剂的烟酰胺衍生物
GB0220953D0 (en)	2002-09-10	2002-10-23	Novartis Ag	Organic compounds
GB2394417A (en) *	2002-10-24	2004-04-28	Novartis Ag	Solid dispersion comprising a piperidine substance P antagonist and a carrier
JP2006523692A (ja)	2003-04-18	2006-10-19	イーライリリーアンドカンパニー	５−ｈｔ１ｆ作用薬としての（ピペリジニルオキシ）フェニル、（ピペリジニルオキシ）ピリジニル、（ピペリジニルスルファニル）フェニル、および（ピペリジニルスルファニル）ピリジニル化合物
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ATE550019T1 (de)	2005-05-17	2012-04-15	Merck Sharp & Dohme	Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en)	2005-07-15	2011-06-07	Albany Molecular Research, Inc.	Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
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US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
BRPI0806245B1 (pt)	2007-01-10	2022-01-25	Msd Italia S.R.L.	Compostos de fórmula i e seus usos
WO2009002495A1 (en)	2007-06-27	2008-12-31	Merck & Co., Inc.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
EP2413932A4 (en)	2009-04-01	2012-09-19	Merck Sharp & Dohme	HAMMER OF ACT ACTIVITY
CN102595902B (zh)	2009-05-12	2015-04-29	阿尔巴尼分子研究公司	7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途
JP5739415B2 (ja)	2009-05-12	2015-06-24	ブリストル−マイヤーズスクウィブカンパニー	（Ｓ）−７−（［１，２，４］トリアゾロ［１，５−ａ］ピリジン−６−イル）−４−（３，４−ジクロロフェニル）−１，２，３，４−テトラヒドロイソキノリンの結晶形態およびその使用
ES2446971T3 (es)	2009-05-12	2014-03-11	Albany Molecular Research, Inc.	Tetrahidroisoquinolinas sustituidas con arilo, heteroarilo, y heterociclo y su uso
CA2777043C (en)	2009-10-14	2015-12-15	Schering Corporation	Substituted piperidines that increase p53 activity and the uses thereof
CN103068980B (zh)	2010-08-02	2017-04-05	瑟纳治疗公司	使用短干扰核酸（siNA）的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1（CTNNB1）基因表达的抑制
RU2745848C2 (ru)	2010-08-17	2021-04-01	Сирна Терапьютикс, Инк.	ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3919620A1 (en)	2012-05-02	2021-12-08	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
CA2882950A1 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
SMT201700595T1 (it)	2012-11-28	2018-03-08	Merck Sharp & Dohme	Composizioni e metodi per trattare il cancro
WO2014100065A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3706742B1 (en)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833667B1 (en)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5 inhibitors
CA3108388A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
CN111808017B (zh) *	2020-08-05	2023-11-28	国家纳米科学中心	一种含氮杂环化合物及其制备方法和应用

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SU1593569A3 (ru) *	1982-07-30	1990-09-15	Janssen Pharmaceutica Nv	Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
DK386089A (da) *	1988-08-12	1990-02-13	Japan Tobacco Inc	Katekolderivater
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
US5145967A (en) *	1989-04-20	1992-09-08	Anaquest, Inc.	Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
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FR2659323B1 (fr) *	1990-03-07	1992-06-12	Synthelabo	Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
JPH0794439B2 (ja) *	1990-05-31	1995-10-11	フアイザー・インコーポレイテツド	置換ピペリジンの製造法
JPH072740B2 (ja) *	1990-06-01	1995-01-18	フアイザー・インコーポレイテツド	３―アミノ―２―アリールキヌクリジン
ATE121389T1 (de) *	1990-09-28	1995-05-15	Pfizer	Ringverknüpfte analoge von stickstoffenthaltenden nichtaromatischen heterocyclen.
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TW397825B (en) *	1994-10-14	2000-07-11	Novartis Ag	Aroyl-piperidine derivatives

1995
- 1995-10-02 TW TW084110255A patent/TW397825B/zh not_active IP Right Cessation
- 1995-10-05 AT AT95810628T patent/ATE178602T1/de active
- 1995-10-05 DK DK95810628T patent/DK0707006T3/da active
- 1995-10-05 EP EP95810628A patent/EP0707006B1/de not_active Expired - Lifetime
- 1995-10-05 ES ES95810628T patent/ES2132580T3/es not_active Expired - Lifetime
- 1995-10-05 DE DE59505575T patent/DE59505575D1/de not_active Expired - Lifetime
- 1995-10-10 MY MYPI95003026A patent/MY114679A/en unknown
- 1995-10-10 AU AU33174/95A patent/AU705851B2/en not_active Ceased
- 1995-10-11 IL IL11557295A patent/IL115572A/en not_active IP Right Cessation
- 1995-10-11 FI FI954829A patent/FI114795B/fi not_active IP Right Cessation
- 1995-10-12 CA CA002160444A patent/CA2160444C/en not_active Expired - Fee Related
- 1995-10-12 NZ NZ280212A patent/NZ280212A/en not_active IP Right Cessation
- 1995-10-13 JP JP7265610A patent/JP3022951B2/ja not_active Expired - Fee Related
- 1995-10-13 ZA ZA958647A patent/ZA958647B/xx unknown
- 1995-10-13 HU HU9502973A patent/HUT74103A/hu not_active Application Discontinuation
- 1995-10-13 RU RU95117719/04A patent/RU2158731C2/ru not_active IP Right Cessation
- 1995-10-13 CN CN95116776A patent/CN1066445C/zh not_active Expired - Fee Related
- 1995-10-13 NO NO954067A patent/NO308034B1/no not_active IP Right Cessation
- 1995-10-13 KR KR1019950035296A patent/KR100413985B1/ko not_active Expired - Fee Related
- 1995-10-13 MX MX9504349A patent/MX9504349A/es unknown
1996
- 1996-03-02 SA SA96160637A patent/SA96160637B1/ar unknown
1997
- 1997-10-30 US US08/961,546 patent/US5965562A/en not_active Expired - Fee Related
1999
- 1999-06-15 GR GR990401590T patent/GR3030515T3/el unknown

Also Published As

Publication number	Publication date
NZ280212A (en)	2001-10-26
FI114795B (fi)	2004-12-31
NO954067L (no)	1996-04-15
MX9504349A (es)	1997-03-29
HUT74103A (en)	1996-11-28
NO954067D0 (no)	1995-10-13
CN1066445C (zh)	2001-05-30
SA96160637B1 (ar)	2005-06-14
CN1133839A (zh)	1996-10-23
KR960014121A (ko)	1996-05-22
EP0707006A1 (de)	1996-04-17
RU2158731C2 (ru)	2000-11-10
KR100413985B1 (ko)	2004-03-26
AU705851B2 (en)	1999-06-03
AU3317495A (en)	1996-04-26
MY114679A (en)	2002-12-31
CA2160444A1 (en)	1996-04-15
DE59505575D1 (de)	1999-05-12
ES2132580T3 (es)	1999-08-16
HU9502973D0 (en)	1995-12-28
ATE178602T1 (de)	1999-04-15
GR3030515T3 (en)	1999-10-29
CA2160444C (en)	2006-11-28
EP0707006B1 (de)	1999-04-07
US5965562A (en)	1999-10-12
NO308034B1 (no)	2000-07-10
FI954829A0 (fi)	1995-10-11
IL115572A (en)	2001-05-20
IL115572A0 (en)	1996-01-19
FI954829L (fi)	1996-04-15
JP3022951B2 (ja)	2000-03-21
TW397825B (en)	2000-07-11
ZA958647B (en)	1996-04-15
JPH08176145A (ja)	1996-07-09

Publication	Publication Date	Title
ATE178602T1 (de)	1999-04-15	Aroyl-piperidin-derivate
DE3683175D1 (de)	1992-02-13	Azolylmethyloxirane - ihre herstellung und verwendung als pflanzenschutzmittel.
PT795025E (pt)	2003-09-30	Preparacao enantiosselectiva de sulfoxidos farmaceuticamente aceitaveis por bio-reducao
DE69704679D1 (de)	2001-05-31	4-phenylpiperidin-derivate
ATE207905T1 (de)	2001-11-15	Tricyclische pyrazol-derivate
FI862621A0 (fi)	1986-06-18	Estrar av (met)-akrylsyror och deras anvaendning.
NO994115L (no)	1999-08-25	Nye 1,4-diazacykloheptanderivater og deres anvendelse i haaroksydasjonsfargestoffer
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