NO308034B1 - Nye aroylpiperidinderivater, farmasøytisk preparat inneholdende slike derivater og anvendelse derav - Google Patents

Nye aroylpiperidinderivater, farmasøytisk preparat inneholdende slike derivater og anvendelse derav

Info

Publication number
NO308034B1
NO308034B1 NO954067A NO954067A NO308034B1 NO 308034 B1 NO308034 B1 NO 308034B1 NO 954067 A NO954067 A NO 954067A NO 954067 A NO954067 A NO 954067A NO 308034 B1 NO308034 B1 NO 308034B1
Authority
NO
Norway
Prior art keywords
derivatives
new
aroylpiperidine
pharmaceutical preparations
preparations containing
Prior art date
Application number
NO954067A
Other languages
English (en)
Norwegian (no)
Other versions
NO954067L (no
NO954067D0 (no
Inventor
Silvio Ofner
Siem Jacob Veenstra
Walter Schilling
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO954067D0 publication Critical patent/NO954067D0/no
Publication of NO954067L publication Critical patent/NO954067L/no
Publication of NO308034B1 publication Critical patent/NO308034B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
NO954067A 1994-10-14 1995-10-13 Nye aroylpiperidinderivater, farmasøytisk preparat inneholdende slike derivater og anvendelse derav NO308034B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH309194 1994-10-14

Publications (3)

Publication Number Publication Date
NO954067D0 NO954067D0 (no) 1995-10-13
NO954067L NO954067L (no) 1996-04-15
NO308034B1 true NO308034B1 (no) 2000-07-10

Family

ID=4248427

Family Applications (1)

Application Number Title Priority Date Filing Date
NO954067A NO308034B1 (no) 1994-10-14 1995-10-13 Nye aroylpiperidinderivater, farmasøytisk preparat inneholdende slike derivater og anvendelse derav

Country Status (23)

Country Link
US (1) US5965562A (da)
EP (1) EP0707006B1 (da)
JP (1) JP3022951B2 (da)
KR (1) KR100413985B1 (da)
CN (1) CN1066445C (da)
AT (1) ATE178602T1 (da)
AU (1) AU705851B2 (da)
CA (1) CA2160444C (da)
DE (1) DE59505575D1 (da)
DK (1) DK0707006T3 (da)
ES (1) ES2132580T3 (da)
FI (1) FI114795B (da)
GR (1) GR3030515T3 (da)
HU (1) HUT74103A (da)
IL (1) IL115572A (da)
MX (1) MX9504349A (da)
MY (1) MY114679A (da)
NO (1) NO308034B1 (da)
NZ (1) NZ280212A (da)
RU (1) RU2158731C2 (da)
SA (1) SA96160637B1 (da)
TW (1) TW397825B (da)
ZA (1) ZA958647B (da)

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TW537894B (en) * 1998-05-26 2003-06-21 Novartis Ag A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist
WO2000010545A2 (en) * 1998-08-25 2000-03-02 Novartis Ag Use of substance p antagonists for the treatment of chronic fatigue syndrome and/or fibromyalgia and use of nk-1 receptor antagonists for the treatment of chronic fatigue syndrome
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US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
DK1246806T3 (da) 1999-11-03 2008-06-16 Amr Technology Inc Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
JP2001294582A (ja) * 2000-04-12 2001-10-23 Fuji Chemical Industries Ltd 光学活性アミノブチロラクトンの製造法
MXPA03000275A (es) 2000-07-11 2004-12-13 Albany Molecular Res Inc Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
CN100369898C (zh) * 2002-02-12 2008-02-20 史密丝克莱恩比彻姆公司 用作p38抑制剂的烟酰胺衍生物
GB0220953D0 (en) 2002-09-10 2002-10-23 Novartis Ag Organic compounds
GB2394417A (en) * 2002-10-24 2004-04-28 Novartis Ag Solid dispersion comprising a piperidine substance P antagonist and a carrier
JP2006523692A (ja) 2003-04-18 2006-10-19 イーライ リリー アンド カンパニー 5−ht1f作用薬としての(ピペリジニルオキシ)フェニル、(ピペリジニルオキシ)ピリジニル、(ピペリジニルスルファニル)フェニル、および(ピペリジニルスルファニル)ピリジニル化合物
UA91341C2 (ru) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
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US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme HAMMER OF ACT ACTIVITY
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JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用
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CA2777043C (en) 2009-10-14 2015-12-15 Schering Corporation Substituted piperidines that increase p53 activity and the uses thereof
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
RU2745848C2 (ru) 2010-08-17 2021-04-01 Сирна Терапьютикс, Инк. ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
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WO2014120748A1 (en) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as hdm2 inhibitors
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FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
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TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives

Also Published As

Publication number Publication date
NZ280212A (en) 2001-10-26
FI114795B (fi) 2004-12-31
NO954067L (no) 1996-04-15
MX9504349A (es) 1997-03-29
HUT74103A (en) 1996-11-28
NO954067D0 (no) 1995-10-13
CN1066445C (zh) 2001-05-30
SA96160637B1 (ar) 2005-06-14
CN1133839A (zh) 1996-10-23
KR960014121A (ko) 1996-05-22
EP0707006A1 (de) 1996-04-17
RU2158731C2 (ru) 2000-11-10
DK0707006T3 (da) 1999-10-18
KR100413985B1 (ko) 2004-03-26
AU705851B2 (en) 1999-06-03
AU3317495A (en) 1996-04-26
MY114679A (en) 2002-12-31
CA2160444A1 (en) 1996-04-15
DE59505575D1 (de) 1999-05-12
ES2132580T3 (es) 1999-08-16
HU9502973D0 (en) 1995-12-28
ATE178602T1 (de) 1999-04-15
GR3030515T3 (en) 1999-10-29
CA2160444C (en) 2006-11-28
EP0707006B1 (de) 1999-04-07
US5965562A (en) 1999-10-12
FI954829A0 (fi) 1995-10-11
IL115572A (en) 2001-05-20
IL115572A0 (en) 1996-01-19
FI954829L (fi) 1996-04-15
JP3022951B2 (ja) 2000-03-21
TW397825B (en) 2000-07-11
ZA958647B (en) 1996-04-15
JPH08176145A (ja) 1996-07-09

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