DK0710651T3 - Fremgangsmåde til fremstilling af en decahydroisoquinolino-alfa,alfa'-diamino-alkohol - Google Patents
Fremgangsmåde til fremstilling af en decahydroisoquinolino-alfa,alfa'-diamino-alkoholInfo
- Publication number
- DK0710651T3 DK0710651T3 DK95114205T DK95114205T DK0710651T3 DK 0710651 T3 DK0710651 T3 DK 0710651T3 DK 95114205 T DK95114205 T DK 95114205T DK 95114205 T DK95114205 T DK 95114205T DK 0710651 T3 DK0710651 T3 DK 0710651T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- reacting
- lower alkyl
- alpha
- r1oconhch
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 2
- -1 halomethyl lithium Chemical compound 0.000 abstract 5
- 229910052744 lithium Inorganic materials 0.000 abstract 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000001367 organochlorosilanes Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229960005190 phenylalanine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH290494 | 1994-09-23 | ||
| CH373694 | 1994-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0710651T3 true DK0710651T3 (da) | 2001-05-14 |
Family
ID=25691689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95114205T DK0710651T3 (da) | 1994-09-23 | 1995-09-11 | Fremgangsmåde til fremstilling af en decahydroisoquinolino-alfa,alfa'-diamino-alkohol |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US5591885A (2) |
| EP (1) | EP0710651B1 (2) |
| JP (1) | JP3819955B2 (2) |
| KR (1) | KR100418237B1 (2) |
| CN (3) | CN1116284C (2) |
| AT (1) | ATE198740T1 (2) |
| DE (1) | DE59508973D1 (2) |
| DK (1) | DK0710651T3 (2) |
| ES (1) | ES2154310T3 (2) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
| KR100411856B1 (ko) * | 1995-02-03 | 2004-05-20 | 카네카 코포레이션 | α-할로케톤,α-할로히드린및에폭사이드의제조법 |
| WO1997028105A1 (fr) * | 1996-01-29 | 1997-08-07 | Kaneka Corporation | Procede de reduction de composes de carbonyle |
| DK0847994T3 (da) | 1996-12-11 | 2003-07-28 | Hoffmann La Roche | Fremgangsmåde til fremstilling af blandede anhydrider |
| JP4482783B2 (ja) * | 1999-01-28 | 2010-06-16 | 味の素株式会社 | α−アミノケトン類の製造方法 |
| US6605732B1 (en) | 1999-05-03 | 2003-08-12 | Aerojet Fine Chemicals Llc | Clean, high-yield preparation of S,S and R,S amino acid isosteres |
| JP4143787B2 (ja) * | 1999-07-28 | 2008-09-03 | 味の素株式会社 | α−アミノハロメチルケトン誘導体の製造方法 |
| DE10143742A1 (de) | 2001-09-06 | 2003-03-27 | Consortium Elektrochem Ind | Verfahren zur Herstellung von alpha-Halogenketonen |
| US7038553B2 (en) * | 2002-10-03 | 2006-05-02 | International Business Machines Corporation | Scalable computer system having surface-mounted capacitive couplers for intercommunication |
| EP1604662A1 (en) * | 2004-06-08 | 2005-12-14 | Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft | 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus |
| BRPI0919257B8 (pt) * | 2008-09-24 | 2021-05-25 | Zach System | processo de preparação de nebivolol |
| CN102127061B (zh) * | 2010-01-15 | 2016-02-17 | 浙江华海药业股份有限公司 | 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| US5430041A (en) * | 1991-05-10 | 1995-07-04 | Hoffmann-La Roche Inc. | Amino acid derivatives having antiviral activity |
| JP2551901B2 (ja) * | 1991-07-26 | 1996-11-06 | エフ エム シー コーポレーション | 接触アルキル化方法 |
| JPH06184069A (ja) * | 1991-11-19 | 1994-07-05 | Lonza Ag | α−ヒドロキシ−β−アミノカルボン酸の製造方法 |
| US5380849A (en) * | 1992-11-09 | 1995-01-10 | Merck & Co., Inc. | Process for optically pure decahydroisoqiunolines |
| US5455353A (en) * | 1993-03-24 | 1995-10-03 | Hoffmann-La Roche Inc. | 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides |
| DE59401846D1 (de) * | 1993-07-15 | 1997-04-03 | Hoffmann La Roche | Verfahren zur Herstellung eines N-tert.Butylisochinolin-3-carboxamid Derivates und Zwischenprodukte in diesem Verfahren |
| US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
-
1995
- 1995-08-11 US US08/514,329 patent/US5591885A/en not_active Expired - Lifetime
- 1995-09-11 DK DK95114205T patent/DK0710651T3/da active
- 1995-09-11 DE DE59508973T patent/DE59508973D1/de not_active Expired - Lifetime
- 1995-09-11 AT AT95114205T patent/ATE198740T1/de active
- 1995-09-11 ES ES95114205T patent/ES2154310T3/es not_active Expired - Lifetime
- 1995-09-11 EP EP95114205A patent/EP0710651B1/de not_active Expired - Lifetime
- 1995-09-18 JP JP26204995A patent/JP3819955B2/ja not_active Expired - Lifetime
- 1995-09-21 CN CN95116887A patent/CN1116284C/zh not_active Expired - Lifetime
- 1995-09-22 KR KR1019950031290A patent/KR100418237B1/ko not_active Expired - Lifetime
-
1996
- 1996-09-18 US US08/718,109 patent/US5684176A/en not_active Expired - Lifetime
-
1997
- 1997-07-25 US US08/900,413 patent/US5847144A/en not_active Expired - Lifetime
-
1998
- 1998-07-09 US US09/112,651 patent/US5977388A/en not_active Expired - Lifetime
- 1998-11-16 US US09/192,656 patent/US5965733A/en not_active Expired - Lifetime
-
1999
- 1999-12-30 CN CN99127411A patent/CN1111156C/zh not_active Expired - Lifetime
- 1999-12-30 CN CNB991274121A patent/CN1133620C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1127251A (zh) | 1996-07-24 |
| CN1133620C (zh) | 2004-01-07 |
| CN1275563A (zh) | 2000-12-06 |
| CN1116284C (zh) | 2003-07-30 |
| JPH0899959A (ja) | 1996-04-16 |
| US5684176A (en) | 1997-11-04 |
| US5591885A (en) | 1997-01-07 |
| KR100418237B1 (ko) | 2004-07-23 |
| US5965733A (en) | 1999-10-12 |
| EP0710651B1 (de) | 2001-01-17 |
| US5977388A (en) | 1999-11-02 |
| JP3819955B2 (ja) | 2006-09-13 |
| DE59508973D1 (de) | 2001-02-22 |
| KR960010629A (ko) | 1996-04-20 |
| CN1111156C (zh) | 2003-06-11 |
| EP0710651A1 (de) | 1996-05-08 |
| CN1275562A (zh) | 2000-12-06 |
| ATE198740T1 (de) | 2001-02-15 |
| ES2154310T3 (es) | 2001-04-01 |
| US5847144A (en) | 1998-12-08 |
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