DK0711350T3 - Clavulansyre dehydrogenase, fremstilling og anvendelse af produktion af clavulansyre - Google Patents

Clavulansyre dehydrogenase, fremstilling og anvendelse af produktion af clavulansyre

Info

Publication number
DK0711350T3
DK0711350T3 DK94924775T DK94924775T DK0711350T3 DK 0711350 T3 DK0711350 T3 DK 0711350T3 DK 94924775 T DK94924775 T DK 94924775T DK 94924775 T DK94924775 T DK 94924775T DK 0711350 T3 DK0711350 T3 DK 0711350T3
Authority
DK
Denmark
Prior art keywords
clavulanic acid
production
dehydrogenase
acid dehydrogenase
clavulanic
Prior art date
Application number
DK94924775T
Other languages
English (en)
Inventor
Stephen William Elson
Neville Hubert Nicholson
Stefan Roland Woroniecki
Janice Arnell
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0711350T3 publication Critical patent/DK0711350T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D503/00Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94924775T 1993-07-24 1994-07-15 Clavulansyre dehydrogenase, fremstilling og anvendelse af produktion af clavulansyre DK0711350T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939315393A GB9315393D0 (en) 1993-07-24 1993-07-24 Novel product
PCT/EP1994/002346 WO1995003416A1 (en) 1993-07-24 1994-07-15 Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid

Publications (1)

Publication Number Publication Date
DK0711350T3 true DK0711350T3 (da) 2003-07-07

Family

ID=10739405

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94924775T DK0711350T3 (da) 1993-07-24 1994-07-15 Clavulansyre dehydrogenase, fremstilling og anvendelse af produktion af clavulansyre

Country Status (10)

Country Link
US (1) US6692950B1 (da)
EP (2) EP0711350B1 (da)
JP (1) JPH09502085A (da)
AT (1) ATE234927T1 (da)
AU (1) AU7494294A (da)
DE (1) DE69432304T2 (da)
DK (1) DK0711350T3 (da)
ES (1) ES2194871T3 (da)
GB (1) GB9315393D0 (da)
WO (1) WO1995003416A1 (da)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1504425A (en) 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
GB1504426A (en) 1975-10-13 1978-03-22 Beecham Group Ltd Clavulanic acid derivatives
GB1573153A (en) 1977-02-26 1980-08-13 Beecham Group Ltd 2-hydroxy - 4 - oxa - 1 - azobicyclo(3,2,0)-heptan-7-one derivatives
AU600655B2 (en) * 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance

Also Published As

Publication number Publication date
EP1236729A1 (en) 2002-09-04
AU7494294A (en) 1995-02-20
US6692950B1 (en) 2004-02-17
JPH09502085A (ja) 1997-03-04
DE69432304T2 (de) 2003-12-11
DE69432304D1 (de) 2003-04-24
GB9315393D0 (en) 1993-09-08
EP0711350A1 (en) 1996-05-15
WO1995003416A1 (en) 1995-02-02
EP0711350B1 (en) 2003-03-19
ES2194871T3 (es) 2003-12-01
ATE234927T1 (de) 2003-04-15

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