ES2194871T3 - Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico. - Google Patents

Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico.

Info

Publication number
ES2194871T3
ES2194871T3 ES94924775T ES94924775T ES2194871T3 ES 2194871 T3 ES2194871 T3 ES 2194871T3 ES 94924775 T ES94924775 T ES 94924775T ES 94924775 T ES94924775 T ES 94924775T ES 2194871 T3 ES2194871 T3 ES 2194871T3
Authority
ES
Spain
Prior art keywords
clavulanic acid
dehydrogenase
preparation
production
clavulanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94924775T
Other languages
English (en)
Inventor
Stephen William Elson
Neville Hubert Nicholson
Stefan Roland Woroniecki
Janice Arnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2194871T3 publication Critical patent/ES2194871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

UN COMPUESTO DE FORMULA (I), DONDE R=H O N O UNA SAL DEL MISMO Y UNA ENZIMA, OBTENIBLES DE ESPECIES STREPTOMICES, CON UNA ACTIVIDAD DE HIDROGENASA DE ACIDO CLAVULANICO QUE ES CAPAZ DE CONVERTIR (I) EN ACIDO CLAVULANICO.
ES94924775T 1993-07-24 1994-07-15 Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico. Expired - Lifetime ES2194871T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939315393A GB9315393D0 (en) 1993-07-24 1993-07-24 Novel product

Publications (1)

Publication Number Publication Date
ES2194871T3 true ES2194871T3 (es) 2003-12-01

Family

ID=10739405

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94924775T Expired - Lifetime ES2194871T3 (es) 1993-07-24 1994-07-15 Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico.

Country Status (10)

Country Link
US (1) US6692950B1 (es)
EP (2) EP1236729A1 (es)
JP (1) JPH09502085A (es)
AT (1) ATE234927T1 (es)
AU (1) AU7494294A (es)
DE (1) DE69432304T2 (es)
DK (1) DK0711350T3 (es)
ES (1) ES2194871T3 (es)
GB (1) GB9315393D0 (es)
WO (1) WO1995003416A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ177159A (en) 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1504425A (en) 1975-08-20 1978-03-22 Beecham Group Ltd Salts of clavulanic acid
GB1504426A (en) 1975-10-13 1978-03-22 Beecham Group Ltd Clavulanic acid derivatives
GB1573153A (en) 1977-02-26 1980-08-13 Beecham Group Ltd 2-hydroxy - 4 - oxa - 1 - azobicyclo(3,2,0)-heptan-7-one derivatives
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance

Also Published As

Publication number Publication date
JPH09502085A (ja) 1997-03-04
AU7494294A (en) 1995-02-20
EP0711350A1 (en) 1996-05-15
WO1995003416A1 (en) 1995-02-02
DE69432304D1 (de) 2003-04-24
DE69432304T2 (de) 2003-12-11
ATE234927T1 (de) 2003-04-15
EP0711350B1 (en) 2003-03-19
EP1236729A1 (en) 2002-09-04
GB9315393D0 (en) 1993-09-08
DK0711350T3 (da) 2003-07-07
US6692950B1 (en) 2004-02-17

Similar Documents

Publication Publication Date Title
ES2070660B1 (es) Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
AU7125291A (en) Inhibitors of nitric oxide biosynthesis
EP0742209A3 (en) Process for the preparation of an optically active quinoline demevalonolacton and process for the preparation of a salt of an optically active quinoline demevalolon
AU2623192A (en) Antifungal agent
MX9403286A (es) Acido valerico substituido.
ES2052714T3 (es) Un proceso para la preparacion de un compuesto denominado "cornexistina".
AU7415387A (en) Imidazolesulfonamide derivatives and herbicides
ES544752A0 (es) Un procedimiento para la preparacion de carbapenems.
IL124523A0 (en) Pesticides
ES544753A0 (es) Un procedimiento para la preparacion de carbapenems.
AU657397B2 (en) 3,4-diaryl-(5H)-furan-2-one based compounds with fungicidal activity
ATE82291T1 (de) Clavamderivate, herstellung und zwischenprodukte.
ES2194871T3 (es) Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico.
EP0453574A4 (en) Cephalosporin derivative
AU5715586A (en) Process for the production of 17``-ethynyl-17``-hydroxy-18- methyl-4,15-estradien-3-one, and the novel starting compounds for this process
AU566243B2 (en) Optically active imidazolylpropanols
AU560424B2 (en) Esters of 2-bromo-4-methylimidazole-5-carboxylic acid
PH27481A (en) Novel compounds
ES544266A0 (es) Un procedimiento para preparar acido azetidin-3-carboxilico o una sal del mismo
AU2874989A (en) Agent for animal growth promotion
ZW12890A1 (en) Novel compound
ES2092730T3 (es) Procedimiento microbiologico para la preparacion de acido 5-hidroxi-2-pirazina-carboxilico.
AU7547996A (en) New 4-imidazolidinone compound, process for its preparation and the pharmaceutical compositions which contain it
EP0272644A3 (en) Intermediates and their use in the synthesis of organic compounds
EP0264951A3 (en) Procaterol-derivatives