DK0721342T3 - Polypeptider fra Semaphorin genfamilien - Google Patents

Polypeptider fra Semaphorin genfamilien

Info

Publication number
DK0721342T3
DK0721342T3 DK94928057T DK94928057T DK0721342T3 DK 0721342 T3 DK0721342 T3 DK 0721342T3 DK 94928057 T DK94928057 T DK 94928057T DK 94928057 T DK94928057 T DK 94928057T DK 0721342 T3 DK0721342 T3 DK 0721342T3
Authority
DK
Denmark
Prior art keywords
semaphorin
semaphorins
nucleic acids
cell growth
methods
Prior art date
Application number
DK94928057T
Other languages
Danish (da)
English (en)
Inventor
Corey S Goodman
Alex L Kolodkin
David Matthes
David R Bentley
Timothy O'connor
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK0721342T3 publication Critical patent/DK0721342T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/60—New or modified breeds of invertebrates
    • A01K67/61—Genetically modified invertebrates, e.g. transgenic or polyploid
    • A01K67/65—Genetically modified arthropods
    • A01K67/68—Genetically modified insects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
DK94928057T 1993-09-13 1994-09-13 Polypeptider fra Semaphorin genfamilien DK0721342T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/121,713 US5639856A (en) 1993-09-13 1993-09-13 Semaphorin gene family
PCT/US1994/010151 WO1995007706A1 (fr) 1993-09-13 1994-09-13 Famille du gene de la semaphorine

Publications (1)

Publication Number Publication Date
DK0721342T3 true DK0721342T3 (da) 2002-07-15

Family

ID=22398364

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928057T DK0721342T3 (da) 1993-09-13 1994-09-13 Polypeptider fra Semaphorin genfamilien

Country Status (11)

Country Link
US (8) US5639856A (fr)
EP (1) EP0721342B1 (fr)
JP (1) JP3544378B2 (fr)
AT (1) ATE214286T1 (fr)
AU (1) AU683494B2 (fr)
CA (1) CA2171638C (fr)
DE (1) DE69430130T2 (fr)
DK (1) DK0721342T3 (fr)
ES (1) ES2173922T3 (fr)
PT (1) PT721342E (fr)
WO (1) WO1995007706A1 (fr)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5654173A (en) * 1996-08-23 1997-08-05 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
WO1997020928A1 (fr) * 1995-12-06 1997-06-12 Sumitomo Pharmaceuticals Company, Limited Nouvelle semaphorine z et gene la codant
WO1998011216A1 (fr) * 1996-09-11 1998-03-19 Sumitomo Pharmaceuticals Company, Limited Nouveau gene de semaphorine: semaphorine y
US20070299005A1 (en) * 1996-09-24 2007-12-27 Tanox, Inc. Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
EP0932678B2 (fr) * 1996-09-24 2010-03-10 Genentech, Inc. Famille de genes codant les peptides lies a l'apoptose, peptides ainsi codes et leurs procedes d'utilisation
EP0945505A4 (fr) * 1996-10-09 2002-11-27 Sumitomo Pharma Nouveau gene de semaphorine: la semaphorine w
CA2271681A1 (fr) * 1996-11-15 1998-05-28 Sumitomo Pharmaceuticals Co., Ltd. Nouveaux genes de semaphorine (i)
EP0892047A3 (fr) * 1997-07-09 2000-03-08 Hoechst Marion Roussel Deutschland GmbH Semaphorine L humaine et murine
US6428965B1 (en) 1997-07-17 2002-08-06 The Johns Hopkins University Screening assays for the interaction of semaphorins and neuropilins
US20030022293A1 (en) * 1997-09-18 2003-01-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6130068A (en) 1998-10-26 2000-10-10 Immunex Corporation Viral encoded semaphorin protein receptor DNA and polypeptides
WO1999021997A1 (fr) * 1997-10-28 1999-05-06 Immunex Corporation Adn et polypeptides recepteurs des proteines de semaphorine a codage viral
US7214497B2 (en) 1997-10-28 2007-05-08 Immunex Corporation Viral encoded semaphorin protein receptor DNA and polypeptides
US6562949B1 (en) 1997-10-28 2003-05-13 Immunex Corporation Antibodies to viral encoded semaphorin protein receptor polypeptides
US6635421B1 (en) * 1997-12-09 2003-10-21 Children's Medical Center Corporation Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
WO1999032511A1 (fr) 1997-12-22 1999-07-01 Ono Pharmaceutical Co., Ltd. Peptides, procede de dosage du pepsinogene ii humain ou de la pepsine ii humaine et necessaire de dosage
JPH11187882A (ja) * 1997-12-26 1999-07-13 Ono Pharmaceut Co Ltd 新規なポリペプチド、その製造方法、そのポリペプチドをコードするｃＤＮＡ、そのｃＤＮＡからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのペプチドまたは抗体を含有する薬学的組成物
EP1066317A2 (fr) * 1998-01-30 2001-01-10 Smithkline Beecham Plc Nouveaux composes
EP0933425A1 (fr) * 1998-01-30 1999-08-04 Smithkline Beecham Plc Polypeptides et polynucléotides de la familie du semaphorin
US20030166132A1 (en) * 1998-08-26 2003-09-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1135488A1 (fr) * 1998-11-26 2001-09-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Semaphorine humaine 6a-1(sema6a-1), gene implique dans des mecanismes de developpement et de regeneration neuronaux pendant l'apoptose, et son utilisation en tant que cible potentielle de medicaments
EP1210368A2 (fr) * 1999-09-08 2002-06-05 Immunex Corporation Modulation par semaphorines de l'efflux cellulaire
US20080213878A1 (en) * 1999-10-19 2008-09-04 Gregory Donoho Novel human membrane proteins and polynucleotides encoding the same
US6815538B2 (en) * 2000-03-20 2004-11-09 Lexicon Genetics Incorporated Human secreted proteins and polynucleotides encoding the same
AU1450101A (en) * 1999-11-02 2001-05-14 Zymogenetics Inc. Human semaphorin
WO2001038491A2 (fr) * 1999-11-08 2001-05-31 The General Hospital Corporation Domaines de semaphorine
WO2001088133A2 (fr) * 2000-05-18 2001-11-22 Lexicon Genetics Incorporated Nouveaux homologues humains de semaphorine et polynucleotides codant ceux-ci
AU2001274923A1 (en) * 2000-05-23 2001-12-03 Lexicon Genetics Incorporated Novel human thrombospondin-like proteins and polynucleotides encoding the same
WO2002009756A1 (fr) * 2000-07-28 2002-02-07 Sumitomo Pharmaceuticals Company, Limited Promoteurs de la regeneration des nerfs contenant un inhibiteur de semaphorine en tant qu'ingredient actif
EP1418834A4 (fr) * 2001-07-20 2007-04-04 Sinai School Medicine Procedes servant a diagnostiquer et a traiter la maladie d'alzheimer et la maladie de parkinson
EP1429801A1 (fr) * 2001-09-26 2004-06-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Neuropiline comme nouvelle cible therapeutique pour la modulation de reponses immunitaires
US7781413B2 (en) * 2001-10-31 2010-08-24 Board Of Regents, The University Of Texas System SEMA3B inhibits tumor growth and induces apoptosis in cancer cells
WO2003066821A2 (fr) * 2002-02-04 2003-08-14 The Johns Hopkins University Molecules interagissant avec des polynucleotides et polypeptides casl (mical), et procedes d'utilisation associes
EP1442749A1 (fr) 2003-01-31 2004-08-04 Institut National De La Sante Et De La Recherche Medicale (Inserm) Utilisation d'un anticorps anti-CD100 pour le traitement et le diagnostic d'une maladie inflammatoire du système nerveux central
FR2876913A1 (fr) * 2004-10-22 2006-04-28 Centre Nat Rech Scient Modulation de la transmission synaptique par les semaphorines et ses applications
US7919594B2 (en) 2007-02-14 2011-04-05 Vaccinex, Inc. Human anti-CD100 antibodies
WO2010129917A2 (fr) 2009-05-08 2010-11-11 Vaccinex, Inc. Anticorps anti-cd100 et leurs méthodes d'utilisation
AU2012322721B2 (en) 2011-10-11 2016-05-05 Vaccinex, Inc. Use of semaphorin-4D binding molecules for modulation of blood brain barrier permeability
US9090709B2 (en) 2012-03-28 2015-07-28 Vaccinex, Inc. Anti-SEMA4D antibodies and epitopes
US10494440B2 (en) 2012-05-11 2019-12-03 Vaccinex, Inc. Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
US9975933B2 (en) * 2013-05-23 2018-05-22 Ajou University Industry-Academic Cooperation Foundation Tumor tissue-penetrating peptide specific to neuropilin and fusion protein having same peptide fused therein
BR112015032690B1 (pt) 2013-06-25 2020-03-10 Vaccinex, Inc. Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase
NZ630881A (en) 2013-10-10 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treatment of atherosclerosis
NZ630892A (en) 2013-10-21 2016-03-31 Vaccinex Inc Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
RU2722832C2 (ru) * 2015-02-23 2020-06-04 Сигалл Терапьютикс Сас Неприродные семафорины класса 3 и их медицинское применение

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2188583T3 (es) * 1991-06-24 2003-07-01 Chiron Corp Polipeptidos para el virus de la hepatitis c (hcv).
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5416197A (en) * 1993-10-15 1995-05-16 Trustees Of The University Of Pennsylvania Antibodies which bind human collapsin
US5807806A (en) * 1997-06-12 1998-09-15 Nippon Soda Co., Ltd. Benzoylpyrazole derivatives having specific substituents and herbicide

Also Published As

Publication number Publication date
CA2171638C (fr) 2001-05-29
PT721342E (pt) 2002-09-30
US7153936B2 (en) 2006-12-26
CA2171638A1 (fr) 1995-03-23
AU7724094A (en) 1995-04-03
EP0721342A4 (fr) 1998-07-29
ATE214286T1 (de) 2002-03-15
US5639856A (en) 1997-06-17
WO1995007706A1 (fr) 1995-03-23
US20070033669A1 (en) 2007-02-08
US5935865A (en) 1999-08-10
AU683494B2 (en) 1997-11-13
US20030166849A1 (en) 2003-09-04
EP0721342A1 (fr) 1996-07-17
US5807826A (en) 1998-09-15
JPH09505725A (ja) 1997-06-10
US6344544B1 (en) 2002-02-05
ES2173922T3 (es) 2002-11-01
EP0721342B1 (fr) 2002-03-13
JP3544378B2 (ja) 2004-07-21
US6013781A (en) 2000-01-11
DE69430130T2 (de) 2002-08-22
US20080312158A1 (en) 2008-12-18
DE69430130D1 (de) 2002-04-18

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