DK0725778T3 - Rekombinant produktion af hidtil ukendte polyketider - Google Patents

Rekombinant produktion af hidtil ukendte polyketider

Info

Publication number
DK0725778T3
DK0725778T3 DK94928169T DK94928169T DK0725778T3 DK 0725778 T3 DK0725778 T3 DK 0725778T3 DK 94928169 T DK94928169 T DK 94928169T DK 94928169 T DK94928169 T DK 94928169T DK 0725778 T3 DK0725778 T3 DK 0725778T3
Authority
DK
Denmark
Prior art keywords
polyketides
novel
recombinant production
novel polyketides
production
Prior art date
Application number
DK94928169T
Other languages
Danish (da)
English (en)
Inventor
Chaitan Khosla
David A Hopwood
Susanne Ebert-Khosla
Robert Mcdaniel
Hong Fu
Camilla Kao
Original Assignee
Univ Leland Stanford Junior
Innes John Centre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26821834&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0725778(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/238,811 external-priority patent/US5672491A/en
Application filed by Univ Leland Stanford Junior, Innes John Centre filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of DK0725778T3 publication Critical patent/DK0725778T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
DK94928169T 1993-09-20 1994-09-20 Rekombinant produktion af hidtil ukendte polyketider DK0725778T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12373293A 1993-09-20 1993-09-20
US16430193A 1993-12-08 1993-12-08
US08/238,811 US5672491A (en) 1993-09-20 1994-05-06 Recombinant production of novel polyketides
PCT/US1994/010643 WO1995008548A1 (en) 1993-09-20 1994-09-20 Recombinant production of novel polyketides

Publications (1)

Publication Number Publication Date
DK0725778T3 true DK0725778T3 (da) 2001-12-17

Family

ID=26821834

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94928169T DK0725778T3 (da) 1993-09-20 1994-09-20 Rekombinant produktion af hidtil ukendte polyketider

Country Status (11)

Country Link
US (7) US6022731A (de)
EP (1) EP0725778B1 (de)
JP (1) JPH09505983A (de)
AT (2) ATE206164T1 (de)
AU (1) AU678058B2 (de)
CA (1) CA2171629A1 (de)
DE (2) DE69434408T2 (de)
DK (1) DK0725778T3 (de)
ES (2) ES2240259T3 (de)
PT (1) PT725778E (de)
WO (1) WO1995008548A1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500960B1 (en) 1995-07-06 2002-12-31 Stanford University (Board Of Trustees Of The Leland Stanford Junior University) Method to produce novel polyketides
WO1995008548A1 (en) * 1993-09-20 1995-03-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US6558942B1 (en) 1994-05-06 2003-05-06 The Leland Stanford Junior University Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US5824485A (en) * 1995-04-24 1998-10-20 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
EP1493814A1 (de) 1995-07-06 2005-01-05 The Leland Stanford Junior University Zellfreie Synthese von Polyketiden
US6600029B1 (en) 1995-12-19 2003-07-29 Regents Of The University Of Minnesota Metabolic engineering of polyhydroxyalkanoate monomer synthases
US5998194A (en) * 1995-12-21 1999-12-07 Abbott Laboratories Polyketide-associated sugar biosynthesis genes
US5783431A (en) * 1996-04-24 1998-07-21 Chromaxome Corporation Methods for generating and screening novel metabolic pathways
US6242211B1 (en) 1996-04-24 2001-06-05 Terragen Discovery, Inc. Methods for generating and screening novel metabolic pathways
JP2009219493A (ja) * 1996-06-08 2009-10-01 Biotica Technology Ltd ポリケチド類及びそれらの合成
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
CA2259420C (en) * 1996-07-05 2007-09-18 Biotica Technology Limited Erythromycins and process for their preparation
US6960453B1 (en) 1996-07-05 2005-11-01 Biotica Technology Limited Hybrid polyketide synthases combining heterologous loading and extender modules
EP0929681B1 (de) * 1996-08-20 2006-09-13 Novartis AG Rifamycin biosynthese genkluster
US6033883A (en) 1996-12-18 2000-03-07 Kosan Biosciences, Inc. Production of polyketides in bacteria and yeast
US6399789B1 (en) * 1996-12-18 2002-06-04 Kosan Biosciences, Inc. Multi-plasmid method for preparing large libraries of polyketides and non-ribosomal peptides
US6902913B2 (en) 1997-04-30 2005-06-07 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6117659A (en) * 1997-04-30 2000-09-12 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
US6503741B1 (en) 1998-05-28 2003-01-07 Kosan Biosciences, Inc. Polyketide synthase genes from Streptomyces venezuelae
US6969584B2 (en) * 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
CN1188520C (zh) 1997-07-10 2005-02-09 高山生物科学股份有限公司 在植物中生产聚酮化合物
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
US6090601A (en) * 1998-01-23 2000-07-18 Kosan Bioscience Sorangium polyketide synthase
US6280999B1 (en) 1998-01-23 2001-08-28 Kosan Bioscience Sorangium polyketide synthases and encoding DNA therefor
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
US6265202B1 (en) * 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
GB9814006D0 (en) * 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
US6150513A (en) * 1998-09-16 2000-11-21 Kosan Biosciences, Inc. Polyketide synthase enzymes and recombinant DNA constructs therefor
EP1117801B1 (de) 1998-10-02 2006-11-29 Kosan Biosciences, Inc. Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen
WO2000024907A2 (en) 1998-10-28 2000-05-04 Kosan Biosciences, Inc. Library of novel "unnatural" natural products
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
CN100381566C (zh) 1998-11-20 2008-04-16 科森生物科学公司 产生环氧噻酮及其衍生物的重组方法和材料
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
US20040005673A1 (en) 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US7001748B2 (en) 1999-02-09 2006-02-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of making polyketides using hybrid polyketide synthases
CA2359801A1 (en) 1999-02-09 2000-08-17 Rajesh S. Gokhale Methods to mediate polyketide synthase module effectiveness
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
MXPA02003754A (es) 1999-10-13 2003-10-14 Univ Leland Stanford Junior Biosintesis de sustratos de policetido sintasa.
US6939691B1 (en) 1999-10-13 2005-09-06 Board Of Trustees Of The Leland Stanford Junior University E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
ATE391789T1 (de) 1999-12-10 2008-04-15 Invitrogen Corp Verwendung einer vielzahl von rekombinationsstellen mit einzigartiger spezifität beim rekombinatorischen klonen
CA2399198A1 (en) 2000-02-18 2001-08-23 Christopher Carreras Motilide compounds
AU2001248588B2 (en) 2000-04-13 2006-02-02 Biotica Technology Limited Hybrid glycosylated products and their production and use
AU2001275012A1 (en) 2000-05-30 2001-12-11 Kosan Biosciences, Inc. Design of polyketide synthase genes
FI111270B (fi) * 2001-03-19 2003-06-30 Galilaeus Oy Angusykliinien biosynteesin geeniryhmittymä ja sen käyttö yhdisteiden tuottamiseksi lääkeaineseulontaa varten
US20030194784A1 (en) * 2001-04-17 2003-10-16 Sherman David H. DNA encoding methymycin and pikromycin
AU2002254822A1 (en) * 2001-04-26 2002-11-11 Ecopia Biosciences Inc. Genes and proteins for the biosynthesis of polyketides
DE60210096D1 (de) * 2001-07-26 2006-05-11 Ecopia Biosciences Inc Gene und proteine zur rosaramicin biosynthese
US20040161839A1 (en) * 2001-10-05 2004-08-19 Hung-Wen Liu Method to alter sugar moieties
GB0125043D0 (en) * 2001-10-17 2001-12-12 Biotica Tech Ltd Production, detection and use of transformant cells
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
US20060110789A1 (en) * 2002-03-04 2006-05-25 Gokhale Rajesh S Methods to mediate polyketide synthase module effectiveness
US6989131B2 (en) * 2002-03-12 2006-01-24 Uop Llc Catalytic reactor with integral evaporator
AU2003248694A1 (en) * 2002-06-13 2003-12-31 Kosan Biosciences, Inc. Methods and cells for improved production of polyketides
AU2003253949A1 (en) * 2002-07-15 2004-02-02 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
US20040132055A1 (en) * 2002-10-24 2004-07-08 Leonard Katz Recombinant chalcomycin polyketide synthase and modifying genes
US7067290B2 (en) * 2002-11-12 2006-06-27 Kosan Biosciences Incorporated Method for production of polyketides
AU2003298864A1 (en) 2002-12-06 2004-06-30 Kosan Biosciences, Inc. Disorazole polyketide synthase encoding polynucleotides
US7799904B2 (en) * 2003-06-13 2010-09-21 University Of Kentucky Research Foundation Gilvocarcin gene cluster, recombinant production and use thereof
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
KR100549690B1 (ko) 2003-10-23 2006-02-07 상하이 지아오통 대학 에프알-008 폴리케타이드 합성에 관여하는 유전자
US7229814B2 (en) 2004-05-05 2007-06-12 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
US7566558B2 (en) 2006-07-28 2009-07-28 Regents Of The University Of Michigan Nucleic acids and polypeptides involved in the production of cryptophycin
US8759031B2 (en) 2007-04-12 2014-06-24 Wisconsin Alumni Research Foundation Type I polyketide synthase extender units
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность
EP2254995A4 (de) * 2008-03-28 2011-05-25 Univ California Herstellung von dicarboxylsäuren mithilfe von polyketidsynthasen
CN102014623A (zh) * 2008-04-29 2011-04-13 加利福尼亚大学董事会 使用聚酮化物合酶制备生物燃料
JP5789190B2 (ja) * 2008-09-24 2015-10-07 シャンハイ インスティテュート オブ オーガニック ケミストリー，チャイニーズ アカデミー オブ サイエンシズ 新規の遺伝子クラスター
US8852902B2 (en) 2010-11-22 2014-10-07 The Regents Of The University Of California Producing a trimethylpentanoic acid using hybrid polyketide synthases
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
AU2012272644B2 (en) 2011-06-23 2017-03-23 Rho Renewables, Inc. Recombinant production systems for aromatic molecules
US8864373B2 (en) * 2011-09-12 2014-10-21 National Semiconductor Corporation Small highly accurate battery temperature monitoring circuit
US10233431B2 (en) 2014-02-26 2019-03-19 The Regents Of The University Of California Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
WO2016112295A1 (en) 2015-01-09 2016-07-14 Warp Drive Bio, Inc. Compounds that participate in cooperative binding and uses thereof
TW201629069A (zh) 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
CA3000822A1 (en) 2015-10-01 2017-04-06 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
CA3020594A1 (en) * 2016-04-12 2017-10-19 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
US11781128B2 (en) 2016-07-29 2023-10-10 Isomerase Therapeutics Limited Methods for producing hybrid polyketide synthase genes and polyketides
CN110506120A (zh) 2016-10-28 2019-11-26 银杏生物制品公司 用于生产化合物的组合物和方法
CN109679969B (zh) * 2019-01-16 2022-09-02 河南省商业科学研究所有限责任公司 参与调控链霉菌中act产量的细胞被合成基因
CN109679980B (zh) * 2019-01-16 2022-09-02 河南省商业科学研究所有限责任公司 参与调控链霉菌中act产量的氨基酸代谢基因
CN121471132A (zh) 2019-11-04 2026-02-06 锐新医药公司 Ras抑制剂
WO2021091956A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
MX2022005359A (es) 2019-11-04 2022-06-02 Revolution Medicines Inc Inhibidores de ras.
CN113969255A (zh) 2020-07-24 2022-01-25 北京华昊中天生物医药股份有限公司 生产脱环氧埃坡霉素b的重组菌及其用途
IL301298A (en) 2020-09-15 2023-05-01 Revolution Medicines Inc Indole derivatives as RAS inhibitors in cancer therapy
IL308195A (en) 2021-05-05 2024-01-01 Revolution Medicines Inc RAS inhibitors for cancer treatment
EP4106060A1 (de) 2021-06-18 2022-12-21 Kemiwatt Biobasierter wässriger organischer elektrolyt für eine wässrige organische redox-flow-batterie
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092388B2 (de) 1982-04-16 1994-10-26 Eli Lilly And Company Klonierungsvektoren
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
US5824513A (en) 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
US6060234A (en) 1991-01-17 2000-05-09 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US6063561A (en) 1991-01-17 2000-05-16 Abbott Laboratories Polyketide derivatives and recombinant methods for making same
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
WO1995008548A1 (en) * 1993-09-20 1995-03-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation

Also Published As

Publication number Publication date
ES2164713T3 (es) 2002-03-01
US5843718A (en) 1998-12-01
US5830750A (en) 1998-11-03
DE69434408D1 (de) 2005-07-21
US20020110874A1 (en) 2002-08-15
US6022731A (en) 2000-02-08
DE69428451T2 (de) 2002-04-18
US6399382B1 (en) 2002-06-04
WO1995008548A1 (en) 1995-03-30
EP0725778A4 (de) 1998-11-11
ATE206164T1 (de) 2001-10-15
US20060127986A1 (en) 2006-06-15
DE69434408T2 (de) 2006-03-16
JPH09505983A (ja) 1997-06-17
PT725778E (pt) 2002-03-28
CA2171629A1 (en) 1995-03-30
AU678058B2 (en) 1997-05-15
EP0725778A1 (de) 1996-08-14
US7312048B2 (en) 2007-12-25
AU7731794A (en) 1995-04-10
US6214573B1 (en) 2001-04-10
EP0725778B1 (de) 2001-09-26
ES2240259T3 (es) 2005-10-16
ATE297992T1 (de) 2005-07-15
US6969611B2 (en) 2005-11-29
DE69428451D1 (de) 2001-10-31

Similar Documents

Publication Publication Date Title
ATE206164T1 (de) Rekombinante herstellung von neuen polyketiden
DE69635489D1 (de) Rekombinante produktion von neuen polyketiden
EP1568774A3 (de) Recombinante Herstellung von Polyketiden
DE69634127D1 (de) Zellfreie synthese von polyketiden
DE69820038D1 (de) Prozessueberwachungsvorrichtung
MXPA02004666A (es) Gelatinas recombinantes.
DK0960109T3 (da) Fremgangsmåde til fremstilling af tolterodin
DE69632630D1 (de) Enzym mit aminopeptidaseactivität
DE60009759D1 (de) Signalangepasstes filter unter verwendung von vorgegebener kombinationen im zeitmultiplex-verfahren
DE69637844D1 (de) Neues tgf-beta-ahnliches cytokin
WO2002037687A3 (en) Method of performing huffman decoding
IL136667A0 (en) Methods of producing anti-angiogenic proteins: endostatin, angiostatin or restin, using a pichia yeast expression system
IL112329A0 (en) Sucrose isomerases dna, sequences coding therefor , and processes for the preparation on non-cariogenic sugars utilizing the same
DK0885296T3 (da) Et enzym med galactanaseaktivitet
ATE343369T1 (de) Neue verwendung von proteinhydrolysaten
DK0659276T3 (da) Immunoassay til eftervisning af collagen eller collagenfragmenter
FR2716588B1 (fr) Système de codage convolutionnel et de décodage de viterbi transparent aux sauts de phase de pi et pi/2, applicable notamment aux transmissions AMRT.
DE69807930D1 (de) Produktion von hochdruckgas
BR9916460A (pt) Produção de ácido ascórbico usando levedura
FI852088A7 (fi) Yhtenäiset, jäykät, vapaasti seisovat, kaasun läpäisevät, pienlämpötilasidoksiset hiekkaraemuotit.
EP0613951A3 (de) Polysaccharid, Verfahren zur Herstellung, Verwendung und Azotobacter beijerinckii TNM1.
AU4288300A (en) Unsupported flat linoleum structure and method of producing same
PT633928E (pt) Microrganismos processo de preparacao e utilizacao
ATE264394T1 (de) Klonierung der udp-galaktose-epimerase
UA41926C2 (uk) Прокат бульбоподібного профілю та спосіб його виготовлення