DK0725795T3 - Enkelt-kæde form af glycoprotein-hormon-kvartetten - Google Patents

Enkelt-kæde form af glycoprotein-hormon-kvartetten

Info

Publication number
DK0725795T3
DK0725795T3 DK95928220T DK95928220T DK0725795T3 DK 0725795 T3 DK0725795 T3 DK 0725795T3 DK 95928220 T DK95928220 T DK 95928220T DK 95928220 T DK95928220 T DK 95928220T DK 0725795 T3 DK0725795 T3 DK 0725795T3
Authority
DK
Denmark
Prior art keywords
glycoprotein
chain
forms
glycoprotein hormone
beta subunits
Prior art date
Application number
DK95928220T
Other languages
English (en)
Inventor
Irving Boime
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0725795T3 publication Critical patent/DK0725795T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95928220T 1994-08-12 1995-08-01 Enkelt-kæde form af glycoprotein-hormon-kvartetten DK0725795T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28939694A 1994-08-12 1994-08-12
US31059094A 1994-09-22 1994-09-22
US33462994A 1994-11-04 1994-11-04
US35159194A 1994-12-07 1994-12-07
PCT/US1995/009664 WO1996005224A1 (en) 1994-08-12 1995-08-01 Single-chain forms of the glycoprotein hormone quartet

Publications (1)

Publication Number Publication Date
DK0725795T3 true DK0725795T3 (da) 2004-05-17

Family

ID=27501506

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95928220T DK0725795T3 (da) 1994-08-12 1995-08-01 Enkelt-kæde form af glycoprotein-hormon-kvartetten

Country Status (14)

Country Link
EP (1) EP0725795B1 (da)
KR (1) KR960704932A (da)
CN (1) CN1157408C (da)
AT (1) ATE257843T1 (da)
AU (1) AU703718B2 (da)
CA (1) CA2173750C (da)
DE (1) DE69532436T2 (da)
DK (1) DK0725795T3 (da)
ES (1) ES2210307T3 (da)
FI (1) FI120150B (da)
HU (1) HU227311B1 (da)
NO (1) NO317394B1 (da)
PT (1) PT725795E (da)
WO (1) WO1996005224A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0751782T3 (da) * 1994-02-18 2007-01-29 Applied Research Systems Anvendelse af et ikke-neutraliserende antistof, som er specifikt for beta-subunit'en i luteiniserende hormon, til forbedring af fertilitet
EP0974599A4 (en) * 1996-11-12 2002-06-12 Teikoku Hormone Mfg Co Ltd RECOMBINANT SINGLE STRANDED HORSE CHORIONGONADOTROPINE
US5883073A (en) * 1997-04-03 1999-03-16 Washington University Single-chain double-alpha peptide
US6693074B1 (en) * 1997-09-19 2004-02-17 Washington University Cystine depleted glycoprotein hormones
CN1277633A (zh) * 1997-09-22 2000-12-20 马里兰大学巴尔的摩分校 促甲状腺激素的突变体及其制备方法
US6635256B1 (en) * 1998-10-19 2003-10-21 Washington University Glycoprotein hormone compositions comprising two β subunits and methods of use thereof
US6103501A (en) * 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
CA2344277A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
JP2001333772A (ja) 2000-04-25 2001-12-04 Washington Univ 可変性の活性を有する単鎖稔性ホルモン
AU2001283319A1 (en) * 2000-08-11 2002-02-25 Applied Research Systems Ars Holding N.V. Glycoproteins and methods of use thereof
WO2002036626A1 (en) * 2000-11-02 2002-05-10 Maxygen Aps Single-chain multimeric polypeptides
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
EA011390B1 (ru) 2004-09-02 2009-02-27 Эли Лилли Энд Компани Мутантные белки (мутеины) фактора роста фибробластов 21
KR20140053991A (ko) 2011-07-18 2014-05-08 아츠 바이올로직스 에이/에스 장기간 작용하는 황체 형성 호르몬 (ｌｈ) 화합물
EP2968391A1 (en) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539862B (zh) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 一种长效重组促卵泡激素及其应用
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
US20220267401A1 (en) * 2016-03-22 2022-08-25 Universidade De São Paulo - Usp Method for producing and purifying hybrid or non-hybrid recombinant glycoprotein hormones, hybrid or non-hybrid recombinant glycoprotein hormones, expression vectors and uses of the recombinant glycoprotein hormones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578328B1 (en) * 1983-11-02 1999-12-29 Applied Research Systems ARS Holding N.V. Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
WO1991016922A1 (en) * 1990-05-08 1991-11-14 University Of Medicine & Dentistry Of New Jersey Analogs of glycoprotein hormones having altered immunological characteristics, efficacy and/or receptor specificity

Also Published As

Publication number Publication date
EP0725795A4 (en) 1998-05-06
HU227311B1 (en) 2011-03-28
ES2210307T3 (es) 2004-07-01
CN1131952A (zh) 1996-09-25
EP0725795B1 (en) 2004-01-14
DE69532436D1 (de) 2004-02-19
NO317394B1 (no) 2004-10-25
FI961600A0 (fi) 1996-04-11
AU3206695A (en) 1996-03-07
WO1996005224A1 (en) 1996-02-22
EP0725795A1 (en) 1996-08-14
CN1157408C (zh) 2004-07-14
HUT75900A (en) 1997-05-28
FI120150B (fi) 2009-07-15
NO961433L (no) 1996-06-11
NO961433D0 (no) 1996-04-11
CA2173750A1 (en) 1996-02-22
ATE257843T1 (de) 2004-01-15
DE69532436T2 (de) 2004-11-25
PT725795E (pt) 2004-05-31
CA2173750C (en) 2011-03-22
FI961600L (fi) 1996-04-11
AU703718B2 (en) 1999-04-01
KR960704932A (ko) 1996-10-09

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