BRPI0514790A - muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano - Google Patents

muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano

Info

Publication number
BRPI0514790A
BRPI0514790A BRPI0514790-5A BRPI0514790A BRPI0514790A BR PI0514790 A BRPI0514790 A BR PI0514790A BR PI0514790 A BRPI0514790 A BR PI0514790A BR PI0514790 A BRPI0514790 A BR PI0514790A
Authority
BR
Brazil
Prior art keywords
mutein
human
fgf
pharmaceutical composition
biologically active
Prior art date
Application number
BRPI0514790-5A
Other languages
English (en)
Inventor
Christopher Carl Frye
Lihua Huang
Radmila Micanovic
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0514790A publication Critical patent/BRPI0514790A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

MUTEìNA DE FGF-21 DE HUMANO, OU UM SEU PEPTìDEO BIOLOGICAMENTE ATIVO, MéTODO PARA PRODUZIR A MUTEìNA, COMPOSIçãO FARMACêUTICA, E, USO DA MUTEìNA DE FGF-21 DE HUMANO. A presente invenção refere-se às novas muteínas de fator 21 de crescimento de fibroblasto de humano com capacidade de O-glicosilação reduzida quando expressadas em levedura comparadas com FGF-21 de humano de tipo selvagem. Tanto a proteína quanto a respectiva espécie de ácido nucleico codificador são descritas. A invenção também se refere às modalidades de vetores e de células hospedeiras para a propagação de citadas seqüências de ácido nucleico e à produção de citadas muteínas. Também são descritos métodos para tratar diabetes 2, obesidade, ou síndrome metabólica.
BRPI0514790-5A 2004-09-02 2005-07-26 muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano BRPI0514790A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60680504P 2004-09-02 2004-09-02
PCT/US2005/026398 WO2006028595A2 (en) 2004-09-02 2005-07-26 Muteins of fibroblast growth factor 21

Publications (1)

Publication Number Publication Date
BRPI0514790A true BRPI0514790A (pt) 2008-06-24

Family

ID=36036790

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514790-5A BRPI0514790A (pt) 2004-09-02 2005-07-26 muteìna de fgf-21 de humano, ou um seu peptìdeo biologicamente ativo, método para produzir a muteìna, composição farmacêutica, e, uso da muteìna de fgf-21 de humano

Country Status (21)

Country Link
US (1) US7582607B2 (pt)
EP (2) EP1789442B1 (pt)
JP (1) JP4809352B2 (pt)
KR (1) KR100854198B1 (pt)
CN (1) CN101010338B (pt)
AT (1) ATE444307T1 (pt)
AU (1) AU2005283025B2 (pt)
BR (1) BRPI0514790A (pt)
CA (1) CA2575753A1 (pt)
DE (1) DE602005016946D1 (pt)
DK (1) DK1789442T3 (pt)
EA (1) EA011390B1 (pt)
ES (1) ES2332057T3 (pt)
HR (1) HRP20090597T1 (pt)
IL (1) IL181573A0 (pt)
MX (1) MX2007002616A (pt)
NO (1) NO20071327L (pt)
PL (1) PL1789442T3 (pt)
PT (1) PT1789442E (pt)
SI (1) SI1789442T1 (pt)
WO (1) WO2006028595A2 (pt)

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AU2005283025A1 (en) 2006-03-16
KR20070050454A (ko) 2007-05-15
EA200700533A1 (ru) 2007-08-31
JP2008511323A (ja) 2008-04-17
EA011390B1 (ru) 2009-02-27
PT1789442E (pt) 2009-11-11
HRP20090597T1 (hr) 2009-12-31
CN101010338B (zh) 2011-06-15
US7582607B2 (en) 2009-09-01
PL1789442T3 (pl) 2010-02-26
IL181573A0 (en) 2007-07-04
ATE444307T1 (de) 2009-10-15
WO2006028595A2 (en) 2006-03-16
CN101010338A (zh) 2007-08-01
KR100854198B1 (ko) 2008-08-26
NO20071327L (no) 2007-05-29
EP2161281A1 (en) 2010-03-10
MX2007002616A (es) 2007-05-16
SI1789442T1 (sl) 2010-01-29
DE602005016946D1 (de) 2009-11-12
CA2575753A1 (en) 2006-03-16
US20080103096A1 (en) 2008-05-01
EP1789442B1 (en) 2009-09-30
ES2332057T3 (es) 2010-01-25
JP4809352B2 (ja) 2011-11-09
WO2006028595A3 (en) 2007-01-18
AU2005283025B2 (en) 2011-06-30
EP1789442A2 (en) 2007-05-30
DK1789442T3 (da) 2009-11-16

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