DK0728016T3 - Anvendelse af anti-idiotypiske antistoffer til forebyggelse af hyperakut afstødning af xenotransplantater - Google Patents

Anvendelse af anti-idiotypiske antistoffer til forebyggelse af hyperakut afstødning af xenotransplantater

Info

Publication number
DK0728016T3
DK0728016T3 DK94930693T DK94930693T DK0728016T3 DK 0728016 T3 DK0728016 T3 DK 0728016T3 DK 94930693 T DK94930693 T DK 94930693T DK 94930693 T DK94930693 T DK 94930693T DK 0728016 T3 DK0728016 T3 DK 0728016T3
Authority
DK
Denmark
Prior art keywords
antibodies
animal
idiotypic antibodies
human
well
Prior art date
Application number
DK94930693T
Other languages
English (en)
Inventor
David K C Cooper
Eugen Koren
Original Assignee
Oklahoma Med Res Found
Integris Baptist Med Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Integris Baptist Med Center filed Critical Oklahoma Med Res Found
Application granted granted Critical
Publication of DK0728016T3 publication Critical patent/DK0728016T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK94930693T 1993-10-12 1994-10-12 Anvendelse af anti-idiotypiske antistoffer til forebyggelse af hyperakut afstødning af xenotransplantater DK0728016T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/133,934 US5560911A (en) 1993-10-12 1993-10-12 Method of inhibiting acute complement mediated cytotoxicity with anti-idiotypic antibodies
PCT/US1994/011488 WO1995010303A1 (en) 1993-10-12 1994-10-12 Use of anti-idiotypic antibodies to prevent hyperacute rejection of xenografts

Publications (1)

Publication Number Publication Date
DK0728016T3 true DK0728016T3 (da) 1999-09-20

Family

ID=22460983

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94930693T DK0728016T3 (da) 1993-10-12 1994-10-12 Anvendelse af anti-idiotypiske antistoffer til forebyggelse af hyperakut afstødning af xenotransplantater

Country Status (9)

Country Link
US (2) US5560911A (da)
EP (1) EP0728016B1 (da)
AT (1) ATE176758T1 (da)
AU (1) AU688806B2 (da)
CA (1) CA2172819C (da)
DE (1) DE69416601T2 (da)
DK (1) DK0728016T3 (da)
ES (1) ES2131218T3 (da)
WO (1) WO1995010303A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689597A4 (en) * 1993-03-16 1998-10-21 Austin Research Inst USE OF PIG GAL-g (a) (1,3) GALACTOSYL TRANSFERASE FOR XENOGENE THERAPIES
US6030614A (en) * 1994-05-13 2000-02-29 Plasmaselect Gmbh Teterow Ameliorating immunological rejection of allograft
US5785966A (en) * 1994-06-15 1998-07-28 Coles; John G. Inhibition of human xenogenic or allogenic antibodies to reduce xenograft or allograft rejection in human recipients
US5869035A (en) * 1996-11-13 1999-02-09 Human Gene Therapy Research Institute Methods and compositions for inducing complement destruction of tissue
CA2279542A1 (en) * 1997-02-05 1998-08-06 The General Hospital Corporation Tolerance to natural antibody antigens
US6096725A (en) * 1997-07-02 2000-08-01 Neose Technologies, Inc. Methods of using αGal oligosaccharides as immune system targeting agents
US7026446B1 (en) * 1997-12-24 2006-04-11 Diatech Pty Ltd. Bifunctional molecules
JP2005521497A (ja) * 2002-03-25 2005-07-21 ワシントン・ユニバーシティ キメラ膵臓
EP1544215A1 (en) * 2003-12-17 2005-06-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Human anti-idiotypic antibody fragments that mimic HER-2/neu
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
WO2012092665A1 (en) * 2011-01-04 2012-07-12 Network Immunology Inc. Method for facilitating tissue transplantation
US20140115728A1 (en) 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT89107A (pt) * 1987-11-30 1989-11-30 Idec Pharma Corp Metodo e meios para a seleccao de anticorpos anti-idiotipos e seu uso para o diagnostico, monitorizacao, tratamento e/ou prevencao de doencas cancerosas, da autoimunidade ou infecciosas
US5215904A (en) * 1989-01-27 1993-06-01 Wisconsin Alumni Research Foundation Method for producing a recombinant mammal in vivo
AU1025692A (en) * 1991-02-06 1992-08-13 Ciba-Geigy Ag Novel chimeric antiidiotypic monoclonal antibodies
JPH09508277A (ja) * 1994-01-27 1997-08-26 ブレサゲン リミテッド ヒト異種移植における超急性拒絶の管理のための物質及び方法

Also Published As

Publication number Publication date
EP0728016B1 (en) 1999-02-17
EP0728016A1 (en) 1996-08-28
CA2172819C (en) 2000-04-04
WO1995010303A1 (en) 1995-04-20
AU7973694A (en) 1995-05-04
ES2131218T3 (es) 1999-07-16
US5728812A (en) 1998-03-17
US5560911A (en) 1996-10-01
ATE176758T1 (de) 1999-03-15
AU688806B2 (en) 1998-03-19
DE69416601T2 (de) 1999-07-22
DE69416601D1 (de) 1999-03-25
CA2172819A1 (en) 1995-04-20

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