ATE221382T1 - Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen - Google Patents

Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen

Info

Publication number
ATE221382T1
ATE221382T1 AT94919227T AT94919227T ATE221382T1 AT E221382 T1 ATE221382 T1 AT E221382T1 AT 94919227 T AT94919227 T AT 94919227T AT 94919227 T AT94919227 T AT 94919227T AT E221382 T1 ATE221382 T1 AT E221382T1
Authority
AT
Austria
Prior art keywords
cells
surrogate
pct
organ graft
animal
Prior art date
Application number
AT94919227T
Other languages
English (en)
Inventor
William E Beschorner
Original Assignee
Ximerex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ximerex Inc filed Critical Ximerex Inc
Application granted granted Critical
Publication of ATE221382T1 publication Critical patent/ATE221382T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Transplanting Machines (AREA)
  • External Artificial Organs (AREA)
  • Water Treatment By Electricity Or Magnetism (AREA)
AT94919227T 1993-05-24 1994-05-24 Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen ATE221382T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6537093A 1993-05-24 1993-05-24
PCT/US1994/005844 WO1994027622A1 (en) 1993-05-24 1994-05-24 Surrogate tolerogenesis for the development of tolerance to xenografts

Publications (1)

Publication Number Publication Date
ATE221382T1 true ATE221382T1 (de) 2002-08-15

Family

ID=22062242

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94919227T ATE221382T1 (de) 1993-05-24 1994-05-24 Die erzeugung von toleranz gegen fremdtransplantate durch tolerogenese mit hilfe von ersatzlebewesen

Country Status (8)

Country Link
US (1) US6060049A (de)
EP (1) EP0700297B1 (de)
JP (1) JP4236279B2 (de)
AT (1) ATE221382T1 (de)
AU (1) AU693452B2 (de)
CA (1) CA2163517C (de)
DE (1) DE69431107T2 (de)
WO (1) WO1994027622A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610288B1 (en) * 1995-05-26 2003-08-26 Diacrin, Inc. Porcine hepatocytes for use in treatment of disorders characterized by insufficient liver function
EP1253941B1 (de) * 2000-01-25 2008-09-17 Board Of Regents Of The University Of Nebraska Für die transplantation präparierte organe und abstossungsresistenz
AU2001245550A1 (en) * 2000-03-09 2001-09-17 Lee Walters Applications of immune system tolerance to treatment of various diseases
IL142802A (en) * 2000-04-27 2015-01-29 Enzo Therapeutics Inc Use of one or more HBV antigens for the preparation of oral pharmaceutical preparations for the treatment of a person with active HBV infection or hepatocellular carcinoma
JP2004518405A (ja) 2000-07-27 2004-06-24 アポゲーネ・ゲーエムベーハー・ウント・コー・カーゲー 組換えタンパク質、細胞、および生物を産生するための体細胞クローニング遺伝子移入
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US7780993B2 (en) * 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
US20030096016A1 (en) * 2001-09-07 2003-05-22 Yeda Research And Development Co. Ltd. Methods of kidney transplantation utilizing developing nephric tissue
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
EP1497435A4 (de) * 2002-04-19 2005-07-27 Univ Pittsburgh Aus plazenta abgeleitete stammzellen und deren verwendungen
WO2006038211A2 (en) * 2004-10-04 2006-04-13 Yeda Research And Development Co. Ltd. Disease treatment via developing non-syngeneic graft transplantation
IL165425A0 (en) * 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US20060147429A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Facilitated cellular reconstitution of organs and tissues
US20060148080A1 (en) * 2004-12-30 2006-07-06 Paul Diamond Methods for supporting and producing human cells and tissues in non-human mammal hosts
WO2006113220A2 (en) * 2005-04-13 2006-10-26 Ximerex, Inc. Transgenic mammals expressing human preproinsulin
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
US8263823B2 (en) * 2008-10-20 2012-09-11 Adimmu Institute Inc. Immunocompetent xenograft model
WO2010047676A1 (en) * 2008-10-20 2010-04-29 Yangxin Fu An immunocompetent xenograft model
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012092665A1 (en) * 2011-01-04 2012-07-12 Network Immunology Inc. Method for facilitating tissue transplantation
WO2015061550A1 (en) * 2013-10-24 2015-04-30 Kansas State University Research Foundation Immune competent models of human disease
US11172657B2 (en) 2017-09-19 2021-11-16 Pormedtec Co., Ltd. Method for developing organ that lacks specific functional cell

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2026340B (en) * 1978-07-03 1982-12-22 Ash P Stabilising microvesicles
US4406885A (en) * 1978-12-28 1983-09-27 Research Corporation Preparation of native oncornavirus envelope subunits and vaccines therefrom
DE3063736D1 (en) * 1979-03-27 1983-07-21 Nat Res Dev Improvements in or relating to immunological preparations
US4624917A (en) * 1982-02-17 1986-11-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for the production of human T-cell growth factor
JPS6339820A (ja) * 1986-08-05 1988-02-20 Kingo Yoshida 拒絶反応抑制，幼若細胞移植による不老長寿法
JPS63170322A (ja) * 1986-12-30 1988-07-14 Kingo Yoshida 幼若臓器・器管・組織移植による延命長寿法
US5004681B1 (en) * 1987-11-12 2000-04-11 Biocyte Corp Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
JPH01132528A (ja) * 1987-11-19 1989-05-25 Kingo Yoshida 母体胎児免疫抑制を応用した若細胞移植による不老長寿法並びに病気治療法
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
WO1991018615A1 (en) * 1990-05-25 1991-12-12 Systemix, Inc. Human peripheral blood cells in an immunocompromised host
DK0667904T3 (da) * 1991-11-05 2002-06-03 Univ Leland Stanford Junior Suppressor- og progenitor-celler

Also Published As

Publication number Publication date
EP0700297A4 (de) 1997-04-09
DE69431107T2 (de) 2003-03-27
EP0700297A1 (de) 1996-03-13
JPH09500618A (ja) 1997-01-21
DE69431107D1 (de) 2002-09-05
EP0700297B1 (de) 2002-07-31
AU693452B2 (en) 1998-07-02
CA2163517A1 (en) 1994-12-08
AU7044594A (en) 1994-12-20
JP4236279B2 (ja) 2009-03-11
WO1994027622A1 (en) 1994-12-08
US6060049A (en) 2000-05-09
CA2163517C (en) 2011-03-15

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