DK0731787T3 - Krystallinsk, polymorf form af (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)-propyl]-1-cyclopentylcarbonyl)-tyrosin - Google Patents

Krystallinsk, polymorf form af (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)-propyl]-1-cyclopentylcarbonyl)-tyrosin

Info

Publication number: DK0731787T3
Authority: DK; Denmark
Prior art keywords: polymorphic form; crystalline; mesyllysylamino; cyclopentylcarbonyl; tyrosine
Prior art date: 1993-12-04

Application number

DK95900719T

Other languages

Danish (da)

English (en)

Inventor

Peter James Dunn

Michael Leslie Hughes

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-04

Filing date

1994-11-09

Publication date

1999-08-30

1994-11-09 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

1999-08-30 Application granted granted Critical

1999-08-30 Publication of DK0731787T3 publication Critical patent/DK0731787T3/da

Links

LPUDGHQMOAHMMF-JBACZVJFSA-N (2s)-2-[[[(2s)-6-amino-2-(methanesulfonamido)hexanoyl]amino]methyl]-3-[1-[[(1s)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl]cyclopentyl]propanoic acid Chemical compound N([C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C(=O)C1(C[C@@H](CNC(=O)[C@H](CCCCN)NS(=O)(=O)C)C(O)=O)CCCC1 LPUDGHQMOAHMMF-JBACZVJFSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Pyrrole Compounds (AREA)

DK95900719T 1993-12-04 1994-11-09 Krystallinsk, polymorf form af (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)-propyl]-1-cyclopentylcarbonyl)-tyrosin DK0731787T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939324931A GB9324931D0 (en)	1993-12-04	1993-12-04	Glutaramide derivatives
PCT/EP1994/003750 WO1995015308A1 (en)	1993-12-04	1994-11-09	Crystalline, polymorphic form of (s,s,s)-n-(1-[2-carboxy-3-(n2-mesyllysylamino)propyl]-1-cyclopentylcarbonyl)tyrosine

Publications (1)

Publication Number	Publication Date
DK0731787T3 true DK0731787T3 (da)	1999-08-30

Family

ID=10746163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95900719T DK0731787T3 (da)	1993-12-04	1994-11-09	Krystallinsk, polymorf form af (S,S,S)-N-(1-[2-carboxy-3-(N2-mesyllysylamino)-propyl]-1-cyclopentylcarbonyl)-tyrosin

Country Status (26)

Country	Link
US (1)	US6180665B1 (cs)
EP (1)	EP0731787B1 (cs)
JP (1)	JP2701988B2 (cs)
KR (1)	KR100203314B1 (cs)
CN (1)	CN1068586C (cs)
AT (1)	ATE175664T1 (cs)
CA (1)	CA2178085C (cs)
CZ (1)	CZ296428B6 (cs)
DE (1)	DE69416003T2 (cs)
DK (1)	DK0731787T3 (cs)
EG (1)	EG20562A (cs)
ES (1)	ES2128031T3 (cs)
FI (1)	FI120305B (cs)
GB (1)	GB9324931D0 (cs)
GR (1)	GR3029590T3 (cs)
HU (1)	HU225959B1 (cs)
IL (1)	IL111791A (cs)
MY (1)	MY115430A (cs)
NO (1)	NO306714B1 (cs)
NZ (1)	NZ276087A (cs)
PE (1)	PE9296A1 (cs)
PL (1)	PL178559B1 (cs)
RU (1)	RU2131869C1 (cs)
TW (2)	TW434210B (cs)
WO (1)	WO1995015308A1 (cs)
ZA (1)	ZA949595B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2420043A1 (en)	2000-08-29	2002-03-07	Riverside Forest Products Limited	Collapsible bin
FR2824477B1 (fr) *	2001-05-09	2005-09-09	Ethypharm Lab Prod Ethiques	Granules enrobes a base d'inhibiteur de l'enzyme de conversion de l'anfiotensine, leur procede de preparation et comprimes orodispersibles contenant les granules enrobes
US6975515B2 (en)	2001-08-15	2005-12-13	Agilent Technologies, Inc.	Electrical module
WO2004072040A1 (en) *	2003-02-12	2004-08-26	Ciba Specialty Chemicals Holding Inc.	Crystalline forms of pitavastatin calcium
WO2005123702A1 (en) *	2004-06-15	2005-12-29	Pfizer Limited	Neutral endopeptidase inhibitor polymorph
CN109350736A (zh) *	2018-09-20	2019-02-19	南通大学	防治运动病、梅尼埃病的药物及心房钠尿肽的医药用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8820844D0 (en) *	1988-09-05	1988-10-05	Pfizer Ltd	Therapeutic agents
US5208236A (en)	1992-09-23	1993-05-04	Schering Corporation	N-(acylaminomethyl)glutaryl amino acids and use

1993
- 1993-12-04 GB GB939324931A patent/GB9324931D0/en active Pending
1994
- 1994-11-07 TW TW083110283A patent/TW434210B/zh not_active IP Right Cessation
- 1994-11-07 TW TW089110999A patent/TW534901B/zh not_active IP Right Cessation
- 1994-11-09 CN CN94194942A patent/CN1068586C/zh not_active Expired - Fee Related
- 1994-11-09 WO PCT/EP1994/003750 patent/WO1995015308A1/en not_active Ceased
- 1994-11-09 KR KR1019960702912A patent/KR100203314B1/ko not_active Expired - Fee Related
- 1994-11-09 CZ CZ0160496A patent/CZ296428B6/cs not_active IP Right Cessation
- 1994-11-09 ES ES95900719T patent/ES2128031T3/es not_active Expired - Lifetime
- 1994-11-09 JP JP7515356A patent/JP2701988B2/ja not_active Expired - Fee Related
- 1994-11-09 RU RU96115251A patent/RU2131869C1/ru not_active IP Right Cessation
- 1994-11-09 PL PL94314794A patent/PL178559B1/pl not_active IP Right Cessation
- 1994-11-09 EP EP95900719A patent/EP0731787B1/en not_active Expired - Lifetime
- 1994-11-09 CA CA002178085A patent/CA2178085C/en not_active Expired - Fee Related
- 1994-11-09 NZ NZ276087A patent/NZ276087A/en not_active IP Right Cessation
- 1994-11-09 US US08/648,001 patent/US6180665B1/en not_active Expired - Fee Related
- 1994-11-09 DK DK95900719T patent/DK0731787T3/da active
- 1994-11-09 AT AT95900719T patent/ATE175664T1/de not_active IP Right Cessation
- 1994-11-09 HU HU9601506A patent/HU225959B1/hu not_active IP Right Cessation
- 1994-11-09 DE DE69416003T patent/DE69416003T2/de not_active Expired - Lifetime
- 1994-11-28 IL IL11179194A patent/IL111791A/en not_active IP Right Cessation
- 1994-11-28 PE PE1994255868A patent/PE9296A1/es not_active Application Discontinuation
- 1994-11-29 MY MYPI94003169A patent/MY115430A/en unknown
- 1994-12-01 EG EG75294A patent/EG20562A/xx active
- 1994-12-02 ZA ZA949595A patent/ZA949595B/xx unknown
1996
- 1996-06-03 FI FI962322A patent/FI120305B/fi not_active IP Right Cessation
- 1996-06-04 NO NO962294A patent/NO306714B1/no not_active IP Right Cessation
1999
- 1999-03-05 GR GR990400677T patent/GR3029590T3/el unknown

Also Published As

Publication number	Publication date
TW434210B (en)	2001-05-16
NZ276087A (en)	1997-11-24
KR960706470A (ko)	1996-12-09
HUT74683A (en)	1997-01-28
EP0731787A1 (en)	1996-09-18
AU684114B2 (en)	1997-12-04
PL314794A1 (en)	1996-09-30
CA2178085C (en)	2002-09-03
IL111791A (en)	2002-09-12
GB9324931D0 (en)	1994-01-26
HU225959B1 (en)	2008-01-28
MY115430A (en)	2003-06-30
AU8142494A (en)	1995-06-19
EG20562A (en)	1999-08-30
ATE175664T1 (de)	1999-01-15
EP0731787B1 (en)	1999-01-13
WO1995015308A1 (en)	1995-06-08
ZA949595B (en)	1996-06-03
JPH09500654A (ja)	1997-01-21
FI962322L (fi)	1996-06-03
CZ296428B6 (cs)	2006-03-15
NO962294D0 (no)	1996-06-04
RU2131869C1 (ru)	1999-06-20
HU9601506D0 (en)	1996-07-29
FI962322A0 (fi)	1996-06-03
ES2128031T3 (es)	1999-05-01
KR100203314B1 (ko)	1999-06-15
FI120305B (fi)	2009-09-15
CN1068586C (zh)	2001-07-18
TW534901B (en)	2003-06-01
DE69416003D1 (en)	1999-02-25
PL178559B1 (pl)	2000-05-31
IL111791A0 (en)	1995-01-24
JP2701988B2 (ja)	1998-01-21
CN1142816A (zh)	1997-02-12
DE69416003T2 (de)	1999-05-27
US6180665B1 (en)	2001-01-30
NO962294L (no)	1996-06-04
GR3029590T3 (en)	1999-06-30
NO306714B1 (no)	1999-12-13
CA2178085A1 (en)	1995-06-08
CZ160496A3 (en)	1996-11-13
PE9296A1 (es)	1996-04-04

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YU34896A (sh)	1999-09-27	Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
NO955047L (no)	1995-12-13	Sekundære aminer som antidiabetiske og antifedme-midler
DE69729583D1 (de)	2004-07-22	N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-on derivative als faktor xa inhibitoren
BR9806296B1 (pt)	2010-05-18	compostos de ácido sulfìnico, mistura, composição e uso dos mesmos.
NO961377D0 (no)	1996-04-03	Distamycin A-analoger som antitumor eller antivirale midler
EA200200510A1 (ru)	2002-10-31	4-карбоксиамино-2-этил-1,2,3,4-тетрагидрохинолин в кристаллической форме как ингибитор сетр
DK0532515T3 (da)	1997-04-21	Fremstilling af substituerede piperidiner
NZ331875A (en)	2000-01-28	Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs
ES2162907T3 (es)	2002-01-16	3-acilaminobenzacepinas.
DK0619806T3 (da)	1996-02-05	Fremstilling af substituerede piperidiner
BR9807988A (pt)	2000-03-08	Processo para a preparação de um composto, e, composto.
NO962294D0 (no)	1996-06-04	Krystallinsk, polymorf form av (S,S,S)-N-(1-[2-karboksy-3-(N2-mesyllysylamino)propylÅ-1-cyklopentylkarbonyl)-tyrosin
DE60235365D1 (de)	2010-04-01	Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
DK0745081T3 (da)	2002-05-21	Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer
BR0010488A (pt)	2002-02-13	Tienocicloalqu(en)ilamino-1,3,5-triazinas substituìdas
DK0613896T3 (da)	1999-04-26	Fremgangsmåde til fremstilling af sulfonylurinstofderivater
PL343546A1 (en)	2001-08-27	Processes for preparing intermediates
DK0971907T3 (da)	2002-06-10	Fremgangsmåde til fremstilling af 1,3-disubstituerede 2-nitroguanidiner
DK1320527T3 (da)	2008-12-01	Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
DE50206142D1 (de)	2006-05-11	Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
IL128835A (en)	2001-01-11	Intermediates for the preparation of crystalline, polymorphic (sss) -n- (1-[2-carboxy-3-(n<2>-mesyllysylamino)propyl]-1-cyclopentylcarbonyl) tyrosine
DK1572615T3 (da)	2010-06-14	Fremgangsmåde til syntese af peptider indeholdende en 4-hydroxyprolin-substruktur
EP1007511A4 (en)	2001-07-11	PRODUCTION OF BETA MEHTYLCARBAPENEM INTERMEDIATE PRODUCTS