DK0732928T3 - Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler - Google Patents

Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Info

Publication number
DK0732928T3
DK0732928T3 DK95901141T DK95901141T DK0732928T3 DK 0732928 T3 DK0732928 T3 DK 0732928T3 DK 95901141 T DK95901141 T DK 95901141T DK 95901141 T DK95901141 T DK 95901141T DK 0732928 T3 DK0732928 T3 DK 0732928T3
Authority
DK
Denmark
Prior art keywords
alkyl
silyl
phenols
cholesterol levels
serum cholesterol
Prior art date
Application number
DK95901141T
Other languages
English (en)
Inventor
Simon J T Mao
Mark T Yates
Roger A Parker
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0732928T3 publication Critical patent/DK0732928T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
DK95901141T 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler DK0732928T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10
EP95901141A EP0732928B1 (en) 1993-12-10 1994-11-03 Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols

Publications (1)

Publication Number Publication Date
DK0732928T3 true DK0732928T3 (da) 2005-04-18

Family

ID=22598245

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04016883T DK1468692T3 (da) 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom
DK95901141T DK0732928T3 (da) 1993-12-10 1994-11-03 Fremgangsmåde til sænkning af serumcholesterolnuiveauer med 2,6-di-alkyl-4-silyl-phenoler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04016883T DK1468692T3 (da) 1993-12-10 1994-11-03 Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom

Country Status (16)

Country Link
EP (3) EP1468693A3 (da)
JP (1) JPH09511222A (da)
CN (1) CN1092517C (da)
AT (2) ATE324113T1 (da)
AU (1) AU681731B2 (da)
CA (1) CA2177968C (da)
DE (2) DE69434720T2 (da)
DK (2) DK1468692T3 (da)
ES (2) ES2233937T3 (da)
HU (1) HU220761B1 (da)
IL (1) IL111905A (da)
NO (1) NO311868B1 (da)
NZ (1) NZ276285A (da)
PT (2) PT732928E (da)
WO (1) WO1995015760A1 (da)
ZA (1) ZA949663B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
ATE356113T1 (de) 1997-05-14 2007-03-15 Atherogenics Inc Probucolbernsteinsäureester zur hemmung der expression von vcam-1
ES2190592T3 (es) * 1997-06-24 2003-08-01 Aventis Pharma Inc Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes.
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
AU7588498A (en) * 1997-06-25 1999-01-04 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-{ (dimethyl-4-methoxyphenylsilyl) -methyloxy}phenol and 2,6-di-t-butyl-4-{ (dimethyl-2-methoxy-phenylsilyl) -methyloxy}phenol
AU8282798A (en) 1997-07-01 1999-01-25 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
AU1911200A (en) * 1998-11-09 2000-05-29 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
CA2428753C (en) 2000-11-17 2013-05-21 Universita Degli Studi Di Cagliari Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
IL162533A0 (en) 2001-12-19 2005-11-20 Atherogenics Inc Chalcone derivatives and their use to treat diseases
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
US7173129B2 (en) 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
JP2007509054A (ja) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド 血管健康を促進するシリルフェノール
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
EP2139320A4 (en) 2007-03-26 2010-09-08 Salutria Pharmaceuticals Llc METHODS AND COMPOSITIONS OF PROBUCOL DERIVATIVES FOR THE TREATMENT OF DIABETES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (da) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions

Also Published As

Publication number Publication date
EP1468692B1 (en) 2006-04-26
AU1049995A (en) 1995-06-27
ATE285238T1 (de) 2005-01-15
DE69434198D1 (de) 2005-01-27
DE69434720D1 (de) 2006-06-01
JPH09511222A (ja) 1997-11-11
EP1468693A2 (en) 2004-10-20
HU9601590D0 (en) 1996-08-28
IL111905A (en) 2001-04-30
DE69434720T2 (de) 2007-05-16
ATE324113T1 (de) 2006-05-15
EP0732928A1 (en) 1996-09-25
HU220761B1 (hu) 2002-05-28
ES2263094T3 (es) 2006-12-01
PT1468692E (pt) 2006-09-29
ES2233937T3 (es) 2005-06-16
EP1468692A3 (en) 2004-11-03
HUT74015A (en) 1996-10-28
ZA949663B (en) 1995-08-15
IL111905A0 (en) 1995-03-15
EP1468692A2 (en) 2004-10-20
EP1468693A3 (en) 2004-11-03
CA2177968C (en) 2000-03-28
WO1995015760A1 (en) 1995-06-15
NO962415D0 (no) 1996-06-07
NO311868B1 (no) 2002-02-11
CN1092517C (zh) 2002-10-16
NO962415L (no) 1996-06-07
PT732928E (pt) 2005-03-31
CN1140995A (zh) 1997-01-22
CA2177968A1 (en) 1995-06-15
AU681731B2 (en) 1997-09-04
EP0732928B1 (en) 2004-12-22
DK1468692T3 (da) 2006-08-28
DE69434198T2 (de) 2005-12-29
NZ276285A (en) 2004-11-26

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