PT732928E - Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois - Google Patents

Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois

Info

Publication number: PT732928E
Authority: PT; Portugal
Prior art keywords: silyphenois; dialquil; cholesterol levels; serum cholesterol; reducing serum
Prior art date: 1993-12-10

Application number

PT95901141T

Other languages

English (en)

Inventor

Roger A Parker

Simon J T Mao

Mark T Yates

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-11-03

Publication date

2005-03-31

1994-11-03 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

2005-03-31 Publication of PT732928E publication Critical patent/PT732928E/pt

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
-1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

PT95901141T 1993-12-10 1994-11-03 Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois PT732928E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16528193A	1993-12-10	1993-12-10

Publications (1)

Publication Number	Publication Date
PT732928E true PT732928E (pt)	2005-03-31

Family

ID=22598245

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT04016883T PT1468692E (pt)	1993-12-10	1994-11-03	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma
PT95901141T PT732928E (pt)	1993-12-10	1994-11-03	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT04016883T PT1468692E (pt)	1993-12-10	1994-11-03	Utilizacao de 2,6-dialquil-4-sililfenois para o tratamento do xantoma

Country Status (16)

Country	Link
EP (3)	EP0732928B1 (pt)
JP (1)	JPH09511222A (pt)
CN (1)	CN1092517C (pt)
AT (2)	ATE285238T1 (pt)
AU (1)	AU681731B2 (pt)
CA (1)	CA2177968C (pt)
DE (2)	DE69434720T2 (pt)
DK (2)	DK1468692T3 (pt)
ES (2)	ES2233937T3 (pt)
HU (1)	HU220761B1 (pt)
IL (1)	IL111905A (pt)
NO (1)	NO311868B1 (pt)
NZ (1)	NZ276285A (pt)
PT (2)	PT1468692E (pt)
WO (1)	WO1995015760A1 (pt)
ZA (1)	ZA949663B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
IL164568A0 (en)	1997-05-14	2005-12-18	Atherogenics Inc	Compounds and methods for the inhibition of the expression of vcam-1
ES2190592T3 (es) *	1997-06-24	2003-08-01	Aventis Pharma Inc	Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes.
JP2002506443A (ja) *	1997-06-25	2002-02-26	アベンティス・ファーマスーティカルズ・インコーポレイテッド	２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
US6133467A (en) *	1997-06-25	2000-10-17	Hoechst Marion Roussel, Inc.	2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2294247C (en)	1997-07-01	2004-10-26	Atherogenics, Inc.	Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en)	1998-11-09	2005-05-03	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
CN1332849A (zh) *	1998-11-09	2002-01-23	埃瑟若詹尼克斯公司	降低血浆胆固醇水平的方法和组合物
US6821738B2 (en)	1999-01-20	2004-11-23	The Board Of Regents For Oklahoma State University	Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (en)	2000-11-17	2002-05-23	Idenix (Cayman) Limited	Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CN1596240A (zh)	2001-12-19	2005-03-16	阿特罗吉尼克斯公司	查耳酮衍生物及其治疗疾病的用途
US6960683B2 (en)	2002-07-12	2005-11-01	Atherogenics, Inc.	Salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en)	2003-06-06	2004-12-16	Atherogenics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) *	2003-10-17	2005-05-06	Amylin Pharmaceuticals, Inc.	Silyl phenols for promoting vascular health
WO2005112914A2 (en)	2004-04-20	2005-12-01	Atherogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2008118948A1 (en)	2007-03-26	2008-10-02	Atherogenics, Inc.	Methods and compositions of derivatives of probucol for the treatment of diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE349046B (pt) *	1966-12-23	1972-09-18	C Guevne
FR2230376A1 (en) *	1973-05-24	1974-12-20	Gueyne Jean	Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) *	1975-04-21	1976-11-19	Cortial	Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) *	1982-07-12	1987-06-02	American Cyanamid Company	Antiatherosclerotic silanes
US4900757A (en) *	1988-12-08	1990-02-13	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) *	1990-07-05	1994-03-25	Merrell Dow Pharma	Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) *	1990-07-05	1992-10-13	Merrell Dow Pharmaceuticals Inc.	2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

1994
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 EP EP95901141A patent/EP0732928B1/en not_active Expired - Lifetime
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-11-03 EP EP04016884A patent/EP1468693A3/en not_active Withdrawn
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en not_active Ceased
- 1994-11-03 EP EP04016883A patent/EP1468692B1/en not_active Expired - Lifetime
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1092517C (zh)	2002-10-16
NO962415D0 (no)	1996-06-07
DE69434720D1 (de)	2006-06-01
EP1468693A2 (en)	2004-10-20
CN1140995A (zh)	1997-01-22
DK1468692T3 (da)	2006-08-28
PT1468692E (pt)	2006-09-29
DE69434720T2 (de)	2007-05-16
EP1468692B1 (en)	2006-04-26
WO1995015760A1 (en)	1995-06-15
NO962415L (no)	1996-06-07
HU220761B1 (hu)	2002-05-28
CA2177968A1 (en)	1995-06-15
HU9601590D0 (en)	1996-08-28
IL111905A (en)	2001-04-30
EP0732928B1 (en)	2004-12-22
AU1049995A (en)	1995-06-27
ZA949663B (en)	1995-08-15
ES2263094T3 (es)	2006-12-01
AU681731B2 (en)	1997-09-04
ES2233937T3 (es)	2005-06-16
NZ276285A (en)	2004-11-26
CA2177968C (en)	2000-03-28
ATE324113T1 (de)	2006-05-15
EP1468692A2 (en)	2004-10-20
DE69434198D1 (de)	2005-01-27
DE69434198T2 (de)	2005-12-29
JPH09511222A (ja)	1997-11-11
EP0732928A1 (en)	1996-09-25
IL111905A0 (en)	1995-03-15
NO311868B1 (no)	2002-02-11
EP1468692A3 (en)	2004-11-03
ATE285238T1 (de)	2005-01-15
HUT74015A (en)	1996-10-28
EP1468693A3 (en)	2004-11-03
DK0732928T3 (da)	2005-04-18

Publication	Publication Date	Title
PT732928E (pt)	2005-03-31	Metodo para a reducao dos niveis de colesterol serico com 2,6-dialquil-4-sililfenois
CA2046051A1 (en)	1992-01-06	2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
NO308739B1 (no)	2000-10-23	Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
BR1101017A (pt)	1999-12-07	Distamicina a análoga; processo para a apresentação de um composto; composição farmacêutica contendo um composto; e uso de um composto
DE69705480D1 (de)	2001-08-09	Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
PT98362A (pt)	1992-05-29	Processo para a preparacao de derivados de tioalquiltio-cefalosporina e de composicoes farmaceuticas que os contem
PT81855B (pt)	1987-11-30	Processo de preparacao de arilciclobutilalquilaminas e de composicoes farmaceuticas que as contem
FI882477A0 (fi)	1988-05-26	>nya alkansulfonanilidderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska blandningar.
EP0712398A1 (en)	1996-05-22	BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2140393T3 (es)	2000-03-01	Compuestos de penem.
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
ATE156487T1 (de)	1997-08-15	Mercapto-acetamid-derivate
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus
DK0532725T3 (da)	1997-06-02	Isoxazolderivater som lysfilterpræparater
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use