DK0734385T3 - Substituerede 2-carboxyalkyl-3-(fluorphenyl)-8-(3-halopropen-2-yl) nortropaner og deres anvendelse som kontrastmidler til neurodegenerative lidelser - Google Patents

Substituerede 2-carboxyalkyl-3-(fluorphenyl)-8-(3-halopropen-2-yl) nortropaner og deres anvendelse som kontrastmidler til neurodegenerative lidelser

Info

Publication number
DK0734385T3
DK0734385T3 DK95900419T DK95900419T DK0734385T3 DK 0734385 T3 DK0734385 T3 DK 0734385T3 DK 95900419 T DK95900419 T DK 95900419T DK 95900419 T DK95900419 T DK 95900419T DK 0734385 T3 DK0734385 T3 DK 0734385T3
Authority
DK
Denmark
Prior art keywords
halopropen
nortropanes
carboxyalkyl
fluorophenyl
substituted
Prior art date
Application number
DK95900419T
Other languages
English (en)
Inventor
David R Elmaleh
Bertha K Madras
Peter Meltzer
Robert N Hanson
Original Assignee
Harvard College
Gen Hospital Corp
Univ Northeastern
Organix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Gen Hospital Corp, Univ Northeastern, Organix Inc filed Critical Harvard College
Application granted granted Critical
Publication of DK0734385T3 publication Critical patent/DK0734385T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK95900419T 1993-10-25 1994-10-24 Substituerede 2-carboxyalkyl-3-(fluorphenyl)-8-(3-halopropen-2-yl) nortropaner og deres anvendelse som kontrastmidler til neurodegenerative lidelser DK0734385T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/142,584 US5493026A (en) 1993-10-25 1993-10-25 Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
PCT/US1994/012225 WO1995011901A1 (en) 1993-10-25 1994-10-24 Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging agents for neurodegenerative disorders

Publications (1)

Publication Number Publication Date
DK0734385T3 true DK0734385T3 (da) 2002-08-05

Family

ID=22500439

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95900419T DK0734385T3 (da) 1993-10-25 1994-10-24 Substituerede 2-carboxyalkyl-3-(fluorphenyl)-8-(3-halopropen-2-yl) nortropaner og deres anvendelse som kontrastmidler til neurodegenerative lidelser

Country Status (7)

Country Link
US (2) US5493026A (da)
EP (2) EP0734385B1 (da)
AT (1) ATE216385T1 (da)
DE (1) DE69430438T2 (da)
DK (1) DK0734385T3 (da)
ES (1) ES2172571T3 (da)
WO (1) WO1995011901A1 (da)

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WO1996039198A1 (en) * 1995-06-06 1996-12-12 RESEARCH BIOCHEMICALS, LIMITED PARTNERSHIP, doing business as RESEARCH BIOCHEMICALS INTERNATIONAL, A MASSACHUSETTS LIMITED PARTNERSHIP, WHOSE SOLE GENERAL PARTNER IS RBI MANAGEMENT, INC. Iodinated neuroprobes for mapping monoamine reuptake sites
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US7081238B2 (en) * 1995-11-03 2006-07-25 The President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
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FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
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US6344179B1 (en) 1999-04-22 2002-02-05 Emory University Fluoralkenyl nortropanes
US7553478B2 (en) * 1999-05-12 2009-06-30 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
US20100143248A1 (en) * 1999-06-28 2010-06-10 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment of adhd by assessing the dopamine transporter level
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US6440970B1 (en) 2000-05-25 2002-08-27 Targacept, Inc. Pharmaceutical compositions and methods for use
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Also Published As

Publication number Publication date
DE69430438T2 (de) 2002-11-21
US5493026A (en) 1996-02-20
WO1995011901A1 (en) 1995-05-04
ES2172571T3 (es) 2002-10-01
EP0734385B1 (en) 2002-04-17
EP0734385A4 (en) 1997-05-07
US5853696A (en) 1998-12-29
EP0734385A1 (en) 1996-10-02
EP1081147A2 (en) 2001-03-07
ATE216385T1 (de) 2002-05-15
DE69430438D1 (de) 2002-05-23

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