ES2172571T3 - 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos. - Google Patents

2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos.

Info

Publication number
ES2172571T3
ES2172571T3 ES95900419T ES95900419T ES2172571T3 ES 2172571 T3 ES2172571 T3 ES 2172571T3 ES 95900419 T ES95900419 T ES 95900419T ES 95900419 T ES95900419 T ES 95900419T ES 2172571 T3 ES2172571 T3 ES 2172571T3
Authority
ES
Spain
Prior art keywords
nortropans
halopropen
carboxialquil
fluorophenil
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95900419T
Other languages
English (en)
Inventor
David R Elmaleh
Bertha K Madras
Peter Meltzer
Robert N Hanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NORTHEASTERN, University of
General Hospital Corp
Organix Inc
Harvard University
Original Assignee
NORTHEASTERN, University of
General Hospital Corp
Organix Inc
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NORTHEASTERN, University of, General Hospital Corp, Organix Inc, Harvard University filed Critical NORTHEASTERN, University of
Application granted granted Critical
Publication of ES2172571T3 publication Critical patent/ES2172571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN CIERTOS ANALOGOS DE LA COCAINA UTILES PARA LA FORMACION DE IMAGENES DE LOS RECEPTORES DE LA COCAINA Y DE LOS RECEPTORES DE LA DOPAMINA. TAMBIEN SE PRESENTAN ANALOGOS UTILES PARA DIAGNOSTICOS MEDIANTE LA FORMACION DE IMAGENES PARA LA ENFERMEDAD DE PARKINSON.
ES95900419T 1993-10-25 1994-10-24 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos. Expired - Lifetime ES2172571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/142,584 US5493026A (en) 1993-10-25 1993-10-25 Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders

Publications (1)

Publication Number Publication Date
ES2172571T3 true ES2172571T3 (es) 2002-10-01

Family

ID=22500439

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95900419T Expired - Lifetime ES2172571T3 (es) 1993-10-25 1994-10-24 2-carboxialquil-3-(fluorofenil)-8-(3-halopropen-2-il) nortropanos sustituidos y su uso como agentes de representacion de imagenes para trastornos neurodegenerativos.

Country Status (7)

Country Link
US (2) US5493026A (es)
EP (2) EP0734385B1 (es)
AT (1) ATE216385T1 (es)
DE (1) DE69430438T2 (es)
DK (1) DK0734385T3 (es)
ES (1) ES2172571T3 (es)
WO (1) WO1995011901A1 (es)

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JP3731005B2 (ja) * 1995-06-06 2006-01-05 ジーイー ヘルスケア リミテッド モノアミン再取込み部位をマッピングするためのヨウ素標識ニューロプローブ
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US7081238B2 (en) * 1995-11-03 2006-07-25 The President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US6001330A (en) * 1997-09-12 1999-12-14 Elmaleh; David R. Diagnostic and therapeutic alkylenediamine compounds and process
US6525386B1 (en) * 1998-03-10 2003-02-25 Masimo Corporation Non-protruding optoelectronic lens
US6344179B1 (en) 1999-04-22 2002-02-05 Emory University Fluoralkenyl nortropanes
US7553478B2 (en) * 1999-05-12 2009-06-30 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
CA2285516C (en) * 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
US20100143248A1 (en) * 1999-06-28 2010-06-10 President And Fellows Of Harvard College Methods for diagnosing and monitoring treatment of adhd by assessing the dopamine transporter level
US6440970B1 (en) 2000-05-25 2002-08-27 Targacept, Inc. Pharmaceutical compositions and methods for use
JP2003534344A (ja) 2000-05-25 2003-11-18 ターガセプト，インコーポレイテッド ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
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CA2480742A1 (en) * 2002-03-28 2003-12-04 President And Fellows Of Harvard College Tropane compounds
JP4611017B2 (ja) * 2002-04-30 2011-01-12 エモリー ユニバーシティー 腫瘍画像化化合物
WO2005037832A2 (en) * 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
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US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
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US7732607B2 (en) * 2005-08-22 2010-06-08 Anatoly Mazurov Heteroaryl-substituted diazatricycloalkanes and methods of use thereof
TWI389889B (zh) 2006-05-09 2013-03-21 Targacept Inc （２ｓ）-（４ｅ）-ｎ-甲基-５-〔３-（５-異丙氧基吡啶）基〕-４-戊烯-２-胺之新穎多晶型
US8017785B2 (en) 2006-05-09 2011-09-13 Astrazeneca Ab Salt forms of (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)y1]-4-penten 2-amine
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TW200845977A (en) * 2007-03-30 2008-12-01 Targacept Inc Sub-type selective azabicycloalkane derivatives
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
EP2209497B1 (en) * 2007-09-26 2017-11-22 Philips Intellectual Property & Standards GmbH Compounds for use in a method of differentially diagnosing by spect different types of dementia
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US8084018B2 (en) * 2007-10-31 2011-12-27 Alseres Pharmaceuticals, Inc. Methods for imaging dopamine transporter level
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DE102008047314B4 (de) * 2008-09-16 2012-08-30 Johannes Gutenberg-Universität Mainz Radioaktiv-markierte Cyclopropan-Derivate DAT-affiner Tropane
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
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TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
US8802694B2 (en) 2009-12-07 2014-08-12 Targacept, Inc. 3,6-diazabicyclo[3.1.1]heptanes as neuronal nicotinic acetycholine receptor ligands
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Also Published As

Publication number Publication date
DE69430438T2 (de) 2002-11-21
EP1081147A2 (en) 2001-03-07
WO1995011901A1 (en) 1995-05-04
EP0734385A4 (en) 1997-05-07
DK0734385T3 (da) 2002-08-05
DE69430438D1 (de) 2002-05-23
EP0734385B1 (en) 2002-04-17
EP0734385A1 (en) 1996-10-02
US5493026A (en) 1996-02-20
US5853696A (en) 1998-12-29
ATE216385T1 (de) 2002-05-15

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