DK0737475T3 - Anvendelse af en muscarin antagonist til fremstilling af et medikament til behandling og regulering af okular udvikling - Google Patents

Anvendelse af en muscarin antagonist til fremstilling af et medikament til behandling og regulering af okular udvikling

Info

Publication number: DK0737475T3
Authority: DK; Denmark
Prior art keywords: antagonist; medicament; regulation; manufacture; treatment
Prior art date: 1989-06-21

Application number

DK96108497T

Other languages

English (en)

Inventor

Alan M Laties

Richard A Stone

Original Assignee

Univ Pennsylvania

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-21

Filing date

1990-06-14

Publication date

2001-10-08

1990-05-11 Priority claimed from US07/522,241 external-priority patent/US5122522A/en

1990-06-14 Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania

2001-10-08 Application granted granted Critical

2001-10-08 Publication of DK0737475T3 publication Critical patent/DK0737475T3/da

Links

229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
239000003149 muscarinic antagonist Substances 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 4
108010009685 Cholinergic Receptors Proteins 0.000 abstract 2
102000034337 acetylcholine receptors Human genes 0.000 abstract 2
230000000903 blocking effect Effects 0.000 abstract 2
230000001537 neural effect Effects 0.000 abstract 2
VSWPGAIWKHPTKX-UHFFFAOYSA-N 1-methyl-10-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one Chemical compound C1CN(C)CCN1CC(=O)N1C2=CC=CC=C2NC(=O)C2=CSC(C)=C21 VSWPGAIWKHPTKX-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
NXFZJIUCRCSWRK-UHFFFAOYSA-N cyclohexyl-[(4,4-dimethylpiperazin-4-ium-1-yl)methyl]-hydroxy-(2-methoxyphenyl)silane Chemical compound COC1=CC=CC=C1[Si](O)(C1CCCCC1)CN1CC[N+](C)(C)CC1 NXFZJIUCRCSWRK-UHFFFAOYSA-N 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
210000000609 ganglia Anatomy 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000003551 muscarinic effect Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
RMHMFHUVIITRHF-UHFFFAOYSA-N pirenzepine Chemical group C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 RMHMFHUVIITRHF-UHFFFAOYSA-N 0.000 abstract 1
229960004633 pirenzepine Drugs 0.000 abstract 1
210000002460 smooth muscle Anatomy 0.000 abstract 1
229950004351 telenzepine Drugs 0.000 abstract 1
210000001519 tissue Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96108497T 1989-06-21 1990-06-14 Anvendelse af en muscarin antagonist til fremstilling af et medikament til behandling og regulering af okular udvikling DK0737475T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36929389A	1989-06-21	1989-06-21
US07/522,241 US5122522A (en)	1989-06-21	1990-05-11	Treatment and control of ocular development

Publications (1)

Publication Number	Publication Date
DK0737475T3 true DK0737475T3 (da)	2001-10-08

Family

ID=27004525

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96108497T DK0737475T3 (da)	1989-06-21	1990-06-14	Anvendelse af en muscarin antagonist til fremstilling af et medikament til behandling og regulering af okular udvikling

Country Status (9)

Country	Link
US (2)	US5356892A (da)
EP (1)	EP0478694B1 (da)
JP (4)	JP3165436B2 (da)
AT (3)	ATE147626T1 (da)
CA (1)	CA2058768C (da)
DE (3)	DE69033246T2 (da)
DK (1)	DK0737475T3 (da)
ES (2)	ES2136686T3 (da)
WO (1)	WO1990015604A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1336490C (en) *	1988-06-03	1995-08-01	Paul Michael Iuvone	Pharmacological treatment of ocular development
ES2136686T3 (es) *	1989-06-21	1999-12-01	Univ Pennsylvania	Tratamiento y control de desarrollo ocular con agonistas colinergicos.
WO1993013777A1 (en) *	1992-01-21	1993-07-22	Merck & Co., Inc.	Method of using m1-selective antimuscarinic pyridobenzodiazepinones in axial myopia therapy
US5716952A (en) *	1992-03-18	1998-02-10	Allergan	Method for reducing intraocular pressure in the mammalian eye by administration of muscarinic antagonists
US5385939A (en) *	1993-04-30	1995-01-31	The Trustees Of The University Of Pennsylvania	GABA-ergic modulation of eye growth
US5756508A (en) *	1995-10-31	1998-05-26	Merck & Co., Inc.	Muscarine antagonists
CA2276287C (en) *	1997-01-06	2007-10-30	Klaus Trier Aps	Screening method for compounds active in treating myopia and hypermetropia
US6291466B1 (en)	1998-07-30	2001-09-18	Allergan Sales, Inc.	Cholinergic agents in the treatment of presbyopia
MXPA02007039A (es) *	2000-01-18	2003-09-25	Univ Pennsylvania	Crecimiento ocular y antagonistas nicotinicos.
BR0210013A (pt) *	2001-05-25	2004-08-10	Valley Forge Pharmaceuticals	Gel oftálmico de pirenzepina
ITUB20160876A1 (it)	2016-02-19	2017-08-19	Dambrosio Enzo Maria	Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU188852B (en) *	1983-03-16	1986-05-28	Richter Gedeon Vegyeszeti Gyar Rt,Hu	Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer
US4865599A (en) *	1986-08-18	1989-09-12	Houston Biotechnology, Inc.	Ophthalmic compositions for treating nerve degeneration
CA1336490C (en) *	1988-06-03	1995-08-01	Paul Michael Iuvone	Pharmacological treatment of ocular development
US5122522A (en) *	1989-06-21	1992-06-16	The Trustees Of The University Of Pennsylvania	Treatment and control of ocular development
ES2136686T3 (es) *	1989-06-21	1999-12-01	Univ Pennsylvania	Tratamiento y control de desarrollo ocular con agonistas colinergicos.
US5360801A (en) *	1989-06-21	1994-11-01	The Trustees Of The University Of Pennsylvania	Pharmacological stimulation of eye growth
US5055302A (en) *	1990-02-22	1991-10-08	Trustees Of The University Of Pennsylvania	Neuropeptide control of ocular growth
US5385939A (en) *	1993-04-30	1995-01-31	The Trustees Of The University Of Pennsylvania	GABA-ergic modulation of eye growth

1990
- 1990-06-14 ES ES94112616T patent/ES2136686T3/es not_active Expired - Lifetime
- 1990-06-14 EP EP90911118A patent/EP0478694B1/en not_active Expired - Lifetime
- 1990-06-14 WO PCT/US1990/003444 patent/WO1990015604A1/en not_active Ceased
- 1990-06-14 AT AT90911118T patent/ATE147626T1/de not_active IP Right Cessation
- 1990-06-14 DE DE69033246T patent/DE69033246T2/de not_active Expired - Fee Related
- 1990-06-14 ES ES96108497T patent/ES2159661T3/es not_active Expired - Lifetime
- 1990-06-14 JP JP51011290A patent/JP3165436B2/ja not_active Expired - Fee Related
- 1990-06-14 DE DE69033775T patent/DE69033775T2/de not_active Expired - Fee Related
- 1990-06-14 CA CA002058768A patent/CA2058768C/en not_active Expired - Fee Related
- 1990-06-14 AT AT96108497T patent/ATE203666T1/de not_active IP Right Cessation
- 1990-06-14 AT AT94112616T patent/ATE183085T1/de not_active IP Right Cessation
- 1990-06-14 DE DE69029734T patent/DE69029734T2/de not_active Expired - Fee Related
- 1990-06-14 DK DK96108497T patent/DK0737475T3/da active
1992
- 1992-03-24 US US07/856,626 patent/US5356892A/en not_active Expired - Lifetime
1994
- 1994-06-29 US US08/268,035 patent/US5637604A/en not_active Expired - Fee Related
2000
- 2000-02-17 JP JP2000039526A patent/JP3461778B2/ja not_active Expired - Fee Related
- 2000-07-11 JP JP2000210057A patent/JP2001081046A/ja active Pending
2003
- 2003-11-27 JP JP2003397487A patent/JP2004075695A/ja active Pending

Also Published As

Publication number	Publication date
US5356892A (en)	1994-10-18
HK1007681A1 (en)	1999-04-23
DE69033775T2 (de)	2001-11-15
JPH05500502A (ja)	1993-02-04
ATE183085T1 (de)	1999-08-15
EP0478694A4 (en)	1992-07-29
DE69033775D1 (de)	2001-09-06
CA2058768A1 (en)	1990-12-22
EP0478694B1 (en)	1997-01-15
JP2001081046A (ja)	2001-03-27
ATE147626T1 (de)	1997-02-15
WO1990015604A1 (en)	1990-12-27
US5637604A (en)	1997-06-10
ATE203666T1 (de)	2001-08-15
JP3461778B2 (ja)	2003-10-27
CA2058768C (en)	2004-08-03
DE69033246T2 (de)	1999-12-02
JP2004075695A (ja)	2004-03-11
DE69029734T2 (de)	1997-05-28
DE69029734D1 (de)	1997-02-27
JP2000204049A (ja)	2000-07-25
JP3165436B2 (ja)	2001-05-14
ES2159661T3 (es)	2001-10-16
ES2136686T3 (es)	1999-12-01
EP0478694A1 (en)	1992-04-08
DE69033246D1 (de)	1999-09-16

Publication	Publication Date	Title
HUP0203870A2 (hu)	2003-03-28	Adenozinreceptor agonistát vagy antagonistát tartalmazó gyógyászati készítmény
EP1100480A2 (en)	2001-05-23	Cholinergic agents in the treatment of presbyopia
PL336007A1 (en)	2000-06-05	Chemical compounds of benzocycloheptathiophene
BR9906772A (pt)	2000-09-26	Uso de ácido 11-(3-dimetilamino-propilideno)-6,11diidrodibenz[b,e]o xepin-2-acético para a fabricação de um medicamento para tratamento de desordens inflamatórias oftálmicas não-alérgicas e para prevenção de neovascularização ocular
EP0348360A3 (en)	1991-10-23	Pharmacological use of uridine in the treatment of nervous disorders
DE68918099D1 (de)	1994-10-13	Pharmazeutische behandlung einer augenentwicklung.
IE810785L (en)	1981-10-18	Anti-inflammatory ophthalmic composition
ATE183085T1 (de)	1999-08-15	Behandlung und regulierung der augenentwicklung mit cholinergischen agonisten
KR920702622A (ko)	1992-10-06	안구 발육의 치료 및 조절
JPH08511024A (ja)	1996-11-19	眼内圧を低下させる方法および組成物
UA41329C2 (uk)	2001-09-17	Фармацевтична композиція для лікування порушень серцевого ритму у великих ссавців та людей, похідні 3-фенілсульфоніл-3,7-діазабіцикло[3,3,1]нонану та лікарський засіб для лікування аритмії
HUT61467A (en)	1993-01-28	Process for producing pharmaceutical compositions comprising quisqualate receptor antagonist quinoxalinedione and suitable for treating parkinson's disease
CA2369054A1 (en)	1990-12-27	Treatment and control of ocular development
BR9708922A (pt)	1999-08-03	Piridil-e pirimidil-piperazinas no tratamento de doenças causadas por substâncias usadas em excesso
JPS6426518A (en)	1989-01-27	Remedy for hyperophthalmotony
JPS5572193A (en)	1980-05-30	9100dihydroo4hhbenzo45cycloheptaa 122bthiophenee499imine
BE1002099A3 (fr)	1990-07-03	Nouvelles quinazolinones tetracycliques, leur preparation et leur utilisation comme medicaments.
KR890001555A (ko)	1989-03-27	요산 배설용 조성물
TODOROV et al.	1991	Possible role of the α1-adrenoceptor in the modulation of adrenergic co-transmission in the guinea-pig vas deferens
James	1997	Drug-related neuropathy: low acetylcarnitine levels found
Tanaka et al.	1988	Effects of D-phenylalanine and proglumide on the inhibitory system of analgesia
CH648756A5 (it)	1985-04-15	(2-benzofuril)-(p-clorofenil)-carbinolo come normolipidemizzante e antiaggregante piastrinico.
IT1250634B (it)	1995-04-21	Enantiomeri di 2-(alfa tenoiltio) propionilglicina, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono