DK0737685T5 - Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse - Google Patents

Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse

Info

Publication number: DK0737685T5
Authority: DK; Denmark
Prior art keywords: alkyl; aryl; substd; arylalkyl; cycloalkyl
Prior art date: 1995-04-14

Application number

DK96400778T

Other languages

English (en)

Other versions

DK0737685T3 (da

Inventor

Marie-Claude Viaud

Daniel Mazeas

Herve Vandepoel

Pierre Renard

Bruno Pfeiffer

Philippe Delagrange

Gerald Guillaumet

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-14

Filing date

1996-04-11

Publication date

2001-01-02

1996-04-11 Application filed by Adir filed Critical Adir

2000-10-09 Application granted granted Critical

2000-10-09 Publication of DK0737685T3 publication Critical patent/DK0737685T3/da

2001-01-02 Publication of DK0737685T5 publication Critical patent/DK0737685T5/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
125000003118 aryl group Chemical group 0.000 abstract 5
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000001188 haloalkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
XWIYUCRMWCHYJR-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CC=C2NC=CC2=N1 XWIYUCRMWCHYJR-UHFFFAOYSA-N 0.000 abstract 1
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
YRTCKZIKGWZNCU-UHFFFAOYSA-N furo[3,2-b]pyridine Chemical compound C1=CC=C2OC=CC2=N1 YRTCKZIKGWZNCU-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 abstract 1
DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 1
125000004665 trialkylsilyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pyridine Compounds (AREA)

DK96400778T 1995-04-14 1996-04-11 Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse DK0737685T5 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9504504A FR2732969B1 (fr)	1995-04-14	1995-04-14	Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
DK0737685T3 DK0737685T3 (da)	2000-10-09
DK0737685T5 true DK0737685T5 (da)	2001-01-02

Family

ID=9478127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96400778T DK0737685T5 (da)	1995-04-14	1996-04-11	Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse

Country Status (16)

Country	Link
US (1)	US5714495A (da)
EP (1)	EP0737685B1 (da)
JP (1)	JP3723274B2 (da)
CN (1)	CN1058967C (da)
AT (1)	ATE194839T1 (da)
AU (1)	AU700071B2 (da)
CA (1)	CA2174033C (da)
DE (1)	DE69609371T2 (da)
DK (1)	DK0737685T5 (da)
ES (1)	ES2150642T3 (da)
FR (1)	FR2732969B1 (da)
GR (1)	GR3034620T3 (da)
NO (1)	NO305988B1 (da)
NZ (1)	NZ286360A (da)
PT (1)	PT737685E (da)
ZA (1)	ZA962934B (da)

Families Citing this family (39)

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Publication number	Priority date	Publication date	Assignee	Title
US5977131A (en) *	1997-04-09	1999-11-02	Pfizer Inc.	Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents
EP1178045B1 (en) *	1997-04-09	2003-05-28	Pfizer Inc.	Azaindole-ethylamine derivatives as nicotine acetylchlorine receptor binding agents
FR2763335B1 (fr) *	1997-05-16	2000-11-24	Adir	Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HRP20000209A2 (en)	1997-10-20	2001-04-30	Hoffmann La Roche	Bicyclic kinase inhibitors
US6025366A (en) *	1998-04-02	2000-02-15	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
WO1999051234A1 (en) *	1998-04-02	1999-10-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
CA2325995A1 (en) *	1998-04-02	1999-10-14	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
AU3210799A (en) *	1998-04-02	1999-10-25	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
EP1067930A4 (en) *	1998-04-02	2002-09-18	Merck & Co Inc	GONADOLIBER'S ANTAGONISTS
US6110931A (en) *	1998-04-02	2000-08-29	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US6228867B1 (en)	1998-04-02	2001-05-08	Merck & Co., Inc.	Antagonists of gonadotropin releasing hormone
US6232320B1 (en) *	1998-06-04	2001-05-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory compounds
US6696439B1 (en)	1999-02-26	2004-02-24	Eli Lilly And Company	5-HT1F agonists
JP2002537398A (ja) *	1999-02-26	2002-11-05	イーライ・リリー・アンド・カンパニー	５−ｈｔ１ｆアゴニスト
FR2799757B1 (fr) *	1999-10-15	2001-12-14	Adir	Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HUP0203895A3 (en) *	1999-12-24	2004-09-28	Aventis Pharma Ltd West Mallin	Substituted azaindoles and pharmaceutical compositions containing them and their use
GB0108770D0 (en)	2001-04-06	2001-05-30	Eisai London Res Lab Ltd	Inhibitors
GB0115109D0 (en)	2001-06-21	2001-08-15	Aventis Pharma Ltd	Chemical compounds
US6921762B2 (en)	2001-11-16	2005-07-26	Amgen Inc.	Substituted indolizine-like compounds and methods of use
EP2292615A1 (en) *	2002-02-01	2011-03-09	AstraZeneca AB	Quinazoline compounds
EP1490365B1 (en)	2002-03-28	2010-02-10	Eisai R&D Management Co., Ltd.	Azaindoles as inhibitors of c-jun n-terminal kinases
KR20040111445A (ko)	2002-03-28	2004-12-31	에자이 가부시키가이샤	신경퇴행성 질환 치료용 ｃ─ＪｕｎＮ─말단 키나아제억제제로서의 ７─아자인돌
ATE375349T1 (de)	2002-08-02	2007-10-15	Merck & Co Inc	Substituierte furo(2,3-b)pyridin derivate
US7432375B2 (en) *	2003-03-06	2008-10-07	Eisai R & D Management Co., Ltd.	JNK inhibitors
GB0305142D0 (en)	2003-03-06	2003-04-09	Eisai London Res Lab Ltd	Synthesis
US7612086B2 (en)	2003-05-16	2009-11-03	Eisai R & D Management Co. Ltd.	JNK inhibitors
GB0405055D0 (en) *	2004-03-05	2004-04-07	Eisai London Res Lab Ltd	JNK inhibitors
DK1784404T3 (da) *	2004-09-03	2012-02-13	Yuhan Corp	Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling
ES2426920T3 (es) *	2004-09-03	2013-10-25	Yuhan Corporation	Derivados de pirrolo[3,2-B]piridina y procesos para su preparación
US20060183758A1 (en) *	2005-02-17	2006-08-17	Cb Research And Development, Inc.	Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
GB0516156D0 (en) *	2005-08-05	2005-09-14	Eisai London Res Lab Ltd	JNK inhibitors
AU2006284751A1 (en) *	2005-09-01	2007-03-08	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
CL2007002617A1 (es)	2006-09-11	2008-05-16	Sanofi Aventis	Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
CN101605795A (zh) *	2006-12-08	2009-12-16	武田药品工业株式会社	三环化合物及其药物用途
WO2011109932A1 (en) *	2010-03-09	2011-09-15	F.Hoffmann-La Roche Ag	Novel process for the manufacture of 5-halogenated-7-azaindoles
EP2940022B1 (en) *	2014-04-30	2020-09-02	Masarykova Univerzita	Furopyridines as inhibitors of protein kinases
CN106045995B (zh) *	2016-06-13	2017-07-11	菏泽学院	一种5‑溴‑1H‑吡咯并[2,3‑b]吡啶的合成方法
ES2974634T3 (es)	2018-12-21	2024-06-28	Celgene Corp	Inhibidores de tienopiridinas de RIPK2
EP4735441A1 (en)	2023-06-28	2026-05-06	Psylo Pty Ltd	Pyrrolopyridine compounds for the treatment of mental illnesses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2680366B1 (fr) *	1991-08-13	1995-01-20	Adir	Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5552428A (en) *	1992-06-24	1996-09-03	Instituto Farmacologico Lombardo-Iflo, S.A.S.	Compounds effective in the treatment of circadian rhythms and related disorders, the novel pharmaceutical preparations and novel method of application
US6075037A (en) *	1994-06-09	2000-06-13	Smithkline Beecham Corporation	Endothelin receptor antagonists
CA2195850A1 (en) *	1994-08-03	1996-02-15	Asta Medica Aktiengesellschaft	Substituted indoles
US5541228A (en) *	1994-10-14	1996-07-30	Bristol-Myers Squibb Co.	Melatonergic agents

1995
- 1995-04-14 FR FR9504504A patent/FR2732969B1/fr not_active Expired - Fee Related
1996
- 1996-04-11 AT AT96400778T patent/ATE194839T1/de not_active IP Right Cessation
- 1996-04-11 EP EP96400778A patent/EP0737685B1/fr not_active Expired - Lifetime
- 1996-04-11 DE DE69609371T patent/DE69609371T2/de not_active Expired - Fee Related
- 1996-04-11 PT PT96400778T patent/PT737685E/pt unknown
- 1996-04-11 DK DK96400778T patent/DK0737685T5/da active
- 1996-04-11 ES ES96400778T patent/ES2150642T3/es not_active Expired - Lifetime
- 1996-04-12 CN CN96104624A patent/CN1058967C/zh not_active Expired - Fee Related
- 1996-04-12 CA CA002174033A patent/CA2174033C/fr not_active Expired - Fee Related
- 1996-04-12 ZA ZA962934A patent/ZA962934B/xx unknown
- 1996-04-12 AU AU50629/96A patent/AU700071B2/en not_active Ceased
- 1996-04-12 NO NO961457A patent/NO305988B1/no unknown
- 1996-04-12 US US08/631,234 patent/US5714495A/en not_active Expired - Fee Related
- 1996-04-12 NZ NZ286360A patent/NZ286360A/en unknown
- 1996-04-15 JP JP09242896A patent/JP3723274B2/ja not_active Expired - Fee Related
2000
- 2000-10-13 GR GR20000402305T patent/GR3034620T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2732969B1 (fr)	1997-05-16
CA2174033C (fr)	2001-07-24
CN1058967C (zh)	2000-11-29
ZA962934B (en)	1996-10-17
AU700071B2 (en)	1998-12-17
DE69609371D1 (de)	2000-08-24
EP0737685B1 (fr)	2000-07-19
JP3723274B2 (ja)	2005-12-07
CN1139111A (zh)	1997-01-01
AU5062996A (en)	1996-10-24
NZ286360A (en)	1997-09-22
CA2174033A1 (fr)	1996-10-15
NO961457D0 (no)	1996-04-12
US5714495A (en)	1998-02-03
DK0737685T3 (da)	2000-10-09
ES2150642T3 (es)	2000-12-01
GR3034620T3 (en)	2001-01-31
JPH08291172A (ja)	1996-11-05
DE69609371T2 (de)	2001-02-22
PT737685E (pt)	2000-10-31
NO961457L (no)	1996-10-15
FR2732969A1 (fr)	1996-10-18
EP0737685A1 (fr)	1996-10-16
ATE194839T1 (de)	2000-08-15
NO305988B1 (no)	1999-08-30

Publication	Publication Date	Title
DK0737685T3 (da)	2000-10-09	Pyrinderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske sammensætninger, der indeholder disse
DK131893D0 (da)	1993-11-24	2-(substitueret methyl)-4-(substitueret ethoxy)-5-(lavere alkyl)-pyridinforbindelser, farmaceutisk praeparat, som indeholder saadanne samt anvendelse af en saadan forbindelse til fremstilling af et farmaceutisk praeparat
NO304946B1 (no)	1999-03-08	Xantinderivat samt dets anvendelse
ATE204269T1 (de)	2001-09-15	Substituierte biphenyl- oder phenylpyridinderivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
HUP0000610A2 (hu)	2000-09-28	Fájdalomcsillapító hatású piperidinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
DK0506532T3 (da)	1995-02-20	Indolderivater, fremgangsmåde til fremstilling heraf samt lægemidler indeholdende disse
ES8404990A1 (es)	1984-05-16	Un procedimiento para la preparacion de derivados de prolina.
EP0299493A3 (en)	1990-05-23	N-û(2-oxopyrrolidin-1-yl)-acetyl¨piperazine derivatives and drug for senile dementia
ES2136947T3 (es)	1999-12-01	Amidas triciclicas, sus procedimientos de preparacion y las composiciones farmaceuticas que las contienen.
DK0873993T3 (da)	2002-06-10	Hidtil ukendte heterocykliske forbindelser, fremgangsmåde til deres fremstilling og sammensætninger indeholdende dem
PT916671E (pt)	2002-06-28	Novos inibidores de metaloproteases processo para a sua preparacao e as suas composicoes farmaceuticas que os contem
DK406587D0 (da)	1987-08-04	1,4-dihydropyridinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
EP0278610A3 (en)	1990-03-14	Novel pyridinyl-s-triazine derivatives, method for production thereof and a fungicide containing them as the active ingredient
DE2963724D1 (en)	1982-11-04	Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them