DK0739355T3 - Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf - Google Patents

Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf

Info

Publication number
DK0739355T3
DK0739355T3 DK95909223T DK95909223T DK0739355T3 DK 0739355 T3 DK0739355 T3 DK 0739355T3 DK 95909223 T DK95909223 T DK 95909223T DK 95909223 T DK95909223 T DK 95909223T DK 0739355 T3 DK0739355 T3 DK 0739355T3
Authority
DK
Denmark
Prior art keywords
proteins
kallikrein
analogs
inhibiting
disclosed
Prior art date
Application number
DK95909223T
Other languages
English (en)
Inventor
Robert Charles Ladner
William Markland
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/208,264 external-priority patent/US6057287A/en
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of DK0739355T3 publication Critical patent/DK0739355T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK95909223T 1994-01-11 1995-01-11 Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf DK0739355T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17996494A 1994-01-11 1994-01-11
US08/208,264 US6057287A (en) 1994-01-11 1994-03-10 Kallikrein-binding "Kunitz domain" proteins and analogues thereof
PCT/US1995/000299 WO1995021601A2 (en) 1994-01-11 1995-01-11 Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof

Publications (1)

Publication Number Publication Date
DK0739355T3 true DK0739355T3 (da) 2005-01-24

Family

ID=26875859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95909223T DK0739355T3 (da) 1994-01-11 1995-01-11 Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf

Country Status (10)

Country Link
US (3) US5795865A (da)
EP (1) EP0739355B1 (da)
JP (1) JP3805785B2 (da)
AT (1) ATE275583T1 (da)
CA (1) CA2180950C (da)
DE (1) DE69533472T2 (da)
DK (1) DK0739355T3 (da)
ES (1) ES2227545T3 (da)
PT (1) PT739355E (da)
WO (1) WO1995021601A2 (da)

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US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
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US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
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US20060025329A1 (en) * 1997-02-06 2006-02-02 Todd Hembrough Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
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US5981471A (en) 1997-02-06 1999-11-09 Entremed, Inc. Compositions and methods for inhibiting cellular proliferation
AU7553698A (en) * 1997-05-12 1998-12-08 Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno Method and construct for inhibition of cell migration
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
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US6087473A (en) * 1999-05-26 2000-07-11 Zymogenetics, Inc. Kunitz domain polypeptide and materials and methods for making it
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WO2001046230A2 (en) * 1999-12-22 2001-06-28 Zymogenetics, Inc. Kunitz domain polypeptide zkun11
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US7153829B2 (en) * 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
TR201900937T4 (tr) 2002-08-28 2019-02-21 Dyax Corp Organların ve dokuların muhafaza edilmesine yönelik yöntem.
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US6989369B2 (en) * 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
US8975370B2 (en) 2003-04-04 2015-03-10 Universite De Lausanne Inhibitor proteins of a protease and use thereof
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US8841259B2 (en) * 2005-02-24 2014-09-23 Joslin Diabetes Center Compositions and methods for treating vascular permeability
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US8828703B2 (en) 2005-12-29 2014-09-09 Dyax Corp. Protease inhibition
DK1976985T3 (da) * 2005-12-29 2013-10-21 Univ California Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
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WO2014113712A1 (en) 2013-01-20 2014-07-24 Dyax Corp. Evaluation and treatment of bradykinin-mediated disorders
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Also Published As

Publication number Publication date
PT739355E (pt) 2005-01-31
CA2180950C (en) 2005-03-29
WO1995021601A2 (en) 1995-08-17
DE69533472T2 (de) 2006-01-12
ATE275583T1 (de) 2004-09-15
US5994125A (en) 1999-11-30
US5795865A (en) 1998-08-18
EP0739355A1 (en) 1996-10-30
JP3805785B2 (ja) 2006-08-09
ES2227545T3 (es) 2005-04-01
US6333402B1 (en) 2001-12-25
JPH09511131A (ja) 1997-11-11
DE69533472D1 (de) 2004-10-14
EP0739355B1 (en) 2004-09-08
CA2180950A1 (en) 1995-08-17
WO1995021601A3 (en) 1995-09-21

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