ATE136221T1 - Osteo-induktive pharmazeutische formulierungen - Google Patents

Osteo-induktive pharmazeutische formulierungen

Info

Publication number: ATE136221T1
Authority: AT; Austria
Prior art keywords: pharmaceutical formulations; inductive; osteo; cartilage; formulations
Prior art date: 1990-06-18

Application number

AT91911720T

Other languages

English (en)

Inventor

Tobin N Gerhart

Elizabeth A Wang

Mary Jo Kriz

Original Assignee

Genetics Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-18

Filing date

1991-06-18

Publication date

1996-04-15

1991-06-18 Application filed by Genetics Inst filed Critical Genetics Inst

1996-04-15 Application granted granted Critical

1996-04-15 Publication of ATE136221T1 publication Critical patent/ATE136221T1/de

Links

230000002138 osteoinductive effect Effects 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
210000000988 bone and bone Anatomy 0.000 abstract 2
210000000845 cartilage Anatomy 0.000 abstract 2
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 abstract 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
239000000504 antifibrinolytic agent Substances 0.000 abstract 1
230000007547 defect Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000003001 serine protease inhibitor Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physical Education & Sports Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Rheumatology (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91911720T 1990-06-18 1991-06-18 Osteo-induktive pharmazeutische formulierungen ATE136221T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/539,756 US5364839A (en)	1990-06-18	1990-06-18	Osteoinductive pharmaceutical formulations

Publications (1)

Publication Number	Publication Date
ATE136221T1 true ATE136221T1 (de)	1996-04-15

Family

ID=24152509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91911720T ATE136221T1 (de)	1990-06-18	1991-06-18	Osteo-induktive pharmazeutische formulierungen

Country Status (10)

Country	Link
US (1)	US5364839A (de)
EP (1)	EP0535091B1 (de)
JP (1)	JP3191937B2 (de)
AT (1)	ATE136221T1 (de)
CA (1)	CA2085750C (de)
DE (1)	DE69118535T2 (de)
DK (1)	DK0535091T3 (de)
ES (1)	ES2088006T3 (de)
GR (1)	GR3019901T3 (de)
WO (1)	WO1991019510A1 (de)

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US6197325B1 (en)	1990-11-27	2001-03-06	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
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US6638912B2 (en)	1995-05-01	2003-10-28	The Regents Of The University Of California	Peptide compositions mimicking TGF-β activity
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US5700774A (en) *	1996-03-26	1997-12-23	Genetics Institute, Inc.	Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
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JP2002515793A (ja)	1996-10-23	2002-05-28	オーレイテックインターヴェンションズインコーポレイテッド	椎間円板を治療するための方法及び装置
US6593290B1 (en) *	1996-11-01	2003-07-15	Genentech, Inc.	Treatment of inner ear hair cells
US7255712B1 (en)	1997-04-15	2007-08-14	Active Implants Corporation	Bone growth promoting implant
CN1068793C (zh) *	1997-04-17	2001-07-25	中国人民解放军第四军医大学全军创伤骨科研究所	骨生长刺激素注射剂及其制备方法
CA2312009A1 (en) *	1997-11-28	1999-06-10	Roche Diagnostics Gmbh	An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
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DE19841698A1 (de) *	1998-09-11	2000-03-16	Curative Technologies Gmbh	Wachstumsfaktor-enthaltende Zusammensetzung zur Heilung von Gewebeschäden
PT1141014E (pt)	1999-01-06	2005-04-29	Genentech Inc	Variante mutante do factor de crescimento semelhante a insulina (igf-i)
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
EP2286847A1 (de)	1999-10-15	2011-02-23	Genetics Institute, LLC	Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine
JP2003528149A (ja)	2000-03-24	2003-09-24	ジェネンテック・インコーポレーテッド	軟骨性疾患の治療のためのインスリンの使用
DE10020125A1 (de) *	2000-04-18	2001-10-25	Friedrich Schiller Uni Jena Bu	Agens für den postoperativen Einsatz nach Entfernung von Knochentumoren
ES2301547T3 (es)	2000-05-16	2008-07-01	Genentech, Inc.	Tratamiento de trastornos del cartilago.
ES2304401T3 (es)	2000-10-16	2008-10-16	Genentech, Inc.	Metodos de tratamiento que utilizan polipeptidos wisp.
US20020114795A1 (en)	2000-12-22	2002-08-22	Thorne Kevin J.	Composition and process for bone growth and repair
US7226587B2 (en)	2001-06-01	2007-06-05	Wyeth	Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
US20030124118A1 (en) *	2001-11-27	2003-07-03	Rasmus Rojkjaer	Pharmaceutical composition comprising factor VII polypeptides and protein S inhibitors
US20080057059A1 (en) *	2001-11-09	2008-03-06	Novo Nordisk Healthcare A/G	Pharmaceutical Composition Comprising Factor VII Polypeptides and Protein S Inhibitors
JP2005510516A (ja) *	2001-11-09	2005-04-21	ノボノルディスクヘルスケアアクチェンゲゼルシャフト	Ｖｉｉ因子ポリペプチドおよびプロテインｓ阻害剤を含む薬学的組成物
CN1596091A (zh)	2001-12-04	2005-03-16	迪斯酋有限公司	用于承重用途的植入体
CN100586398C (zh)	2002-05-23	2010-02-03	活性移植公司	植入体
ES2282904T3 (es)	2003-09-12	2007-10-16	Wyeth	Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas.
US20060239951A1 (en) *	2005-03-30	2006-10-26	Alexandre Valentin	Methods for stimulating hair growth by administering BMPs
WO2006105161A2 (en) *	2005-03-30	2006-10-05	Cartilix, Inc.	Coated medical device
US7718616B2 (en)	2006-12-21	2010-05-18	Zimmer Orthobiologics, Inc.	Bone growth particles and osteoinductive composition thereof
WO2009064838A1 (en)	2007-11-15	2009-05-22	Amgen, Inc.	Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration
KR20150002874A (ko)	2008-05-05	2015-01-07	노비뮨 에스 에이	항-ｉｌ-１７ａ／ｉｌ-１７ｆ 교차-반응성 항체 및 그의 사용 방법
US8137671B2 (en)	2009-05-05	2012-03-20	Genentech, Inc.	Anti-IL-17F antibodies
WO2012068135A1 (en)	2010-11-15	2012-05-24	Zimmer Orthobiologics, Inc.	Bone void fillers
US11596712B2 (en)	2017-10-19	2023-03-07	Genera Istrazivanja D.O.O.	Autologous bone graft substitute composition
WO2019076484A1 (en) *	2017-10-19	2019-04-25	Perform Biologics, Inc.	SUBSTITUTE OF AUTOLOGOUS BONE TRANSPLANT
WO2025168104A1 (en) *	2024-02-08	2025-08-14	Angitia Biomedicines Limited	Pharmaceutical composition for inducing new bone formation and method for enhancing spinal fusion and treating bone defects

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US4186448A (en) *	1976-04-16	1980-02-05	Brekke John H	Device and method for treating and healing a newly created bone void
SU733665A1 (ru) *	1978-03-30	1980-05-15	Семипалатинский Государственный Медицинский Институт	Способ остеосинтеза трубчатых костей
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EP0166263A1 (de) *	1984-05-31	1986-01-02	Green Cross Corporation	Füllmaterial für Knochendefekte oder Knochenhohlräume, Kit oder Set zur Herstellung dieses Füllmaterials
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US5108436A (en) *	1988-09-29	1992-04-28	Collagen Corporation	Implant fixation
DE3939346A1 (de) *	1989-11-29	1991-06-06	Behringwerke Ag	Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide

1990
- 1990-06-18 US US07/539,756 patent/US5364839A/en not_active Expired - Lifetime
1991
- 1991-06-18 EP EP91911720A patent/EP0535091B1/de not_active Expired - Lifetime
- 1991-06-18 DK DK91911720.0T patent/DK0535091T3/da active
- 1991-06-18 DE DE69118535T patent/DE69118535T2/de not_active Expired - Fee Related
- 1991-06-18 WO PCT/US1991/004337 patent/WO1991019510A1/en not_active Ceased
- 1991-06-18 JP JP51154491A patent/JP3191937B2/ja not_active Expired - Fee Related
- 1991-06-18 CA CA002085750A patent/CA2085750C/en not_active Expired - Fee Related
- 1991-06-18 AT AT91911720T patent/ATE136221T1/de not_active IP Right Cessation
- 1991-06-18 ES ES91911720T patent/ES2088006T3/es not_active Expired - Lifetime
1996
- 1996-05-13 GR GR960401283T patent/GR3019901T3/el unknown

Also Published As

Publication number	Publication date
DK0535091T3 (da)	1996-05-06
WO1991019510A1 (en)	1991-12-26
DE69118535T2 (de)	1996-09-26
CA2085750C (en)	2003-02-18
EP0535091B1 (de)	1996-04-03
ES2088006T3 (es)	1996-08-01
JPH05507930A (ja)	1993-11-11
EP0535091A1 (de)	1993-04-07
GR3019901T3 (en)	1996-08-31
JP3191937B2 (ja)	2001-07-23
CA2085750A1 (en)	1991-12-19
US5364839A (en)	1994-11-15
DE69118535D1 (de)	1996-05-09

Legal Events

Date	Code	Title
1996-11-15	UEP	Publication of translation of european patent specification
2003-02-15	EEFA	Change of the company name
2005-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69118535D1 (de)	1996-05-09	Osteo-induktive pharmazeutische formulierungen
NO971889D0 (no)	1997-04-24	Forbindelser og sammensetninger for levering av aktive midler
ATE230757T1 (de)	2003-01-15	Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten
EP0693928A4 (de)	1998-06-03	Aminozucker- und glykosaminoglykanzusammensetzung zur behandlung und reparatus von bindegewebe
DE69835279D1 (de)	2006-08-31	Zusammensetzungen und verfahren zur behandlung von infektionen unter verwendung von kationischen peptiden allein oder in kombination mit antibiotika
PT739355E (pt)	2005-01-31	Proteinas de 'dominio de kunitz' inibidoras de calicreina e seus analogos
DK0484401T3 (da)	1996-09-30	Fremstilling af vaskulær endothelcellevækstfaktor
FI961037A0 (fi)	1996-03-06	Valmisteet osteogenisten proteiinien antamiseksi
ATE73459T1 (de)	1992-03-15	Pharmazeutische zusammensetzungen, welche ein dipeptid enthalten.
EP0625340A3 (de)	1995-03-29	Manschette zur Heilbeschleunigung von Knochendefekten.
DE69232323D1 (de)	2002-02-07	Verwendung von Adenosinantagonisten zur Vorbeugung und Behandlung von Pankreatitis und Ulcera
ATE187740T1 (de)	2000-01-15	Modifizierte proteine und peptide enthaltende pharmazeutische mittel
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ITMI931649A1 (it)	1995-01-23	Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
RU94046091A (ru)	1996-09-27	Полипептидные антагонисты бомбезина, фармацевтическая композиция и способ лечения
ATE253589T1 (de)	2003-11-15	Bmp-5-derivate
DE69420229D1 (de)	1999-09-30	Pharmazeutische Zusammensetzung zur Behandlung von AIDS
IL83775A (en)	1991-12-15	Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis
DK0687270T3 (da)	2000-10-30	Osteogene vækstoligopeptider og farmaceutiske præparater indeholdende disse
EP1080724A4 (de)	2004-06-23	Zusammenstellung die die mpt-aktivität mindert
NZ235497A (en)	1993-05-26	Peptides (possibly related to hirudin) and pharmaceutical compositions for reducing blood coagulation