DK0741728T3 - Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter - Google Patents

Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter

Info

Publication number: DK0741728T3
Authority: DK; Denmark
Prior art keywords: synthesis; carbapene; intermediates; improved method; compound
Prior art date: 1994-01-25

Application number

DK95909293T

Other languages

English (en)

Inventor

Thomas Meng-Han Liu

Joseph E Lynch

Ralph P Volante

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-25

Filing date

1995-01-20

Publication date

2001-09-03

1995-01-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2001-09-03 Application granted granted Critical

2001-09-03 Publication of DK0741728T3 publication Critical patent/DK0741728T3/da

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
239000002841 Lewis acid Substances 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000008049 diazo compounds Chemical class 0.000 abstract 1
238000006345 epimerization reaction Methods 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
-1 methyl compound Chemical class 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229910052703 rhodium Inorganic materials 0.000 abstract 1
239000010948 rhodium Substances 0.000 abstract 1
MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK95909293T 1994-01-25 1995-01-20 Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter DK0741728T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/186,207 US5493018A (en)	1994-01-25	1994-01-25	Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
PCT/US1995/000855 WO1995019979A1 (en)	1994-01-25	1995-01-20	Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number	Publication Date
DK0741728T3 true DK0741728T3 (da)	2001-09-03

Family

ID=22684063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95909293T DK0741728T3 (da)	1994-01-25	1995-01-20	Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter

Country Status (12)

Country	Link
US (1)	US5493018A (da)
EP (1)	EP0741728B1 (da)
JP (1)	JPH09508124A (da)
AT (1)	ATE201874T1 (da)
AU (1)	AU677762B2 (da)
CA (1)	CA2178935A1 (da)
DE (1)	DE69521199T2 (da)
DK (1)	DK0741728T3 (da)
ES (1)	ES2157323T3 (da)
GR (1)	GR3036005T3 (da)
PT (1)	PT741728E (da)
WO (1)	WO1995019979A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7682603B2 (en) *	2003-07-25	2010-03-23	The Trustees Of The University Of Pennsylvania	Polymersomes incorporating highly emissive probes
KR100959027B1 (ko)	2007-11-12	2010-05-24	성균관대학교산학협력단	아연 화합물을 보조 촉매로 이용하는 페넴 중간체의 제조방법
DK2326648T3 (da) *	2008-07-30	2012-10-15	Ranbaxy Lab Ltd	Fremgangsmåde til fremstillingen af carbapenemforbindelser
KR101049267B1 (ko) *	2008-10-22	2011-07-13	제이더블유중외제약 주식회사	베타-메틸 비닐 포스페이트 카바페넴의 입체 선택적 제조방법
WO2011048583A1 (en)	2009-10-23	2011-04-28	Ranbaxy Laboratories Limited	Process for the preparation of carbapenem compounds
CN101891766A (zh) *	2010-07-20	2010-11-24	深圳市海滨制药有限公司	一种β甲基碳青霉烯类抗生素母核的制备方法
WO2017132321A1 (en)	2016-01-29	2017-08-03	The Johns Hopkins University	Novel inhibitors of bacterial growth

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4349687A (en) *	1980-01-14	1982-09-14	Merck & Co., Inc.	Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4499278A (en) *	1980-01-14	1985-02-12	Merck & Co., Inc.	Trans-3-carboxymethylene-4-carboxy-5-methyl-delta2-isoxazoline as intermediate
US4287123A (en) *	1980-01-14	1981-09-01	Merck & Co., Inc.	Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4739048A (en) *	1980-05-29	1988-04-19	Merck & Co., Inc.	Process for the preparation of thienamycin and intermediates
US4378315A (en) *	1980-05-29	1983-03-29	Merck & Co., Inc.	Process for the preparation of thienamycin and intermediates
US4473502A (en) *	1981-04-08	1984-09-25	Merck & Co., Inc.	Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4467107A (en) *	1981-04-08	1984-08-21	Merck & Co., Inc.	1-Hydroxyethyl-2-amino pentanedioic acid derivatives
US4816577A (en) *	1986-04-07	1989-03-28	Merck & Co., Inc.	Process for producing 1-beta-methylcarbapenem antibiotic intermediates
US4866171A (en) *	1987-04-11	1989-09-12	Lederle (Japan), Ltd.	(1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5051502A (en) *	1990-06-06	1991-09-24	University Of Notre Dame Du Lac	Rhodium catalyzed cyclization process for bicyclic β-lactams

1994
- 1994-01-25 US US08/186,207 patent/US5493018A/en not_active Expired - Lifetime
1995
- 1995-01-20 DE DE69521199T patent/DE69521199T2/de not_active Expired - Fee Related
- 1995-01-20 AU AU17302/95A patent/AU677762B2/en not_active Ceased
- 1995-01-20 DK DK95909293T patent/DK0741728T3/da active
- 1995-01-20 WO PCT/US1995/000855 patent/WO1995019979A1/en not_active Ceased
- 1995-01-20 JP JP7519697A patent/JPH09508124A/ja active Pending
- 1995-01-20 ES ES95909293T patent/ES2157323T3/es not_active Expired - Lifetime
- 1995-01-20 EP EP95909293A patent/EP0741728B1/en not_active Expired - Lifetime
- 1995-01-20 CA CA002178935A patent/CA2178935A1/en not_active Abandoned
- 1995-01-20 PT PT95909293T patent/PT741728E/pt unknown
- 1995-01-20 AT AT95909293T patent/ATE201874T1/de not_active IP Right Cessation
2001
- 2001-06-07 GR GR20010400120T patent/GR3036005T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0741728B1 (en)	2001-06-06
ATE201874T1 (de)	2001-06-15
WO1995019979A1 (en)	1995-07-27
DE69521199T2 (de)	2001-11-08
AU677762B2 (en)	1997-05-01
PT741728E (pt)	2001-09-28
DE69521199D1 (de)	2001-07-12
US5493018A (en)	1996-02-20
EP0741728A1 (en)	1996-11-13
GR3036005T3 (en)	2001-09-28
AU1730295A (en)	1995-08-08
JPH09508124A (ja)	1997-08-19
ES2157323T3 (es)	2001-08-16
EP0741728A4 (en)	1997-04-02
CA2178935A1 (en)	1995-07-27

Similar Documents

Publication	Publication Date	Title
DK0923568T5 (da)	2003-11-03	Hidtil ukendte benzofuran-4-carboxamider
DE69303032D1 (de)	1996-07-11	Als süsstoffe brauchbare verbindungen und hir herstellungsverfahren
ATE229960T1 (de)	2003-01-15	Verfahren zur herstellung von 13-ether-derivaten von milbemycinen und zwischenprodukte
ES2126697T3 (es)	1999-04-01	Inhibidores de enzimas de conversion de angiotensina que contienen lactamas de anillos multiples.
NO975727D0 (no)	1997-12-05	Fremstilling av levulinsyre fra karbohydratholdige materialer
DK0915866T3 (da)	2002-06-10	Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre
DK0645389T3 (da)	1997-03-10	Fremgangsmåde til fremstilling af imidazopyridinderivater
DK0741728T3 (da)	2001-09-03	Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter
ATE225774T1 (de)	2002-10-15	Imidazolidinonderivate als korrosionsinhibitoren
FI875596A0 (fi)	1987-12-18	Foerfarande foer framstaellning av tienyletylaminer och aeven ditienyletylaminer.
EA199900221A1 (ru)	1999-08-26	Синтез бисиндолилмалеимидов
DE69431824D1 (de)	2003-01-16	Verfahren zur Herstellung von Schwefelhaltigen Imidazolderivaten und erhaltene Zwischenprodukte
ES2097594T3 (es)	1997-04-01	Procedimiento para la preparacion de derivados de imidazopiridina.
FI951350A0 (fi)	1995-03-22	Menetelmä substituoitujen imisadsoliyhdisteiden käyttökelpoisten välituotteiden syntetisoimiseksi
LV10234A (lv)	1994-10-20	Trijodbenzola savienojumu iegusanas metode
DK16783D0 (da)	1983-01-17	Fremgangsmade til fremstilling af 3-(1h-tetrazol-5-yl)-4(3h)-quinazolinoner
FI982486A0 (fi)	1998-11-17	Välituotteet bis-atsa-bisyklisille ahdistusta lievittäville aineille
FI902590A0 (fi)	1990-05-24	Foerfarande foer framstaellning av 2-oxoindol-1-karboxamider.
ATE106871T1 (de)	1994-06-15	Pyridinderivate und verfahren zu ihrer synthese.
DE69524462D1 (de)	2002-01-24	Verwendung der Seminalribonuklease als antimetastatische Verbindung
RU94045824A (ru)	1996-07-10	Способ получения 3-карбониландростадиен-17-карбоксамидов
IT8622825A0 (it)	1986-12-23	Intermedi per la sintesi dicomposti organici.
ATE169908T1 (de)	1998-09-15	Verfahren zur herstellung von gegebenenfalls 2- substituierten 5-chlorimidazol-4-carbaldehyden
ES8603861A1 (es)	1986-01-01	Un procedimiento para preparar derivados sustituidos de 1,3 -dioxano
DE69615570D1 (de)	2001-10-31	Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten