DK2326648T3 - Fremgangsmåde til fremstillingen af carbapenemforbindelser - Google Patents
Fremgangsmåde til fremstillingen af carbapenemforbindelserInfo
- Publication number
- DK2326648T3 DK2326648T3 DK09786765.9T DK09786765T DK2326648T3 DK 2326648 T3 DK2326648 T3 DK 2326648T3 DK 09786765 T DK09786765 T DK 09786765T DK 2326648 T3 DK2326648 T3 DK 2326648T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- carbapenem compounds
- carbapenem
- compounds
- Prior art date
Links
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1808DE2008 | 2008-07-30 | ||
| PCT/IB2009/053332 WO2010013223A1 (en) | 2008-07-30 | 2009-07-30 | Process for the preparation of carbapenem compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2326648T3 true DK2326648T3 (da) | 2012-10-15 |
Family
ID=41066372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09786765.9T DK2326648T3 (da) | 2008-07-30 | 2009-07-30 | Fremgangsmåde til fremstillingen af carbapenemforbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8841444B2 (da) |
| EP (1) | EP2326648B1 (da) |
| KR (1) | KR20110049823A (da) |
| AU (1) | AU2009277936B2 (da) |
| CA (1) | CA2732619A1 (da) |
| DK (1) | DK2326648T3 (da) |
| ES (1) | ES2391713T3 (da) |
| PT (1) | PT2326648E (da) |
| WO (1) | WO2010013223A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293894B2 (en) * | 2006-11-20 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
| WO2011048583A1 (en) * | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
| US8580985B2 (en) * | 2011-12-19 | 2013-11-12 | Biosynthetic Technologies, Llc | Processes for preparing estolide base oils and oligomeric compounds that include cross metathesis |
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| US4273709A (en) * | 1979-07-23 | 1981-06-16 | Merck & Co., Inc. | Process for the preparation of thienamycin and intermediates |
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| US4282148A (en) * | 1980-01-14 | 1981-08-04 | Merck & Co., Inc. | Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid |
| US4499278A (en) * | 1980-01-14 | 1985-02-12 | Merck & Co., Inc. | Trans-3-carboxymethylene-4-carboxy-5-methyl-delta2-isoxazoline as intermediate |
| US4350631A (en) * | 1980-12-18 | 1982-09-21 | Merck & Co., Inc. | 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates |
| US4360684A (en) * | 1981-04-08 | 1982-11-23 | Merck & Co., Inc. | Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid |
| US4552873A (en) | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| US4683296A (en) * | 1983-03-07 | 1987-07-28 | Bristol-Myers Company | Carbapenem intermediates |
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| US5310897A (en) * | 1984-12-27 | 1994-05-10 | Sumitomo Pharmaceuticals Co., Ltd. | Beta-lactams and their production |
| US5104984A (en) * | 1985-03-29 | 1992-04-14 | Merck & Co., Inc. | Enantioselective process for producing 1-beta-methyl carbapenem antibiotic intermediates |
| US4833167A (en) * | 1985-06-10 | 1989-05-23 | Merck & Co., Inc. | 2-aza-substituted 1-carbadethiapen-2-em-3-carboxylic acids |
| EP0213610A1 (en) * | 1985-08-31 | 1987-03-11 | Lederle (Japan) Ltd. | Azetidin-2-one derivatives and process for production thereof |
| JPS62169781A (ja) | 1986-01-21 | 1987-07-25 | Sankyo Co Ltd | β−ラクタム化合物 |
| US5231179A (en) * | 1986-01-27 | 1993-07-27 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds and their production |
| EP0243686B1 (en) * | 1986-03-27 | 1992-07-15 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production |
| GB8607921D0 (en) * | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
| IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| JPS63112558A (ja) | 1986-10-30 | 1988-05-17 | Fujisawa Pharmaceut Co Ltd | ４−（１−置換アリル）−２−アゼチジノン化合物の製造方法 |
| JP2510860B2 (ja) | 1987-02-02 | 1996-06-26 | 住友製薬株式会社 | 新規なβ−ラクタム誘導体の製造方法 |
| US4866171A (en) * | 1987-04-11 | 1989-09-12 | Lederle (Japan), Ltd. | (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate |
| JPS63284176A (ja) | 1987-05-15 | 1988-11-21 | Nippon Redarii Kk | （１ｒ，５ｒ，６ｓ）−６−〔（１ｒ）−１−ヒドロキシエチル〕−１−メチルカルバペネム−３−カルボン酸誘導体の高立体選択的製造方法 |
| EP0300657B1 (en) | 1987-07-17 | 1993-03-31 | Merck & Co. Inc. | 4-substituted 3-oxobutanoate ester derivatives |
| DK168047B1 (da) * | 1987-12-07 | 1994-01-24 | Lederle Japan Ltd | (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse. |
| JP2592110B2 (ja) | 1988-09-27 | 1997-03-19 | 日本レダリー株式会社 | カルバペネム化合物の製造法 |
| JPH02178262A (ja) | 1988-12-28 | 1990-07-11 | Sumitomo Pharmaceut Co Ltd | １―（２′―ハロプロピオニル）ピロリジン―２―オン誘導体 |
| JPH0380417A (ja) | 1989-08-23 | 1991-04-05 | Tdk Corp | 磁気記録媒体および磁気記録媒体の製造方法 |
| JPH03219833A (ja) | 1990-01-24 | 1991-09-27 | Mitsubishi Electric Corp | 冷凍えびおよびその製造方法 |
| CA2036960A1 (en) | 1990-02-26 | 1991-08-27 | Thomas A. Rano | Novel synthesis of carbapenem intermediates |
| JPH04117382A (ja) | 1990-09-06 | 1992-04-17 | Tanabe Seiyaku Co Ltd | １―メチルカルバペネム誘導体及びその製法 |
| JP3080417B2 (ja) | 1991-02-28 | 2000-08-28 | 日本ワイスレダリー株式会社 | 結晶形態の１−メチル−２−ジフエニルホスホリルオキシ−カルバペネム化合物 |
| JP3219833B2 (ja) | 1991-03-30 | 2001-10-15 | 日本ワイスレダリー株式会社 | ４−置換プロピルアゼチジン−２−オン誘導体の製造方法 |
| JPH04368365A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | アゼチジノン誘導体の製法 |
| JPH04368386A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | １−メチルカルバペネム−３−カルボン酸の製造法 |
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| JP2902178B2 (ja) | 1991-10-15 | 1999-06-07 | 鐘淵化学工業株式会社 | ４−（１，２−置換または非置換アリル）−２−アゼチジノン化合物からのカルバペネム合成中間体の製造法 |
| DE69231883T2 (de) * | 1991-12-09 | 2001-10-04 | Takasago International Corp., Tokio/Tokyo | 4-(1,1-Dialkoxycarbonyl-Alkyl)Azetidin-2-on-Derivate zur Herstellung von 4-(1-Carboxy-Alkyl)Azetidin-2-on-Derivaten |
| US5731431A (en) * | 1991-12-26 | 1998-03-24 | Nippon Soda Co., Ltd. | Process for preparing 4-substituted azetidinone derivatives |
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| JP2569455B2 (ja) * | 1992-03-06 | 1997-01-08 | 田辺製薬株式会社 | β−ラクタム誘導体の製法 |
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| JP3479720B2 (ja) | 1992-07-08 | 2003-12-15 | 武田薬品工業株式会社 | カルバペネム類の製造法 |
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| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| JPH0713058A (ja) | 1993-06-25 | 1995-01-17 | Hitachi Electron Eng Co Ltd | 対物レンズの光軸調整方法 |
| DE69405922T2 (de) * | 1993-06-30 | 1998-01-29 | Nippon Soda Co | Verfahren zur Herstellung von 4-substituierten Azetidinon-Derivaten |
| US5493018A (en) * | 1994-01-25 | 1996-02-20 | Merck & Co., Inc. | Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid |
| US5578722A (en) * | 1994-03-29 | 1996-11-26 | Sumitomo Pharmaceuticals Co., Ltd. | Process for preparing carbapenem compounds |
| JP3388874B2 (ja) | 1994-04-06 | 2003-03-24 | 住友製薬株式会社 | β−ラクタム化合物の製造方法 |
| JP3787819B2 (ja) | 1994-07-14 | 2006-06-21 | 日本曹達株式会社 | アゼチジノン化合物及びその製造方法 |
| JP3761096B2 (ja) | 1994-12-20 | 2006-03-29 | 塩野義製薬株式会社 | ２−アルキル置換カルバペネム誘導体の製造方法 |
| JP3834798B2 (ja) | 1995-05-16 | 2006-10-18 | 日本曹達株式会社 | アゼチジノン化合物の製造方法 |
| JPH08325261A (ja) | 1995-05-26 | 1996-12-10 | Nippon Soda Co Ltd | アゼチジノン化合物の製造方法 |
| AR002507A1 (es) | 1995-06-28 | 1998-03-25 | Merck & Co Inc | Proceso mejorado para sintetizar intermediarios de carbapenem |
| JPH0931054A (ja) | 1995-07-17 | 1997-02-04 | Nippon Soda Co Ltd | アゼチジノン化合物及びその製造方法 |
| JPH0931075A (ja) | 1995-07-19 | 1997-02-04 | Nippon Soda Co Ltd | カルバペネム中間体の製造方法 |
| JP3954670B2 (ja) | 1996-05-28 | 2007-08-08 | 株式会社カネカ | カルバペネム抗生物質中間体の製造法 |
| JPH1077263A (ja) | 1996-09-05 | 1998-03-24 | Nippon Soda Co Ltd | アゼチジノン誘導体の製造方法 |
| JP4170405B2 (ja) | 1996-09-06 | 2008-10-22 | 日本曹達株式会社 | アゼチジノン誘導体の製造法 |
| US5973142A (en) * | 1997-01-21 | 1999-10-26 | Yasuda; Nobuyoshi | Process for synthesizing carbapenem intermediates |
| US6080854A (en) * | 1997-08-25 | 2000-06-27 | Merck & Co., Inc. | Process for synthesizing carbapenem intermediates |
| US6162911A (en) * | 1997-09-09 | 2000-12-19 | Merck & Co., Inc. | Crystalline imidazole complexes as carbapenem intermediates and synthesis |
| JP2000007676A (ja) | 1998-06-23 | 2000-01-11 | Nippon Soda Co Ltd | カルバペネム化合物の製造方法 |
| JP3450193B2 (ja) * | 1998-07-24 | 2003-09-22 | 高砂香料工業株式会社 | ４−置換アゼチジノン誘導体の製造方法 |
| JP4283913B2 (ja) | 1998-07-30 | 2009-06-24 | 株式会社カネカ | ４−置換アゼチジニルペンタン酸誘導体の製造法 |
| JP4028098B2 (ja) | 1998-07-30 | 2007-12-26 | 株式会社カネカ | カルバペネム抗生物質中間体の製造方法 |
| KR100377448B1 (ko) * | 2000-08-10 | 2003-03-26 | 동화약품공업주식회사 | 카바페넴 항생물질의 중간체 및 그의 제조방법 |
| US20020049315A1 (en) | 2000-09-06 | 2002-04-25 | Williams John M. | Crystalline forms of carbapenem intermediates |
| JP4274739B2 (ja) | 2001-05-10 | 2009-06-10 | 塩野義製薬株式会社 | アセチルチオピロリジン誘導体の製法 |
| JP2002338572A (ja) | 2002-03-22 | 2002-11-27 | Takeda Chem Ind Ltd | カルバペネム類の製造法 |
| JP2003277390A (ja) | 2002-03-25 | 2003-10-02 | Takasago Internatl Corp | アゼチジノン化合物の製造方法 |
| JP3467265B2 (ja) | 2002-07-31 | 2003-11-17 | 日本ワイスレダリー株式会社 | アゼチジノン化合物の結晶 |
-
2009
- 2009-07-30 AU AU2009277936A patent/AU2009277936B2/en not_active Ceased
- 2009-07-30 CA CA2732619A patent/CA2732619A1/en not_active Abandoned
- 2009-07-30 PT PT09786765T patent/PT2326648E/pt unknown
- 2009-07-30 KR KR1020117004258A patent/KR20110049823A/ko not_active Ceased
- 2009-07-30 WO PCT/IB2009/053332 patent/WO2010013223A1/en not_active Ceased
- 2009-07-30 DK DK09786765.9T patent/DK2326648T3/da active
- 2009-07-30 EP EP09786765A patent/EP2326648B1/en not_active Not-in-force
- 2009-07-30 US US13/056,837 patent/US8841444B2/en not_active Expired - Fee Related
- 2009-07-30 ES ES09786765T patent/ES2391713T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009277936A1 (en) | 2010-02-04 |
| PT2326648E (pt) | 2012-10-31 |
| WO2010013223A1 (en) | 2010-02-04 |
| CA2732619A1 (en) | 2010-02-04 |
| EP2326648B1 (en) | 2012-09-19 |
| AU2009277936B2 (en) | 2014-11-27 |
| US20110224426A1 (en) | 2011-09-15 |
| KR20110049823A (ko) | 2011-05-12 |
| ES2391713T3 (es) | 2012-11-29 |
| US8841444B2 (en) | 2014-09-23 |
| EP2326648A1 (en) | 2011-06-01 |
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