DK0741740T3 - Fremgangsmåde til fremstilling af usymmetriske phosphorsyrediestere samt deres salte - Google Patents

Fremgangsmåde til fremstilling af usymmetriske phosphorsyrediestere samt deres salte

Info

Publication number: DK0741740T3
Authority: DK; Denmark
Prior art keywords: pct; organic solvent; phosphoric acid; acid; salt
Prior art date: 1994-01-28

Application number

DK95905641T

Other languages

English (en)

Inventor

Einhard Kiegel

Harald Zilch

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-28

Filing date

1995-01-21

Publication date

1999-10-18

1995-01-21 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

1999-10-18 Application granted granted Critical

1999-10-18 Publication of DK0741740T3 publication Critical patent/DK0741740T3/da

Links

150000003839 salts Chemical class 0.000 title abstract 4
229910000147 aluminium phosphate Inorganic materials 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Substances OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 title abstract 2
-1 phosphoric acid diesters Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 4
239000003960 organic solvent Substances 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012043 crude product Substances 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
230000008020 evaporation Effects 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
150000002500 ions Chemical class 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
150000003014 phosphoric acid esters Chemical class 0.000 abstract 1
238000004237 preparative chromatography Methods 0.000 abstract 1
150000003222 pyridines Chemical class 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Fuel Cell (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK95905641T 1994-01-28 1995-01-21 Fremgangsmåde til fremstilling af usymmetriske phosphorsyrediestere samt deres salte DK0741740T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4402492A DE4402492A1 (de)	1994-01-28	1994-01-28	Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern
PCT/EP1995/000219 WO1995020596A1 (de)	1994-01-28	1995-01-21	Verfahren zur herstellung von unsymmetrischen phosphorsäurediestern

Publications (1)

Publication Number	Publication Date
DK0741740T3 true DK0741740T3 (da)	1999-10-18

Family

ID=6508875

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95905641T DK0741740T3 (da)	1994-01-28	1995-01-21	Fremgangsmåde til fremstilling af usymmetriske phosphorsyrediestere samt deres salte

Country Status (17)

Country	Link
US (1)	US5734042A (da)
EP (1)	EP0741740B1 (da)
JP (1)	JP3609411B2 (da)
KR (1)	KR100242357B1 (da)
AT (1)	ATE178610T1 (da)
AU (1)	AU1417195A (da)
BR (1)	BR9506654A (da)
CA (1)	CA2181474C (da)
DE (2)	DE4402492A1 (da)
DK (1)	DK0741740T3 (da)
ES (1)	ES2132618T3 (da)
FI (1)	FI115836B (da)
HU (1)	HU222438B1 (da)
PL (1)	PL179560B1 (da)
SI (1)	SI9520031A (da)
TW (1)	TW399059B (da)
WO (1)	WO1995020596A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU711367B2 (en) *	1994-11-12	1999-10-14	Heidelberg Pharma Holding Gmbh	Lipid-splitting enzyme
US7026469B2 (en)	2000-10-19	2006-04-11	Wake Forest University School Of Medicine	Compositions and methods of double-targeting virus infections and cancer cells
GB0608876D0 (en)	2006-05-05	2006-06-14	Medivir Ab	Combination therapy
WO2021198725A1 (de)	2020-03-30	2021-10-07	Chiracon Gmbh	Fosalvudin und fozivudintidoxil zur anwendung bei der behandlung der krankheit covid-19 und die verwendung von deren strukturvereinfachten derivaten

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5289681A (en) *	1976-01-22	1977-07-27	Yamasa Shoyu Co Ltd	Preparation of aracytidine -5# phosphoric acid ester derivatives
JPS552602A (en) *	1978-06-20	1980-01-10	Yamasa Shoyu Co Ltd	1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester
JPS552601A (en) *	1978-06-20	1980-01-10	Yamasa Shoyu Co Ltd	Anti-tumor agent for non-injection use
DD138213A1 (de) *	1978-08-03	1979-10-17	Hans Brachwitz	Verfahren zur herstellung von 1-0-alkyl(acyl)-3-chlor-3-desoxy-glycero-2-phosphorsaeure-omega-halogenalkylestern
DE3263939D1 (en) *	1981-12-09	1985-07-04	Teijin Ltd	5-fluoro-2'-deoxyuridine derivatives and a process for the preparation thereof
IT1238683B (it) *	1990-02-09	1993-09-01	Istituto Chemioterapico	Procedimento di preparazione di l-a-glicerilfosforil-d-myoinositolo e suoi sali da fosfatidi grezzi o parzialmente purificati
IT1240614B (it) *	1990-03-30	1993-12-17	Istituto Chemioterapico Italiano Fine Chimicals	Procedimento per la separazione dei principali componenti di una miscela di fosfolipidi grezzi deacilati
IT1254991B (it) *	1992-06-24	1995-10-11	Chemi Spa	Procedimento per la preparazione di glicerofosfolipidi
DE4226279A1 (de) *	1992-08-08	1994-02-10	Boehringer Mannheim Gmbh	Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE4321978A1 (de) *	1993-07-01	1995-01-12	Boehringer Mannheim Gmbh	Liponucleotide von Desoxynucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

1994
- 1994-01-28 DE DE4402492A patent/DE4402492A1/de not_active Withdrawn
1995
- 1995-01-21 JP JP51987395A patent/JP3609411B2/ja not_active Expired - Fee Related
- 1995-01-21 US US08/682,571 patent/US5734042A/en not_active Expired - Lifetime
- 1995-01-21 EP EP95905641A patent/EP0741740B1/de not_active Expired - Lifetime
- 1995-01-21 AU AU14171/95A patent/AU1417195A/en not_active Abandoned
- 1995-01-21 AT AT95905641T patent/ATE178610T1/de not_active IP Right Cessation
- 1995-01-21 HU HU9602062A patent/HU222438B1/hu not_active IP Right Cessation
- 1995-01-21 DK DK95905641T patent/DK0741740T3/da active
- 1995-01-21 ES ES95905641T patent/ES2132618T3/es not_active Expired - Lifetime
- 1995-01-21 WO PCT/EP1995/000219 patent/WO1995020596A1/de not_active Ceased
- 1995-01-21 SI SI9520031A patent/SI9520031A/sl not_active IP Right Cessation
- 1995-01-21 PL PL95315671A patent/PL179560B1/pl not_active IP Right Cessation
- 1995-01-21 KR KR1019960704058A patent/KR100242357B1/ko not_active Expired - Fee Related
- 1995-01-21 DE DE59505592T patent/DE59505592D1/de not_active Expired - Lifetime
- 1995-01-21 CA CA002181474A patent/CA2181474C/en not_active Expired - Fee Related
- 1995-01-21 BR BR9506654A patent/BR9506654A/pt not_active IP Right Cessation
- 1995-01-24 TW TW084100605A patent/TW399059B/zh not_active IP Right Cessation
1996
- 1996-07-29 FI FI963005A patent/FI115836B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
SI9520031A (en)	1997-04-30
BR9506654A (pt)	1997-09-16
WO1995020596A1 (de)	1995-08-03
HUT74709A (en)	1997-02-28
DE4402492A1 (de)	1995-08-03
EP0741740A1 (de)	1996-11-13
CA2181474A1 (en)	1995-08-03
US5734042A (en)	1998-03-31
HU222438B1 (hu)	2003-07-28
FI963005L (fi)	1996-07-29
TW399059B (en)	2000-07-21
ES2132618T3 (es)	1999-08-16
ATE178610T1 (de)	1999-04-15
JPH09508135A (ja)	1997-08-19
FI115836B (fi)	2005-07-29
CA2181474C (en)	2008-04-29
EP0741740B1 (de)	1999-04-07
AU1417195A (en)	1995-08-15
KR100242357B1 (ko)	2000-02-01
PL315671A1 (en)	1996-11-25
JP3609411B2 (ja)	2005-01-12
FI963005A0 (fi)	1996-07-29
PL179560B1 (pl)	2000-09-29
DE59505592D1 (de)	1999-05-12
HU9602062D0 (en)	1996-09-30

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