DK0744940T3 - Medikamenter, vacciner og hormoner i polylactidovertrukne mikrokugler - Google Patents

Medikamenter, vacciner og hormoner i polylactidovertrukne mikrokugler

Info

Publication number: DK0744940T3
Authority: DK; Denmark
Prior art keywords: cellulose; hydroxypropyl; microspheres; vaccines; hormones
Prior art date: 1994-02-17

Application number

DK95908842T

Other languages

Danish (da)

English (en)

Inventor

Pankaj Modi

Original Assignee

Pankaj Modi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-02-17

Filing date

1995-02-14

Publication date

1999-07-26

1994-02-17 Priority claimed from US08/197,754 external-priority patent/US5569468A/en

1994-02-17 Priority claimed from US08/197,756 external-priority patent/US5417982A/en

1995-02-14 Application filed by Pankaj Modi filed Critical Pankaj Modi

1999-07-26 Application granted granted Critical

1999-07-26 Publication of DK0744940T3 publication Critical patent/DK0744940T3/da

Links

229940079593 drug Drugs 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 3
229940088597 hormone Drugs 0.000 title abstract 3
239000005556 hormone Substances 0.000 title abstract 3
239000004005 microsphere Substances 0.000 title abstract 3
229960005486 vaccine Drugs 0.000 title abstract 3
238000002483 medication Methods 0.000 title 1
229920000747 poly(lactic acid) Polymers 0.000 title 1
-1 polysucrose Polymers 0.000 abstract 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 4
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
229920002472 Starch Polymers 0.000 abstract 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 2
239000011159 matrix material Substances 0.000 abstract 2
229920000642 polymer Polymers 0.000 abstract 2
239000008107 starch Substances 0.000 abstract 2
235000019698 starch Nutrition 0.000 abstract 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical class CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
241000283690 Bos taurus Species 0.000 abstract 1
239000001856 Ethyl cellulose Substances 0.000 abstract 1
229920001917 Ficoll Polymers 0.000 abstract 1
239000001828 Gelatine Substances 0.000 abstract 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
SGXDXUYKISDCAZ-UHFFFAOYSA-N N,N-diethylglycine Chemical compound CCN(CC)CC(O)=O SGXDXUYKISDCAZ-UHFFFAOYSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
229920002873 Polyethylenimine Polymers 0.000 abstract 1
229920001710 Polyorthoester Polymers 0.000 abstract 1
239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical class [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
229920002988 biodegradable polymer Polymers 0.000 abstract 1
239000004621 biodegradable polymer Substances 0.000 abstract 1
229920001400 block copolymer Polymers 0.000 abstract 1
239000001768 carboxy methyl cellulose Chemical class 0.000 abstract 1
229920002301 cellulose acetate Chemical class 0.000 abstract 1
239000011248 coating agent Substances 0.000 abstract 1
238000000576 coating method Methods 0.000 abstract 1
238000013270 controlled release Methods 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229920001249 ethyl cellulose Polymers 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
229920000159 gelatin Polymers 0.000 abstract 1
235000019322 gelatine Nutrition 0.000 abstract 1
229960002520 hepatitis vaccine Drugs 0.000 abstract 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
229920003063 hydroxymethyl cellulose Polymers 0.000 abstract 1
229940031574 hydroxymethyl cellulose Drugs 0.000 abstract 1
239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229920000141 poly(maleic anhydride) Chemical class 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920001451 polypropylene glycol Polymers 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
239000000661 sodium alginate Chemical class 0.000 abstract 1
235000010413 sodium alginate Nutrition 0.000 abstract 1
229940005550 sodium alginate Drugs 0.000 abstract 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
229920001027 sodium carboxymethylcellulose Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Manufacturing Of Micro-Capsules (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK95908842T 1994-02-17 1995-02-14 Medikamenter, vacciner og hormoner i polylactidovertrukne mikrokugler DK0744940T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/197,754 US5569468A (en)	1994-02-17	1994-02-17	Vaccine delivery system for immunization, using biodegradable polymer microspheres
US08/197,756 US5417982A (en)	1994-02-17	1994-02-17	Controlled release of drugs or hormones in biodegradable polymer microspheres
PCT/CA1995/000074 WO1995022318A1 (fr)	1994-02-17	1995-02-14	Medicaments, vaccins et hormones incorpores dans des microspheres recouvertes de polylactides

Publications (1)

Publication Number	Publication Date
DK0744940T3 true DK0744940T3 (da)	1999-07-26

Family

ID=26893130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95908842T DK0744940T3 (da)	1994-02-17	1995-02-14	Medikamenter, vacciner og hormoner i polylactidovertrukne mikrokugler

Country Status (8)

Country	Link
EP (1)	EP0744940B1 (fr)
JP (1)	JPH09509161A (fr)
AT (1)	ATE173160T1 (fr)
AU (1)	AU1702395A (fr)
CA (1)	CA2180424C (fr)
DE (1)	DE69505949T2 (fr)
DK (1)	DK0744940T3 (fr)
WO (1)	WO1995022318A1 (fr)

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US7053134B2 (en)	2002-04-04	2006-05-30	Scimed Life Systems, Inc.	Forming a chemically cross-linked particle of a desired shape and diameter
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US7101566B2 (en)	2002-06-28	2006-09-05	Ethicon, Inc.	Polymer coated microparticles for sustained release
US7842377B2 (en)	2003-08-08	2010-11-30	Boston Scientific Scimed, Inc.	Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en)	2002-08-09	2008-11-11	Boston Scientific Scimed, Inc.	Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en)	2002-08-30	2011-09-06	Boston Scientific Scimed, Inc.	Embolization
US7588825B2 (en)	2002-10-23	2009-09-15	Boston Scientific Scimed, Inc.	Embolic compositions
US7883490B2 (en)	2002-10-23	2011-02-08	Boston Scientific Scimed, Inc.	Mixing and delivery of therapeutic compositions
US7976823B2 (en)	2003-08-29	2011-07-12	Boston Scientific Scimed, Inc.	Ferromagnetic particles and methods
WO2005072710A2 (fr)	2004-01-28	2005-08-11	Johns Hopkins University	Medicaments et particules de transport de genes se deplaçant rapidement a travers les barrieres muqueuses
US7736671B2 (en)	2004-03-02	2010-06-15	Boston Scientific Scimed, Inc.	Embolization
US8173176B2 (en)	2004-03-30	2012-05-08	Boston Scientific Scimed, Inc.	Embolization
US7311861B2 (en)	2004-06-01	2007-12-25	Boston Scientific Scimed, Inc.	Embolization
US8425550B2 (en)	2004-12-01	2013-04-23	Boston Scientific Scimed, Inc.	Embolic coils
US7858183B2 (en)	2005-03-02	2010-12-28	Boston Scientific Scimed, Inc.	Particles
US7727555B2 (en)	2005-03-02	2010-06-01	Boston Scientific Scimed, Inc.	Particles
US7963287B2 (en)	2005-04-28	2011-06-21	Boston Scientific Scimed, Inc.	Tissue-treatment methods
US9463426B2 (en)	2005-06-24	2016-10-11	Boston Scientific Scimed, Inc.	Methods and systems for coating particles
US9693967B2 (en)	2005-09-07	2017-07-04	Southwest Research Institute	Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US8007509B2 (en)	2005-10-12	2011-08-30	Boston Scientific Scimed, Inc.	Coil assemblies, components and methods
US8152839B2 (en)	2005-12-19	2012-04-10	Boston Scientific Scimed, Inc.	Embolic coils
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US7501179B2 (en)	2005-12-21	2009-03-10	Boston Scientific Scimed, Inc.	Block copolymer particles
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SA07280459B1 (ar)	2006-08-25	2011-07-20	بيورديو فارما إل. بي.	أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
US8414927B2 (en)	2006-11-03	2013-04-09	Boston Scientific Scimed, Inc.	Cross-linked polymer particles
KR101411349B1 (ko)	2010-12-24	2014-06-25	주식회사 삼양바이오팜	생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물
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US11596599B2 (en)	2012-05-03	2023-03-07	The Johns Hopkins University	Compositions and methods for ophthalmic and/or other applications
WO2013166408A1 (fr)	2012-05-03	2013-11-07	Kala Pharmaceuticals, Inc.	Nanoparticules pharmaceutiques présentant un transport muqueux amélioré
US9827191B2 (en)	2012-05-03	2017-11-28	The Johns Hopkins University	Compositions and methods for ophthalmic and/or other applications
CA2900652C (fr)	2013-02-15	2021-05-04	Kala Pharmaceuticals, Inc.	Composes therapeutiques et utilisations de ceux-ci
US9688688B2 (en)	2013-02-20	2017-06-27	Kala Pharmaceuticals, Inc.	Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CN107915751A (zh)	2013-02-20	2018-04-17	卡拉制药公司	治疗性化合物和其用途
WO2015066482A1 (fr)	2013-11-01	2015-05-07	Kala Pharmaceuticals, Inc.	Formes cristallines de composés thérapeutiques et leurs utilisations
US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
JP7366544B2 (ja)	2016-04-26	2023-10-23	アデアファーマシューティカルズユーエスエー，インク．	非経口投与用の生分解性ポリマーミクロスフェア組成物
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1995
- 1995-02-14 DK DK95908842T patent/DK0744940T3/da active
- 1995-02-14 JP JP7521481A patent/JPH09509161A/ja not_active Ceased
- 1995-02-14 AT AT95908842T patent/ATE173160T1/de active
- 1995-02-14 AU AU17023/95A patent/AU1702395A/en not_active Abandoned
- 1995-02-14 EP EP95908842A patent/EP0744940B1/fr not_active Expired - Lifetime
- 1995-02-14 WO PCT/CA1995/000074 patent/WO1995022318A1/fr not_active Ceased
- 1995-02-14 DE DE69505949T patent/DE69505949T2/de not_active Expired - Lifetime
- 1995-02-14 CA CA002180424A patent/CA2180424C/fr not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE173160T1 (de)	1998-11-15
JPH09509161A (ja)	1997-09-16
AU1702395A (en)	1995-09-04
CA2180424A1 (fr)	1995-08-24
CA2180424C (fr)	1999-05-04
DE69505949D1 (de)	1998-12-17
WO1995022318A1 (fr)	1995-08-24
EP0744940B1 (fr)	1998-11-11
EP0744940A1 (fr)	1996-12-04
DE69505949T2 (de)	1999-06-02

Publication	Publication Date	Title
ATE173160T1 (de)	1998-11-15	Arzneimittel, impfstoffe und hormone in polylaktidbeschichteten mikropartikel
KR920002135A (ko)	1992-02-28	대장에서만 방출할수 있는 피복시킨 고체 약물형태
ATE345781T1 (de)	2006-12-15	Drei verschiedene polymertypen enthaltende formulierung mit verzögerter freigabe
KR920702618A (ko)	1992-10-06	약제학적 제형
US5885615A (en)	1999-03-23	Pharmaceutical controlled release tablets containing a carrier made of cross-linked amylose and hydroxypropylmethylcellulose
AU570712B2 (en)	1988-03-24	Crosslinked, porous polymers for controlled drug delivery
Pal et al.	2006	Development of carboxymethyl cellulose acrylate for various biomedical applications
DK0952822T3 (da)	2003-07-21	Mikropartikler af chitosan-gelatine A
IT1241417B (it)	1994-01-14	Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
CO4700474A1 (es)	1998-12-29	Formulacion oral de 2-metil-tieno-benzodiacepina
DE69121675D1 (de)	1996-10-02	Mikrosphäre enthaltende pharmazeutische Zusammensetzung mit kontrollierter Freigabe und Verfahren zur Herstellung
ATE287260T1 (de)	2005-02-15	Formulierung mit einer vorgeformten öffnung zur gesteuerten freisetzung
CA2312710A1 (fr)	1999-06-17	Formulation a liberation prolongee contenant trois types differents de polymeres et comprime prepare a partir de cette formulation
HUP9904174A2 (hu)	2000-04-28	Bőrön át történő adagoláshoz szánt gyógyszerkészítmények
KR870000069A (ko)	1987-02-16	안정한 고체 제형의 제조 방법
DK0669129T3 (da)	2002-02-25	Ekspanderbare lægemiddelformer med kontrolleret afgivelse af aktivt stof
ES2001897A6 (es)	1988-07-01	Procedimiento para la fabricacion de una tableta de liberacion controlada
WO1998022097A2 (fr)	1998-05-28	Composition d'une matrice a liberation controlee utilisant un melange d'acide poly(acrylique) et d'un polymere ou d'un monomere polaire
ATE151283T1 (de)	1997-04-15	Arzneimittel mit kontrollierter wirkstoffabgabe
KR900009071A (ko)	1990-07-02	점착성 제피정
DE69918310D1 (de)	2004-07-29	Tablette mit verzögerter freigabe enthaltend einen blutzuckersenkenden wirkstoff und einen antihyperglyzemischen wirkstoff
ATE158172T1 (de)	1997-10-15	Pulverförmige pharmazeutische zusammensetzung
JPS57130907A (en)	1982-08-13	Amlgam coating agent