ES2001897A6 - Procedimiento para la fabricacion de una tableta de liberacion controlada - Google Patents
Procedimiento para la fabricacion de una tableta de liberacion controladaInfo
- Publication number
- ES2001897A6 ES2001897A6 ES8601418A ES8601418A ES2001897A6 ES 2001897 A6 ES2001897 A6 ES 2001897A6 ES 8601418 A ES8601418 A ES 8601418A ES 8601418 A ES8601418 A ES 8601418A ES 2001897 A6 ES2001897 A6 ES 2001897A6
- Authority
- ES
- Spain
- Prior art keywords
- water
- insoluble
- controlled release
- release tablet
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000013270 controlled release Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA FABRICACION DE UNA TABLETA DE LIBERACION CONTROLADA, CARACTERIZADO PORQUE COMPRENDE: A) GRANULAR AL MENOS UNA SUSTANCIA FARMACEUTICAMENTE ACTIVA, SOLUBLE EN AGUA, QUE ESTA DISPERSADA EN UN EXCIPIENTE POLIMERICO INSOLUBLE EN AGUA, NO DIGERIBLE; Y B) UNA SUSTANCIA POLIMERICA INSOLUBLE EN AGUA, QUE ES HINCHABLE BAJO LA INFLUENCIA DE AGUA Y QUE CONSTITUYEN UN NUCLEO I), II) COMPRIMIR EL GRANULADO OBTENIDO A UNA TABLETA; Y REVESTIR LA TABLETA CON UN MATERIAL DE REVESTIMIENTO, CONSISTENTE ESENCIALMENTE EN UNA PELICULA DE DIFUSION ELASTICA, INSOLUBLE EN AGUA Y SEMIPERMEABLE, DE UN POLIMERO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858521494A GB8521494D0 (en) | 1985-08-29 | 1985-08-29 | Controlled release tablet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2001897A6 true ES2001897A6 (es) | 1988-07-01 |
Family
ID=10584426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8601418A Expired ES2001897A6 (es) | 1985-08-29 | 1986-08-27 | Procedimiento para la fabricacion de una tableta de liberacion controlada |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4784858A (es) |
| EP (1) | EP0213083A3 (es) |
| JP (1) | JPS6251614A (es) |
| AU (1) | AU592363B2 (es) |
| DK (1) | DK409586A (es) |
| ES (1) | ES2001897A6 (es) |
| FI (1) | FI863429A7 (es) |
| GB (1) | GB8521494D0 (es) |
| GR (1) | GR862207B (es) |
| HU (1) | HU195736B (es) |
| IL (1) | IL79836A (es) |
| NZ (1) | NZ217387A (es) |
| PH (1) | PH22469A (es) |
| PT (1) | PT83265B (es) |
| ZA (1) | ZA866533B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2114423A1 (es) * | 1993-12-09 | 1998-05-16 | Egyt Gyogyszervegyeszeti Gyar | Nuevas composiciones farmaceuticas de liberacion de farmaco controlada por difusion-osmosis y procesos para preparar las mismas. |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8519310D0 (en) * | 1985-07-31 | 1985-09-04 | Zyma Sa | Granular active substances |
| US4892742A (en) * | 1985-11-18 | 1990-01-09 | Hoffmann-La Roche Inc. | Controlled release compositions with zero order release |
| IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
| US5342622A (en) * | 1986-05-16 | 1994-08-30 | The State Of Victoria | Subdermal biocompatible implants |
| US4789549A (en) * | 1987-03-09 | 1988-12-06 | Warner-Lambert Company | Sustained release dosage forms |
| DE3720757A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
| FR2618073B1 (fr) * | 1987-07-16 | 1990-09-07 | Pf Medicament | Comprimes de type a matrice hydrophile a base de salbutamol et leur procede de preparation |
| US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
| DE3809764A1 (de) * | 1988-03-23 | 1989-10-05 | Knoll Ag | Mischung aus alginaten und polyacrylaten und deren verwendung |
| US5230901A (en) * | 1988-03-23 | 1993-07-27 | Knoll Ag | Sustained release tablet of a mixture of alginates and polyacrylates |
| US5019397A (en) * | 1988-04-21 | 1991-05-28 | Alza Corporation | Aqueous emulsion for pharmaceutical dosage form |
| IE60383B1 (en) * | 1988-05-27 | 1994-07-13 | Elan Corp Plc | Controlled release pharmaceutical formulation |
| NO882653D0 (no) * | 1988-06-15 | 1988-06-15 | Apothekernes Lab | Doseringsform. |
| US5612059A (en) * | 1988-08-30 | 1997-03-18 | Pfizer Inc. | Use of asymmetric membranes in delivery devices |
| IE69270B1 (en) * | 1989-01-03 | 1996-08-21 | Sterling Winthrop Inc | Controlled-release low-dose aspirin |
| US4970081A (en) * | 1989-01-03 | 1990-11-13 | Sterling Drug Inc. | Controlled-release, low-dose aspirin formulation and method of treating vascular occlusive disease therewith |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5030452A (en) * | 1989-01-12 | 1991-07-09 | Pfizer Inc. | Dispensing devices powered by lyotropic liquid crystals |
| US5108756A (en) * | 1989-01-12 | 1992-04-28 | Pfizer Inc. | Dispensing devices powered by lyotropic liquid crystals |
| DD295760A5 (de) * | 1989-01-31 | 1991-11-14 | Martin-Luther-Universitaet Halle Wittenberg,De | Arzneistoffreigabesystem mit kotrollierter wirkstoffreisetzung |
| US4992277A (en) * | 1989-08-25 | 1991-02-12 | Schering Corporation | Immediate release diltiazem formulation |
| US5000962A (en) * | 1989-08-25 | 1991-03-19 | Schering Corporation | Long acting diltiazem formulation |
| US6482516B1 (en) * | 1993-07-20 | 2002-11-19 | Banner Pharmacaps, Inc. | Enrobed tablet |
| EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
| ATE114472T1 (de) * | 1989-09-21 | 1994-12-15 | American Cyanamid Co | System des typs ''einmal täglich'' zur gepulsten minocyclinabgabe. |
| US5175003A (en) * | 1990-04-06 | 1992-12-29 | Biosytes Usa, Inc. | Dual mechanism controlled release system for drug dosage forms |
| US5013728A (en) * | 1990-05-04 | 1991-05-07 | Colgate - Palmolive Company | Composition for treating osteoporosis and hormonal imbalance |
| JP2572673B2 (ja) * | 1990-07-25 | 1997-01-16 | エスエス製薬株式会社 | 徐放性錠剤 |
| DE69107461T2 (de) * | 1990-08-07 | 1995-06-22 | Pfizer | Verwendung von interfacial polymerisierten membranen in abgabevorrichtungen. |
| US5153005A (en) * | 1990-12-11 | 1992-10-06 | Colgate-Palmolive Company | Composition and method for preventing fluorosis |
| US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
| DE4138513A1 (de) * | 1991-11-23 | 1993-05-27 | Basf Ag | Feste pharmazeutische retardform |
| US5407686A (en) * | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5472712A (en) * | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US7070806B2 (en) * | 1992-01-27 | 2006-07-04 | Purdue Pharma Lp | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5262173A (en) * | 1992-03-02 | 1993-11-16 | American Cyanamid Company | Pulsatile once-a-day delivery systems for minocycline |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US5945125A (en) * | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
| WO1997026865A1 (en) * | 1996-01-29 | 1997-07-31 | Edward Mendell Co., Inc. | Sustained release excipient |
| SE9603667D0 (sv) * | 1996-10-08 | 1996-10-08 | Astra Ab | Pharmaceutical compositions |
| US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| WO1999001111A1 (en) | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Stabilized sustained release tramadol formulations |
| US20050048102A1 (en) * | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| US6723342B1 (en) | 1999-02-08 | 2004-04-20 | Fmc Corporation | Edible coating composition |
| US6432448B1 (en) * | 1999-02-08 | 2002-08-13 | Fmc Corporation | Edible coating composition |
| US6500462B1 (en) * | 1999-10-29 | 2002-12-31 | Fmc Corporation | Edible MCC/PGA coating composition |
| US7108866B1 (en) | 1999-12-10 | 2006-09-19 | Biovall Laboratories International Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
| US20060153914A1 (en) * | 1999-12-10 | 2006-07-13 | Biovail Laboratories International S.R.L. | Chronotherapeutic diltiazem formulations and the administration thereof |
| CA2395231C (en) | 1999-12-23 | 2006-08-15 | Pfizer Products Inc. | Hydrogel-driven layered drug dosage form |
| EP1339395A2 (en) | 2000-11-28 | 2003-09-03 | Fmc Corporation | Edible pga (propylene glycol alginate) coating composition |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| US7504395B2 (en) * | 2001-07-20 | 2009-03-17 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder |
| US6663896B1 (en) | 2001-08-01 | 2003-12-16 | Alvin S. Blum | Delayed release aspirin for vascular obstruction prophylaxis |
| US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| AU2003219117A1 (en) * | 2002-03-28 | 2003-10-13 | Synthon B.V. | Extended release venlafaxine formulations |
| SE0201110D0 (sv) * | 2002-04-12 | 2002-04-12 | Astrazeneca Ab | New film coating |
| SE0202353D0 (sv) * | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
| US20050084531A1 (en) * | 2003-10-16 | 2005-04-21 | Jatin Desai | Tablet with aqueous-based sustained release coating |
| GB0400452D0 (en) * | 2004-01-09 | 2004-02-11 | Norton Healthcare Ltd | A pharmaceutical composition |
| US20060099262A1 (en) * | 2004-11-08 | 2006-05-11 | Biokey, Inc. | Methods and formulations for making controlled release oral dosage form |
| US7994220B2 (en) | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
| AU2007275581B2 (en) | 2006-07-21 | 2011-09-08 | Biodelivery Sciences International, Inc. | Transmucosal delivery devices with enhanced uptake |
| CA2923102C (en) * | 2007-08-13 | 2019-10-15 | Omeho Life Sciences Inc. | Abuse resistant drugs, method of use and method of making |
| US20120244218A1 (en) | 2011-03-25 | 2012-09-27 | Durkee Shane E | Calcium supplement |
| WO2013026064A1 (en) | 2011-08-18 | 2013-02-21 | Biodelivery Sciences International, Inc. | Abuse-resistant mucoadhesive devices for delivery of buprenorphine |
| US9901539B2 (en) | 2011-12-21 | 2018-02-27 | Biodelivery Sciences International, Inc. | Transmucosal drug delivery devices for use in chronic pain relief |
| WO2014146093A2 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
| US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
| US10434113B2 (en) | 2016-12-16 | 2019-10-08 | The Charlotte Mecklenburg Hospital Authority | Compositions and methods for treating muscular dystrophy and other disorders |
| US20200061092A1 (en) * | 2018-08-24 | 2020-02-27 | The Charlotte Mecklenburg Hospital Authority D/B/A Atrium Health | Methods and compositions for treating disorders associated with muscle weakness |
| EP3788884A1 (de) * | 2019-09-05 | 2021-03-10 | Delica AG | Kompostierbare kapsel sowie deren herstellung und verwendung |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1468172A (en) * | 1973-03-28 | 1977-03-23 | Benzon As Alfred | Oral drug preparations |
| DE2336218C3 (de) * | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
| FR2377196A1 (fr) * | 1977-01-13 | 1978-08-11 | Lipha | Composition medicamenteuse a usage oral |
| US4248858A (en) * | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4252786A (en) * | 1979-11-16 | 1981-02-24 | E. R. Squibb & Sons, Inc. | Controlled release tablet |
| EP0052075A1 (de) * | 1980-11-12 | 1982-05-19 | Ciba-Geigy Ag | Körnige Arzneimittel-Retardform |
| DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| DK151608C (da) * | 1982-08-13 | 1988-06-20 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse |
| DK152744C (da) * | 1982-08-13 | 1988-10-31 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat |
| DK62184D0 (da) * | 1984-02-10 | 1984-02-10 | Benzon As Alfred | Diffusionsovertrukket polydepotpraeparat |
| CH658188A5 (de) * | 1984-03-23 | 1986-10-31 | Ciba Geigy Ag | Lagerstabile schnellzerfallende pharmazeutische presslinge. |
| US4666704A (en) * | 1985-05-24 | 1987-05-19 | International Minerals & Chemical Corp. | Controlled release delivery system for macromolecules |
-
1985
- 1985-08-29 GB GB858521494A patent/GB8521494D0/en active Pending
-
1986
- 1986-08-22 US US06/899,112 patent/US4784858A/en not_active Expired - Fee Related
- 1986-08-25 IL IL79836A patent/IL79836A/xx unknown
- 1986-08-25 FI FI863429A patent/FI863429A7/fi not_active IP Right Cessation
- 1986-08-25 EP EP86810381A patent/EP0213083A3/en not_active Ceased
- 1986-08-27 PT PT83265A patent/PT83265B/pt not_active IP Right Cessation
- 1986-08-27 PH PH34186A patent/PH22469A/en unknown
- 1986-08-27 GR GR862207A patent/GR862207B/el unknown
- 1986-08-27 ES ES8601418A patent/ES2001897A6/es not_active Expired
- 1986-08-28 HU HU863721A patent/HU195736B/hu not_active IP Right Cessation
- 1986-08-28 JP JP61200230A patent/JPS6251614A/ja active Pending
- 1986-08-28 NZ NZ217387A patent/NZ217387A/xx unknown
- 1986-08-28 AU AU62033/86A patent/AU592363B2/en not_active Ceased
- 1986-08-28 ZA ZA866533A patent/ZA866533B/xx unknown
- 1986-08-28 DK DK409586A patent/DK409586A/da not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2114423A1 (es) * | 1993-12-09 | 1998-05-16 | Egyt Gyogyszervegyeszeti Gyar | Nuevas composiciones farmaceuticas de liberacion de farmaco controlada por difusion-osmosis y procesos para preparar las mismas. |
Also Published As
| Publication number | Publication date |
|---|---|
| DK409586A (da) | 1987-03-01 |
| FI863429A7 (fi) | 1987-03-01 |
| IL79836A0 (en) | 1986-11-30 |
| HUT41642A (en) | 1987-05-28 |
| US4784858A (en) | 1988-11-15 |
| AU592363B2 (en) | 1990-01-11 |
| GR862207B (en) | 1986-12-31 |
| HU195736B (en) | 1988-07-28 |
| PT83265A (en) | 1986-09-01 |
| PH22469A (en) | 1988-09-12 |
| EP0213083A3 (en) | 1988-02-03 |
| IL79836A (en) | 1990-09-17 |
| EP0213083A2 (en) | 1987-03-04 |
| JPS6251614A (ja) | 1987-03-06 |
| FI863429A0 (fi) | 1986-08-25 |
| GB8521494D0 (en) | 1985-10-02 |
| PT83265B (pt) | 1989-05-12 |
| NZ217387A (en) | 1989-08-29 |
| AU6203386A (en) | 1987-03-05 |
| DK409586D0 (da) | 1986-08-28 |
| ZA866533B (en) | 1987-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001102 |