DK0748329T3 - 3"-desmethoxyderivater af erythromycin og azithromycin - Google Patents

3"-desmethoxyderivater af erythromycin og azithromycin

Info

Publication number: DK0748329T3
Authority: DK; Denmark
Prior art keywords: azithromycin; erythromycin; alkyl; image; desmethoxy derivatives
Prior art date: 1994-03-04

Application number

DK95906455T

Other languages

Danish (da)

English (en)

Inventor

Bingwei V Yang

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-02

Publication date

1999-11-22

1995-02-02 Application filed by Pfizer filed Critical Pfizer

1999-11-22 Application granted granted Critical

1999-11-22 Publication of DK0748329T3 publication Critical patent/DK0748329T3/da

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229960004099 azithromycin Drugs 0.000 title 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000003544 oxime group Chemical group 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

DK95906455T 1994-03-04 1995-02-02 3"-desmethoxyderivater af erythromycin og azithromycin DK0748329T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/206,551 US5441939A (en)	1994-03-04	1994-03-04	3"-desmethoxy derivatives of erythromycin and azithromycin
PCT/IB1995/000074 WO1995023808A1 (fr)	1994-03-04	1995-02-02	Derives de 3''-desmethoxy d'erythromycine et d'azithromycine

Publications (1)

Publication Number	Publication Date
DK0748329T3 true DK0748329T3 (da)	1999-11-22

Family

ID=22766886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95906455T DK0748329T3 (da)	1994-03-04	1995-02-02	3"-desmethoxyderivater af erythromycin og azithromycin

Country Status (11)

Country	Link
US (1)	US5441939A (fr)
EP (1)	EP0748329B1 (fr)
JP (1)	JP3083102B2 (fr)
AT (1)	ATE181923T1 (fr)
CA (1)	CA2184734C (fr)
DE (1)	DE69510659T2 (fr)
DK (1)	DK0748329T3 (fr)
ES (1)	ES2133175T3 (fr)
FI (1)	FI110780B (fr)
GR (1)	GR3031092T3 (fr)
WO (1)	WO1995023808A1 (fr)

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JPH0537506U (ja) *	1991-10-31	1993-05-21	横浜ゴム株式会社	タイヤ滑り止め装置
HN1998000086A (es)	1997-06-11	1999-03-08	Pfizer Prod Inc	Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6407074B1 (en)	1997-06-11	2002-06-18	Pfizer Inc	C-4″-substituted macrolide derivatives
HN1998000074A (es) *	1997-06-11	1999-01-08	Pfizer Prod Inc	Derivados de macrolidos c-4 sustituidos
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
US6100240A (en) *	1998-10-09	2000-08-08	Pfizer Inc	Macrolide derivatives
CA2292359C (fr) *	1999-01-28	2004-09-28	Pfizer Products Inc.	Nouveaux azalides et procede de fabrication
US6239113B1 (en) *	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
US7056893B2 (en) *	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
EP1189912B1 (fr) *	1999-05-18	2008-04-16	Pfizer Products Inc.	Nouvelles formes cristallines d'un macrolide
IL145739A0 (en) *	1999-05-24	2002-07-25	Pfizer Prod Inc	13-methyl-erythromycin derivatives
AU2001214115A1 (en) *	2000-08-01	2002-02-13	Habil F. Khorakiwala	Process for the preparation of anhydrous azithromycin
DE60114028T2 (de)	2000-08-23	2006-07-13	Wockhardt Ltd.	Verfahren zur herstellung von wasserfreiem azithromycin
WO2002088158A1 (fr)	2001-04-27	2002-11-07	Pfizer Products Inc.	Procede de preparation de derives de 9-deoxo-9a-aza-9a-homoerythromycine a substitues en 4''
US7273853B2 (en) *	2002-05-13	2007-09-25	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US6878691B2 (en) *	2002-05-13	2005-04-12	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US7064110B2 (en) *	2002-05-13	2006-06-20	Enanta Pharmaceuticals, Inc.	6-11 bicycle ketolide derivatives
WO2005061526A1 (fr) *	2003-11-20	2005-07-07	Enanta Pharmaceuticals, Inc.	Derives de ketolide 6-11 bicycliques
CN101955508B (zh) *	2003-11-20	2015-04-15	埃纳恩塔制药公司	6-11双环酮大环内酯衍生物
WO2005067564A2 (fr) *	2004-01-07	2005-07-28	Enanta Pharmaceuticals, Inc.	Derives d'erythromycine 6-11 bicyclique
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060046970A1 (en) *	2004-08-31	2006-03-02	Insite Vision Incorporated	Topical otic compositions and methods of topical treatment of prevention of otic infections
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
US8354383B2 (en) *	2007-09-17	2013-01-15	Enanta Pharmaceuticals, Inc.	6,11-bridged biaryl macrolides
US8273720B2 (en) *	2007-09-17	2012-09-25	Enanta Pharmaceuticals, Inc.	6,11-bicyclolides: bridged biaryl macrolide derivatives
KR101223158B1 (ko) *	2007-09-17	2013-01-17	이난타 파마슈티칼스, 인코포레이티드	6,11-다리걸친 바이아릴 매크로라이드
EP3612543B1 (fr)	2017-04-20	2022-11-23	Rising Tide Foundation	Dérivés d'azithromycine contenant un ion phosphonium en tant qu'agents anticancéreux
US11427606B2 (en)	2017-04-20	2022-08-30	Rising Tide Foundation	Azithromycin derivatives containing a phosphonium ion as anticancer agents
WO2018195434A1 (fr)	2017-04-21	2018-10-25	Lisanti Michael P	Vitamine c et doxycycline : polythérapie létale synthétique pour éradiquer des cellules souches cancéreuses (csc)
WO2018195446A1 (fr)	2017-04-21	2018-10-25	Lisanti Michael P	Ciblage de cellules souches cancéreuses hypoxiques (csc) à l'aide de doxycycline : implications pour améliorer une thérapie anti-angiogénique
US11160821B2 (en)	2017-05-19	2021-11-02	Lunella Biotech, Inc.	Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2018213764A1 (fr)	2017-05-19	2018-11-22	Lunella Biotech, Inc.	Diagnostic compagnon pour inhibiteurs mitochondriaux
CU20190106A7 (es)	2017-06-26	2020-11-30	Lunella Biotech Inc	Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
SI8311553A8 (en) *	1983-07-18	1995-06-30	Pliva Pharm & Chem Works	Process for preparing 7,16-dioxa-2-aza-10-0-cladynosil-12-0-desosaminyl-4,5-dihydroxy-6- ethyl-3,5,9,11,13,15-hexamethylbicyclo (11.2.1.) hexadeca-1(2)-ene-8-ones
JPS60126296A (ja) *	1983-12-13	1985-07-05	Kyowa Hakko Kogyo Co Ltd	３，３”，４”−トリ−ｏ−アシルスピラマイシン１
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2062932A1 (fr) *	1991-03-15	1992-09-16	Robert R. Wilkening	9-desoxo-9(z)-hydroxyiminoerythromycine a et derives ortho
CA2064634C (fr) *	1991-04-04	1998-08-04	James V. Heck	Derives de 9-desoxo-8a-aza-8a-homoerythromycine a modifies en positions 4"- et 8a
CA2065222A1 (fr) *	1991-04-09	1992-10-10	Robert R. Wilkening	Procede d'obtention d'iminoethers cycliques de 8a-aza-8a-homoerythromycine
JP6152837B2 (ja)	2014-09-26	2017-06-28	Ｊｆｅスチール株式会社	冷延鋼板の製造方法及び圧延機

1994
- 1994-03-04 US US08/206,551 patent/US5441939A/en not_active Expired - Lifetime
1995
- 1995-02-02 AT AT95906455T patent/ATE181923T1/de not_active IP Right Cessation
- 1995-02-02 DE DE69510659T patent/DE69510659T2/de not_active Expired - Fee Related
- 1995-02-02 DK DK95906455T patent/DK0748329T3/da active
- 1995-02-02 WO PCT/IB1995/000074 patent/WO1995023808A1/fr not_active Ceased
- 1995-02-02 JP JP07522795A patent/JP3083102B2/ja not_active Expired - Fee Related
- 1995-02-02 EP EP95906455A patent/EP0748329B1/fr not_active Expired - Lifetime
- 1995-02-02 CA CA002184734A patent/CA2184734C/fr not_active Expired - Fee Related
- 1995-02-02 ES ES95906455T patent/ES2133175T3/es not_active Expired - Lifetime
- 1995-03-03 FI FI951003A patent/FI110780B/fi active
1999
- 1999-08-26 GR GR990402175T patent/GR3031092T3/el unknown

Also Published As

Publication number	Publication date
JPH09511498A (ja)	1997-11-18
WO1995023808A1 (fr)	1995-09-08
DE69510659D1 (en)	1999-08-12
JP3083102B2 (ja)	2000-09-04
FI951003A0 (fi)	1995-03-03
CA2184734C (fr)	1999-08-03
CA2184734A1 (fr)	1995-09-08
GR3031092T3 (en)	1999-12-31
FI951003L (fi)	1995-09-05
ES2133175T3 (es)	1999-09-01
EP0748329A1 (fr)	1996-12-18
EP0748329B1 (fr)	1999-07-07
FI110780B (fi)	2003-03-31
US5441939A (en)	1995-08-15
ATE181923T1 (de)	1999-07-15
DE69510659T2 (de)	1999-10-21

Publication	Publication Date	Title
ATE181923T1 (de)	1999-07-15	3''-desmethoxyderivate von erythromycin und azithromycin
WO1996023788B1 (fr)	1996-09-19	Phenyloxazolidinone substituee par un noyau heteroaromatique comme agent antimicrobien
NZ302844A (en)	1999-06-29	Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones
DK0706393T3 (da)	2000-04-03	Immun-undertrykkende og antiallergiske forbindelser, f.eks. N-(3-oxohexanoyl)homoserin-lacton
NZ508918A (en)	2003-03-28	2-(Purin-9-YL)-tetrahydrofuran-3,4-diol derivatives useful for the treatment of inflammation
NZ239165A (en)	1993-09-27	Drug conjugate (a-o-w-z) a -t, the crosslinking group containing a cycloalkyl ring, and pharmaceutical compositions
TW354293B (en)	1999-03-11	Prodrugs of paclitaxel derivatives
CA2085345A1 (fr)	1991-12-16	Derives pyrimidiques de nucleosides
DE60039238D1 (de)	2008-07-31	C-2-modifizierte erythromycinderivate
AU2888892A (en)	1993-05-03	3-ureido-benzodiazepinones useful as antagonists of cck or of gastrine
FI920349A0 (fi)	1992-01-27	Foerfarande foer framstaellning av nya tetrazolderivat och deras anvaendning.
TW200500806A (en)	2005-01-01	Resist composition and patterning process
EP1468692A3 (fr)	2004-11-03	Utilisation de 2,6-dialkyl-4-silyl-phenols pour traiter le xanthome
DK0769296T3 (da)	2001-10-22	Anvendelse af et natrium- eller lysiniumsalt af crotonsyreamidderivater til fremstilling af et lægemiddel til behandling af cancer
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TW354780B (en)	1999-03-21	2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
TW353661B (en)	1999-03-01	New derivatives of erythromycin, their preparation process and their use as medicaments
DK0381989T3 (da)	1992-03-23	4-epi-4-amino-anthracycliner
PL364698A1 (en)	2004-12-13	Novel vitamin d analogues
DE69131774D1 (de)	1999-12-16	Antibakterielle penem-ester derivate
NZ334367A (en)	2000-11-24	Compositions comprising a carbanate and a valine amide for controlling harmful fungi
IT1251158B (it)	1995-05-04	13-diidro-3'-(2-alcossi-4-morfolinil)antracicline
ES8104318A1 (es)	1981-04-16	Un procedimiento para la preparacion de un derivado de una 1, epi-fortimicina.
ES8107249A1 (es)	1981-10-01	Un procedimiento para la preparacion de derivados de 2-epi- fortimicina.
SG47940A1 (en)	1998-04-17	Light screening agent