DK0748329T3 - 3"-desmethoxyderivater af erythromycin og azithromycin - Google Patents

3"-desmethoxyderivater af erythromycin og azithromycin

Info

Publication number: DK0748329T3
Authority: DK; Denmark
Prior art keywords: azithromycin; erythromycin; alkyl; image; desmethoxy derivatives
Prior art date: 1994-03-04

Application number

DK95906455T

Other languages

Danish (da)

English (en)

Inventor

Bingwei V Yang

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-04

Filing date

1995-02-02

Publication date

1999-11-22

1995-02-02 Application filed by Pfizer filed Critical Pfizer

1999-11-22 Application granted granted Critical

1999-11-22 Publication of DK0748329T3 publication Critical patent/DK0748329T3/da

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
229960004099 azithromycin Drugs 0.000 title 1
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000003544 oxime group Chemical group 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

DK95906455T 1994-03-04 1995-02-02 3"-desmethoxyderivater af erythromycin og azithromycin DK0748329T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/206,551 US5441939A (en)	1994-03-04	1994-03-04	3"-desmethoxy derivatives of erythromycin and azithromycin
PCT/IB1995/000074 WO1995023808A1 (en)	1994-03-04	1995-02-02	3''-desmethoxy derivatives of erythromycin and azithromycin

Publications (1)

Publication Number	Publication Date
DK0748329T3 true DK0748329T3 (da)	1999-11-22

Family

ID=22766886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95906455T DK0748329T3 (da)	1994-03-04	1995-02-02	3"-desmethoxyderivater af erythromycin og azithromycin

Country Status (11)

Country	Link
US (1)	US5441939A (ja)
EP (1)	EP0748329B1 (ja)
JP (1)	JP3083102B2 (ja)
AT (1)	ATE181923T1 (ja)
CA (1)	CA2184734C (ja)
DE (1)	DE69510659T2 (ja)
DK (1)	DK0748329T3 (ja)
ES (1)	ES2133175T3 (ja)
FI (1)	FI110780B (ja)
GR (1)	GR3031092T3 (ja)
WO (1)	WO1995023808A1 (ja)

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HN1998000074A (es) *	1997-06-11	1999-01-08	Pfizer Prod Inc	Derivados de macrolidos c-4 sustituidos
HN1998000086A (es) *	1997-06-11	1999-03-08	Pfizer Prod Inc	Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
AP9801420A0 (en) *	1998-01-02	1998-12-31	Pfizer Prod Inc	Novel macrolides.
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
US6100240A (en) *	1998-10-09	2000-08-08	Pfizer Inc	Macrolide derivatives
CA2411293A1 (en) *	1999-01-28	2000-07-28	Pfizer Products Inc.	Novel azalides and methods of making same
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
US7056893B2 (en) *	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
DE60038610T2 (de) *	1999-05-18	2009-06-25	Pfizer Products Inc., Groton	Neue kristalline formen eines makrolidantibiotikums
HUP0201516A3 (en) *	1999-05-24	2003-03-28	Pfizer Prod Inc	13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
WO2002009640A2 (en) *	2000-08-01	2002-02-07	Shiva Prasad Singh	Process for the preparation of anhydrous azithromycin
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
RU2263117C2 (ru)	2001-04-27	2005-10-27	Пфайзер Продактс Инк.	Способ получения 4"-замещенных производных 9-деоксо-9а-аза-9а-гомоэритромицина а
US7273853B2 (en) *	2002-05-13	2007-09-25	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US6878691B2 (en) *	2002-05-13	2005-04-12	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide derivatives
US7064110B2 (en) *	2002-05-13	2006-06-20	Enanta Pharmaceuticals, Inc.	6-11 bicycle ketolide derivatives
AU2003295869A1 (en) *	2003-11-20	2005-07-14	Enanta Pharmaceuticals, Inc.	6-11 bicyclic ketolide drivatives
CN101955508B (zh) *	2003-11-20	2015-04-15	埃纳恩塔制药公司	6-11双环酮大环内酯衍生物
US7414030B2 (en) *	2004-01-07	2008-08-19	Enanta Pharmaceuticals, Inc.	6-11 Bicyclic erythromycin derivatives
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US20060046970A1 (en) *	2004-08-31	2006-03-02	Insite Vision Incorporated	Topical otic compositions and methods of topical treatment of prevention of otic infections
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
EP2203435B1 (en) *	2007-09-17	2018-07-18	Enanta Pharmaceuticals, Inc.	6, 11-bridged biaryl macrolides
US8354383B2 (en) *	2007-09-17	2013-01-15	Enanta Pharmaceuticals, Inc.	6,11-bridged biaryl macrolides
US8273720B2 (en) *	2007-09-17	2012-09-25	Enanta Pharmaceuticals, Inc.	6,11-bicyclolides: bridged biaryl macrolide derivatives
CA3060892A1 (en)	2017-04-20	2018-10-25	Rising Tide Foundation	Azithromycin derivatives containing a phosphonium ion as anticancer agents
CN110799516A (zh)	2017-04-20	2020-02-14	来兴泰德基金会	作为抗癌剂的包含鏻离子的阿奇霉素衍生物
US11197872B2 (en)	2017-04-21	2021-12-14	Lunella Biotech, Inc.	Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs)
EP3612177A4 (en)	2017-04-21	2021-01-13	Lunella Biotech, Inc.	TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
PH12019502594A1 (en)	2017-05-19	2020-10-26	Lunella Biotech Inc	Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
CA3063450A1 (en)	2017-05-19	2018-11-22	Lunella Biotech, Inc.	Companion diagnostics for mitochondrial inhibitors
KR102854338B1 (ko)	2017-06-26	2025-09-03	루넬라 바이오테크 인코포레이티드	미토케토신: 암 세포에서 케톤 대사를 표적화하는 미토콘드리아-기반의 치료제

Family Cites Families (14)

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Publication number	Priority date	Publication date	Assignee	Title
SI8110592A8 (en) *	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
YU43658B (en) *	1983-07-18	1989-10-31	Pliva Pharm & Chem Works	Process for preparing 7,16-dioxa-2-aza-10-0-cladinosyl-12,0-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethyl-bicyclo(11.2.1)hexadeca-1(2)-ene-8
JPS60126296A (ja) *	1983-12-13	1985-07-05	Kyowa Hakko Kogyo Co Ltd	３，３”，４”−トリ−ｏ−アシルスピラマイシン１
US4518590A (en) *	1984-04-13	1985-05-21	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
GB8521402D0 (en) *	1985-08-28	1985-10-02	Beecham Group Plc	Chemical compounds
CA2062932A1 (en) *	1991-03-15	1992-09-16	Robert R. Wilkening	9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2064634C (en) *	1991-04-04	1998-08-04	James V. Heck	9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
CA2065222A1 (en) *	1991-04-09	1992-10-10	Robert R. Wilkening	Process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
JP6152837B2 (ja)	2014-09-26	2017-06-28	Ｊｆｅスチール株式会社	冷延鋼板の製造方法及び圧延機

1994
- 1994-03-04 US US08/206,551 patent/US5441939A/en not_active Expired - Lifetime
1995
- 1995-02-02 EP EP95906455A patent/EP0748329B1/en not_active Expired - Lifetime
- 1995-02-02 CA CA002184734A patent/CA2184734C/en not_active Expired - Fee Related
- 1995-02-02 ES ES95906455T patent/ES2133175T3/es not_active Expired - Lifetime
- 1995-02-02 DK DK95906455T patent/DK0748329T3/da active
- 1995-02-02 AT AT95906455T patent/ATE181923T1/de not_active IP Right Cessation
- 1995-02-02 DE DE69510659T patent/DE69510659T2/de not_active Expired - Fee Related
- 1995-02-02 JP JP07522795A patent/JP3083102B2/ja not_active Expired - Fee Related
- 1995-02-02 WO PCT/IB1995/000074 patent/WO1995023808A1/en not_active Ceased
- 1995-03-03 FI FI951003A patent/FI110780B/fi active
1999
- 1999-08-26 GR GR990402175T patent/GR3031092T3/el unknown

Also Published As

Publication number	Publication date
JPH09511498A (ja)	1997-11-18
JP3083102B2 (ja)	2000-09-04
FI951003A0 (fi)	1995-03-03
DE69510659T2 (de)	1999-10-21
FI951003L (fi)	1995-09-05
WO1995023808A1 (en)	1995-09-08
DE69510659D1 (en)	1999-08-12
EP0748329B1 (en)	1999-07-07
ATE181923T1 (de)	1999-07-15
FI110780B (fi)	2003-03-31
GR3031092T3 (en)	1999-12-31
CA2184734C (en)	1999-08-03
ES2133175T3 (es)	1999-09-01
CA2184734A1 (en)	1995-09-08
US5441939A (en)	1995-08-15
EP0748329A1 (en)	1996-12-18

Publication	Publication Date	Title
DK0748329T3 (da)	1999-11-22	3"-desmethoxyderivater af erythromycin og azithromycin
WO1996023788B1 (en)	1996-09-19	Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials
IL113101A0 (en)	1995-06-29	Anthracycline derivatives and their preparation
NZ302844A (en)	1999-06-29	Antimicrobial hetero-aromatic ring substituted phenyloxazolidinones
DK0706393T3 (da)	2000-04-03	Immun-undertrykkende og antiallergiske forbindelser, f.eks. N-(3-oxohexanoyl)homoserin-lacton
NZ508918A (en)	2003-03-28	2-(Purin-9-YL)-tetrahydrofuran-3,4-diol derivatives useful for the treatment of inflammation
EP1288199A4 (en)	2005-10-12	INHIBITORS OF MMP-12
CA2085345A1 (en)	1991-12-16	Pyrimidine nucleoside derivatives
DE60039238D1 (de)	2008-07-31	C-2-modifizierte erythromycinderivate
AU2888892A (en)	1993-05-03	3-ureido-benzodiazepinones useful as antagonists of cck or of gastrine
TW200500806A (en)	2005-01-01	Resist composition and patterning process
FI920349A0 (fi)	1992-01-27	Foerfarande foer framstaellning av nya tetrazolderivat och deras anvaendning.
EP1468692A3 (en)	2004-11-03	Use of 2,6-di-alkyl-4-silyl-phenols for treating xanthoma
TW350757B (en)	1999-01-21	Benzisoxazole derivatives and pesticidal compositions containing them
TW354780B (en)	1999-03-21	2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents
TW353661B (en)	1999-03-01	New derivatives of erythromycin, their preparation process and their use as medicaments
DE69029781D1 (de)	1997-03-06	Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung
PL364698A1 (en)	2004-12-13	Novel vitamin d analogues
ATE72445T1 (de)	1992-02-15	4'-epi-4'-aminoanthracycline.
DE69131774D1 (de)	1999-12-16	Antibakterielle penem-ester derivate
NZ334367A (en)	2000-11-24	Compositions comprising a carbanate and a valine amide for controlling harmful fungi
IT1251158B (it)	1995-05-04	13-diidro-3'-(2-alcossi-4-morfolinil)antracicline
ES8104318A1 (es)	1981-04-16	Un procedimiento para la preparacion de un derivado de una 1, epi-fortimicina.
ES8107249A1 (es)	1981-10-01	Un procedimiento para la preparacion de derivados de 2-epi- fortimicina.
SE8305306D0 (sv)	1983-09-29	Alkyl-bensylidenderivat