DK0751930T3 - Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer - Google Patents

Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer

Info

Publication number: DK0751930T3
Authority: DK; Denmark
Prior art keywords: alkyl; amino; alkoxy; hydroxy; nitric oxide
Prior art date: 1994-03-24

Application number

DK95914809T

Other languages

English (en)

Inventor

Foe S Tjoeng

Mark G Currie

Kam F Fok

Keith Webber

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-24

Filing date

1995-03-24

Publication date

2000-04-17

1995-03-24 Application filed by Searle & Co filed Critical Searle & Co

2000-04-17 Application granted granted Critical

2000-04-17 Publication of DK0751930T3 publication Critical patent/DK0751930T3/da

Links

125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title abstract 2
239000000236 nitric oxide synthase inhibitor Substances 0.000 title abstract 2
CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 8
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000004093 cyano group Chemical group *C#N 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000004950 trifluoroalkyl group Chemical group 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000001188 haloalkyl group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
239000011593 sulfur Substances 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical group ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
150000003973 alkyl amines Chemical group 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
-1 aromatic hydrocarbon radical Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003536 tetrazoles Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C391/00—Compounds containing selenium

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyridine Compounds (AREA)

DK95914809T 1994-03-24 1995-03-24 Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer DK0751930T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US21816094A	1994-03-24	1994-03-24
PCT/US1995/003589 WO1995025717A1 (en)	1994-03-24	1995-03-24	Amidino derivatives useful as nitric oxide synthase inhibitors

Publications (1)

Publication Number	Publication Date
DK0751930T3 true DK0751930T3 (da)	2000-04-17

Family

ID=22813994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95914809T DK0751930T3 (da)	1994-03-24	1995-03-24	Amidinoderivater anvendelige som nitrogenoxid-synthase-inhibitorer

Country Status (9)

Country	Link
EP (1)	EP0751930B1 (da)
AT (1)	ATE188467T1 (da)
AU (1)	AU2190895A (da)
DE (1)	DE69514341T2 (da)
DK (1)	DK0751930T3 (da)
ES (1)	ES2141347T3 (da)
GR (1)	GR3032365T3 (da)
PT (1)	PT751930E (da)
WO (1)	WO1995025717A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684008A (en) *	1994-11-09	1997-11-04	G. D. Searle & Co.	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) *	1996-03-06	1999-11-09	G.D. Searle & Co.	Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) *	1996-03-06	1999-08-31	G.D. Searle & Co.	Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981556A (en) *	1997-07-22	1999-11-09	G.D. Searle & Co.	1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
WO1999051215A2 (en) *	1998-04-06	1999-10-14	Fujisawa Pharmaceutical Co., Ltd.	Immunosuppressive imidazole derivatives and their combination preparations with tacrolimus or cyclosporins
US6552052B2 (en)	1998-06-10	2003-04-22	Monsanto/G.D. Searle	Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors
WO2000026195A1 (en) *	1998-10-30	2000-05-11	G.D. Searle & Co.	Novel amino acid heterocyclic amide derivatives useful as nitric oxide synthase inhibitors
WO2000044731A1 (en) *	1999-01-27	2000-08-03	G.D. Searle & Co.	Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
AU4329000A (en) *	1999-04-19	2000-11-02	G.D. Searle & Co.	Novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
AU6216900A (en) *	1999-07-15	2001-02-05	Monsanto Company	Oligomeric amino acid derivatives useful as nitric oxide synthase inhibitors
ATE295832T1 (de)	2000-03-24	2005-06-15	Pharmacia Corp	Amidino-verbindung sowie salze davon verwendbar als hemmstoffe der stickstoffmonoxid-synthase
AR034120A1 (es)	2000-04-13	2004-02-04	Pharmacia Corp	Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
US6787668B2 (en)	2000-04-13	2004-09-07	Pharmacia Corporation	2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
US6956131B2 (en)	2000-04-13	2005-10-18	Pharmacia Corporation	2-amino-3, 4 heptenoic compounds useful as nitric oxide synthase inhibitors
US6545170B2 (en)	2000-04-13	2003-04-08	Pharmacia Corporation	2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
AR032318A1 (es)	2000-04-13	2003-11-05	Pharmacia Corp	Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa
AR030416A1 (es)	2000-04-13	2003-08-20	Pharmacia Corp	COMPUESTO DERIVADO HALOGENADO DEL ACIDO 2-AMINO-3,4 HEPTENOICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE Y SU USO EN LA FABRICACION DE UN MEDICAMENTO uTIL COMO INHIBIDOR DE LA OXIDO NITRICO SINTETASA
US6344473B1 (en)	2000-08-07	2002-02-05	G.D. Searle & Co.	Imidazoles useful as nitric oxide synthase inhibitors
AR031609A1 (es) *	2000-09-15	2003-09-24	Pharmacia Corp	Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa
AR031129A1 (es) *	2000-09-15	2003-09-10	Pharmacia Corp	Derivados de los acidos 2-amino-2-alquil-4-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
TWI290130B (en) *	2000-09-15	2007-11-21	Pharmacia Corp	2-Amino-2alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
AR031608A1 (es)	2000-09-15	2003-09-24	Pharmacia Corp	Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa
AR035585A1 (es) *	2000-09-15	2004-06-16	Pharmacia Corp	Derivados del acido 2-amino-2-alquil-4-heptenoico, composicion farmaceutica y su uso en la fabricacion de medicamentos
US7012098B2 (en)	2001-03-23	2006-03-14	Pharmacia Corporation	Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
BR0313204A (pt) *	2002-08-02	2005-06-28	Pharmacia Corp	Métodos para tratamento e prevenção de condições gastrointestinais
RU2314290C2 (ru)	2002-08-23	2008-01-10	Фармация Корпорейшн	Кристаллическая твердая форма 1,5 гидрохлорида (2s,5z)-2-амино-7-(этанимидоиламино)-2-метилгепт-5-еноевой кислоты, способ ее получения, фармацевтическая композиция на ее основе
GB201512635D0 (en)	2015-07-17	2015-08-26	Ucl Business Plc	Uses of therapeutic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9127376D0 (en) *	1991-12-24	1992-02-19	Wellcome Found	Amidino derivatives
US5281627A (en) *	1992-05-28	1994-01-25	Cornell Research Foundation, Inc.	Substituted arginines and substituted homoarginines and use thereof

1995
- 1995-03-24 DE DE69514341T patent/DE69514341T2/de not_active Expired - Fee Related
- 1995-03-24 DK DK95914809T patent/DK0751930T3/da active
- 1995-03-24 ES ES95914809T patent/ES2141347T3/es not_active Expired - Lifetime
- 1995-03-24 PT PT95914809T patent/PT751930E/pt unknown
- 1995-03-24 EP EP95914809A patent/EP0751930B1/en not_active Expired - Lifetime
- 1995-03-24 WO PCT/US1995/003589 patent/WO1995025717A1/en not_active Ceased
- 1995-03-24 AT AT95914809T patent/ATE188467T1/de not_active IP Right Cessation
- 1995-03-24 AU AU21908/95A patent/AU2190895A/en not_active Abandoned
2000
- 2000-01-14 GR GR20000400063T patent/GR3032365T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2190895A (en)	1995-10-09
PT751930E (pt)	2000-04-28
DE69514341D1 (en)	2000-02-10
EP0751930B1 (en)	2000-01-05
GR3032365T3 (en)	2000-04-27
ES2141347T3 (es)	2000-03-16
WO1995025717A1 (en)	1995-09-28
ATE188467T1 (de)	2000-01-15
DE69514341T2 (de)	2000-05-18
EP0751930A1 (en)	1997-01-08

Publication	Publication Date	Title
ATE188467T1 (de)	2000-01-15	Amidino-derivative als no-synthese-inhibitoren
UY28149A1 (es)	2004-07-30	Compuestos quimicos
NO20051600L (no)	2005-06-13	1,4-disubstituerte piperidinderivater og anvendelse derav som 11-betaHSD1 inhibitorer
ATE282614T1 (de)	2004-12-15	Phenylharnstoff und phenylthioharnstoffderivate
WO1999033858A3 (en)	1999-09-16	Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
NO20060972L (no)	2006-05-02	Pyridylderivater og deres anvendelse som terapeutiske midler
YU64092A (sh)	1995-03-27	Fluoralkoksibenzamino derivati heterocikličnih jedinjenja koja sadrže azot
ES449191A1 (es)	1977-12-01	Un procedimiento de preparacion de derivados de 4,5,6,7-te- trahidro-tieno-(2,3-c)-piridina.
NO20053215L (no)	2005-09-01	Pyrazolderivater med anvendelse som COX-1-inhibitorer.
BRPI0506817A (pt)	2007-05-29	inibidores seletivos de quinase
MXPA05006920A (es)	2006-02-10	Compuestos de quinazolina.
NZ524559A (en)	2004-12-24	2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors
BR0013041A (pt)	2002-07-16	Composto heterociclico e composição farmacêutica para tratar e prevenir doenças mediadas por cgmp-pde, seu uso e método
HUP9902410A2 (hu)	1999-11-29	Amidinszármazékok, előállításuk, trombininhibitorként való alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
DE60324461D1 (de)	2008-12-11	Therapeutische quinazolin-derivate
DK0790987T3 (da)	2001-11-12	Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer
ATE182889T1 (de)	1999-08-15	Bicyclische amidinderivate als no-synthetase inhibitoren
DE602004015277D1 (de)	2008-09-04	Substituierte-1-phthalazinamine als vr-1-antagonisten
ATE383340T1 (de)	2008-01-15	Unsymmetrische zyklische diaminverbindung
MX2025003324A (es)	2025-05-02	Inhibidores de sik heterociclicos
DE69817810D1 (de)	2003-10-09	Cyanoguanidine als zellproliferation inhibitoren
EA199901096A1 (ru)	2000-08-28	Цианогуанидины в качестве ингибиторов пролиферации клеток
BG105123A (en)	2001-11-30	Tetrahydroquinaline derivatives as glycine antagonists
CA2186224A1 (en)	1995-09-28	Amidino derivatives useful as nitric oxide synthase inhibitors
DK1150974T3 (da)	2002-12-02	Heterocykliske derivater som inhibitor af faktor Xa