ATE282614T1 - Phenylharnstoff und phenylthioharnstoffderivate - Google Patents

Phenylharnstoff und phenylthioharnstoffderivate

Info

Publication number: ATE282614T1
Authority: AT; Austria
Prior art keywords: phenyl urea; phenylthiourea derivatives; phenylthiourea; derivatives; urea
Prior art date: 1999-02-12

Application number

AT00907553T

Other languages

English (en)

Inventor

Steven Coulton

Amanda Johns

Roderick Alan Porter

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-12

Filing date

2000-02-10

Publication date

2004-12-15

1999-02-12 Priority claimed from GBGB9903241.9A external-priority patent/GB9903241D0/en

1999-11-08 Priority claimed from GBGB9926441.8A external-priority patent/GB9926441D0/en

2000-02-10 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE282614T1 publication Critical patent/ATE282614T1/de

Links

LUBJCRLGQSPQNN-UHFFFAOYSA-N 1-Phenylurea Chemical compound NC(=O)NC1=CC=CC=C1 LUBJCRLGQSPQNN-UHFFFAOYSA-N 0.000 title 2
FULZLIGZKMKICU-UHFFFAOYSA-N N-phenylthiourea Chemical class NC(=S)NC1=CC=CC=C1 FULZLIGZKMKICU-UHFFFAOYSA-N 0.000 title 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Rheumatology (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Addiction (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Immunology (AREA)
Otolaryngology (AREA)

AT00907553T 1999-02-12 2000-02-10 Phenylharnstoff und phenylthioharnstoffderivate ATE282614T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9903241.9A GB9903241D0 (en)	1999-02-12	1999-02-12	Compounds
GBGB9926441.8A GB9926441D0 (en)	1999-11-08	1999-11-08	Compounds
PCT/EP2000/001142 WO2000047580A2 (en)	1999-02-12	2000-02-10	Phenyl urea and phenyl thiourea derivatives

Publications (1)

Publication Number	Publication Date
ATE282614T1 true ATE282614T1 (de)	2004-12-15

Family

ID=26315127

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00907553T ATE282614T1 (de)	1999-02-12	2000-02-10	Phenylharnstoff und phenylthioharnstoffderivate

Country Status (8)

Country	Link
US (1)	US6596730B1 (de)
EP (1)	EP1144409B1 (de)
JP (1)	JP2002536447A (de)
AT (1)	ATE282614T1 (de)
AU (1)	AU2910600A (de)
DE (1)	DE60015927T2 (de)
ES (1)	ES2231158T3 (de)
WO (1)	WO2000047580A2 (de)

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WO2002090355A1 (en)	2001-05-05	2002-11-14	Smithkline Beecham P.L.C.	N-aroyl cyclic amines
GB0115862D0 (en) *	2001-06-28	2001-08-22	Smithkline Beecham Plc	Compounds
CZ20033437A3 (cs)	2001-06-28	2004-09-15	Smithkline Beecham P.L.C.	N-Aroylové cyklické aminové deriváty jako antagonisté orexinového receptoru
CA2460051A1 (en) *	2002-07-09	2004-01-15	Actelion Pharmaceuticals Ltd.	7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives
RU2334735C2 (ru)	2002-10-11	2008-09-27	Актелион Фармасьютиклз Лтд.	Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина
WO2004054979A1 (ja) *	2002-12-18	2004-07-01	Takeda Pharmaceutical Company Limited	Ｊｎｋ阻害剤
US20040142950A1 (en) *	2003-01-17	2004-07-22	Bunker Amy Mae	Amide and ester matrix metalloproteinase inhibitors
ES2297413T3 (es) *	2003-04-28	2008-05-01	Actelion Pharmaceuticals Ltd.	Derivados de quinoxalinona-3-ona utilizados como antagonistas del receptor de orexina.
US20050125041A1 (en) *	2003-11-05	2005-06-09	Xiaoyi Min	Methods for ventricular pacing
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CA2557163C (en)	2004-03-01	2011-08-16	Idorsia Pharmaceuticals Ltd	Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
FR2874011B1 (fr)	2004-08-03	2007-06-15	Sanofi Synthelabo	Derives de sulfonamides, leur preparation et leur application en therapeutique
WO2006081522A2 (en) *	2005-01-26	2006-08-03	The Regents Of The Unversity Of California	Modulation of nmda receptor currents via orexin receptor and/or crf receptor
US7501395B2 (en)	2005-04-25	2009-03-10	Eisai R & D Management Co., Ltd.	Method of screening for antianxiety drugs
WO2007024754A1 (en) *	2005-08-22	2007-03-01	Amgen Inc.	Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes
EP2049110B1 (de)	2006-07-14	2014-08-20	Merck Sharp & Dohme Corp.	Verbrückte diazepanorexin-rezeptorantagonisten
PE20081229A1 (es)	2006-12-01	2008-08-28	Merck & Co Inc	Antagonistas de receptor de orexina de diazepam sustituido
JP2010527924A (ja)	2007-05-18	2010-08-19	メルク・シャープ・エンド・ドーム・コーポレイション	オキソ架橋ジアゼパンオレキシン受容体アンタゴニスト
AU2008260647A1 (en)	2007-05-23	2008-12-11	Merck Sharp & Dohme Corp.	Cyclopropyl pyrrolidine orexin receptor antagonists
NZ580887A (en)	2007-05-23	2012-03-30	Merck Sharp & Dohme	Pyridyl piperidine orexin receptor antagonists
US7941217B1 (en) *	2008-03-25	2011-05-10	Pacesetter, Inc.	Techniques for promoting biventricular synchrony and stimulation device efficiency using intentional fusion
US20090299423A1 (en) *	2008-06-03	2009-12-03	Pacesetter, Inc.	Systems and methods for determining inter-atrial conduction delays using multi-pole left ventricular pacing/sensing leads
AU2009324238A1 (en)	2008-12-02	2010-06-10	Glaxo Group Limited	N-{[(IR,4S,6R-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0] hept-4-yl] methyl}-2-heteroarylamine derivatives and uses thereof
EP2421850A1 (de)	2009-04-24	2012-02-29	Glaxo Group Limited	Als orexinantagonisten verwendete 3-azabicyclo[4.1.0]heptane
JP2013502447A (ja)	2009-08-24	2013-01-24	グラクソグループリミテッド	睡眠障害の治療のためのオレキシン受容体アンタゴニストとしての５−メチル−ピペリジン誘導体
WO2011023585A1 (en)	2009-08-24	2011-03-03	Glaxo Group Limited	Piperidine derivatives used as orexin antagonists
WO2012089607A1 (en)	2010-12-28	2012-07-05	Glaxo Group Limited	Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
WO2012089606A1 (en)	2010-12-28	2012-07-05	Glaxo Group Limited	Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
AR088352A1 (es)	2011-10-19	2014-05-28	Merck Sharp & Dohme	Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
CA2863413A1 (en)	2012-02-07	2013-08-15	Eolas Therapeutics, Inc.	Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en)	2012-02-07	2016-09-13	Eolas Therapeutics, Inc.	Substituted prolines/piperidines as orexin receptor antagonists
UY36272A (es)	2014-08-13	2016-02-29	Eolas Therapeutics Inc	Difluoropirrolidinas como moduladores de los receptores de orexinas
AU2017217931B2 (en)	2016-02-12	2020-10-22	Astrazeneca Ab	Halo-substituted piperidines as orexin receptor modulators
WO2017194548A1 (en)	2016-05-10	2017-11-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
WO2019117148A1 (ja) *	2017-12-12	2019-06-20	国立大学法人筑波大学	スルホンアミド誘導体またはその薬学的に許容される酸付加塩
WO2025124698A1 (en)	2023-12-12	2025-06-19	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators
TW202542165A (zh)	2023-12-19	2025-11-01	瑞士商愛杜西亞製藥有限公司	大環食慾素激動劑

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9302275D0 (en) *	1993-02-05	1993-03-24	Smithkline Beecham Plc	Novel compounds
AR016817A1 (es)	1997-08-14	2001-08-01	Smithkline Beecham Plc	Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento
US6372757B1 (en) *	1998-05-08	2002-04-16	Smithkline Beecham P.L.C.	Phenylurea and phenylthio urea derivatives

2000
- 2000-02-10 EP EP00907553A patent/EP1144409B1/de not_active Expired - Lifetime
- 2000-02-10 DE DE60015927T patent/DE60015927T2/de not_active Expired - Fee Related
- 2000-02-10 WO PCT/EP2000/001142 patent/WO2000047580A2/en not_active Ceased
- 2000-02-10 US US09/913,228 patent/US6596730B1/en not_active Expired - Fee Related
- 2000-02-10 ES ES00907553T patent/ES2231158T3/es not_active Expired - Lifetime
- 2000-02-10 JP JP2000598500A patent/JP2002536447A/ja not_active Withdrawn
- 2000-02-10 AU AU29106/00A patent/AU2910600A/en not_active Abandoned
- 2000-02-10 AT AT00907553T patent/ATE282614T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2002536447A (ja)	2002-10-29
ES2231158T3 (es)	2005-05-16
WO2000047580A2 (en)	2000-08-17
US6596730B1 (en)	2003-07-22
DE60015927D1 (en)	2004-12-23
AU2910600A (en)	2000-08-29
EP1144409A2 (de)	2001-10-17
EP1144409B1 (de)	2004-11-17
WO2000047580A3 (en)	2000-12-21
DE60015927T2 (de)	2005-04-07

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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