DK0763533T3 - Fremstilling til anvendelse af de rene enantiomerer af 8-chlor-6-sulfonyloxy-octansyre og dens alkylestere og de rene enantiomerer af 6,8-dichlor-octansyre og dens alkylestere - Google Patents

Fremstilling til anvendelse af de rene enantiomerer af 8-chlor-6-sulfonyloxy-octansyre og dens alkylestere og de rene enantiomerer af 6,8-dichlor-octansyre og dens alkylestere

Info

Publication number: DK0763533T3
Authority: DK; Denmark
Prior art keywords: formula; acid; chloro; alkyl esters; give
Prior art date: 1995-09-13

Application number

DK96114417T

Other languages

Danish (da)

English (en)

Inventor

Rainer Gewald

Gunter Laban

Thomas Beisswenger

Original Assignee

Asta Medica Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-13

Filing date

1996-09-10

Publication date

2001-09-10

1996-09-10 Application filed by Asta Medica Ag filed Critical Asta Medica Ag

2001-09-10 Application granted granted Critical

2001-09-10 Publication of DK0763533T3 publication Critical patent/DK0763533T3/da

Links

HSKAEXWPLIDFGC-UHFFFAOYSA-N 6,8-dichlorooctanoic acid Chemical compound OC(=O)CCCCC(Cl)CCCl HSKAEXWPLIDFGC-UHFFFAOYSA-N 0.000 title abstract 3
-1 8-chloro-6-sulfonyloxy-octanoic acid Chemical class 0.000 title abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 2
125000005907 alkyl ester group Chemical group 0.000 title 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Substances 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
150000001340 alkali metals Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 abstract 1
IZFHEQBZOYJLPK-ZETCQYMHSA-N (S)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@H](S)CCS IZFHEQBZOYJLPK-ZETCQYMHSA-N 0.000 abstract 1
AGBQKNBQESQNJD-ZETCQYMHSA-N (S)-lipoic acid Chemical compound OC(=O)CCCC[C@H]1CCSS1 AGBQKNBQESQNJD-ZETCQYMHSA-N 0.000 abstract 1
WXPREQDMOKXUIM-UHFFFAOYSA-N 8-chloro-6-hydroxyoctanoic acid Chemical compound ClCCC(O)CCCCC(O)=O WXPREQDMOKXUIM-UHFFFAOYSA-N 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/08—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by replacement of hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

DK96114417T 1995-09-13 1996-09-10 Fremstilling til anvendelse af de rene enantiomerer af 8-chlor-6-sulfonyloxy-octansyre og dens alkylestere og de rene enantiomerer af 6,8-dichlor-octansyre og dens alkylestere DK0763533T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19533881A DE19533881A1 (de)	1995-09-13	1995-09-13	Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester

Publications (1)

Publication Number	Publication Date
DK0763533T3 true DK0763533T3 (da)	2001-09-10

Family

ID=7772033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96114417T DK0763533T3 (da)	1995-09-13	1996-09-10	Fremstilling til anvendelse af de rene enantiomerer af 8-chlor-6-sulfonyloxy-octansyre og dens alkylestere og de rene enantiomerer af 6,8-dichlor-octansyre og dens alkylestere

Country Status (10)

Country	Link
US (1)	US5731448A (fr)
EP (1)	EP0763533B1 (fr)
JP (1)	JPH09221466A (fr)
AT (1)	ATE202098T1 (fr)
DE (2)	DE19533881A1 (fr)
DK (1)	DK0763533T3 (fr)
ES (1)	ES2160195T3 (fr)
GR (1)	GR3036578T3 (fr)
PT (1)	PT763533E (fr)
RU (1)	RU2176641C2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19601787C1 (de) *	1996-01-19	1997-07-24	Asta Medica Ag	Herstellung und Verwendung von Salzen der 6,8-Bis(amidiniumthio)-octansäure
WO2002010422A1 (fr)	2000-07-27	2002-02-07	Viatris Gmbh & Co. Kg	Procede de reduction enantioselective d'alkyl esters d'acide 8-chloro-6-oxo-octanoique
EP1307442A2 (fr) *	2000-08-02	2003-05-07	Basf Aktiengesellschaft	Procede de production d'acide lipoique et d'acide dihydrolipoique
IT1319196B1 (it) *	2000-10-10	2003-09-26	Laboratorio Chimico Int Spa	Sintesi dell'acido r(+)alfa-lipoico.
IT1319194B1 (it) *	2000-10-10	2003-09-26	Laboratorio Chimico Int Spa	Processo per la produzione dell'acido tiottico racemo.
DE10137381A1 (de)	2001-07-31	2003-02-13	Viatris Gmbh	Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
DE10201464B4 (de) *	2002-01-16	2005-06-16	Viatris Gmbh & Co. Kg	Verfahren zur Herstellung reiner Thioctsäure
CN100593534C (zh) *	2007-09-30	2010-03-10	浙江工业大学	一种6,8-二氯辛酸乙酯的化学合成方法
CN101880224B (zh) *	2009-05-08	2013-02-20	上海医药工业研究院	一种6,8-二氯辛酸的拆分方法
CN105524040A (zh) *	2016-02-19	2016-04-27	苏州富士莱医药股份有限公司	一种r-硫辛酸的制备方法
CN105622571A (zh) *	2016-03-08	2016-06-01	苏州富士莱医药股份有限公司	一种r-硫辛酸氨基丁三醇盐的制备方法
DE102017000811A1 (de) *	2017-01-28	2018-08-02	Alzchem Trostberg Gmbh	Verfahren zur Herstellung von Dihydroliponsäure

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2877235A (en) *	1954-05-28	1959-03-10	Du Pont	Alpha-lipoic acid process
US2792406A (en) *	1954-06-01	1957-05-14	Du Pont	Process of preparing alpha-lipoic acid using dichlorooctanoate and metal disulfide
US2980716A (en) *	1954-06-11	1961-04-18	Research Corp	Method for preparing 6, 8-dihalooctanoic esters
FR1176920A (fr) *	1954-07-22	1959-04-17	Merck & Co Inc	Procédé de préparation de l'acide alpha-lipoïque et de ses intermédiaires
CH415604A (de) *	1961-02-02	1966-06-30	Fujisawa Pharmaceutical Co	Verfahren zur Herstellung von Acylthiohalogencaprylsäurederivaten
DE3629116A1 (de) *	1986-08-27	1988-03-10	Asta Pharma Ag	Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
GB8827885D0 (en) *	1988-11-30	1989-01-05	Wellcome Found	Novel heterocyclic pesticidal compounds
DE59308496D1 (de) *	1992-09-08	1998-06-10	Basf Ag	Verbessertes Verfahren zur Herstellung von R/S-gamma-Liponsäure oder R/S-alpha-Liponsäure

1995
- 1995-09-13 DE DE19533881A patent/DE19533881A1/de not_active Withdrawn
1996
- 1996-08-29 US US08/705,212 patent/US5731448A/en not_active Expired - Fee Related
- 1996-09-10 PT PT96114417T patent/PT763533E/pt unknown
- 1996-09-10 EP EP96114417A patent/EP0763533B1/fr not_active Expired - Lifetime
- 1996-09-10 DK DK96114417T patent/DK0763533T3/da active
- 1996-09-10 ES ES96114417T patent/ES2160195T3/es not_active Expired - Lifetime
- 1996-09-10 AT AT96114417T patent/ATE202098T1/de not_active IP Right Cessation
- 1996-09-10 DE DE59607070T patent/DE59607070D1/de not_active Expired - Fee Related
- 1996-09-13 JP JP8243640A patent/JPH09221466A/ja active Pending
- 1996-09-13 RU RU96118235/04A patent/RU2176641C2/ru not_active IP Right Cessation
2001
- 2001-09-11 GR GR20010401435T patent/GR3036578T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE19533881A1 (de)	1997-03-20
GR3036578T3 (en)	2001-12-31
US5731448A (en)	1998-03-24
EP0763533A1 (fr)	1997-03-19
ATE202098T1 (de)	2001-06-15
RU2176641C2 (ru)	2001-12-10
DE59607070D1 (de)	2001-07-19
JPH09221466A (ja)	1997-08-26
EP0763533B1 (fr)	2001-06-13
ES2160195T3 (es)	2001-11-01
PT763533E (pt)	2001-12-28

Publication	Publication Date	Title
DK0763533T3 (da)	2001-09-10	Fremstilling til anvendelse af de rene enantiomerer af 8-chlor-6-sulfonyloxy-octansyre og dens alkylestere og de rene enantiomerer af 6,8-dichlor-octansyre og dens alkylestere
EP0613883A4 (fr)	1994-12-07	Derive d'acide hydroxamique.
NZ222398A (en)	1989-12-21	Sulphone compounds containing peroxycarboxylic acid groups; and bleaching compositions
DE69228627D1 (de)	1999-04-22	Langkettiger Carbonsäureimidester
DE3775675D1 (de)	1992-02-13	Verfahren zur herstellung enantiomerenreiner r-(+)-alpha-liponsaeure und s-(-)-alpha-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer.
DK0495204T3 (da)	1995-08-07	Fremgangsmåde til fremstilling af (6S)- og (6R)-tetrahydrofolsyre
ATE46502T1 (de)	1989-10-15	Pumpfaehige hochkonzentrierte waessrige pasten von alkalisalzen alpha-sulfonierter fettsaeurealkylester und verfahren zu ihrer herstellung.
ATE113660T1 (de)	1994-11-15	Phenylglycidat-stereoisomere, umsetzungsprodukte mit 2-nitrothiophenol und herstellung von diltiazen.
EG24561A (en)	2009-10-25	Process for the preparation of dioxane acetic acidesters
ATE100433T1 (de)	1994-02-15	Verfahren zur herstellung von bromsubstituierten aromatischen estern von alpha-beta-ungesaettigten saeuren.
MX174285B (es)	1994-05-03	Agente de conservacion para plantas
RU96118235A (ru)	1998-11-20	8-ХЛОР-6-СУЛЬФОНИЛОКСИОКТАНОВЫЕ КИСЛОТЫ, ИХ ЭФИРЫ, ЭФИРЫ 6,8-ДИХЛОРОКТАНОВОЙ КИСЛОТЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ, СПОСОБ ПОЛУЧЕНИЯ α-ЛИПОЕВОЙ КИСЛОТЫ (ВАРИАНТЫ)
EP0316942A3 (en)	1989-06-28	Manufacture of disulfides
DE69121998D1 (de)	1996-10-17	Verfahren zur Herstellung von organischen Estern und Amiden und Katalysatorsystem dafür
EP0351126A3 (en)	1990-10-24	Process for the production of 02,2'-anhydro-1-(beta-d-arabinofuranosyl)thymine
KR830006183A (ko)	1983-09-20	카르니틴의 알콕시-아실 유도체의 에스테르 제조방법
ES8204996A1 (es)	1982-05-16	Procedimiento de preparacion de 3-(1,2,4-hidroxitriazinil) tiometil cefalosporinas
AU8294401A (en)	2002-02-25	A process for the preparation of alpha' chloroketones
DE59104516D1 (de)	1995-03-16	Verfahren zur herstellung von aminomethanphosphonsäure und aminomethyl-phosphinsäuren.
PT87901A (pt)	1989-06-30	Processo para a preparacao de acidos 2-ariloxipropionicos e de composicoes herbicidas contendo estes compostos
DE69008653D1 (de)	1994-06-09	Verfahren zur Racemisierung von optisch aktiven 4-Phenylbuttersäureestern.
DE3780277D1 (de)	1992-08-13	Stereospezifische ketoreduktion von bicyclooctandion-carbonsaeureestern durch mikroorganismen.
ES8307255A1 (es)	1983-07-01	Procedimiento para preparar derivados de cefalosporina.
KR860000262A (ko)	1986-01-27	3-니트로-디히드로 피리딘의 제조방법
SI0728743T1 (en)	2003-04-30	3-Amino-tetrahydrocarbazol propanoic acid esters