DK0765313T3 - N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria - Google Patents

N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria

Info

Publication number: DK0765313T3
Authority: DK; Denmark
Prior art keywords: diyl; pct; quinolin; bis; phenylene
Prior art date: 1994-06-17

Application number

DK95922495T

Other languages

English (en)

Inventor

Werner Hofheinz

Werner Leupin

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-17

Filing date

1995-06-03

Publication date

2003-12-08

1995-06-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-12-08 Application granted granted Critical

2003-12-08 Publication of DK0765313T3 publication Critical patent/DK0765313T3/da

Links

125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 title abstract 2
239000003430 antimalarial agent Substances 0.000 title 1
150000004985 diamines Chemical class 0.000 title 1
-1 cyclohexane-1,3-diyl Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229960003677 chloroquine Drugs 0.000 abstract 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
201000004792 malaria Diseases 0.000 abstract 1
244000052769 pathogen Species 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Quinoline Compounds (AREA)

DK95922495T 1994-06-17 1995-06-03 N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria DK0765313T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH192894		1994-06-17
PCT/EP1995/002123 WO1995035287A1 (en)	1994-06-17	1995-06-03	N,n'-bis(quinolin-4-yl)-diamine derivatives, their preparation and their use as antimalarials

Publications (1)

Publication Number	Publication Date
DK0765313T3 true DK0765313T3 (da)	2003-12-08

Family

ID=4221871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95922495T DK0765313T3 (da)	1994-06-17	1995-06-03	N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria

Country Status (17)

Country	Link
US (1)	US5736557A (da)
EP (1)	EP0765313B1 (da)
JP (1)	JPH10501540A (da)
CN (1)	CN1120156C (da)
AT (1)	ATE247642T1 (da)
AU (1)	AU691306B2 (da)
CA (1)	CA2192203A1 (da)
DE (1)	DE69531543T2 (da)
DK (1)	DK0765313T3 (da)
ES (1)	ES2204956T3 (da)
IL (1)	IL114099A (da)
MX (1)	MX9606382A (da)
MY (1)	MY115176A (da)
NZ (1)	NZ288223A (da)
PT (1)	PT765313E (da)
WO (1)	WO1995035287A1 (da)
ZA (1)	ZA954796B (da)

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PT876346E (pt) *	1995-11-16	2002-01-30	Hoffmann La Roche	Derivados de quinolina com actividade anti-malaria
US6174897B1 (en)	1996-10-25	2001-01-16	Bayer Aktiengesellschaft	Bis-(quinolyl)-diamines
US5866562A (en) *	1996-10-25	1999-02-02	Bayer Aktiengesellschaft	Ring-bridged bis-quinolines
US5882996A (en) *	1997-10-14	1999-03-16	Industrial Technology Research Institute	Method of self-aligned dual damascene patterning using developer soluble arc interstitial layer
US6479504B1 (en)	1999-06-16	2002-11-12	The University Of Iowa Research Foundation	Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases
KR100520168B1 (ko) *	1999-06-21	2005-10-10	주식회사 하이닉스반도체	화학증폭형 레지스트에 첨가되는 새로운 페닐렌디아민계 유도체
DE10008522A1 (de) *	2000-02-24	2001-09-06	Hassan Jomaa	Verwendung von 2-PHenylendiaminderivaten zur Behandlung von Infektionen
GB0112834D0 (en)	2001-05-25	2001-07-18	Smithkline Beecham Plc	Medicaments
US6818772B2 (en) *	2002-02-22	2004-11-16	Abbott Laboratories	Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor
WO2003070244A1 (en) *	2002-02-22	2003-08-28	Abbott Laboratories	Antagonist of melanin concentrating hormone and their uses
WO2007056580A2 (en) *	2005-11-08	2007-05-18	Pharmadyn, Inc.	Methods and compositions for treating diseases associated with pathogenic proteins
US8440695B2 (en) *	2005-11-09	2013-05-14	St Jude Children's Research Hospital	Use of chloroquine to treat metabolic syndrome
US20110045100A1 (en) *	2008-03-05	2011-02-24	Georgetown University	Antimalarial Quinolines and Methods of Use Thereof
CA2743903A1 (en) *	2008-11-18	2010-05-27	The Government Of The United States Of America D.B.A.The Department Of V Eterans Affairs	Compounds for treating parasitic disease
CA2772085A1 (en)	2009-08-27	2011-03-03	The U.S.A., As Represented By The Secretary, Dept. Of Health And Human S Ervices	Compounds that treat malaria and prevent malaria transmission
EP2394981A1 (en)	2010-06-08	2011-12-14	Lonza Ltd.	Process for the preparation of cis-diaminocycloalkanes
EP2394982A1 (en)	2010-06-08	2011-12-14	Lonza Ltd.	Process for the preparation of cis-diaminocycloalkanes
US9205099B2 (en)	2010-06-22	2015-12-08	Dna Therapeutics	Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
EP2527440A1 (en)	2011-05-27	2012-11-28	Institut Curie	Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
WO2015133280A1 (ja) *	2014-03-03	2015-09-11	公立大学法人名古屋市立大学	抗マラリア活性化合物及び抗マラリア薬
KR20170086518A (ko) *	2014-11-25	2017-07-26	바스프 에스이	시스-풍부 mdach 및 트랜스-풍부 mdach의 제조 방법
JP2019513371A (ja)	2016-04-01	2019-05-30	アビディティーバイオサイエンシーズエルエルシー	核酸ポリペプチド組成物とその使用
US10640456B2 (en)	2016-06-28	2020-05-05	Dai Nippon Printing Co., Ltd.	Compound and intermediate thereof
MX2019008199A (es)	2017-01-06	2019-11-25	Avidity Biosciences Llc	Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
GB201711809D0 (en)	2017-07-21	2017-09-06	Governors Of The Univ Of Alberta	Antisense oligonucleotide
WO2019071028A1 (en)	2017-10-04	2019-04-11	Avidity Biosciences Llc	NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
JP7506601B2 (ja)	2017-12-06	2024-06-26	アビディティーバイオサイエンシーズ，インク．	筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
IL312067B2 (en)	2018-12-21	2025-08-01	Avidity Biosciences Inc	Anti-transferrin receptor antibodies and uses thereof
SG11202107614PA (en)	2019-01-18	2021-08-30	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
AU2020209216A1 (en)	2019-01-18	2021-08-26	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof
US12497615B2 (en)	2019-04-25	2025-12-16	Avidity Biosciences, Inc.	Nucleic acid compositions and methods of multi-exon skipping
KR20220019259A (ko)	2019-06-06	2022-02-16	어비디티 바이오사이언시스 인크.	Una 아미다이트 및 이의 용도
JP7592034B2 (ja)	2019-06-06	2024-11-29	アビディティーバイオサイエンシーズ，インク．	核酸ポリペプチド組成物およびその使用
US11555190B2 (en)	2020-03-19	2023-01-17	Avidity Biosciences, Inc.	Compositions and methods of treating Facioscapulohumeral muscular dystrophy
AU2021241682B2 (en)	2020-03-27	2026-02-12	Avidity Biosciences, Inc.	Compositions and methods of treating muscle dystrophy
US20230416786A1 (en)	2020-11-30	2023-12-28	Cellectis Sa	Use of aminoquinoline compounds for higher gene integration
MX2024003266A (es)	2021-09-16	2024-04-03	Avidity Biosciences Inc	Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
US12071621B2 (en)	2022-04-05	2024-08-27	Avidity Biosciences, Inc.	Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
CN121794380A (zh)	2023-06-27	2026-04-03	艾维迪提生物科学公司	使用prkag2靶向性抗体-寡核苷酸缀合物的组合物和方法
WO2025007063A1 (en)	2023-06-30	2025-01-02	Avidity Biosciences, Inc.	Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates
CN119504738A (zh) *	2023-08-25	2025-02-25	武汉人福创新药物研发中心有限公司	作为mrgprx2拮抗剂的化合物及其制备方法和应用

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US2816893A (en) *		1957-12-17		Improvements in or relating to
US2901484A (en) *	1957-03-04	1959-08-25	Abbott Lab	Bis-quinoliniums
US5510356A (en) *	1991-10-03	1996-04-23	University Of Nebraska Board Of Regents	Bisquinolines and processes for their production and use to treat malaria

1995
- 1995-06-03 DE DE69531543T patent/DE69531543T2/de not_active Expired - Fee Related
- 1995-06-03 JP JP8501566A patent/JPH10501540A/ja not_active Withdrawn
- 1995-06-03 MX MX9606382A patent/MX9606382A/es not_active IP Right Cessation
- 1995-06-03 PT PT95922495T patent/PT765313E/pt unknown
- 1995-06-03 AT AT95922495T patent/ATE247642T1/de not_active IP Right Cessation
- 1995-06-03 CA CA002192203A patent/CA2192203A1/en not_active Abandoned
- 1995-06-03 AU AU27369/95A patent/AU691306B2/en not_active Ceased
- 1995-06-03 DK DK95922495T patent/DK0765313T3/da active
- 1995-06-03 NZ NZ288223A patent/NZ288223A/en unknown
- 1995-06-03 EP EP95922495A patent/EP0765313B1/en not_active Expired - Lifetime
- 1995-06-03 ES ES95922495T patent/ES2204956T3/es not_active Expired - Lifetime
- 1995-06-03 CN CN95193643A patent/CN1120156C/zh not_active Expired - Fee Related
- 1995-06-03 WO PCT/EP1995/002123 patent/WO1995035287A1/en not_active Ceased
- 1995-06-03 US US08/765,751 patent/US5736557A/en not_active Expired - Fee Related
- 1995-06-09 ZA ZA954796A patent/ZA954796B/xx unknown
- 1995-06-12 IL IL11409995A patent/IL114099A/xx not_active IP Right Cessation
- 1995-06-15 MY MYPI95001626A patent/MY115176A/en unknown

Also Published As

Publication number	Publication date
AU2736995A (en)	1996-01-15
ES2204956T3 (es)	2004-05-01
DE69531543T2 (de)	2004-06-24
JPH10501540A (ja)	1998-02-10
CN1120156C (zh)	2003-09-03
CA2192203A1 (en)	1995-12-28
AU691306B2 (en)	1998-05-14
NZ288223A (en)	1997-11-24
IL114099A0 (en)	1995-10-31
MX9606382A (es)	1997-03-29
MY115176A (en)	2003-04-30
EP0765313A1 (en)	1997-04-02
ATE247642T1 (de)	2003-09-15
EP0765313B1 (en)	2003-08-20
DE69531543D1 (de)	2003-09-25
ZA954796B (en)	1996-01-03
WO1995035287A1 (en)	1995-12-28
CN1153513A (zh)	1997-07-02
IL114099A (en)	2000-02-29
US5736557A (en)	1998-04-07
PT765313E (pt)	2003-11-28

Publication	Publication Date	Title
DK0765313T3 (da)	2003-12-08	N,N'-bis (quinolin-4-yl)-diaminderivater, fremstilling deraf og anvendelse deraf som midler mod malaria
MX9504349A (es)	1997-03-29	Derivados de aroilpiperidina.
FI943948A0 (fi)	1994-08-26	Heterosykliset hiilihappojohdannaiset
JO2354B1 (en)	2006-12-12	New derivatives of aromatic fluoroglycosides and drugs containing these compounds and their use
MY119150A (en)	2005-04-30	Azetidine derivatives, their preparation and medicaments containing them
DK0579833T3 (da)	1997-09-15	Ethanolaminderivater med anti-pollakisuria-virkning
ES2191341T3 (es)	2003-09-01	Derivados de la 2-fenoxianilina.
DK0689534T3 (da)	2003-02-03	Amidderivater som 5-HT1A-ligander
MX9301701A (es)	1993-09-01	Derivados de fenotiazina para el tratamiento de la isquema y la hipoxia, composiciones farmaceuticas que los contienen y procedimiento para la preparacion de dichas composiciones farmaceuticas.
DK0678089T3 (da)	1996-11-18	N-Acylpyrrolidiner og lægemidler til behandling eller forebyggelse af cholecystokinin- og gastrin-relaterede forstyrrelser
DK0699198T3 (da)	1999-11-22	N-benzoylmethyl-substituerede paroxetinderivater
NO952559D0 (no)	1995-06-26	N-acyl-pyrrolidiner og medikamenter for behandling eller prevensjon av cholecystokinin- og gastrin-relaterte mangler
ES2099973T3 (es)	1997-06-01	Derivados de ureido-acetamida su preparacion y los medicamentos que los contienen.
BR9507668A (pt)	1997-10-07	Intermédio para preparar um composto farmaceuticamente atívo
ES2084485T3 (es)	1996-05-01	Procedimiento para la preparacion de amino-2 nitro-7 benzotiazoles.
TH51657A (da)	2002-06-28