DK0770613T3 - Substituerede imidazolidin-2,4-dion-forbindelser som immunmodulatorer - Google Patents

Substituerede imidazolidin-2,4-dion-forbindelser som immunmodulatorer

Info

Publication number: DK0770613T3
Authority: DK; Denmark
Prior art keywords: immunomodulators; dione compounds; substituted imidazolidine; imidazolidine; substituted
Prior art date: 1995-10-27

Application number

DK96116069T

Other languages

English (en)

Inventor

Oswald Dr Zimmer

Stephan Dr Wnendt

Horst Dr Boehlke

Kai Dr Zwingenberger

Cornelia Dr Geist-Rudolf

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-27

Filing date

1996-10-08

Publication date

1999-12-13

1996-10-08 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

1999-12-13 Application granted granted Critical

1999-12-13 Publication of DK0770613T3 publication Critical patent/DK0770613T3/da

Links

WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
239000002955 immunomodulating agent Substances 0.000 title 1
229940121354 immunomodulator Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK96116069T 1995-10-27 1996-10-08 Substituerede imidazolidin-2,4-dion-forbindelser som immunmodulatorer DK0770613T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19540027A DE19540027A1 (de)	1995-10-27	1995-10-27	Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe

Publications (1)

Publication Number	Publication Date
DK0770613T3 true DK0770613T3 (da)	1999-12-13

Family

ID=7775931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96116069T DK0770613T3 (da)	1995-10-27	1996-10-08	Substituerede imidazolidin-2,4-dion-forbindelser som immunmodulatorer

Country Status (22)

Country	Link
US (1)	US6004963A (da)
EP (1)	EP0770613B1 (da)
JP (1)	JPH09188677A (da)
KR (1)	KR100445539B1 (da)
CN (1)	CN1097050C (da)
AR (1)	AR004517A1 (da)
AT (1)	ATE181072T1 (da)
AU (1)	AU707751B2 (da)
CA (1)	CA2188908A1 (da)
CO (1)	CO4750655A1 (da)
DE (2)	DE19540027A1 (da)
DK (1)	DK0770613T3 (da)
ES (1)	ES2135148T3 (da)
GR (1)	GR3030558T3 (da)
HU (1)	HU222120B1 (da)
IL (1)	IL119488A (da)
MX (1)	MX9605023A (da)
PE (1)	PE20011055A1 (da)
PL (1)	PL184446B1 (da)
RU (1)	RU2163603C2 (da)
SI (1)	SI0770613T1 (da)
ZA (1)	ZA968956B (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19732928C2 (de) *	1997-07-31	2000-05-18	Gruenenthal Gmbh	Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
DE19917961A1 (de)	1999-04-21	2000-10-26	Degussa	Verfahren zur Herstellung von Aminosäurederivaten
WO2001007048A1 (en) *	1999-07-21	2001-02-01	Boehringer Ingelheim Pharmaceuticals, Inc.	Small molecules useful in the treatment of inflammatory disease
DK1284973T3 (da)	2000-05-31	2007-10-08	Tanabe Seiyaku Co	Inhibitorer af alfaLbeta2-medieret celleadhæsion
SE0100902D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
SE0100903D0 (sv) *	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
US7354933B2 (en)	2003-01-31	2008-04-08	Aventis Pharma Sa	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) *	2003-01-31	2008-05-30	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US20050203156A1 (en) *	2004-03-12	2005-09-15	Wyeth	Hydantoins having RNase modulatory activity
EP1621536A1 (en) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
FR2896504B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896503B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
AU2013205325B2 (en) *	2006-03-27	2016-03-24	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2012241184B2 (en) *	2006-03-27	2016-01-07	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
AU2016201061B2 (en) *	2006-03-27	2017-03-02	The Regents Of The University Of California	Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
ES2689292T3 (es)	2006-03-27	2018-11-13	The Regents Of The University Of California	Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
NZ572374A (en)	2006-03-29	2011-12-22	Univ California	Diarylthiohydantoin compounds
WO2008021337A1 (en)	2006-08-15	2008-02-21	Wyeth	Oxazinan-2-one derivatives useful as pr modulators
WO2008021309A1 (en) *	2006-08-15	2008-02-21	Wyeth	Imidazolidin-2-one derivatives useful as pr modulators
US7649007B2 (en) *	2006-08-15	2010-01-19	Wyeth Llc	Oxazolidine derivatives as PR modulators
TW200815428A (en)	2006-08-15	2008-04-01	Wyeth Corp	Oxazolidone derivatives as PR modulators
SI2069335T1 (sl) *	2006-09-08	2013-04-30	Actelion Pharmaceuticals Ltd.	Derivati piridin-3-ila kot imunomodulacijska sredstva
EP2220050A2 (en)	2007-10-26	2010-08-25	The Regents Of The University Of California	Diarylhydantoin compounds as androgen receptor modulators
MX2010014572A (es) *	2008-06-27	2011-03-24	Novartis Ag	Compuestos organicos.
NZ596078A (en)	2009-05-12	2013-06-28	Janssen Pharmaceuticals Inc	1,2,4-TRIAZOLO [4,3-a] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
SG10201907588XA (en)	2010-02-16	2019-09-27	Aragon Pharmaceuticals Inc	Androgen Receptor Modulators And Uses Thereof
CN115737643A (zh)	2012-09-26	2023-03-07	阿拉贡药品公司	用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
DK2945628T3 (da)	2013-01-15	2020-05-04	Aragon Pharmaceuticals Inc	Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
MX2020003845A (es)	2017-10-16	2020-11-06	Aragon Pharmaceuticals Inc	Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3382406D1 (de) *	1982-04-08	1991-10-17	Shell Int Research	Neue hydantoine, ihre herstellung und verwendung.
FR2537133A1 (fr) *	1982-12-07	1984-06-08	Rhone Poulenc Sante	Nouveaux derives de la (piperazinyl-1)-5 pyrrolidine, leur preparation et les medicaments qui les contiennent
US4746669A (en) *	1985-12-23	1988-05-24	Merck & Co., Inc.	Substituted thiazoles as immunoregulants
JPH02101065A (ja) *	1988-10-06	1990-04-12	Tanabe Seiyaku Co Ltd	イミダゾリン誘導体及びその製法
FR2656302B1 (fr) *	1989-12-22	1992-05-07	Roussel Uclaf	Nouveau procede de preparation de l'anandron et derives de l'anandron.
CA2095429A1 (en) *	1990-11-06	1992-05-07	Paul E. Bender	Imidazolidinone compounds
IL110296A (en) *	1993-07-16	1999-12-31	Smithkline Beecham Corp	Imidazole compounds process for their preparation and pharmaceutical compositions containing them
DE19529425A1 (de) *	1995-08-10	1997-02-13	Dresden Arzneimittel	Neue, antikonvulsiv wirkende Imidazolin-2,4-dione, die in 1-Stellung einen orthosubstituierten Ar(alk)yl-Rest enthalten, und Verfahren zu deren Herstellung
US7466669B2 (en) *	2003-11-14	2008-12-16	Telefonaktiebolaget Lm Ericsson (Publ)	Reverse link scheduler for CDMA networks

1995
- 1995-10-27 DE DE19540027A patent/DE19540027A1/de not_active Withdrawn
1996
- 1996-09-26 PE PE1996000688A patent/PE20011055A1/es not_active Application Discontinuation
- 1996-10-04 CO CO96052910A patent/CO4750655A1/es unknown
- 1996-10-08 AT AT96116069T patent/ATE181072T1/de not_active IP Right Cessation
- 1996-10-08 DE DE59602155T patent/DE59602155D1/de not_active Expired - Fee Related
- 1996-10-08 EP EP96116069A patent/EP0770613B1/de not_active Expired - Lifetime
- 1996-10-08 ES ES96116069T patent/ES2135148T3/es not_active Expired - Lifetime
- 1996-10-08 SI SI9630066T patent/SI0770613T1/xx not_active IP Right Cessation
- 1996-10-08 DK DK96116069T patent/DK0770613T3/da active
- 1996-10-14 AU AU68181/96A patent/AU707751B2/en not_active Ceased
- 1996-10-16 AR ARP960104778A patent/AR004517A1/es unknown
- 1996-10-22 MX MX9605023A patent/MX9605023A/es unknown
- 1996-10-24 ZA ZA968956A patent/ZA968956B/xx unknown
- 1996-10-24 HU HU9602932A patent/HU222120B1/hu not_active IP Right Cessation
- 1996-10-24 JP JP8282701A patent/JPH09188677A/ja active Pending
- 1996-10-25 US US08/738,232 patent/US6004963A/en not_active Expired - Fee Related
- 1996-10-25 RU RU96121181/04A patent/RU2163603C2/ru not_active IP Right Cessation
- 1996-10-25 IL IL11948896A patent/IL119488A/xx not_active IP Right Cessation
- 1996-10-25 KR KR1019960048441A patent/KR100445539B1/ko not_active Expired - Fee Related
- 1996-10-25 PL PL96316706A patent/PL184446B1/pl not_active IP Right Cessation
- 1996-10-25 CA CA002188908A patent/CA2188908A1/en not_active Abandoned
- 1996-10-26 CN CN96121960A patent/CN1097050C/zh not_active Expired - Fee Related
1999
- 1999-06-17 GR GR990401639T patent/GR3030558T3/el unknown

Also Published As

Publication number	Publication date
KR970021076A (ko)	1997-05-28
JPH09188677A (ja)	1997-07-22
HUP9602932A2 (hu)	1998-07-28
IL119488A0 (en)	1997-01-10
HU9602932D0 (en)	1996-12-30
HU222120B1 (hu)	2003-04-28
AR004517A1 (es)	1998-12-16
PL316706A1 (en)	1997-04-28
AU6818196A (en)	1997-05-01
SI0770613T1 (en)	1999-10-31
PL184446B1 (pl)	2002-10-31
ZA968956B (en)	1997-05-29
ATE181072T1 (de)	1999-06-15
RU2163603C2 (ru)	2001-02-27
HUP9602932A3 (en)	1998-08-28
PE20011055A1 (es)	2001-12-29
MX9605023A (es)	1997-06-28
EP0770613A1 (de)	1997-05-02
CN1152573A (zh)	1997-06-25
GR3030558T3 (en)	1999-10-29
DE19540027A1 (de)	1997-04-30
CN1097050C (zh)	2002-12-25
AU707751B2 (en)	1999-07-22
DE59602155D1 (de)	1999-07-15
CO4750655A1 (es)	1999-03-31
US6004963A (en)	1999-12-21
EP0770613B1 (de)	1999-06-09
IL119488A (en)	2001-01-11
KR100445539B1 (ko)	2004-12-30
CA2188908A1 (en)	1997-04-28
ES2135148T3 (es)	1999-10-16
HK1010367A1 (en)	1999-06-17

Publication	Publication Date	Title
ATE181072T1 (de)	1999-06-15	Substituierte imidazolidin-2,4-dion-verbindungen als immunodulatoren
DE59501802D1 (de)	1998-05-14	Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
DK0894497T3 (da)	2004-05-03	Anvendelse af substituerede imidazolin-2,4-dion-forbindelser som smertestillende midler
BR9707786B1 (pt)	2009-12-01	composto.
EE04834B1 (et)	2007-06-15	Tselekoksiibiühendid
DZ1666A1 (fr)	2002-02-17	Composés hétérobicycliques.
ZA97175B (en)	1997-11-04	Novel substituted imidazole compounds.
FI972901A7 (fi)	1997-09-08	Määrätyt 1,4,5-trisubstituoidut imidatsoliyhdisteet, jotka ovat käyttö kelpoisia sytokiineinä
ID20744A (id)	1999-02-25	Senyawa 2-metoksibenzopenona untuk fungisida
NO996572L (no)	1999-12-30	Nye substituerte imidazolforbindelser
NO20005083D0 (no)	2000-10-09	Amidinforbindelser
TR199501561A2 (tr)	1996-07-21	Imidazol türevleri.
BR9813566B1 (pt)	2010-07-13	composição biocida estabilizada contendo compostos de halopropinila.
NL1009835A1 (nl)	1999-02-22	Vloeibaar-kristallijne verbindingen.
EP0668270A3 (fr)	1995-10-11	Dérivés de 2-imidazoline-5-ones fongicides.
BR9804301B1 (pt)	2008-11-18	compostos espirocÍclicos.
DE69628458D1 (de)	2003-07-03	25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
DE59811182D1 (de)	2004-05-19	Heterocyclische Verbindungen
NL1013652A1 (nl)	2000-05-25	Piperazinonderivaten.
DK0944601T3 (da)	2003-06-10	Heterocykliske quanidinylaminoforbindelser som alfa-2-adrenoceptoragonister
ITTO980741A0 (it)	1998-09-03	Procedimento di preparazione di composti del tipo arilamminoalchilidenemalonati.
TR199802196A3 (tr)	1999-10-21	Heterosiklik bilesimler.
ID19787A (id)	1998-07-30	Senyawa 25-hidroksi-16-ena-26,27-bishomo-kolekalsiferol
FI973556A0 (fi)	1997-08-29	Foerfarande foer styrning av en debitering fraon en tjaenstfoerbrukare i ett telenaet
TR199600665A2 (tr)	1997-03-21	Asimetrik trifenilendioksazin bilesikleri.