DK0771813T3 - Alkylxanthinphosphonater og alkylxanthinphosphinoxider og deres anvendelse som lægemidler - Google Patents

Alkylxanthinphosphonater og alkylxanthinphosphinoxider og deres anvendelse som lægemidler

Info

Publication number: DK0771813T3
Authority: DK; Denmark
Prior art keywords: alkyl; alkylxanthine; xanthin; cycloalkyl; phosphonic acid
Prior art date: 1995-11-02

Application number

DK96116861T

Other languages

English (en)

Inventor

Guenter Dr Billen

Ismahan Dr Okyayuz-Baklouti

Hiristo Db Anagnostopulos

Stefan Dr Muellner

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1996-10-21

Publication date

2002-04-29

1996-10-21 Application filed by Hoechst Ag filed Critical Hoechst Ag

2002-04-29 Application granted granted Critical

2002-04-29 Publication of DK0771813T3 publication Critical patent/DK0771813T3/da

Links

MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 title abstract 2
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 10
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
HECXOUILYSTMJL-UHFFFAOYSA-N 3-(1,3-dimethyl-2,6-dioxopurin-7-yl)propylphosphonic acid Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CCCP(O)(O)=O)C=N2 HECXOUILYSTMJL-UHFFFAOYSA-N 0.000 abstract 1
XYLDTGNZSGZWCG-UHFFFAOYSA-N 4-(1,3-dimethyl-2,6-dioxopurin-7-yl)butylphosphonic acid Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CCCCP(O)(O)=O)C=N2 XYLDTGNZSGZWCG-UHFFFAOYSA-N 0.000 abstract 1
QAXXINFWWUWJQT-UHFFFAOYSA-N 5-(1,3-dimethoxy-2,6-dioxopurin-7-yl)pentylphosphonic acid Chemical compound O=C1N(OC)C(=O)N(OC)C2=C1N(CCCCCP(O)(O)=O)C=N2 QAXXINFWWUWJQT-UHFFFAOYSA-N 0.000 abstract 1
YZVDGDRWAASLMX-UHFFFAOYSA-N 7-(4-diethoxyphosphorylbutyl)-1,3-dimethylpurine-2,6-dione Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2CCCCP(=O)(OCC)OCC YZVDGDRWAASLMX-UHFFFAOYSA-N 0.000 abstract 1
-1 Alkyl xanthine phosphonates Chemical class 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK96116861T 1995-11-02 1996-10-21 Alkylxanthinphosphonater og alkylxanthinphosphinoxider og deres anvendelse som lægemidler DK0771813T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19540798A DE19540798A1 (de)	1995-11-02	1995-11-02	Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
US08/741,591 US5728686A (en)	1995-11-02	1996-10-31	Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as pharmaceuticals

Publications (1)

Publication Number	Publication Date
DK0771813T3 true DK0771813T3 (da)	2002-04-29

Family

ID=26020012

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96116861T DK0771813T3 (da)	1995-11-02	1996-10-21	Alkylxanthinphosphonater og alkylxanthinphosphinoxider og deres anvendelse som lægemidler

Country Status (10)

Country	Link
US (1)	US5728686A (da)
EP (1)	EP0771813B1 (da)
JP (1)	JP4150086B2 (da)
CN (1)	CN1158855A (da)
AT (1)	ATE212029T1 (da)
CA (1)	CA2189222A1 (da)
DE (2)	DE19540798A1 (da)
DK (1)	DK0771813T3 (da)
ES (1)	ES2170825T3 (da)
PT (1)	PT771813E (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2185837T3 (es) *	1996-06-07	2003-05-01	Hoechst Ag	Utilizacion de derivados de teofilina para el tratamiento y la profilaxis de las enfermedades de choque, nuevos compuestos de xantina y procedimientos para su produccion.
WO1999031101A1 (en) *	1997-12-17	1999-06-24	University Of South Florida	Adenosine receptor antagonists with improved bioactivity
GB2333041A (en) *	1998-01-13	1999-07-14	Johnson & Johnson Medical Ltd	Wound Composition
US20040122011A1 (en) *	1998-12-23	2004-06-24	Pharmacia Corporation	Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
JP2002538135A (ja)	1999-03-01	2002-11-12	エランファーマシューティカルズ，インコーポレイテッド	α４β７レセプターアンタゴニストとして有用なα−アミノ酢酸誘導体
FR2804867B1 (fr) *	2000-02-15	2002-09-20	Hoechst Marion Roussel Inc	Application de derives de xanthine pour la preparation d'un medicament destine a la prevention ou au traitement de l'osteoporose
WO2003008396A1 (en) *	2001-07-16	2003-01-30	Nikken Chemicals Co., Ltd.	Optically active oxazine derivative
DE60307628T2 (de) *	2002-05-31	2007-08-09	Schering Corporation	Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen
SI1509525T1 (sl) *	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2005002626A2 (en) *	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Therapeutic phosphonate compounds
DK2041181T3 (da) *	2006-06-08	2011-08-29	Helmholtz Zentrum Muenchen	Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3525801A1 (de) *	1985-07-19	1987-01-22	Hoechst Ag	Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
SE8801729D0 (sv) *	1988-05-06	1988-05-06	Astra Ab	Purine derivatives for use in therapy
EP0557876B1 (de) *	1992-02-22	1996-12-11	Hoechst Aktiengesellschaft	Verwendung von Xanthinderivaten zur Behandlung von Muskelschädigungen nach vollständiger Unterbrechung der Blutzirkulation
ATE199906T1 (de) *	1993-06-29	2001-04-15	Mitsubishi Chem Corp	Phosphonat-nukleotid ester-derivate
AU717243B2 (en) *	1994-12-29	2000-03-23	Regents Of The University Of California, The	Compounds for inhibition of ceramide-mediated signal transduction

1995
- 1995-11-02 DE DE19540798A patent/DE19540798A1/de not_active Withdrawn
1996
- 1996-10-21 PT PT96116861T patent/PT771813E/pt unknown
- 1996-10-21 AT AT96116861T patent/ATE212029T1/de active
- 1996-10-21 DE DE59608590T patent/DE59608590D1/de not_active Expired - Lifetime
- 1996-10-21 EP EP96116861A patent/EP0771813B1/de not_active Expired - Lifetime
- 1996-10-21 DK DK96116861T patent/DK0771813T3/da active
- 1996-10-21 ES ES96116861T patent/ES2170825T3/es not_active Expired - Lifetime
- 1996-10-30 CN CN96122094A patent/CN1158855A/zh active Pending
- 1996-10-30 CA CA002189222A patent/CA2189222A1/en not_active Abandoned
- 1996-10-31 US US08/741,591 patent/US5728686A/en not_active Expired - Lifetime
- 1996-11-01 JP JP30552496A patent/JP4150086B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0771813A1 (de)	1997-05-07
DE19540798A1 (de)	1997-05-07
ATE212029T1 (de)	2002-02-15
ES2170825T3 (es)	2002-08-16
PT771813E (pt)	2002-07-31
JPH09124671A (ja)	1997-05-13
MX9605315A (es)	1997-05-31
CN1158855A (zh)	1997-09-10
EP0771813B1 (de)	2002-01-16
DE59608590D1 (de)	2002-02-21
US5728686A (en)	1998-03-17
JP4150086B2 (ja)	2008-09-17
CA2189222A1 (en)	1997-05-03

Publication	Publication Date	Title
DK0771813T3 (da)	2002-04-29	Alkylxanthinphosphonater og alkylxanthinphosphinoxider og deres anvendelse som lægemidler
WO1993010091A3 (en)	1993-06-24	Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
CA2050639A1 (en)	1992-03-06	Arylalkylamines, process for preparing them and pharmaceutical compositions containing them
NZ511067A (en)	2003-03-28	Serine protease inhibiting isoquinoline derivatives and their use for treating or preventing thrombin-mediated or thrombin-associated diseases
DK1327660T3 (da)	2005-07-25	Stabilisatorkombinationer til chlorholdige polymer
BG101402A (en)	1997-10-31	Apoliprotein-b synthesis inhibitors
NO943895D0 (no)	1994-10-14	Galantaminderivater, en fremgangsmåte for fremstilling samt deres anvendelse som medikamenter
WO1992010504A3 (en)	1992-09-17	Phosphonic acid derivatives useful as antiinflammatory agents
EP0845525A3 (en)	1999-03-03	Cleaning, disinfecting and bleaching composition
SI0808628T1 (en)	2000-04-30	Use of non-peptide bradykinin antagonists for treating and preventing chronic fibrogenetic liver diseases, acute liver diseases and complications thereof
FR2663328B1 (fr)	1994-08-05	Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.
FI960149A0 (fi)	1996-01-12	Kumariinien ja karbostyriilien käyttö PLA2:n estäjinä, uusia kumariineja ja karbostyriilejä, menetelmä niiden valmistamiseksi ja lääkkeitä
ATE167187T1 (de)	1998-06-15	Chinuclidinestern, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ATE133939T1 (de)	1996-02-15	Indan-1,3-dion und indan-1,2,3-trionderivate, verfahren zu ihrer herstellung und ihrer therapeutische verwendung
ES2173513T3 (es)	2002-10-16	Composiciones fungicidas.
NO306615B1 (no)	1999-11-29	Kinoksaliner, deres anvendelse samt medikamenter inneholdende kinoksalinene
AU6602594A (en)	1995-01-12	New phosphonic acid compounds, process for preparing them and pharmaceutical compositions containing them
AU1498895A (en)	1995-09-28	Novel aminoalkyl benzoazolinones and benzothiazolinones, process for their preparation and the pharmaceutical compositions which contain them
AU4842297A (en)	1998-06-18	New N-benzylpiperazine compounds, process for their preparation and the pharmaceutical compositions which contain them
DE69701301D1 (de)	2000-03-23	Substituierte Benzylderivate von Polyalkylenpolyaminen und ihre Verwendung in kosmetischen und pharmazeutischen Zusammensetzungen
GR3024453T3 (en)	1997-11-28	5-(piperazinylalkyl)-1,5-benzothiazepinones useful as calcium antagonists.
TR200001262T2 (tr)	2001-01-22	Alzheimer tipi yaşlılık demansının tedavisi için aktif muhteviyatların kombinasyonu
IE791510L (en)	1980-03-08	Anti-arthritic hydroxyacetic acid derivatives
DE59606328D1 (de)	2001-02-22	Verfahren zur Herstellung von gegebenenfalls 2-substituierten 5-Chlor-imidazol-4-carbaldehyden
NO177675C (no)	1995-11-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive P-substituerte propan-fosfinsyre forbindelser