DK0779888T3 - Pyrimido[5,4-d]pyrimidiner, lægemidler indeholdende disse forbindelser, anvendelse deraf og fremgangsmåder til fremstilling - Google Patents

Pyrimido[5,4-d]pyrimidiner, lægemidler indeholdende disse forbindelser, anvendelse deraf og fremgangsmåder til fremstilling

Info

Publication number
DK0779888T3
DK0779888T3 DK95931988T DK95931988T DK0779888T3 DK 0779888 T3 DK0779888 T3 DK 0779888T3 DK 95931988 T DK95931988 T DK 95931988T DK 95931988 T DK95931988 T DK 95931988T DK 0779888 T3 DK0779888 T3 DK 0779888T3
Authority
DK
Denmark
Prior art keywords
pyrimido
pyrimidines
compounds
preparation
methods
Prior art date
Application number
DK95931988T
Other languages
Danish (da)
English (en)
Inventor
Den Von Thomas R
Georg Dahmann
Thomas Metz
Frank Himmelsbach
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4431867A external-priority patent/DE4431867A1/de
Priority claimed from DE1995103151 external-priority patent/DE19503151A1/de
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0779888T3 publication Critical patent/DK0779888T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)
  • Luminescent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK95931988T 1994-09-07 1995-09-05 Pyrimido[5,4-d]pyrimidiner, lægemidler indeholdende disse forbindelser, anvendelse deraf og fremgangsmåder til fremstilling DK0779888T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE4431867A DE4431867A1 (de) 1994-09-07 1994-09-07 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995103151 DE19503151A1 (de) 1995-02-01 1995-02-01 Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995121386 DE19521386A1 (de) 1995-02-01 1995-06-13 Pyrimido/5,4-d/pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995128672 DE19528672A1 (de) 1995-02-01 1995-08-04 Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/003482 WO1996007657A1 (fr) 1994-09-07 1995-09-05 Pyrimido[5,4-d]pyrimidines, medicaments contenant ces composes, leur utilisation et leur procede de fabrication

Publications (1)

Publication Number Publication Date
DK0779888T3 true DK0779888T3 (da) 1999-10-25

Family

ID=27436041

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95931988T DK0779888T3 (da) 1994-09-07 1995-09-05 Pyrimido[5,4-d]pyrimidiner, lægemidler indeholdende disse forbindelser, anvendelse deraf og fremgangsmåder til fremstilling

Country Status (26)

Country Link
US (1) US5707989A (fr)
EP (1) EP0779888B1 (fr)
JP (1) JP3184533B2 (fr)
CN (1) CN1047778C (fr)
AT (1) ATE179420T1 (fr)
AU (1) AU688972B2 (fr)
BG (1) BG62969B1 (fr)
CA (1) CA2199401C (fr)
CZ (1) CZ295781B6 (fr)
DE (1) DE59505789D1 (fr)
DK (1) DK0779888T3 (fr)
EE (1) EE9700211A (fr)
ES (1) ES2133800T3 (fr)
FI (1) FI112947B (fr)
GR (1) GR3030589T3 (fr)
HK (1) HK1000837A1 (fr)
HU (1) HUT77744A (fr)
IL (1) IL115185A0 (fr)
MX (1) MX9701662A (fr)
NO (1) NO307833B1 (fr)
NZ (1) NZ292909A (fr)
PL (1) PL319042A1 (fr)
RO (1) RO120342B1 (fr)
SK (1) SK284277B6 (fr)
TW (1) TW414798B (fr)
WO (1) WO1996007657A1 (fr)

Families Citing this family (47)

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IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
TW321649B (fr) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
EP0824525B1 (fr) * 1995-04-27 2001-06-13 AstraZeneca AB Derives de quinazoline
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (fr) 1996-02-13 2006-07-18 Zeneca Limited Derives de la quinazoline utilises comme inhibiteurs du vegf
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
DE19608588A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19608653A1 (de) * 1996-03-06 1997-09-11 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19613691A1 (de) 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
CN100503580C (zh) 1996-04-12 2009-06-24 沃尼尔·朗伯公司 酪氨酸激酶的不可逆抑制剂
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
US6391874B1 (en) 1996-07-13 2002-05-21 Smithkline Beecham Corporation Fused heterocyclic compounds as protein tyrosine kinase inhibitors
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
PT1244647E (pt) 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
US20030207878A1 (en) * 2000-08-09 2003-11-06 Hennequin Lawrent Francois Andre Chemical compounds
DE10115921A1 (de) 2001-03-30 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
CA2531327A1 (fr) * 2003-07-03 2005-01-13 Myriad Genetics, Inc. Composes et leur utilisation therapeutique
AU2004298448B2 (en) 2003-12-18 2010-09-09 Janssen Pharmaceutica N.V. Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CA2592900A1 (fr) 2005-01-03 2006-07-13 Myriad Genetics Inc. Composes et utilisation therapeutique associee
BRPI0707916A2 (pt) * 2006-01-13 2011-05-17 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem e uso destes compostos
CA2654583C (fr) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Derives de quinazoline de type mtki
AU2008281849B2 (en) 2007-07-27 2013-11-28 Janssen Pharmaceutica Nv Pyrrolopyrimidines
TW201014860A (en) * 2008-09-08 2010-04-16 Boehringer Ingelheim Int New chemical compounds
EP2398797B1 (fr) 2009-02-17 2013-11-06 Boehringer Ingelheim International GmbH Dérivés des pyrimido[5,4-d]pyrimidine pour l'inhibition des tyrosine kinases
EP2473487B1 (fr) 2009-09-03 2016-10-26 Bristol-Myers Squibb Company Quinazolines comme inhibiteurs des canaux ioniques potassiques
EP2646429B1 (fr) * 2010-12-01 2014-10-15 Janssen Pharmaceutica NV Antagonistes de ccr2 consistant en des cyclohexylamino-4-pipéridinyl-acétamides substitués en position 4
US20130023531A1 (en) 2011-01-27 2013-01-24 Boehringer Ingelheim International Gmbh Pyrimido[5,4-d]pyrimidylamino phenyl sulfonamides as serine/threonine kinase inhibitors
WO2012101062A1 (fr) 2011-01-28 2012-08-02 Novartis Ag Composés bi-hétéroaryles substitués en tant qu'inhibiteurs de cdk9 et leurs utilisations
ES2638915T3 (es) * 2011-05-20 2017-10-24 Janssen Pharmaceutica, N.V. Procedimiento de preparación de compuestos usados como inhibidores de SGLT-22
WO2014175370A1 (fr) * 2013-04-25 2014-10-30 塩野義製薬株式会社 Dérivé de pyrrolidine et composition pharmaceutique en contenant
AU2016209046A1 (en) * 2015-01-23 2017-07-20 Aclaris Therapeutics, Inc. Heterocyclic ITK inhibitors for treating inflammation and cancer
CA3096424A1 (fr) 2018-04-12 2019-10-17 Eisai R&D Management Co., Ltd. Derives de pladienolide en tant qu'agents ciblant un complexe d'epissage pour le traitement du cancer
WO2019223766A1 (fr) * 2018-05-25 2019-11-28 上海和誉生物医药科技有限公司 Inhibiteur de fgfr, son procédé de préparation et son utilisation pharmaceutique
US11608343B2 (en) * 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
WO2025240517A1 (fr) * 2024-05-14 2025-11-20 Aleksia Therapeutics, Inc. Composés naphtyridine inhibiteurs de cdk4

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US3031450A (en) * 1959-04-30 1962-04-24 Thomae Gmbh Dr K Substituted pyrimido-[5, 4-d]-pyrimidines
EP0023559B1 (fr) * 1979-07-03 1984-09-19 Dr. Karl Thomae GmbH 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, leur préparation et médicaments les contenant
DE3049207A1 (de) * 1980-12-27 1982-07-29 Dr. Karl Thomae Gmbh, 7950 Biberach Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US5034393A (en) * 1989-07-27 1991-07-23 Dowelanco Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives
DE4325900A1 (de) * 1993-08-02 1995-02-09 Thomae Gmbh Dr K Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IL115185A0 (en) 1995-12-31
ATE179420T1 (de) 1999-05-15
CN1047778C (zh) 1999-12-29
ES2133800T3 (es) 1999-09-16
CZ69197A3 (en) 1997-10-15
SK284277B6 (sk) 2004-12-01
JP3184533B2 (ja) 2001-07-09
HK1000837A1 (en) 2000-11-03
HUT77744A (hu) 1998-07-28
CN1157619A (zh) 1997-08-20
NZ292909A (en) 1998-09-24
GR3030589T3 (en) 1999-10-29
BG101289A (en) 1997-08-29
CZ295781B6 (cs) 2005-11-16
FI970968L (fi) 1997-05-06
JPH10505078A (ja) 1998-05-19
MX9701662A (es) 1998-02-28
NO971038L (no) 1997-05-06
RO120342B1 (ro) 2005-12-30
WO1996007657A1 (fr) 1996-03-14
US5707989A (en) 1998-01-13
CA2199401A1 (fr) 1996-03-04
PL319042A1 (en) 1997-07-21
EE9700211A (et) 1998-04-15
DE59505789D1 (de) 1999-06-02
BG62969B1 (bg) 2000-12-29
AU3521895A (en) 1996-03-27
CA2199401C (fr) 2007-07-10
AU688972B2 (en) 1998-03-19
EP0779888B1 (fr) 1999-04-28
FI112947B (fi) 2004-02-13
FI970968A0 (fi) 1997-03-07
TW414798B (en) 2000-12-11
NO971038D0 (no) 1997-03-06
NO307833B1 (no) 2000-06-05
SK30297A3 (en) 1997-10-08
EP0779888A1 (fr) 1997-06-25

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