DK0784477T3 - Immunterapeutiske stressprotein-peptidkomplekser mod cancer - Google Patents
Immunterapeutiske stressprotein-peptidkomplekser mod cancerInfo
- Publication number
- DK0784477T3 DK0784477T3 DK95916256T DK95916256T DK0784477T3 DK 0784477 T3 DK0784477 T3 DK 0784477T3 DK 95916256 T DK95916256 T DK 95916256T DK 95916256 T DK95916256 T DK 95916256T DK 0784477 T3 DK0784477 T3 DK 0784477T3
- Authority
- DK
- Denmark
- Prior art keywords
- peptide
- stress protein
- mammal
- peptide complexes
- immunotherapeutic
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title 1
- 230000001024 immunotherapeutic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 4
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001176—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/315,892 US5750119A (en) | 1994-01-13 | 1994-09-30 | Immunotherapeutic stress protein-peptide complexes against cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0784477T3 true DK0784477T3 (da) | 2006-07-17 |
Family
ID=23226518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95916256T DK0784477T3 (da) | 1994-09-30 | 1995-04-06 | Immunterapeutiske stressprotein-peptidkomplekser mod cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US5750119A (da) |
| EP (2) | EP1702624A1 (da) |
| JP (3) | JPH10506628A (da) |
| KR (1) | KR970706013A (da) |
| CN (1) | CN1167440A (da) |
| AT (1) | ATE320447T1 (da) |
| AU (1) | AU709643B2 (da) |
| CA (1) | CA2201498A1 (da) |
| DE (1) | DE69534874T2 (da) |
| DK (1) | DK0784477T3 (da) |
| ES (1) | ES2260762T3 (da) |
| PT (1) | PT784477E (da) |
| WO (1) | WO1996010411A1 (da) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997873A (en) | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
| US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| IL123218A0 (en) | 1995-08-18 | 1998-09-24 | Sloan Kettering Inst Cancer | Heat shock protein-based vaccines and immunotherapies |
| US6761892B1 (en) | 1995-08-18 | 2004-07-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6719974B1 (en) | 1995-08-18 | 2004-04-13 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6773707B1 (en) | 1995-08-18 | 2004-08-10 | Sloan-Kettering Institute For Cancer Research | Heat shock protein-based vaccines and immunotherapies |
| US6331299B1 (en) | 1995-08-18 | 2001-12-18 | Sloan-Kettering Institute For Cancer Research | Method for treatment of cancer and infectious disease and compositions useful in same |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5985270A (en) * | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
| US7361330B2 (en) * | 1995-10-04 | 2008-04-22 | Immunex Corporation | Methods of using flt3-ligand in the treatment of fibrosarcoma |
| US20020034517A1 (en) * | 1995-10-04 | 2002-03-21 | Kenneth Brasel | Dendritic cell stimulatory factor |
| EP0950061A4 (en) | 1996-09-20 | 2000-04-12 | Univ New Mexico | Heat shock protein complexes |
| US7157089B1 (en) | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| US6017540A (en) | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| US5830464A (en) | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
| US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| HUP0002760A3 (en) | 1997-05-12 | 2003-03-28 | Aphton Corp Woodland | Immunogenic compositions to the cck-b/gastrin-receptor and methods for the treatment of tumors |
| NZ538399A (en) * | 1997-08-05 | 2007-05-31 | Nventa Biopharma Corp | Fusion protein comprising an HPV E7 protein and a stress protein wherein the E7 protein is joined directly to the amino terminus of the stress protein |
| US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| IL135860A0 (en) * | 1997-10-31 | 2001-05-20 | Sloan Kettering Inst Cancer | Conjugate heat shock protein-binding peptides |
| WO1999023252A1 (en) * | 1997-11-05 | 1999-05-14 | Isis Innovation Limited | Cancer gene |
| US5948646A (en) * | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| WO1999042121A1 (en) * | 1998-02-20 | 1999-08-26 | University Of Miami | Modified heat shock protein-antigenic peptide complex |
| AP1261A (en) * | 1998-02-24 | 2004-03-19 | Sisters Of Providence In Oregon | Composition containing an OX-40 receptor binding agent or a nucleic acid encoding the same and methods for enhancing antigen-specific immune response. |
| CA2328501A1 (en) * | 1998-05-15 | 1999-11-25 | Aphton Corporation | Prevention and treatment of hypergastrinemia |
| GB9818133D0 (en) * | 1998-08-19 | 1998-10-14 | Quadrant Holdings Cambridge | Vaccine |
| AU2004200711B2 (en) * | 1998-08-19 | 2005-11-10 | Immunobiology Limited | Vaccine Comprising Cytokine-Induced Heat Shock Proteins (HSP) |
| US6797480B1 (en) * | 1998-10-05 | 2004-09-28 | University Of Connecticut Health Center | Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents |
| US6475490B1 (en) | 1998-10-19 | 2002-11-05 | Fordham University | Compositions and methods for promoting tissue repair using heat shock proteins |
| US6730302B1 (en) * | 1998-11-24 | 2004-05-04 | Bristol-Myers Squibb Company | Intracellular targeted delivery of compounds by 70 kD heat shock protein |
| WO2001040292A1 (en) * | 1998-11-27 | 2001-06-07 | Novopharm Biotech Inc. | Antigen-binding fragments specific for tumor associated antigens |
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| JP2003504074A (ja) | 1999-07-08 | 2003-02-04 | ストレスゲン バイオテクノロジーズ コーポレイション | インビトロでのTh1様応答の誘導 |
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| US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
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| WO2004074454A2 (en) | 2003-02-20 | 2004-09-02 | University Of Connecticut Health Center | Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes |
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| RU2333767C2 (ru) * | 2006-03-31 | 2008-09-20 | Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") | Вакцинные композиции, способы их применения для профилактики и лечения меланомы и генетические конструкции для получения действующих компонентов композиции |
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- 1995-04-06 EP EP06005126A patent/EP1702624A1/en not_active Withdrawn
- 1995-04-06 KR KR1019970702097A patent/KR970706013A/ko not_active Ceased
- 1995-04-06 EP EP95916256A patent/EP0784477B1/en not_active Expired - Lifetime
- 1995-04-06 AT AT95916256T patent/ATE320447T1/de active
- 1995-04-06 CN CN95196515A patent/CN1167440A/zh active Pending
- 1995-04-06 CA CA002201498A patent/CA2201498A1/en not_active Abandoned
- 1995-04-06 WO PCT/US1995/004347 patent/WO1996010411A1/en not_active Ceased
- 1995-04-06 AU AU22819/95A patent/AU709643B2/en not_active Expired
- 1995-04-06 DK DK95916256T patent/DK0784477T3/da active
- 1995-04-06 ES ES95916256T patent/ES2260762T3/es not_active Expired - Lifetime
- 1995-04-06 PT PT95916256T patent/PT784477E/pt unknown
- 1995-04-06 JP JP8511709A patent/JPH10506628A/ja not_active Withdrawn
- 1995-04-06 DE DE69534874T patent/DE69534874T2/de not_active Expired - Lifetime
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1998
- 1998-04-16 US US09/061,365 patent/US6017544A/en not_active Expired - Lifetime
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2000
- 2000-01-21 US US09/489,218 patent/US6468540B1/en not_active Expired - Fee Related
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2001
- 2001-11-14 US US09/992,613 patent/US20020061316A1/en not_active Abandoned
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2003
- 2003-03-07 US US10/386,775 patent/US20030165519A1/en not_active Abandoned
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2004
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2005
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2007
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| US20050163793A1 (en) | 2005-07-28 |
| US20020061316A1 (en) | 2002-05-23 |
| EP0784477A1 (en) | 1997-07-23 |
| ATE320447T1 (de) | 2006-04-15 |
| JP2005015489A (ja) | 2005-01-20 |
| DE69534874T2 (de) | 2006-12-14 |
| US6017544A (en) | 2000-01-25 |
| US6468540B1 (en) | 2002-10-22 |
| DE69534874D1 (de) | 2006-05-11 |
| JP2008069167A (ja) | 2008-03-27 |
| ES2260762T3 (es) | 2006-11-01 |
| JPH10506628A (ja) | 1998-06-30 |
| EP0784477B1 (en) | 2006-03-15 |
| US5750119A (en) | 1998-05-12 |
| PT784477E (pt) | 2006-08-31 |
| AU709643B2 (en) | 1999-09-02 |
| AU2281995A (en) | 1996-04-26 |
| WO1996010411A1 (en) | 1996-04-11 |
| EP0784477A4 (en) | 2000-06-14 |
| CA2201498A1 (en) | 1996-04-11 |
| EP1702624A1 (en) | 2006-09-20 |
| US20030165519A1 (en) | 2003-09-04 |
| KR970706013A (ko) | 1997-11-03 |
| CN1167440A (zh) | 1997-12-10 |
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