DK0784605T3 - Selektiv fremgangsmåde til deacyleringen af acylforbindelser - Google Patents

Selektiv fremgangsmåde til deacyleringen af acylforbindelser

Info

Publication number
DK0784605T3
DK0784605T3 DK96928423T DK96928423T DK0784605T3 DK 0784605 T3 DK0784605 T3 DK 0784605T3 DK 96928423 T DK96928423 T DK 96928423T DK 96928423 T DK96928423 T DK 96928423T DK 0784605 T3 DK0784605 T3 DK 0784605T3
Authority
DK
Denmark
Prior art keywords
deacylation
acyl compounds
selective procedure
selective
procedure
Prior art date
Application number
DK96928423T
Other languages
English (en)
Inventor
Pater Robertus Mattheus De
Mieke Sibeyn
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of DK0784605T3 publication Critical patent/DK0784605T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK96928423T 1995-08-03 1996-08-05 Selektiv fremgangsmåde til deacyleringen af acylforbindelser DK0784605T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US186095P 1995-08-03 1995-08-03
EP95202125 1995-08-03
PCT/EP1996/003495 WO1997006128A1 (en) 1995-08-03 1996-08-05 Selective process for the deacylation of acylated compounds

Publications (1)

Publication Number Publication Date
DK0784605T3 true DK0784605T3 (da) 2000-07-31

Family

ID=26139544

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96928423T DK0784605T3 (da) 1995-08-03 1996-08-05 Selektiv fremgangsmåde til deacyleringen af acylforbindelser

Country Status (15)

Country Link
EP (1) EP0784605B1 (da)
JP (1) JPH11501218A (da)
CN (1) CN1078583C (da)
AT (1) ATE189804T1 (da)
AU (1) AU6820096A (da)
CA (1) CA2201729C (da)
DE (1) DE69606696T2 (da)
DK (1) DK0784605T3 (da)
ES (1) ES2145479T3 (da)
GR (1) GR3033402T3 (da)
HU (1) HU221636B1 (da)
MX (1) MX9702403A (da)
PT (1) PT784605E (da)
SI (1) SI0784605T1 (da)
WO (1) WO1997006128A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0251582A (ja) * 1988-08-12 1990-02-21 Kyokado Eng Co Ltd 地盤注入用薬液
EP0975789A1 (en) * 1997-02-20 2000-02-02 Dsm N.V. Nitrogen feed in statin fermentation
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
EP1477471A1 (en) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Process for purifying pravastin sodium from a fermentation broth
EP1641447B1 (en) 2003-11-24 2008-10-29 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
GB2255974A (en) * 1991-05-24 1992-11-25 Merck & Co Inc Enzymatic deacylation of simvastatin

Also Published As

Publication number Publication date
WO1997006128A1 (en) 1997-02-20
EP0784605A1 (en) 1997-07-23
ES2145479T3 (es) 2000-07-01
EP0784605B1 (en) 2000-02-16
MX9702403A (es) 1997-06-28
SI0784605T1 (en) 2000-08-31
DE69606696D1 (de) 2000-03-23
HUP9702444A1 (hu) 1998-04-28
DE69606696T2 (de) 2000-08-17
CN1078583C (zh) 2002-01-30
AU6820096A (en) 1997-03-05
CN1164851A (zh) 1997-11-12
HUP9702444A3 (en) 1999-10-28
HU221636B1 (hu) 2002-12-28
JPH11501218A (ja) 1999-02-02
CA2201729C (en) 2002-03-12
PT784605E (pt) 2000-08-31
GR3033402T3 (en) 2000-09-29
ATE189804T1 (de) 2000-03-15
CA2201729A1 (en) 1997-02-20

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