DK0788349T3 - Selegilin-holdigt liposompræparat - Google Patents

Selegilin-holdigt liposompræparat

Info

Publication number: DK0788349T3
Authority: DK; Denmark
Prior art keywords: weight; pct; liposomic; composition; selegilin
Prior art date: 1994-10-24

Application number

DK95935530T

Other languages

Danish (da)

English (en)

Inventor

Jozsef Gaal

Gyula Szebeni

Tamasne Marmarosi

Kalman Magyar

Jozsef Lengyel

Istvan Szatmari

Gnes Turi

Gabor Szekacs

Michael Mezei

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-24

Filing date

1995-10-20

Publication date

2001-11-26

1995-10-20 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

2001-11-26 Application granted granted Critical

2001-11-26 Publication of DK0788349T3 publication Critical patent/DK0788349T3/da

Links

239000002502 liposome Substances 0.000 title 1
MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 title 1
229960003946 selegiline Drugs 0.000 title 1
239000000203 mixture Substances 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
229920000858 Cyclodextrin Polymers 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
208000003926 Myelitis Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
150000002632 lipids Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
201000003152 motion sickness Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Detergent Compositions (AREA)
Manufacturing Of Micro-Capsules (AREA)
Dental Preparations (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK95935530T 1994-10-24 1995-10-20 Selegilin-holdigt liposompræparat DK0788349T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9403073A HU223475B1 (hu)	1994-10-24	1994-10-24	Selegilint tartalmazó liposzoma-készítmény és eljárás ennek előállítására
PCT/HU1995/000052 WO1996012472A1 (en)	1994-10-24	1995-10-20	Liposome composition containing selegilin

Publications (1)

Publication Number	Publication Date
DK0788349T3 true DK0788349T3 (da)	2001-11-26

Family

ID=10985697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95935530T DK0788349T3 (da)	1994-10-24	1995-10-20	Selegilin-holdigt liposompræparat

Country Status (30)

Country	Link
US (1)	US5888536A (ro)
EP (1)	EP0788349B1 (ro)
JP (1)	JPH10507749A (ro)
KR (1)	KR100313149B1 (ro)
CN (1)	CN1084186C (ro)
AT (1)	ATE205387T1 (ro)
AU (1)	AU691348B2 (ro)
BG (1)	BG63327B1 (ro)
BR (1)	BR9509517A (ro)
CA (1)	CA2203513C (ro)
CZ (1)	CZ287349B6 (ro)
DE (1)	DE69522701T2 (ro)
DK (1)	DK0788349T3 (ro)
EE (1)	EE03418B1 (ro)
ES (1)	ES2160718T3 (ro)
FI (1)	FI971743A7 (ro)
HU (1)	HU223475B1 (ro)
IL (1)	IL115754A (ro)
NO (1)	NO316354B1 (ro)
NZ (1)	NZ294660A (ro)
PL (1)	PL183104B1 (ro)
PT (1)	PT788349E (ro)
RO (1)	RO116768B1 (ro)
RU (1)	RU2159106C2 (ro)
SK (1)	SK281599B6 (ro)
TW (1)	TW412420B (ro)
UA (1)	UA44289C2 (ro)
WO (1)	WO1996012472A1 (ro)
YU (1)	YU49313B (ro)
ZA (1)	ZA958999B (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2319318A1 (en) *	1998-01-27	1999-07-29	Thomas N. Thomas	Methods of treatment using mao-a and mao-b inhibitors such as l-deprenyl
DE19814257A1 (de)	1998-03-31	1999-10-07	Asta Medica Ag	Brauseformulierungen
GB9815785D0 (en) *	1998-07-20	1998-09-16	Cerebrus Ltd	Chemical compounds
CN1849112B (zh) *	2003-09-09	2012-06-13	吉里德科学公司	治疗性脂质体
US20080233053A1 (en) *	2005-02-07	2008-09-25	Pharmalight Inc.	Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
CN1813679A (zh) *	2005-11-30	2006-08-09	上海医药(集团)有限公司	一种紫杉烷脂质体冻干组合物及其制备方法
US9445975B2 (en)	2008-10-03	2016-09-20	Access Business Group International, Llc	Composition and method for preparing stable unilamellar liposomal suspension
JP5693026B2 (ja) *	2010-03-12	2015-04-01	株式会社フジモト・コーポレーション	セレギリン含有貼付製剤
JP5623102B2 (ja) *	2010-03-12	2014-11-12	株式会社フジモト・コーポレーション	セレギリン含有貼付製剤
EP2846773A4 (en)	2012-05-10	2015-12-30	Painreform Ltd	DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF
WO2016051424A1 (en) *	2014-09-29	2016-04-07	Council Of Scientific & Industrial Research	A formulation useful for delivery of neuro protecting agent
RS65378B1 (sr) *	2017-03-23	2024-04-30	Lipid Systems Sp Z O O	Visokoefikasna inkapsulacija hidrofilnih jedinjenja u unilamelarne lipozome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH588887A5 (ro) *	1974-07-19	1977-06-15	Battelle Memorial Institute
US4485054A (en) *	1982-10-04	1984-11-27	Lipoderm Pharmaceuticals Limited	Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4761288A (en) *	1984-09-24	1988-08-02	Mezei Associates Limited	Multiphase liposomal drug delivery system
GB8807504D0 (en) *	1988-03-29	1988-05-05	Sandoz Ltd	Improvements in/relating to organic compounds
HU208484B (en) *	1988-08-17	1993-11-29	Chinoin Gyogyszer Es Vegyeszet	Process for producing pharmaceutical composition containing acid additional salt of selegilin as active component for treating schisofrenia
US4937078A (en) *	1988-08-26	1990-06-26	Mezei Associates Limited	Liposomal local anesthetic and analgesic products
CA2039194C (en) *	1990-08-31	1997-01-28	Norton W. Milgram	Uses of l-deprenyl and compositions for same
HU209605B (en) *	1991-04-15	1994-09-28	Chinoin Gyogyszer Es Vegyeszet	Process for production of wather-free transdermal preparation
FR2713087B1 (fr) *	1993-11-30	1996-02-23	Saurat Jean Hilaire	Utilisation de la sélégiline et ses dérivés pour la préparation d'un médicament destiné au traitement du psoriasis.

1994
- 1994-10-24 HU HU9403073A patent/HU223475B1/hu not_active IP Right Cessation
1995
- 1995-10-20 FI FI971743A patent/FI971743A7/fi not_active IP Right Cessation
- 1995-10-20 ES ES95935530T patent/ES2160718T3/es not_active Expired - Lifetime
- 1995-10-20 CZ CZ19971147A patent/CZ287349B6/cs not_active IP Right Cessation
- 1995-10-20 US US08/817,433 patent/US5888536A/en not_active Expired - Fee Related
- 1995-10-20 CA CA002203513A patent/CA2203513C/en not_active Expired - Fee Related
- 1995-10-20 RO RO97-00792A patent/RO116768B1/ro unknown
- 1995-10-20 PT PT95935530T patent/PT788349E/pt unknown
- 1995-10-20 SK SK517-97A patent/SK281599B6/sk unknown
- 1995-10-20 UA UA97052395A patent/UA44289C2/uk unknown
- 1995-10-20 DK DK95935530T patent/DK0788349T3/da active
- 1995-10-20 NZ NZ294660A patent/NZ294660A/en not_active IP Right Cessation
- 1995-10-20 BR BR9509517A patent/BR9509517A/pt not_active IP Right Cessation
- 1995-10-20 EP EP95935530A patent/EP0788349B1/en not_active Expired - Lifetime
- 1995-10-20 KR KR1019970702682A patent/KR100313149B1/ko not_active Expired - Fee Related
- 1995-10-20 CN CN95195853A patent/CN1084186C/zh not_active Expired - Fee Related
- 1995-10-20 DE DE69522701T patent/DE69522701T2/de not_active Expired - Fee Related
- 1995-10-20 AT AT95935530T patent/ATE205387T1/de not_active IP Right Cessation
- 1995-10-20 RU RU97108051/14A patent/RU2159106C2/ru not_active IP Right Cessation
- 1995-10-20 EE EE9700102A patent/EE03418B1/xx not_active IP Right Cessation
- 1995-10-20 PL PL95319875A patent/PL183104B1/pl not_active IP Right Cessation
- 1995-10-20 AU AU37518/95A patent/AU691348B2/en not_active Ceased
- 1995-10-20 WO PCT/HU1995/000052 patent/WO1996012472A1/en not_active Ceased
- 1995-10-20 JP JP8513742A patent/JPH10507749A/ja active Pending
- 1995-10-24 TW TW084111224A patent/TW412420B/zh not_active IP Right Cessation
- 1995-10-24 IL IL11575495A patent/IL115754A/xx not_active IP Right Cessation
- 1995-10-24 ZA ZA958999A patent/ZA958999B/xx unknown
- 1995-10-25 YU YU67195A patent/YU49313B/sh unknown
1997
- 1997-04-22 BG BG101432A patent/BG63327B1/bg unknown
- 1997-04-23 NO NO19971870A patent/NO316354B1/no unknown

Also Published As

Publication number	Publication date
NZ294660A (en)	1998-05-27
SK51797A3 (en)	1997-11-05
PT788349E (pt)	2001-12-28
YU49313B (sh)	2005-06-10
KR100313149B1 (ko)	2002-02-19
NO971870D0 (no)	1997-04-23
HU9403073D0 (en)	1994-12-28
MX9703019A (es)	1997-10-31
EP0788349B1 (en)	2001-09-12
IL115754A (en)	1999-07-14
NO316354B1 (no)	2004-01-19
AU3751895A (en)	1996-05-15
FI971743L (fi)	1997-04-23
BR9509517A (pt)	1997-12-30
CN1163563A (zh)	1997-10-29
IL115754A0 (en)	1996-01-19
FI971743A0 (fi)	1997-04-23
HUT76053A (en)	1997-06-30
BG101432A (bg)	1997-12-30
JPH10507749A (ja)	1998-07-28
TW412420B (en)	2000-11-21
SK281599B6 (sk)	2001-05-10
ES2160718T3 (es)	2001-11-16
KR970706797A (ko)	1997-12-01
RU2159106C2 (ru)	2000-11-20
CZ114797A3 (en)	1997-10-15
RO116768B1 (ro)	2001-06-29
CA2203513A1 (en)	1996-05-02
BG63327B1 (bg)	2001-10-31
ATE205387T1 (de)	2001-09-15
DE69522701D1 (de)	2001-10-18
US5888536A (en)	1999-03-30
CA2203513C (en)	2001-10-09
CZ287349B6 (en)	2000-10-11
EE03418B1 (et)	2001-06-15
UA44289C2 (uk)	2002-02-15
YU67195A (sh)	1998-07-10
PL183104B1 (pl)	2002-05-31
PL319875A1 (en)	1997-09-01
WO1996012472A1 (en)	1996-05-02
CN1084186C (zh)	2002-05-08
ZA958999B (en)	1996-05-15
NO971870L (no)	1997-06-24
FI971743A7 (fi)	1997-04-23
HU223475B1 (hu)	2004-07-28
EE9700102A (et)	1997-10-15
DE69522701T2 (de)	2002-07-11
AU691348B2 (en)	1998-05-14
EP0788349A1 (en)	1997-08-13

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