DK0789700T3 - Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemprodukt - Google Patents
Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemproduktInfo
- Publication number
- DK0789700T3 DK0789700T3 DK95909741T DK95909741T DK0789700T3 DK 0789700 T3 DK0789700 T3 DK 0789700T3 DK 95909741 T DK95909741 T DK 95909741T DK 95909741 T DK95909741 T DK 95909741T DK 0789700 T3 DK0789700 T3 DK 0789700T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparing
- improved process
- biotin intermediate
- biotin
- improved
- Prior art date
Links
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 2
- 235000000638 D-biotin Nutrition 0.000 title 1
- 239000011665 D-biotin Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4411101A DE4411101C2 (de) | 1994-03-30 | 1994-03-30 | Verfahren zur Herstellung eines D-(+)-Biotin-Zwischenproduktes |
| PCT/EP1995/000593 WO1995026965A1 (de) | 1994-03-30 | 1995-02-18 | Verbessertes verfahren zur herstellung eines d-(+)-biotin-zwischenproduktes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0789700T3 true DK0789700T3 (da) | 2002-04-29 |
Family
ID=6514271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95909741T DK0789700T3 (da) | 1994-03-30 | 1995-02-18 | Forbedret fremgangsmåde til fremstilling af et D-(+)-biotin-mellemprodukt |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5847152A (da) |
| EP (1) | EP0789700B1 (da) |
| JP (1) | JP3566297B2 (da) |
| KR (1) | KR100359545B1 (da) |
| CN (1) | CN1046522C (da) |
| DE (2) | DE4411101C2 (da) |
| DK (1) | DK0789700T3 (da) |
| ES (1) | ES2170140T3 (da) |
| WO (1) | WO1995026965A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2193774C (en) * | 1995-12-26 | 2005-02-01 | Norihiko Hirata | Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid |
| DE10001317A1 (de) * | 2000-01-14 | 2001-07-19 | Merck Patent Gmbh | Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien |
| CN101973996B (zh) * | 2010-09-30 | 2012-07-04 | 绍兴文理学院 | 一种生物素中间体酰亚胺单酯化物及其制备方法与应用 |
| CN103772410B (zh) * | 2013-12-31 | 2016-08-31 | 浙江新和成股份有限公司 | 一种d-生物素的合成方法 |
| CN116239604B (zh) * | 2022-12-06 | 2025-09-02 | 江西天新药业股份有限公司 | 生物素前体的精制方法以及制得的生物素前体晶体 |
| EP4495123A1 (en) | 2023-07-19 | 2025-01-22 | DSM IP Assets B.V. | An improved process for producing d-biotin intermediates |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58124791A (ja) * | 1982-01-19 | 1983-07-25 | Sumitomo Chem Co Ltd | ビオチンの製造法 |
| DK43985A (da) * | 1984-03-09 | 1985-09-10 | Hoffmann La Roche | Fremgangsmaade til fremstilling af heterocycliske forbindelser |
| JPH0631249B2 (ja) * | 1984-12-24 | 1994-04-27 | 住友化学工業株式会社 | チオフアン誘導体の製造法 |
| JPH0631250B2 (ja) * | 1985-08-26 | 1994-04-27 | 住友化学工業株式会社 | ヒドロキシテトラヒドロチオフエン誘導体の製造法 |
| CH670644A5 (da) * | 1986-12-18 | 1989-06-30 | Lonza Ag | |
| DE4107121C1 (da) * | 1991-03-06 | 1992-06-11 | Merck Patent Gmbh, 6100 Darmstadt, De |
-
1994
- 1994-03-30 DE DE4411101A patent/DE4411101C2/de not_active Expired - Fee Related
-
1995
- 1995-02-18 JP JP52536695A patent/JP3566297B2/ja not_active Expired - Fee Related
- 1995-02-18 CN CN95192350A patent/CN1046522C/zh not_active Expired - Fee Related
- 1995-02-18 US US08/702,450 patent/US5847152A/en not_active Expired - Fee Related
- 1995-02-18 ES ES95909741T patent/ES2170140T3/es not_active Expired - Lifetime
- 1995-02-18 EP EP95909741A patent/EP0789700B1/de not_active Expired - Lifetime
- 1995-02-18 KR KR1019960705386A patent/KR100359545B1/ko not_active Expired - Fee Related
- 1995-02-18 WO PCT/EP1995/000593 patent/WO1995026965A1/de not_active Ceased
- 1995-02-18 DE DE59510001T patent/DE59510001D1/de not_active Expired - Fee Related
- 1995-02-18 DK DK95909741T patent/DK0789700T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0789700A1 (de) | 1997-08-20 |
| EP0789700B1 (de) | 2002-01-16 |
| JPH09510981A (ja) | 1997-11-04 |
| KR970702281A (ko) | 1997-05-13 |
| JP3566297B2 (ja) | 2004-09-15 |
| DE4411101C2 (de) | 1996-02-01 |
| US5847152A (en) | 1998-12-08 |
| ES2170140T3 (es) | 2002-08-01 |
| DE4411101A1 (de) | 1995-10-05 |
| DE59510001D1 (de) | 2002-02-21 |
| CN1145072A (zh) | 1997-03-12 |
| WO1995026965A1 (de) | 1995-10-12 |
| CN1046522C (zh) | 1999-11-17 |
| KR100359545B1 (ko) | 2003-01-24 |
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