DK0792264T3 - Som hypocholesterolemiske midler velegnede, svovlsubstituerede azetidinonforbindelser - Google Patents

Som hypocholesterolemiske midler velegnede, svovlsubstituerede azetidinonforbindelser

Info

Publication number
DK0792264T3
DK0792264T3 DK95939677T DK95939677T DK0792264T3 DK 0792264 T3 DK0792264 T3 DK 0792264T3 DK 95939677 T DK95939677 T DK 95939677T DK 95939677 T DK95939677 T DK 95939677T DK 0792264 T3 DK0792264 T3 DK 0792264T3
Authority
DK
Denmark
Prior art keywords
aryl
coor6
lower alkyl
nr6r7
substituted
Prior art date
Application number
DK95939677T
Other languages
English (en)
Inventor
Duane A Burnett
Sundeep Dugar
Brian A Mckittrick
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/342,197 external-priority patent/US5624920A/en
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0792264T3 publication Critical patent/DK0792264T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
DK95939677T 1994-11-18 1995-11-15 Som hypocholesterolemiske midler velegnede, svovlsubstituerede azetidinonforbindelser DK0792264T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/342,197 US5624920A (en) 1994-11-18 1994-11-18 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US08/463,619 US5633246A (en) 1994-11-18 1995-06-05 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
PCT/US1995/014134 WO1996016037A1 (en) 1994-11-18 1995-11-15 Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (1)

Publication Number Publication Date
DK0792264T3 true DK0792264T3 (da) 2002-04-22

Family

ID=26992866

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95939677T DK0792264T3 (da) 1994-11-18 1995-11-15 Som hypocholesterolemiske midler velegnede, svovlsubstituerede azetidinonforbindelser

Country Status (24)

Country Link
US (2) US5633246A (da)
EP (1) EP0792264B1 (da)
JP (1) JP2908031B2 (da)
KR (1) KR100235806B1 (da)
CN (1) CN1083833C (da)
AT (1) ATE213726T1 (da)
AU (1) AU698750B2 (da)
BR (1) BR9509669A (da)
CA (1) CA2205202C (da)
CZ (1) CZ289033B6 (da)
DE (1) DE69525643T2 (da)
DK (1) DK0792264T3 (da)
ES (1) ES2169162T3 (da)
FI (1) FI116220B (da)
HU (1) HU227672B1 (da)
MX (1) MX9703577A (da)
NO (1) NO308468B1 (da)
NZ (1) NZ296720A (da)
PL (1) PL184310B1 (da)
PT (1) PT792264E (da)
RU (1) RU2159243C2 (da)
SK (1) SK283860B6 (da)
UA (1) UA54381C2 (da)
WO (1) WO1996016037A1 (da)

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RU2297422C2 (ru) * 2000-12-20 2007-04-20 Шеринг Корпорейшн Замещенные остатком сахара 2-азетидиноны, пригодные для использования в качестве гипохолестеринемических препаратов
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
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US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
EE05453B1 (et) 2001-03-28 2011-08-15 Schering Corporation Protsess asetidinoonvahehendite valmistamiseks
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MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1859796A3 (en) * 2001-09-21 2008-07-02 Schering Corporation Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
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GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
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AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
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CA2517572C (en) * 2003-03-07 2011-12-13 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
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Also Published As

Publication number Publication date
DE69525643T2 (de) 2002-09-26
BR9509669A (pt) 1997-10-28
EP0792264B1 (en) 2002-02-27
NO308468B1 (no) 2000-09-18
CN1083833C (zh) 2002-05-01
FI972099A7 (fi) 1997-05-16
PL184310B1 (pl) 2002-09-30
ES2169162T3 (es) 2002-07-01
DE69525643D1 (de) 2002-04-04
PL320092A1 (en) 1997-09-15
HU227672B1 (en) 2011-11-28
FI972099A0 (fi) 1997-05-16
MX9703577A (es) 1997-08-30
RU2159243C2 (ru) 2000-11-20
EP0792264A1 (en) 1997-09-03
SK283860B6 (sk) 2004-03-02
HK1002558A1 (en) 1998-09-04
ATE213726T1 (de) 2002-03-15
US5744467A (en) 1998-04-28
CZ289033B6 (cs) 2001-10-17
NZ296720A (en) 1999-03-29
NO972272L (no) 1997-05-16
SK61697A3 (en) 1997-12-10
JP2908031B2 (ja) 1999-06-21
US5633246A (en) 1997-05-27
JPH09512833A (ja) 1997-12-22
HUT77088A (hu) 1998-03-02
UA54381C2 (uk) 2003-03-17
KR970707092A (ko) 1997-12-01
WO1996016037A1 (en) 1996-05-30
CA2205202C (en) 2002-01-08
CN1174548A (zh) 1998-02-25
FI116220B (fi) 2005-10-14
AU4140196A (en) 1996-06-17
AU698750B2 (en) 1998-11-05
PT792264E (pt) 2002-07-31
CA2205202A1 (en) 1996-05-30
NO972272D0 (no) 1997-05-16
KR100235806B1 (ko) 2000-02-01
CZ148697A3 (en) 1997-11-12

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