DK0792275T3 - Forbedrede antivirale prodrugs - Google Patents

Forbedrede antivirale prodrugs

Info

Publication number
DK0792275T3
DK0792275T3 DK95940014T DK95940014T DK0792275T3 DK 0792275 T3 DK0792275 T3 DK 0792275T3 DK 95940014 T DK95940014 T DK 95940014T DK 95940014 T DK95940014 T DK 95940014T DK 0792275 T3 DK0792275 T3 DK 0792275T3
Authority
DK
Denmark
Prior art keywords
enhanced antiviral
prodrugs
antiviral prodrugs
enhanced
phosphonoacids
Prior art date
Application number
DK95940014T
Other languages
Danish (da)
English (en)
Inventor
Karl Y Hostetler
Ganesh D Kini Ph D
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK0792275T3 publication Critical patent/DK0792275T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK95940014T 1994-11-15 1995-11-15 Forbedrede antivirale prodrugs DK0792275T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/340,161 US5696277A (en) 1994-11-15 1994-11-15 Antiviral prodrugs
PCT/US1995/014940 WO1996015132A1 (en) 1994-11-15 1995-11-15 Improved antiviral prodrugs

Publications (1)

Publication Number Publication Date
DK0792275T3 true DK0792275T3 (da) 2004-07-05

Family

ID=23332146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95940014T DK0792275T3 (da) 1994-11-15 1995-11-15 Forbedrede antivirale prodrugs

Country Status (11)

Country Link
US (2) US5696277A (de)
EP (1) EP0792275B1 (de)
JP (1) JPH10508858A (de)
AT (1) ATE260926T1 (de)
AU (1) AU700651B2 (de)
CA (1) CA2205136C (de)
DE (1) DE69532642T2 (de)
DK (1) DK0792275T3 (de)
ES (1) ES2217287T3 (de)
PT (1) PT792275E (de)
WO (1) WO1996015132A1 (de)

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Also Published As

Publication number Publication date
ES2217287T3 (es) 2004-11-01
US5696277A (en) 1997-12-09
CA2205136A1 (en) 1996-05-23
EP0792275A1 (de) 1997-09-03
AU700651B2 (en) 1999-01-14
PT792275E (pt) 2004-09-30
AU4163596A (en) 1996-06-06
JPH10508858A (ja) 1998-09-02
DE69532642T2 (de) 2005-06-30
EP0792275B1 (de) 2004-03-03
EP0792275A4 (de) 1998-02-25
US6002029A (en) 1999-12-14
DE69532642D1 (de) 2004-04-08
WO1996015132A1 (en) 1996-05-23
ATE260926T1 (de) 2004-03-15
CA2205136C (en) 2008-01-22

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