DK0795024T3 - Enantioselektiv fremstilling af farmaceutisk aktive sulfoxider ved hjælp af biooxidation - Google Patents

Enantioselektiv fremstilling af farmaceutisk aktive sulfoxider ved hjælp af biooxidation

Info

Publication number
DK0795024T3
DK0795024T3 DK95939460T DK95939460T DK0795024T3 DK 0795024 T3 DK0795024 T3 DK 0795024T3 DK 95939460 T DK95939460 T DK 95939460T DK 95939460 T DK95939460 T DK 95939460T DK 0795024 T3 DK0795024 T3 DK 0795024T3
Authority
DK
Denmark
Prior art keywords
pct
pharmaceutically active
biooxidation
date
sec
Prior art date
Application number
DK95939460T
Other languages
Danish (da)
English (en)
Inventor
Robert Holt
Per Lindberg
Christopher Reeve
Stephen Taylor
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0795024T3 publication Critical patent/DK0795024T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185—Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK95939460T 1994-11-28 1995-11-27 Enantioselektiv fremstilling af farmaceutisk aktive sulfoxider ved hjælp af biooxidation DK0795024T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9423970A GB9423970D0 (en) 1994-11-28 1994-11-28 Oxidation
PCT/SE1995/001415 WO1996017076A1 (en) 1994-11-28 1995-11-27 Enantioselective preparation of pharmaceutically active sulfoxides by biooxidation

Publications (1)

Publication Number Publication Date
DK0795024T3 true DK0795024T3 (da) 2003-04-22

Family

ID=10765078

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95939460T DK0795024T3 (da) 1994-11-28 1995-11-27 Enantioselektiv fremstilling af farmaceutisk aktive sulfoxider ved hjælp af biooxidation

Country Status (11)

Country Link
US (1) US5840552A (de)
EP (1) EP0795024B1 (de)
JP (1) JP3684576B2 (de)
AT (1) ATE232907T1 (de)
AU (1) AU699577B2 (de)
CA (1) CA2203999A1 (de)
DE (1) DE69529686T2 (de)
DK (1) DK0795024T3 (de)
ES (1) ES2191066T3 (de)
GB (1) GB9423970D0 (de)
WO (1) WO1996017076A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) * 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE510650C2 (sv) 1997-05-30 1999-06-14 Astra Ab Ny förening
JP2002507996A (ja) 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー 神経学的障害を治療するためのイミダゾピリミジン類およびイミダゾピリジン類
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
SE9900274D0 (sv) 1999-01-28 1999-01-28 Astra Ab New compound
WO2001014366A1 (en) * 1999-08-25 2001-03-01 Takeda Chemical Industries, Ltd. Process for the preparation of optically active sulfoxide derivatives
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
CN1193024C (zh) 2000-04-28 2005-03-16 武田药品工业株式会社 生产旋光的亚砜衍生物的方法
DE10254167A1 (de) 2002-11-20 2004-06-09 Icon Genetics Ag Verfahren zur Kontrolle von zellulären Prozessen in Pflanzen
AU2003293749B2 (en) 2002-12-06 2009-12-24 Takeda Gmbh Process for preparing (S)-pantoprazole
ES2397380T3 (es) 2002-12-06 2013-03-06 Takeda Gmbh Procedimiento para preparar compuestos activos ópticamente puros
EP1801110A1 (de) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Argininsalz des Esomeprazols
WO2008004245A1 (en) 2006-07-05 2008-01-10 Lupin Limited Process for the preparation of optically pure or optically enriched enantiomers of sulphoxide compounds
WO2011071982A2 (en) 2009-12-08 2011-06-16 Codexis, Inc. Synthesis of prazole compounds
CZ2010790A3 (cs) * 2010-11-01 2011-08-03 Zentiva, K.S. Kmen mikroorganismu Bacillus sp. B71 CCM 7718
HUE037616T2 (hu) 2010-12-08 2018-09-28 Codexis Inc Biokatalizátorok és eljárások armodafinil szintéziséhez
CN108239618A (zh) 2016-12-23 2018-07-03 浙江京新药业股份有限公司 共表达环己酮单加氧酶和异丙醇脱氢酶的基因工程菌及其应用
CN108251466B (zh) * 2016-12-28 2021-07-02 浙江京新药业股份有限公司 一种酶法合成埃索美拉唑的方法
CN107418923B (zh) 2017-09-20 2018-03-23 华东理工大学 伯克霍尔德菌及其应用
FR3097234B1 (fr) * 2019-06-17 2021-06-18 Arkema France Procede selectif de preparation de sulfoxydes par catalyse enzymatique
CN113461663B (zh) * 2020-03-30 2023-11-28 江苏奥赛康药业有限公司 一种质子泵抑制剂艾司奥美拉唑钠的膜分离纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
ES2140391T3 (es) * 1990-06-20 2000-03-01 Astra Ab Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
DE4035455A1 (de) * 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
TNSN95063A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux benzimidazoles substitues
TNSN95062A1 (fr) * 1994-05-27 1996-02-06 Astra Ab Nouveaux derives dialkoxy-pyridinyle-benzimidazole
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation

Also Published As

Publication number Publication date
GB9423970D0 (en) 1995-01-11
DE69529686T2 (de) 2004-01-15
JP3684576B2 (ja) 2005-08-17
AU4126996A (en) 1996-06-19
DE69529686D1 (de) 2003-03-27
EP0795024B1 (de) 2003-02-19
CA2203999A1 (en) 1996-06-06
AU699577B2 (en) 1998-12-10
ES2191066T3 (es) 2003-09-01
WO1996017076A1 (en) 1996-06-06
US5840552A (en) 1998-11-24
EP0795024A1 (de) 1997-09-17
ATE232907T1 (de) 2003-03-15
JPH10510705A (ja) 1998-10-20

Similar Documents

Publication Publication Date Title
ES2191066T3 (es) Preparacion enantioselectiva de sulfoxidos farmaceuticamente activos por biooxidacion.
IT1260468B (it) Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
NO20083728L (no) Analogifremgangsmate for fremstilling av et terapeutisk aktivt nukleosid
NO994722L (no) Ernaeringsformuleringer inneholdende Lacto-N-neotetraose
ID24398A (id) Metode untuk menghasilkan asam l-amino
ATE331731T1 (de) Verfahren zur herstellung von diphtheria toxin
BR0111898A (pt) Métodos de tratamento de doenças de proliferação celular, e de um distúrbio associado com a atividade de cinesina ksp, método de inibição da cinesina ksp, composto, método de triagem de moduladores da cinesina kps, e, método de triagem de compostos que se ligam à cinesina ksp
BR0015110A (pt) Métodos de tratamento de doenças de proliferação celular, de tratamento de um distúrbio associado com a atividade da cinesina ksp, de inibição da cinesina ksp, de triagem de moduladores da cinesina kps e de triagem de compostos que se ligam na cinesina ksp, e, compostos
DE69427704D1 (de) Neue (r)-5-carbamoyl-8-fluor-3-n,n-disubstituierte-amino-3,4-dihydro-2h-1-benzopyrane
DK0756454T3 (da) Sammensætning og fremgangsmåde til bekæmpelse af plantesygdomme
NZ515673A (en) Compositions and methods for labeling of nucleic acid molecules
ATE309811T1 (de) Analgetikum aus schlangengift
AU699625B2 (en) Enzymatic hydrolysis of 4-methylthiobutyronitrile
FR2789399B1 (fr) Procede de fabrication d'extraits de micro-organismes photosynthetiques tels que notamment de spiruline
CO4340718A1 (es) Granulos fungicidas dispersables en agua que contienen n-piridiltoluidina
DK0839211T3 (da) Fremgangsmåde til fremstilling af riboflavin ved hjælp af mikroorganismer med ændret isocitratlyaseaktivitet
AU3166295A (en) Imidazopyridine-azolidinones
BR9915900A (pt) Composto, composição farmacêutica, e, processo para tratar ou inibir distúrbios associados com contração da musculatura lisa.
ATE224195T1 (de) Glucocorticoide zur behandlung von glomerulonephitis
BR9808554A (pt) Esterase do ácido fenólico e o uso da mesma
FR2691161B1 (fr) Enzyme de lévane saccharase, procédé pour sa préparation, micro-organismes qui le produisent et compositions le contenant.
WO2001051093A3 (en) METHODS OF INCREASING THE GLUCOSE RESPONSIVENESS OF PANCREATIC β-CELLS
BRPI0409074A (pt) processos de fermentação com baixas concentrações de nutrientes contendo carbono e nitrogênio
ES2145292T3 (es) Procedimiento bacteriano para la resolucion de cis-dioles racemicos.
DE59914749D1 (de) Ustilipide, verfahren zu deren herstellung sowie deren verwendung