DK0797660T3 - Human-immunodefekt-virus-vacciner og terapeutiske midler indeholdende replikations-svækkede HIV-1 NEF deletions-mutanter - Google Patents
Human-immunodefekt-virus-vacciner og terapeutiske midler indeholdende replikations-svækkede HIV-1 NEF deletions-mutanterInfo
- Publication number
- DK0797660T3 DK0797660T3 DK95944422T DK95944422T DK0797660T3 DK 0797660 T3 DK0797660 T3 DK 0797660T3 DK 95944422 T DK95944422 T DK 95944422T DK 95944422 T DK95944422 T DK 95944422T DK 0797660 T3 DK0797660 T3 DK 0797660T3
- Authority
- DK
- Denmark
- Prior art keywords
- hiv
- nef
- viral
- gene product
- immunodeficiency virus
- Prior art date
Links
- 241000725303 Human immunodeficiency virus Species 0.000 title abstract 5
- 230000002238 attenuated effect Effects 0.000 title abstract 2
- 238000012217 deletion Methods 0.000 title abstract 2
- 230000037430 deletion Effects 0.000 title abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 230000003612 virological effect Effects 0.000 abstract 4
- 239000000725 suspension Substances 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 108700020134 Human immunodeficiency virus 1 nef Proteins 0.000 abstract 2
- 208000007766 Kaposi sarcoma Diseases 0.000 abstract 2
- 208000005384 Pneumocystis Pneumonia Diseases 0.000 abstract 2
- 206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000004698 lymphocyte Anatomy 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 201000000317 pneumocystosis Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001388 Opportunistic Infections Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000120 cytopathologic effect Effects 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 230000003828 downregulation Effects 0.000 abstract 1
- 230000012202 endocytosis Effects 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000021633 leukocyte mediated immunity Effects 0.000 abstract 1
- 230000006674 lysosomal degradation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000029812 viral genome replication Effects 0.000 abstract 1
- 230000007919 viral pathogenicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16061—Methods of inactivation or attenuation
- C12N2740/16062—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36460094A | 1994-12-27 | 1994-12-27 | |
| PCT/US1995/017002 WO1996020273A1 (en) | 1994-12-27 | 1995-12-26 | Human immunodeficiency virus vaccines and therapeutics containing replication-impaired hiv-1 nef-deletion mutants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0797660T3 true DK0797660T3 (da) | 2008-12-15 |
Family
ID=23435246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95944422T DK0797660T3 (da) | 1994-12-27 | 1995-12-26 | Human-immunodefekt-virus-vacciner og terapeutiske midler indeholdende replikations-svækkede HIV-1 NEF deletions-mutanter |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6713064B1 (da) |
| EP (1) | EP0797660B1 (da) |
| JP (1) | JP4587496B2 (da) |
| AT (1) | ATE405635T1 (da) |
| AU (1) | AU718143B2 (da) |
| BR (1) | BR9510473A (da) |
| CA (1) | CA2209135C (da) |
| DE (1) | DE69535817D1 (da) |
| DK (1) | DK0797660T3 (da) |
| ES (1) | ES2313723T3 (da) |
| PT (1) | PT797660E (da) |
| WO (1) | WO1996020273A1 (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112636A0 (en) * | 1994-02-14 | 1995-05-26 | Macfarlane Burnet Ctre Med Res | Non-pathogenic strains of hiv-1 |
| US8124102B2 (en) * | 1994-12-27 | 2012-02-28 | Sateesh Apte | Method for the reduction of viral loads in patients comprising the administration of nef-deficient human immunodeficiency virus (HIV) |
| WO2024048793A1 (ja) * | 2022-09-02 | 2024-03-07 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 感染を治療するための弱毒化ウイルス |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE147782T1 (de) * | 1990-07-12 | 1997-02-15 | Harvard College | Primaten-lentivirus impfstoffe |
| US5851813A (en) * | 1990-07-12 | 1998-12-22 | President And Fellows Of Harvard College | Primate lentivirus antigenic compositions |
| IL112636A0 (en) * | 1994-02-14 | 1995-05-26 | Macfarlane Burnet Ctre Med Res | Non-pathogenic strains of hiv-1 |
-
1995
- 1995-12-26 PT PT95944422T patent/PT797660E/pt unknown
- 1995-12-26 DK DK95944422T patent/DK0797660T3/da active
- 1995-12-26 CA CA002209135A patent/CA2209135C/en not_active Expired - Fee Related
- 1995-12-26 AU AU46474/96A patent/AU718143B2/en not_active Ceased
- 1995-12-26 WO PCT/US1995/017002 patent/WO1996020273A1/en not_active Ceased
- 1995-12-26 JP JP52060096A patent/JP4587496B2/ja not_active Expired - Lifetime
- 1995-12-26 ES ES95944422T patent/ES2313723T3/es not_active Expired - Lifetime
- 1995-12-26 AT AT95944422T patent/ATE405635T1/de active
- 1995-12-26 EP EP95944422A patent/EP0797660B1/en not_active Expired - Lifetime
- 1995-12-26 BR BR9510473A patent/BR9510473A/pt not_active Application Discontinuation
- 1995-12-26 DE DE69535817T patent/DE69535817D1/de not_active Expired - Lifetime
-
1997
- 1997-06-19 US US08/879,099 patent/US6713064B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR9510473A (pt) | 1998-05-26 |
| DE69535817D1 (de) | 2008-10-02 |
| ATE405635T1 (de) | 2008-09-15 |
| JP4587496B2 (ja) | 2010-11-24 |
| EP0797660B1 (en) | 2008-08-20 |
| WO1996020273A1 (en) | 1996-07-04 |
| AU4647496A (en) | 1996-07-19 |
| JPH10511400A (ja) | 1998-11-04 |
| PT797660E (pt) | 2008-11-21 |
| AU718143B2 (en) | 2000-04-06 |
| CA2209135C (en) | 2008-07-08 |
| CA2209135A1 (en) | 1996-07-04 |
| US6713064B1 (en) | 2004-03-30 |
| ES2313723T3 (es) | 2009-03-01 |
| EP0797660A4 (en) | 1999-02-10 |
| EP0797660A1 (en) | 1997-10-01 |
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