DK0800520T3 - Fremgangsmåde til fremstilling af lamotrigin - Google Patents

Fremgangsmåde til fremstilling af lamotrigin

Info

Publication number
DK0800520T3
DK0800520T3 DK95941817T DK95941817T DK0800520T3 DK 0800520 T3 DK0800520 T3 DK 0800520T3 DK 95941817 T DK95941817 T DK 95941817T DK 95941817 T DK95941817 T DK 95941817T DK 0800520 T3 DK0800520 T3 DK 0800520T3
Authority
DK
Denmark
Prior art keywords
pct
sec
formula
date
lamotrigine
Prior art date
Application number
DK95941817T
Other languages
English (en)
Inventor
David Alan Sawyer
Raymond Geoffrey Winter
Andrew Germain
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9426439A external-priority patent/GB9426439D0/en
Priority claimed from GB9426447A external-priority patent/GB9426447D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of DK0800520T3 publication Critical patent/DK0800520T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK95941817T 1994-12-30 1995-12-29 Fremgangsmåde til fremstilling af lamotrigin DK0800520T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9426439A GB9426439D0 (en) 1994-12-30 1994-12-30 Process
GB9426447A GB9426447D0 (en) 1994-12-30 1994-12-30 Process
PCT/GB1995/003048 WO1996020934A1 (en) 1994-12-30 1995-12-29 Process for the preparation of lamotrigine

Publications (1)

Publication Number Publication Date
DK0800520T3 true DK0800520T3 (da) 2002-10-14

Family

ID=26306284

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95941817T DK0800520T3 (da) 1994-12-30 1995-12-29 Fremgangsmåde til fremstilling af lamotrigin

Country Status (13)

Country Link
US (1) US5912345A (da)
EP (1) EP0800520B1 (da)
JP (1) JPH11501007A (da)
AT (1) ATE219487T1 (da)
AU (1) AU4311596A (da)
DE (1) DE69527153T2 (da)
DK (1) DK0800520T3 (da)
ES (1) ES2177672T3 (da)
FI (1) FI972719A7 (da)
HU (1) HU224688B1 (da)
PT (1) PT800520E (da)
RU (1) RU2145602C1 (da)
WO (1) WO1996020934A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420354B1 (en) 1998-06-08 2002-07-16 Advanced Medicine, Inc. Sodium channel drugs and uses
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
US6479498B1 (en) 1999-06-04 2002-11-12 Theravance, Inc. Sodium channel drugs and uses
WO2001049669A1 (en) * 2000-01-03 2001-07-12 Rpg Life Sciences Limited A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
DE10134980C2 (de) * 2001-07-17 2003-05-28 Helm Ag Verfahren zur Herstellung von Lamotrigin
CA2366521C (en) 2001-12-24 2007-03-06 Brantford Chemicals Inc. A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
HU225667B1 (en) * 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
US20120142919A1 (en) * 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
US8486927B2 (en) * 2007-11-09 2013-07-16 Thar Pharmaceuticals Crystalline forms of lamotrigine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
DK153787C (da) * 1979-06-01 1989-01-16 Wellcome Found Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
EP0150677B1 (de) * 1984-01-11 1989-01-18 Ciba-Geigy Ag Herbizide und insektizide Triazinone
ATE39478T1 (de) * 1984-05-29 1989-01-15 Ciba Geigy Ag Verfahren zur herstellung von alphachloracetessigs|uremonomethylamid.
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds

Also Published As

Publication number Publication date
FI972719A0 (fi) 1997-06-24
RU2145602C1 (ru) 2000-02-20
EP0800520A1 (en) 1997-10-15
HUT77346A (hu) 1998-03-30
FI972719L (fi) 1997-08-27
DE69527153T2 (de) 2002-12-19
AU4311596A (en) 1996-07-24
JPH11501007A (ja) 1999-01-26
EP0800520B1 (en) 2002-06-19
ATE219487T1 (de) 2002-07-15
HU224688B1 (hu) 2005-12-28
FI972719A7 (fi) 1997-08-27
ES2177672T3 (es) 2002-12-16
PT800520E (pt) 2002-11-29
WO1996020934A1 (en) 1996-07-11
US5912345A (en) 1999-06-15
DE69527153D1 (de) 2002-07-25

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