ATE186836T1 - Verwendung von 1,5-dideoxy-1,5-imino-d-glucitol n-alkylderivaten zur behandlung von hepatitis b infektionen - Google Patents

Verwendung von 1,5-dideoxy-1,5-imino-d-glucitol n-alkylderivaten zur behandlung von hepatitis b infektionen

Info

Publication number
ATE186836T1
ATE186836T1 AT95905416T AT95905416T ATE186836T1 AT E186836 T1 ATE186836 T1 AT E186836T1 AT 95905416 T AT95905416 T AT 95905416T AT 95905416 T AT95905416 T AT 95905416T AT E186836 T1 ATE186836 T1 AT E186836T1
Authority
AT
Austria
Prior art keywords
glucitol
dideoxy
imino
hepatitis
infections
Prior art date
Application number
AT95905416T
Other languages
English (en)
Inventor
Timothy M Block
Baruch S Blumberg
Raymond A Dwek
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE186836T1 publication Critical patent/ATE186836T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT95905416T 1994-01-13 1994-12-23 Verwendung von 1,5-dideoxy-1,5-imino-d-glucitol n-alkylderivaten zur behandlung von hepatitis b infektionen ATE186836T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18151994A 1994-01-13 1994-01-13

Publications (1)

Publication Number Publication Date
ATE186836T1 true ATE186836T1 (de) 1999-12-15

Family

ID=22664619

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95905416T ATE186836T1 (de) 1994-01-13 1994-12-23 Verwendung von 1,5-dideoxy-1,5-imino-d-glucitol n-alkylderivaten zur behandlung von hepatitis b infektionen

Country Status (14)

Country Link
US (1) US6037351A (de)
EP (1) EP0739205B1 (de)
JP (1) JP3628021B2 (de)
KR (1) KR100348657B1 (de)
CN (1) CN1074921C (de)
AT (1) ATE186836T1 (de)
AU (1) AU1403795A (de)
CA (1) CA2181033C (de)
DE (1) DE69421828T2 (de)
DK (1) DK0739205T3 (de)
ES (1) ES2140652T3 (de)
GR (1) GR3032527T3 (de)
PT (1) PT739205E (de)
WO (1) WO1995019172A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
JP2001522833A (ja) 1997-11-10 2001-11-20 ジー・ディー・サール・アンド・カンパニー 多剤耐性を治療するためのアルキル化イミノ糖類の使用
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
EA004705B1 (ru) * 1998-02-12 2004-06-24 Дж.Д.Серл Энд Ко. Применение n-замещенных 1,5-дидезокси-1,5-имино-d-глюцитных производных для лечения инфекций, вызываемых вирусами гепатита
EP1714676A3 (de) * 1998-02-12 2006-11-15 G.D. Searle LLC. N-substituierte 1,5-dideoxy-1,5-imino-D-glucitol Verbindungen für die Therapie von Hepatitis Virus Infektionen
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A
EP1658846B1 (de) * 1999-02-12 2008-07-30 United Therapeutics Corporation N-(8,8,8-Trifluorooctyl)-1,5-dideoxy-1,5-imino-D-glucitol zur Behandlung von Hepatitis-Virus-Infektionen
WO2001008672A2 (en) * 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
ES2311921T3 (es) * 1999-02-12 2009-02-16 United Therapeutics Corporation N-(8,8,8-trifluorooctil)1-5,-didesoxi-1,5-imino-d-glucitol para tratar infecciones por el virus de la hepatitis.
DE60037664T2 (de) 1999-08-10 2008-12-24 The Chancellor, Masters And Scholars Of The University Of Oxford Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
WO2006085141A2 (en) * 2004-08-13 2006-08-17 Migenix Inc. Compositions and methods for treating or preventing hepadnaviridae infection
CN101489554A (zh) 2006-05-24 2009-07-22 联合治疗公司 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法
CA2666814A1 (en) * 2006-08-21 2008-05-29 United Therapeutics Corporation Combination therapy for treatment of viral infections
US8097728B2 (en) 2007-04-30 2012-01-17 Philadelphia Health & Education Corporation Iminosugar compounds with antiflavirus activity
JP2013233113A (ja) * 2012-05-09 2013-11-21 Osaka Univ 物理的負荷への耐性が向上した細胞の製造方法
RU2743694C1 (ru) * 2019-12-04 2021-02-24 Общество с ограниченной ответственностью "29 февраля" Миглустат N-бутил-1,5-дидезокси-1,5-имино-D-глюцит

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
US4849430A (en) * 1988-03-09 1989-07-18 Monsanto Company Method of inhibiting virus
US4957926A (en) * 1988-12-22 1990-09-18 Monsanto Company Method of treating herpesviruses
US5030638A (en) * 1990-02-26 1991-07-09 G. D. Searle & Co. Method of antiviral enhancement

Also Published As

Publication number Publication date
DK0739205T3 (da) 2000-05-01
DE69421828D1 (de) 1999-12-30
JP3628021B2 (ja) 2005-03-09
WO1995019172A1 (en) 1995-07-20
EP0739205A1 (de) 1996-10-30
US6037351A (en) 2000-03-14
EP0739205B1 (de) 1999-11-24
KR100348657B1 (ko) 2003-08-02
CA2181033C (en) 2007-09-04
GR3032527T3 (en) 2000-05-31
CA2181033A1 (en) 1995-07-20
DE69421828T2 (de) 2000-04-20
AU1403795A (en) 1995-08-01
CN1149253A (zh) 1997-05-07
PT739205E (pt) 2000-04-28
ES2140652T3 (es) 2000-03-01
CN1074921C (zh) 2001-11-21
JPH09508111A (ja) 1997-08-19

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