DK0804417T3 - Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler - Google Patents

Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler

Info

Publication number: DK0804417T3
Authority: DK; Denmark
Prior art keywords: levobupivacaine; racemization; anesthetics; preparation; carboxanilide
Prior art date: 1995-01-18

Application number

DK96900349T

Other languages

Danish (da)

English (en)

Inventor

Ulrich Conrad Chiroscienc Dyer

Marianne Chiroscience Langston

Martin Chiroscience Limi Woods

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-18

Filing date

1996-01-12

Publication date

2003-10-06

1996-01-12 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2003-10-06 Application granted granted Critical

2003-10-06 Publication of DK0804417T3 publication Critical patent/DK0804417T3/da

Links

238000000034 method Methods 0.000 title abstract 3
LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title abstract 2
229960004288 levobupivacaine Drugs 0.000 title abstract 2
229940035674 anesthetics Drugs 0.000 title 1
239000003193 general anesthetic agent Substances 0.000 title 1
UICIJOHWFFTRLI-UHFFFAOYSA-N n-phenylpiperidine-1-carboxamide Chemical compound C1CCCCN1C(=O)NC1=CC=CC=C1 UICIJOHWFFTRLI-UHFFFAOYSA-N 0.000 title 1
230000006340 racemization Effects 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000012736 aqueous medium Substances 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002609 medium Substances 0.000 abstract 1
-1 piperidine-2-carboxanilide compound Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Rolling Contact Bearings (AREA)
Optical Head (AREA)
Beans For Foods Or Fodder (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DK96900349T 1995-01-18 1996-01-12 Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler DK0804417T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9501071.6A GB9501071D0 (en)	1995-01-18	1995-01-18	Racemisation
PCT/GB1996/000067 WO1996022281A1 (en)	1995-01-18	1996-01-12	Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents

Publications (1)

Publication Number	Publication Date
DK0804417T3 true DK0804417T3 (da)	2003-10-06

Family

ID=10768271

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96900349T DK0804417T3 (da)	1995-01-18	1996-01-12	Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler

Country Status (20)

Country	Link
EP (1)	EP0804417B1 (de)
JP (1)	JP4015696B2 (de)
KR (1)	KR100404390B1 (de)
CN (1)	CN1172912C (de)
AT (1)	ATE242214T1 (de)
AU (1)	AU701221B2 (de)
BR (1)	BR9606821A (de)
CA (1)	CA2208522C (de)
DE (1)	DE69628540T2 (de)
DK (1)	DK0804417T3 (de)
ES (1)	ES2201166T3 (de)
FI (1)	FI117437B (de)
GB (1)	GB9501071D0 (de)
HU (1)	HU227426B1 (de)
MX (1)	MX9705428A (de)
NO (1)	NO308843B1 (de)
PL (1)	PL184091B1 (de)
PT (1)	PT804417E (de)
WO (1)	WO1996022281A1 (de)
ZA (1)	ZA96403B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0002246A (pt) *	2000-04-06	2003-04-15	Cristalia Prod Quimicos Farm	Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
US20040001889A1 (en)	2002-06-25	2004-01-01	Guohua Chen	Short duration depot formulations
ATE482695T1 (de)	2002-12-13	2010-10-15	Durect Corp	Orale darreichungsform mit flüssigen hochviskosen trägersystemen
AU2005287175B2 (en)	2004-09-17	2011-12-01	Durect Corporation	Sustained local anesthetic composition containing preferably a sugar ester such as SAIB
US20070027105A1 (en)	2005-07-26	2007-02-01	Alza Corporation	Peroxide removal from drug delivery vehicle
US8337883B2 (en)	2006-11-03	2012-12-25	Durect Corporation	Transdermal delivery systems
EP2219622A1 (de)	2007-12-06	2010-08-25	Durect Corporation	Verfahren zur behandlung von schmerzen, arthritischen zuständen oder entzündung im zusammenhang mit einer chronischen erkrankung
US20100260844A1 (en)	2008-11-03	2010-10-14	Scicinski Jan J	Oral pharmaceutical dosage forms
CN102093284B (zh) *	2010-12-29	2013-05-08	宜昌人福药业有限责任公司	富集哌啶-2-甲酰苯胺类旋光化合物的方法
TW201521769A (zh)	2013-03-15	2015-06-16	Durect Corp	具有流變改質劑以減少溶解變異性之組成物
SG11201811760VA (en)	2016-07-06	2019-01-30	Durect Corp	Oral dosage form with drug composition, barrier layer and drug layer
CN106187864B (zh) *	2016-07-11	2018-11-23	江苏天和制药有限公司	一种由盐酸布比卡因制备高纯度布比卡因碱的方法
CN115666621A (zh)	2020-01-13	2023-01-31	度勒科特公司	具有减少的杂质的持续释放药物递送系统及相关方法
CA3203561A1 (en)	2021-01-12	2022-07-21	Adrian Neil Verity	Sustained release drug delivery systems and related methods
WO2023158722A2 (en) *	2022-02-16	2023-08-24	Teva Pharmaceuticals International Gmbh	Processes for preparation of avacopan and intermediates thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2301498A1 (fr) *	1975-02-20	1976-09-17	Maggioni & C Spa	Methode pour la racemisation d'une lysine optiquement active

1995
- 1995-01-18 GB GBGB9501071.6A patent/GB9501071D0/en active Pending
1996
- 1996-01-12 AT AT96900349T patent/ATE242214T1/de active
- 1996-01-12 JP JP52210296A patent/JP4015696B2/ja not_active Expired - Lifetime
- 1996-01-12 PL PL96321378A patent/PL184091B1/pl unknown
- 1996-01-12 DE DE69628540T patent/DE69628540T2/de not_active Expired - Lifetime
- 1996-01-12 CN CNB961915242A patent/CN1172912C/zh not_active Expired - Lifetime
- 1996-01-12 WO PCT/GB1996/000067 patent/WO1996022281A1/en not_active Ceased
- 1996-01-12 EP EP96900349A patent/EP0804417B1/de not_active Expired - Lifetime
- 1996-01-12 DK DK96900349T patent/DK0804417T3/da active
- 1996-01-12 BR BR9606821A patent/BR9606821A/pt unknown
- 1996-01-12 CA CA002208522A patent/CA2208522C/en not_active Expired - Lifetime
- 1996-01-12 PT PT96900349T patent/PT804417E/pt unknown
- 1996-01-12 HU HU9901418A patent/HU227426B1/hu unknown
- 1996-01-12 MX MX9705428A patent/MX9705428A/es unknown
- 1996-01-12 AU AU43948/96A patent/AU701221B2/en not_active Expired
- 1996-01-12 KR KR1019970704822A patent/KR100404390B1/ko not_active Expired - Lifetime
- 1996-01-12 ES ES96900349T patent/ES2201166T3/es not_active Expired - Lifetime
- 1996-01-18 ZA ZA96403A patent/ZA96403B/xx unknown
1997
- 1997-07-17 NO NO973312A patent/NO308843B1/no not_active IP Right Cessation
- 1997-07-17 FI FI973040A patent/FI117437B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL184091B1 (pl)	2002-08-30
JP4015696B2 (ja)	2007-11-28
NO973312L (no)	1997-07-17
FI973040L (fi)	1997-07-17
JPH11501905A (ja)	1999-02-16
EP0804417A1 (de)	1997-11-05
NO308843B1 (no)	2000-11-06
HUP9901418A3 (en)	2001-01-29
KR100404390B1 (ko)	2004-01-31
FI973040A0 (fi)	1997-07-17
ATE242214T1 (de)	2003-06-15
NO973312D0 (no)	1997-07-17
EP0804417B1 (de)	2003-06-04
AU4394896A (en)	1996-08-07
CA2208522C (en)	2007-03-13
CN1172912C (zh)	2004-10-27
CA2208522A1 (en)	1996-07-25
AU701221B2 (en)	1999-01-21
CN1168134A (zh)	1997-12-17
PT804417E (pt)	2003-09-30
GB9501071D0 (en)	1995-03-08
DE69628540T2 (de)	2004-01-08
ZA96403B (en)	1997-01-20
HUP9901418A2 (hu)	1999-08-30
PL321378A1 (en)	1997-12-08
MX9705428A (es)	1997-11-29
HU227426B1 (en)	2011-05-30
FI117437B (fi)	2006-10-13
DE69628540D1 (de)	2003-07-10
ES2201166T3 (es)	2004-03-16
KR19980701432A (ko)	1998-05-15
WO1996022281A1 (en)	1996-07-25
BR9606821A (pt)	1997-12-23

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