DK0807627T3 - Anilidforbindelser som ACAT-inhibitorer - Google Patents

Anilidforbindelser som ACAT-inhibitorer

Info

Publication number: DK0807627T3
Authority: DK; Denmark
Prior art keywords: compounds; group; oxygen; optionally; pharmaceutical compositions
Prior art date: 1996-05-17

Application number

DK97108154T

Other languages

Danish (da)

English (en)

Inventor

Katsumi Kawamine

Yukihiro Sato

Toshiyuki Edano

Kimiyuki Shibuya

Souhei Tanabe

Masami Shiratsuchi

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1997-05-20

Publication date

2006-04-10

1997-05-20 Application filed by Kowa Co filed Critical Kowa Co

2006-04-10 Application granted granted Critical

2006-04-10 Publication of DK0807627T3 publication Critical patent/DK0807627T3/da

Links

-1 Anilide compounds Chemical class 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
125000004434 sulfur atom Chemical group 0.000 abstract 3
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 abstract 1
239000005516 coenzyme A Substances 0.000 abstract 1
229940093530 coenzyme a Drugs 0.000 abstract 1
KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
125000001174 sulfone group Chemical group 0.000 abstract 1
150000003462 sulfoxides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)

DK97108154T 1996-05-17 1997-05-20 Anilidforbindelser som ACAT-inhibitorer DK0807627T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP15874396		1996-05-17
JP08866097A JP4191269B2 (ja)	1996-05-17	1997-03-25	新規なアニリド化合物及びこれを含有する医薬

Publications (1)

Publication Number	Publication Date
DK0807627T3 true DK0807627T3 (da)	2006-04-10

Family

ID=26430018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97108154T DK0807627T3 (da)	1996-05-17	1997-05-20	Anilidforbindelser som ACAT-inhibitorer

Country Status (7)

Country	Link
US (2)	US6204278B1 (fr)
EP (1)	EP0807627B1 (fr)
JP (1)	JP4191269B2 (fr)
AT (1)	ATE314352T1 (fr)
DE (1)	DE69734952T2 (fr)
DK (1)	DK0807627T3 (fr)
ES (1)	ES2252765T3 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1020451B1 (fr) *	1997-03-25	2005-06-15	Kowa Co., Ltd.	Composes anilide et medicaments les contenant
EP0987254B1 (fr) *	1997-05-26	2004-12-22	Kowa Co., Ltd.	Nouveaux composes de diamine cycliques et medicament contenant ces composes
US6969711B2 (en)	1997-05-26	2005-11-29	Kowa Company, Ltd.	Cyclic diamine compounds and medicine containing the same
JP4402176B2 (ja) *	1997-11-14	2010-01-20	興和株式会社	新規アミド化合物及びこれを含有する医薬
US6849647B1 (en)	1999-07-21	2005-02-01	Kowa Company, Ltd.	Amide compounds and medications containing the same technical field
JP4592130B2 (ja) *	1999-08-05	2010-12-01	大塚化学株式会社	チオ酢酸アミド化合物及び農園芸用殺菌剤
US6622484B2 (en)	2001-02-02	2003-09-23	Caterpillar Inc.	Hystat/split torque modulation
JP4242765B2 (ja) *	2001-08-22	2009-03-25	興和株式会社	血管壁選択的なａｃａｔ阻害剤
US7163944B2 (en) *	2004-01-26	2007-01-16	Kowa Co., Ltd.	Cyclic diamine compound and pharmaceutical containing the same
EP1809759B1 (fr)	2004-10-06	2013-09-11	The Brigham And Women's Hospital, Inc.	Pertinence de niveaux obtenus de marqueurs d'inflammation generalisee ala suite d'un traitement
US8633233B2 (en)	2008-08-06	2014-01-21	Hydra Biosciences, Inc.	Methods and compositions for treating anxiety
JP5523993B2 (ja)	2010-08-31	2014-06-18	富士フイルム株式会社	酸ハロゲン化物の製造方法、及び酸ハロゲン化物
PT2970303T (pt)	2013-03-15	2017-06-23	Hydra Biosciences Inc	Xantinas substituídas e métodos de sua utilização
WO2025194116A1 (fr) *	2024-03-15	2025-09-18	The Regents Of The University Of California	Inhibiteurs de pcsk9 et leurs utilisations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB921791A (en) *	1960-01-21	1963-03-27	Ici Ltd	New dyestuffs
US3720686A (en)	1971-04-01	1973-03-13	Squibb & Sons Inc	Mercaptobenzimidazole derivatives
DE2903966A1 (de)	1979-02-02	1980-08-07	Bayer Ag	Substituierte carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
EP0005501B1 (fr) *	1978-05-20	1981-11-25	Bayer Ag	Heteroaryloxy-acetamides, procédé pour leur préparation et leur utilisation comme herbicides
SE460667B (sv)	1979-09-20	1989-11-06	Nippon Chemiphar Co	Cyklohexankarboxylsyraderivat, foerfarande foer framstaellning daerav samt naemnda derivat foer terapeutisk anvaendning
GB2093835B (en)	1981-01-22	1984-10-31	Nippon Chemiphar Co	Novel guanidinocyclohexanecarboxylic acid derivatives and a process for producing the same
DE3419994A1 (de) *	1984-05-29	1985-12-05	Hoechst Ag, 6230 Frankfurt	Benzoxazolyl- und benzthiazolyl-aminosaeuren, ihre herstellung und verwendung im pflanzenschutz
CA2003283A1 (fr)	1988-12-05	1990-06-05	C. Anne Higley	Imidazoles pour le traitement de l'atherosclerose
WO1991004027A1 (fr)	1989-09-15	1991-04-04	Pfizer Inc.	Nouveaux derives de n-aryle de n-heteroarylamide et d'uree en tant qu'inhibiteurs d'acyl coenzyme a: cholesterol acyl transferase
US5668136A (en)	1990-09-25	1997-09-16	Eisai Co., Ltd.	Trisubstituted benzene derivatives, composition and methods of treatment
JPH04139172A (ja) *	1990-10-01	1992-05-13	Sankyo Co Ltd	α―スルフィニル置換アセトアミド誘導体
US5362878A (en)	1991-03-21	1994-11-08	Pfizer Inc.	Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
US5364875A (en)	1992-05-11	1994-11-15	The Du Pont Merck Pharmaceutical Company	Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5290801A (en) *	1992-05-29	1994-03-01	The Du Pont Merck Pharmaceutical Company	Benzimidazoles for the treatment of atherosclerosis
WO1998035957A1 (fr) *	1997-02-14	1998-08-20	Bayer Corporation	Derives amides actifs comme antagonistes selectifs du recepteur du neuropeptide y

1997
- 1997-03-25 JP JP08866097A patent/JP4191269B2/ja not_active Expired - Lifetime
- 1997-05-19 US US08/858,244 patent/US6204278B1/en not_active Expired - Fee Related
- 1997-05-20 AT AT97108154T patent/ATE314352T1/de not_active IP Right Cessation
- 1997-05-20 DK DK97108154T patent/DK0807627T3/da active
- 1997-05-20 ES ES97108154T patent/ES2252765T3/es not_active Expired - Lifetime
- 1997-05-20 DE DE69734952T patent/DE69734952T2/de not_active Expired - Lifetime
- 1997-05-20 EP EP97108154A patent/EP0807627B1/fr not_active Expired - Lifetime
2001
- 2001-02-21 US US09/789,967 patent/US6825223B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6204278B1 (en)	2001-03-20
JP4191269B2 (ja)	2008-12-03
JPH1029986A (ja)	1998-02-03
EP0807627A3 (fr)	1997-12-03
ES2252765T3 (es)	2006-05-16
EP0807627B1 (fr)	2005-12-28
EP0807627A2 (fr)	1997-11-19
DE69734952D1 (de)	2006-02-02
ATE314352T1 (de)	2006-01-15
US6825223B2 (en)	2004-11-30
DE69734952T2 (de)	2006-07-27
US20020037910A1 (en)	2002-03-28

Publication	Publication Date	Title
DK1424330T3 (da)	2012-01-16	Aktivator for peroxisom proliferator-responsiv receptor delta
PT987254E (pt)	2005-04-29	Compostos de diamina ciclica, originais, e medicamentos que os contem
DK0807627T3 (da)	2006-04-10	Anilidforbindelser som ACAT-inhibitorer
IL120266A (en)	2005-05-17	Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
FI920271A0 (fi)	1992-01-22	Polyamintioler som straolningsskyddande aemnen.
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
FI971227A0 (fi)	1997-03-24	Pyramidinyylipyratsolijohdannaisia
DE60223904D1 (de)	2008-01-17	Benzylaminanalogen
ATE372320T1 (de)	2007-09-15	Cyclische amidderivate
EP1306369A4 (fr)	2007-02-14	Nouveaux composes sulfures et composes intermoleculaires renfermant lesdits composes comme composant
SE8303913D0 (sv)	1983-07-08	Heterocykliska foreningar
AU6517698A (en)	1998-10-20	Novel anilide compounds and drugs containing the same