DK0819132T3 - Fremgangsmåde til fremstilling af anthracyclin-antibiotika - Google Patents

Fremgangsmåde til fremstilling af anthracyclin-antibiotika

Info

Publication number: DK0819132T3
Authority: DK; Denmark
Prior art keywords: pct; preparation; date sep; epimerization; sec
Prior art date: 1995-03-22

Application number

DK96907502T

Other languages

Danish (da)

English (en)

Inventor

Ettore Bigatti

Francesco Bianchi

Original Assignee

Sicor Societo Italiana Cortico

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-22

Filing date

1996-03-19

Publication date

1999-12-27

1996-03-19 Application filed by Sicor Societo Italiana Cortico filed Critical Sicor Societo Italiana Cortico

1999-12-27 Application granted granted Critical

1999-12-27 Publication of DK0819132T3 publication Critical patent/DK0819132T3/da

Links

238000000034 method Methods 0.000 title abstract 2
239000003817 anthracycline antibiotic agent Substances 0.000 title 1
238000006345 epimerization reaction Methods 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
150000007942 carboxylates Chemical class 0.000 abstract 1
WPJRFCZKZXBUNI-HCWXCVPCSA-N daunosamine Chemical group C[C@H](O)[C@@H](O)[C@@H](N)CC=O WPJRFCZKZXBUNI-HCWXCVPCSA-N 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1
125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)

DK96907502T 1995-03-22 1996-03-19 Fremgangsmåde til fremstilling af anthracyclin-antibiotika DK0819132T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95MI000566A IT1275953B1 (it)	1995-03-22	1995-03-22	Procedimento per la preparazione di antibiotici della classe delle antracicline
PCT/EP1996/001174 WO1996029335A1 (en)	1995-03-22	1996-03-19	A process for the preparation of anthracycline antibiotics

Publications (1)

Publication Number	Publication Date
DK0819132T3 true DK0819132T3 (da)	1999-12-27

Family

ID=11371011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96907502T DK0819132T3 (da)	1995-03-22	1996-03-19	Fremgangsmåde til fremstilling af anthracyclin-antibiotika

Country Status (14)

Country	Link
US (1)	US5945518A (de)
EP (1)	EP0819132B1 (de)
JP (1)	JP3983803B2 (de)
AT (1)	ATE181079T1 (de)
AU (1)	AU704101B2 (de)
DE (1)	DE69602834T2 (de)
DK (1)	DK0819132T3 (de)
ES (1)	ES2132901T3 (de)
GR (1)	GR3031195T3 (de)
HU (1)	HU225413B1 (de)
IL (1)	IL117545A (de)
IT (1)	IT1275953B1 (de)
PL (1)	PL182790B1 (de)
WO (1)	WO1996029335A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69609845T2 (de) *	1996-12-16	2000-12-21	Pharmachemie B.V., Haarlem	Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin
KR100785966B1 (ko) *	2000-08-10	2007-12-14	동아제약주식회사	안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) *	2000-08-10	2008-08-04	동아제약주식회사	안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US7053191B2 (en) *	2003-05-21	2006-05-30	Solux Corporation	Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100412084C (zh) *	2003-07-02	2008-08-20	獀洛克斯股份有限公司	热稳定的结晶盐酸表柔比星及其制造方法
US20090099346A1 (en) *	2003-07-02	2009-04-16	Victor Matvienko	Thermally stable crystalline epirubicin hydrochloride
US7388083B2 (en) *	2005-03-07	2008-06-17	Solux Corporation	Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
RU2450013C2 (ru)	2005-12-13	2012-05-10	Солюкс Корпорейшен	Способ получения 4-деметилдаунорубицина
US8802830B2 (en) *	2005-12-20	2014-08-12	Solux Corporation	Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en)	2008-01-08	2013-01-22	Solux Corporation	Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2636676A3 (de)	2009-09-08	2014-01-01	Heraeus Precious Metals GmbH & Co. KG	Kristallisierung von Epidaunorubicin x HCI
US8846882B2 (en)	2011-04-29	2014-09-30	Synbias Pharma Ag	Method of producing 4-demethoxydaunorubicin
WO2015000132A1 (zh) *	2013-07-02	2015-01-08	浙江海正药业股份有限公司	表阿霉素的制备方法及其中间体
CN104861014B (zh) *	2015-06-03	2017-09-29	道中道（菏泽）制药有限公司	一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) *	2016-01-11	2017-07-20	浙江海正药业股份有限公司	一种盐酸表柔比星的制备方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8317037D0 (en) *	1983-06-23	1983-07-27	Erba Farmitalia	6-deoxyanthracyclines
US4537882A (en) *	1984-05-10	1985-08-27	Ohio State University	4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
GB2182926B (en) *	1985-11-19	1989-10-04	Erba Farmitalia	Nitro anthracyclines, process for their preparation and use thereof
GB8614323D0 (en) *	1986-06-12	1986-07-16	Erba Farmitalia	Anthracyclines
IT1196503B (it) *	1986-07-16	1988-11-16	Erba Farmitalia	Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB8803301D0 (en) *	1988-02-12	1988-03-09	Erba Carlo Spa	Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

1995
- 1995-03-22 IT IT95MI000566A patent/IT1275953B1/it active IP Right Grant
1996
- 1996-03-18 IL IL11754596A patent/IL117545A/xx active IP Right Grant
- 1996-03-19 WO PCT/EP1996/001174 patent/WO1996029335A1/en not_active Ceased
- 1996-03-19 EP EP96907502A patent/EP0819132B1/de not_active Expired - Lifetime
- 1996-03-19 ES ES96907502T patent/ES2132901T3/es not_active Expired - Lifetime
- 1996-03-19 HU HU9802336A patent/HU225413B1/hu not_active IP Right Cessation
- 1996-03-19 DE DE69602834T patent/DE69602834T2/de not_active Expired - Lifetime
- 1996-03-19 AT AT96907502T patent/ATE181079T1/de active
- 1996-03-19 DK DK96907502T patent/DK0819132T3/da active
- 1996-03-19 US US08/913,783 patent/US5945518A/en not_active Expired - Lifetime
- 1996-03-19 JP JP52807596A patent/JP3983803B2/ja not_active Expired - Fee Related
- 1996-03-19 AU AU51104/96A patent/AU704101B2/en not_active Ceased
- 1996-03-19 PL PL96322360A patent/PL182790B1/pl not_active IP Right Cessation
1999
- 1999-09-09 GR GR990402289T patent/GR3031195T3/el unknown

Also Published As

Publication number	Publication date
ITMI950566A1 (it)	1996-09-22
GR3031195T3 (en)	1999-12-31
MX9707126A (es)	1997-11-29
JPH11502215A (ja)	1999-02-23
WO1996029335A1 (en)	1996-09-26
HU225413B1 (en)	2006-11-28
ATE181079T1 (de)	1999-06-15
EP0819132A1 (de)	1998-01-21
PL182790B1 (pl)	2002-02-28
HUP9802336A2 (hu)	1999-02-01
EP0819132B1 (de)	1999-06-09
IL117545A0 (en)	1996-07-23
PL322360A1 (en)	1998-01-19
ES2132901T3 (es)	1999-08-16
HUP9802336A3 (en)	1999-11-29
IL117545A (en)	2000-02-17
JP3983803B2 (ja)	2007-09-26
ITMI950566A0 (it)	1995-03-22
US5945518A (en)	1999-08-31
AU704101B2 (en)	1999-04-15
DE69602834D1 (de)	1999-07-15
AU5110496A (en)	1996-10-08
IT1275953B1 (it)	1997-10-24
DE69602834T2 (de)	1999-10-07

Publication	Publication Date	Title
DK0819132T3 (da)	1999-12-27	Fremgangsmåde til fremstilling af anthracyclin-antibiotika
AU2135895A (en)	1995-10-17	Process for the preparation of cyclohexyl-azetidinones
DK0673258T3 (da)	2003-08-25	Polymerbundne camptothecinderivater
GB9312531D0 (en)	1993-08-04	Process
PL314269A1 (en)	1996-09-02	Anthracyclin derivatives
EP0254484A3 (en)	1988-05-25	6-amino anthracyclines, process for their preparation and use thereof
PL306861A1 (en)	1995-04-18	Antracycline conjugates, method of obtaining them and their application as antineoplastic agents
HUT58065A (en)	1992-01-28	Process for producing new 4'-epi-4'-aminoanthracyclines and pharmaceutical composiktions comprising same
AU6241796A (en)	1997-01-30	4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
CA2215930A1 (en)	1996-09-26	A process for the preparation of anthracycline antibiotics
AU7228094A (en)	1995-01-24	Substituted arylthioalkylthiopyridines
HU9501918D0 (en)	1995-09-28	Benzopyranes as potassium channel openers
EP0596112A4 (de)	1994-02-02	Makrolidverbindung und ihre Herstellung.
PT828848E (pt)	2002-07-31	Preparacao de compostos hidroxi por bioconversao com dioxigenase