ATE181079T1 - Verfahren zur herstellung von anthracyclin antibiotica - Google Patents

Verfahren zur herstellung von anthracyclin antibiotica

Info

Publication number
ATE181079T1
ATE181079T1 AT96907502T AT96907502T ATE181079T1 AT E181079 T1 ATE181079 T1 AT E181079T1 AT 96907502 T AT96907502 T AT 96907502T AT 96907502 T AT96907502 T AT 96907502T AT E181079 T1 ATE181079 T1 AT E181079T1
Authority
AT
Austria
Prior art keywords
pct
date sep
antibiotica
epimerization
sec
Prior art date
Application number
AT96907502T
Other languages
English (en)
Inventor
Ettore Bigatti
Francesco Bianchi
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Spa filed Critical Sicor Spa
Application granted granted Critical
Publication of ATE181079T1 publication Critical patent/ATE181079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
AT96907502T 1995-03-22 1996-03-19 Verfahren zur herstellung von anthracyclin antibiotica ATE181079T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI000566A IT1275953B1 (it) 1995-03-22 1995-03-22 Procedimento per la preparazione di antibiotici della classe delle antracicline

Publications (1)

Publication Number Publication Date
ATE181079T1 true ATE181079T1 (de) 1999-06-15

Family

ID=11371011

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96907502T ATE181079T1 (de) 1995-03-22 1996-03-19 Verfahren zur herstellung von anthracyclin antibiotica

Country Status (14)

Country Link
US (1) US5945518A (de)
EP (1) EP0819132B1 (de)
JP (1) JP3983803B2 (de)
AT (1) ATE181079T1 (de)
AU (1) AU704101B2 (de)
DE (1) DE69602834T2 (de)
DK (1) DK0819132T3 (de)
ES (1) ES2132901T3 (de)
GR (1) GR3031195T3 (de)
HU (1) HU225413B1 (de)
IL (1) IL117545A (de)
IT (1) IT1275953B1 (de)
PL (1) PL182790B1 (de)
WO (1) WO1996029335A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69609845T2 (de) * 1996-12-16 2000-12-21 Pharmachemie B.V., Haarlem Verfahren zur Herstellung von Epirubicin oder Zusatzsalzen davon, von Daunorubicin
KR100785966B1 (ko) * 2000-08-10 2007-12-14 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
KR100850408B1 (ko) * 2000-08-10 2008-08-04 동아제약주식회사 안트라싸이클린계 항암제인 에피루비신 및 약학적으로허용되는 그 염의 제조방법
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
RU2450013C2 (ru) 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
EP2636676A3 (de) 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Kristallisierung von Epidaunorubicin x HCI
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin
WO2015000132A1 (zh) * 2013-07-02 2015-01-08 浙江海正药业股份有限公司 表阿霉素的制备方法及其中间体
CN104861014B (zh) * 2015-06-03 2017-09-29 道中道（菏泽）制药有限公司 一种盐酸表阿霉素结晶的制备方法
WO2017120729A1 (zh) * 2016-01-11 2017-07-20 浙江海正药业股份有限公司 一种盐酸表柔比星的制备方法及其中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US4537882A (en) * 1984-05-10 1985-08-27 Ohio State University 4-Demethoxy-3'-desamino-2'-halo-anthracycline and pharmaceutical composition containing same
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
IT1196503B (it) * 1986-07-16 1988-11-16 Erba Farmitalia Procedimento continuo per la trasformazione di 4'-cheto-n-trifluoroacetildaunorubicina in 4'-epi-trifluoroacetildaunorubicina,internmedio per la preparazione di un composto
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin

Also Published As

Publication number Publication date
ITMI950566A1 (it) 1996-09-22
GR3031195T3 (en) 1999-12-31
MX9707126A (es) 1997-11-29
JPH11502215A (ja) 1999-02-23
WO1996029335A1 (en) 1996-09-26
HU225413B1 (en) 2006-11-28
EP0819132A1 (de) 1998-01-21
PL182790B1 (pl) 2002-02-28
HUP9802336A2 (hu) 1999-02-01
EP0819132B1 (de) 1999-06-09
IL117545A0 (en) 1996-07-23
PL322360A1 (en) 1998-01-19
ES2132901T3 (es) 1999-08-16
DK0819132T3 (da) 1999-12-27
HUP9802336A3 (en) 1999-11-29
IL117545A (en) 2000-02-17
JP3983803B2 (ja) 2007-09-26
ITMI950566A0 (it) 1995-03-22
US5945518A (en) 1999-08-31
AU704101B2 (en) 1999-04-15
DE69602834D1 (de) 1999-07-15
AU5110496A (en) 1996-10-08
IT1275953B1 (it) 1997-10-24
DE69602834T2 (de) 1999-10-07

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