DK0821952T3 - Anvendelse af isoxazol- og crotonsyreamidderivater til modulering af apoptose - Google Patents

Anvendelse af isoxazol- og crotonsyreamidderivater til modulering af apoptose

Info

Publication number: DK0821952T3
Authority: DK; Denmark
Prior art keywords: isoxazole; acid derivatives; crotonic acid; modulating apoptosis; halo
Prior art date: 1996-07-31

Application number

DK97112938T

Other languages

English (en)

Inventor

Stefan Dr Muellner

Claudia Dch Dax

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-31

Filing date

1997-07-28

Publication date

2004-06-28

1996-10-01 Priority claimed from DE19640555A external-priority patent/DE19640555A1/de

1997-07-28 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-06-28 Application granted granted Critical

2004-06-28 Publication of DK0821952T3 publication Critical patent/DK0821952T3/da

Links

230000006907 apoptotic process Effects 0.000 title abstract 2
LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical class C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 title 1
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Neurology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

DK97112938T 1996-07-31 1997-07-28 Anvendelse af isoxazol- og crotonsyreamidderivater til modulering af apoptose DK0821952T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19630838		1996-07-31
DE19640555A DE19640555A1 (de)	1996-10-01	1996-10-01	Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Modulation der Apoptose

Publications (1)

Publication Number	Publication Date
DK0821952T3 true DK0821952T3 (da)	2004-06-28

Family

ID=26027963

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97112938T DK0821952T3 (da)	1996-07-31	1997-07-28	Anvendelse af isoxazol- og crotonsyreamidderivater til modulering af apoptose

Country Status (10)

Country	Link
US (1)	US6011051A (da)
EP (1)	EP0821952B1 (da)
JP (1)	JPH1087484A (da)
AT (1)	ATE262901T1 (da)
AU (1)	AU718728B2 (da)
CA (1)	CA2212207C (da)
DE (1)	DE59711463D1 (da)
DK (1)	DK0821952T3 (da)
ES (1)	ES2218623T3 (da)
PT (1)	PT821952E (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19711800A1 (de) *	1997-03-21	1998-09-24	Hoechst Ag	Verlängerung der Expression von transgenen Proteinen durch immunmodulierende Behandlung
DE19860802A1 (de) *	1998-12-30	2000-10-26	Virgene Pharmaceuticals Ag	Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren
WO2001021160A2 (en) *	1999-09-23	2001-03-29	Axxima Pharmaceuticals Aktiengesellschaft	Carboxymide and aniline derivatives as selective inhibitors of pathogens
WO2001041754A2 (en) *	1999-11-30	2001-06-14	Parker Hughes Institute	Inhibitors of collagen-induced platelet aggregation
US6589992B2 (en)	1999-11-30	2003-07-08	Parker Hughes Institute	Inhibiting collagen-induced platelet aggregation
US6458930B1 (en)	2000-11-28	2002-10-01	Cytokinetics, Inc.	Aspergillus fumigatus cofilin
GB0123571D0 (en)	2001-04-05	2001-11-21	Aventis Pharm Prod Inc	Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
DE60231328D1 (de)	2001-12-28	2009-04-09	Asubio Pharma Co Ltd	Cofilin zur förderung der proliferation und/oder differenzierung hämatopoetischer stammzellen und/oder hämatopoetischer vorläuferzellen
GB0224014D0 (en) *	2002-10-15	2002-11-27	Oxford Glycosciences Uk Ltd	A protein involved in therapy
CA2684105C (en) *	2007-05-03	2011-09-06	Pfizer Limited	Pyridine derivatives
JP5820476B2 (ja) *	2010-08-24	2015-11-24	アルギアックスファルマコウティカルスゲーエムベーハーＡＬＧＩＡＸＰｈａｒｍａｃｅｕｔｉｃａｌｓＧｍｂＨ	レフルノミドおよびマロノニトリラマイドの新規の使用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL186239B (nl) *	1975-06-05		Hoechst Ag	Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE3534440A1 (de) *	1985-09-27	1987-04-02	Hoechst Ag	Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) *	1985-09-27	1993-12-07	Hoechst Aktiengesellschaft	Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DD297328A5 (de) *	1989-08-18	1992-01-09	��@��k��Kk��	5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
ES2102367T3 (es) *	1990-05-18	1997-08-01	Hoechst Ag	Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion.
IL99811A (en) *	1990-10-30	1996-03-31	Roussel Uclaf	3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them
DE4127737A1 (de) *	1991-08-22	1993-02-25	Hoechst Ag	Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
NZ244814A (en) *	1991-10-23	1994-06-27	Hoechst Ag	N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and pharmaceutical compositions
GB9200275D0 (en) *	1992-01-08	1992-02-26	Roussel Lab Ltd	Chemical compounds
ES2124800T3 (es) *	1993-01-08	1999-02-16	Hoechst Ag	Empleo de leflunomida para la inhibicion de interleuquina 1 beta.
ES2124801T3 (es) *	1993-01-08	1999-02-16	Hoechst Ag	Empleo de leflunomida para la inhibicion del factor de necrosis de tumores alfa.
DE59407412D1 (de) *	1993-01-08	1999-01-21	Hoechst Ag	Verwendung von Leflunomid zur Hemmung von Interleukin 1 alpha
DK0607777T3 (da) *	1993-01-08	1999-08-16	Hoechst Ag	Anvendelse af leflunomid til inhibering af interleukin 8
TW314467B (da) *	1993-03-31	1997-09-01	Hoechst Ag
GB9313365D0 (en) *	1993-06-29	1993-08-11	Roussel Lab Ltd	Chemical compounds
US5700823A (en) *	1994-01-07	1997-12-23	Sugen, Inc.	Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) *	1994-01-13	1996-05-21	Hoechst Aktiengesellschaft	Method of treating hyperproliferative vascular disease
US5624946A (en) *	1994-07-05	1997-04-29	Williams; James	Use of leflunomide to control and reverse chronic allograft rejection
US5856330A (en) *	1996-07-31	1999-01-05	Hoechst Aktiengesellschaft	Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin

1997
- 1997-07-23 US US08/898,756 patent/US6011051A/en not_active Expired - Lifetime
- 1997-07-28 ES ES97112938T patent/ES2218623T3/es not_active Expired - Lifetime
- 1997-07-28 DK DK97112938T patent/DK0821952T3/da active
- 1997-07-28 EP EP97112938A patent/EP0821952B1/de not_active Expired - Lifetime
- 1997-07-28 AT AT97112938T patent/ATE262901T1/de active
- 1997-07-28 PT PT97112938T patent/PT821952E/pt unknown
- 1997-07-28 DE DE59711463T patent/DE59711463D1/de not_active Expired - Lifetime
- 1997-07-29 AU AU32368/97A patent/AU718728B2/en not_active Ceased
- 1997-07-30 CA CA002212207A patent/CA2212207C/en not_active Expired - Fee Related
- 1997-07-30 JP JP9204344A patent/JPH1087484A/ja active Pending

Also Published As

Publication number	Publication date
AU3236897A (en)	1998-02-05
US6011051A (en)	2000-01-04
CA2212207C (en)	2008-12-30
EP0821952A1 (de)	1998-02-04
PT821952E (pt)	2004-08-31
CA2212207A1 (en)	1998-01-31
ES2218623T3 (es)	2004-11-16
ATE262901T1 (de)	2004-04-15
JPH1087484A (ja)	1998-04-07
AU718728B2 (en)	2000-04-20
DE59711463D1 (de)	2004-05-06
EP0821952B1 (de)	2004-03-31

Publication	Publication Date	Title
DK0780128T3 (da)	2004-10-04	Præparat indeholdende lipoproteiner og crotonsyreamidderivater
DE50013365D1 (de)	2006-10-05	Stabile Salze neuartiger derivative von 3,3-Diphenylpropylaminen
NO883487D0 (no)	1988-08-05	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser.
DK0821952T3 (da)	2004-06-28	Anvendelse af isoxazol- og crotonsyreamidderivater til modulering af apoptose
NZ334976A (en)	2000-10-27	Benzonaphthyridine derivatives and their use for treating airway disorders and dermatoses
DK0769296T3 (da)	2001-10-22	Anvendelse af et natrium- eller lysiniumsalt af crotonsyreamidderivater til fremstilling af et lægemiddel til behandling af cancer
ES2177058T3 (es)	2002-12-01	Compuestos eter piperidinilaminometil trifluorometil ciclicos como antagonistas de la sustancia p.
AU7806491A (en)	1991-12-12	Morpholinourea derivatives
WO2002028844A1 (en)	2002-04-11	Thiazole or oxazole derivatives
DK0821960T3 (da)	2003-07-21	Anvendelse af xanthinderivater i kombination med et 5-isoxazol-4-carboxylsyreamidderivat og/eller et 2-cyano-3-hydroxy-crotonsyre-amidderivat til modulering af apoptose
DK0573464T3 (da)	1997-09-01	Fremgangsmåde til fremstilling af trans-piperidin-2,5-dicarboxylater
DK0387489T3 (da)	1994-02-14	Anvendelse af 2,2,6,6-tetramethyl-4-aminopiperidinamider som fungicider
DK439384D0 (da)	1984-09-14	Derivater af 4-(3-alkynyloxy-2-hydroxypropyl)-piperazin-1-yl-n-phenylacetamid, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende disse
AU3748697A (en)	1998-03-19	2-cyano-3, 5-dihydroxyhex-2-enecarboxamide derivatives
NO972942L (no)	1997-12-29	4-amino-2-ureido-pyrimidin-5-karboksylsyreamider, fremgangsmåter for deres fremstilling, legemidler inneholdende disse forbindelsene og deres anvendelse
DK0814082T3 (da)	2000-08-28	Enolethere og deres anvendelse som fungicider
DK0531119T3 (da)	1995-11-27	N,N,N-trisubstituerede 5-bis-aminomethylen-1,3-dioxan-4,6-dioner som inhibitorer af acyl-CoA: cholesterol-acyltransferase