DK0828726T3 - Tricykliske inhibitorer af matrixmetalloproteinaser - Google Patents

Tricykliske inhibitorer af matrixmetalloproteinaser

Info

Publication number: DK0828726T3
Authority: DK; Denmark
Prior art keywords: matrix metalloproteinases; gelatinase; inhibitors; tricyclic inhibitors; tricyclic
Prior art date: 1995-06-02

Application number

DK96913185T

Other languages

English (en)

Inventor

Andrew David White

Donald Hupe

Joseph Armand Picard

Linda Lea Johnson

Qi-Zhuang Ye

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-04-26

Publication date

2002-01-21

1995-06-02 Priority claimed from US08/460,436 external-priority patent/US5665764A/en

1995-06-02 Priority claimed from US08/460,437 external-priority patent/US5627206A/en

1996-04-26 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2002-01-21 Application granted granted Critical

2002-01-21 Publication of DK0828726T3 publication Critical patent/DK0828726T3/da

Links

102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
102000013382 Gelatinases Human genes 0.000 abstract 1
108010026132 Gelatinases Proteins 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
102000000424 Matrix Metalloproteinase 2 Human genes 0.000 abstract 1
108010016165 Matrix Metalloproteinase 2 Proteins 0.000 abstract 1
102000000422 Matrix Metalloproteinase 3 Human genes 0.000 abstract 1
108010016160 Matrix Metalloproteinase 3 Proteins 0.000 abstract 1
206010027476 Metastases Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010064996 Ulcerative keratitis Diseases 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000009545 invasion Effects 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
208000028169 periodontal disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
230000005747 tumor angiogenesis Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)

DK96913185T 1995-06-02 1996-04-26 Tricykliske inhibitorer af matrixmetalloproteinaser DK0828726T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/460,436 US5665764A (en)	1995-06-02	1995-06-02	Tricyclic inhibitors of matrix metalloproteinases
US08/460,437 US5627206A (en)	1995-06-02	1995-06-02	Tricyclic inhibitor of matrix metalloproteinases
PCT/US1996/005830 WO1996038434A1 (en)	1995-06-02	1996-04-26	Tricyclic inhibitors of matrix metalloproteinases

Publications (1)

Publication Number	Publication Date
DK0828726T3 true DK0828726T3 (da)	2002-01-21

Family

ID=27039692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96913185T DK0828726T3 (da)	1995-06-02	1996-04-26	Tricykliske inhibitorer af matrixmetalloproteinaser

Country Status (13)

Country	Link
EP (1)	EP0828726B1 (da)
JP (1)	JPH11506097A (da)
KR (1)	KR19990022171A (da)
AT (1)	ATE206416T1 (da)
AU (1)	AU717570B2 (da)
CA (1)	CA2220040A1 (da)
DE (1)	DE69615680T2 (da)
DK (1)	DK0828726T3 (da)
ES (1)	ES2165496T3 (da)
MX (1)	MX9708728A (da)
PT (1)	PT828726E (da)
WO (1)	WO1996038434A1 (da)
ZA (1)	ZA964508B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ333063A (en) *	1996-09-04	2000-12-22	Warner Lambert Co	Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors
KR20000068415A (ko)	1996-09-04	2000-11-25	로즈 암스트롱, 크리스틴 에이. 트러트웨인	매트릭스 메탈로프로테이나제 억제용 화합물 및 방법
US6624177B1 (en)	1996-09-04	2003-09-23	Warner-Lambert Company	Matrix metalloproteinase inhibitors and their therapeutic uses
MXPA99001974A (es) *	1996-12-09	2002-03-27	Warner Lambert Co	Metodo para tratar y prevenir fallas cardiacas y dilatacion ventricular.
EP1366765A1 (en) *	1996-12-17	2003-12-03	Warner-Lambert Company Llc	Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing
BR9714142A (pt) *	1996-12-17	2000-02-29	Warner Lambert Co	Uso de inibidores de metaloproteìnases matriciais para tratamento de distúrbios neurológicos e promoção de cicatrização de feridas
WO1999018079A1 (en) *	1997-10-06	1999-04-15	Warner-Lambert Company	Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
OA11589A (en)	1998-07-30	2004-07-30	Warner Lambert Co	Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases.
US6350885B1 (en)	1998-07-30	2002-02-26	Warner-Lambert Company	Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases
DOP2002000334A (es) *	2001-02-14	2002-08-30	Warner Lambert Co	Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz
CA2497658A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Chromone derivatives as matrix metalloproteinase inhibitors
JO2868B1 (en) *	2006-08-22	2015-03-15	رانبكسي لابوراتوريز ليمتد	Inhibitors of metabolic protein protein enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3649651A (en) *	1969-07-02	1972-03-14	American Home Prod	Dibenzofuran derivatives and preparation thereof
US5326760A (en) *	1992-06-29	1994-07-05	Glaxo, Inc.	Aminobutanoic acid compounds having metalloprotease inhibiting properties

1996
- 1996-04-26 DK DK96913185T patent/DK0828726T3/da active
- 1996-04-26 CA CA002220040A patent/CA2220040A1/en not_active Abandoned
- 1996-04-26 EP EP96913185A patent/EP0828726B1/en not_active Expired - Lifetime
- 1996-04-26 KR KR1019970708650A patent/KR19990022171A/ko not_active Ceased
- 1996-04-26 JP JP8536475A patent/JPH11506097A/ja not_active Abandoned
- 1996-04-26 PT PT96913185T patent/PT828726E/pt unknown
- 1996-04-26 AT AT96913185T patent/ATE206416T1/de not_active IP Right Cessation
- 1996-04-26 AU AU55777/96A patent/AU717570B2/en not_active Ceased
- 1996-04-26 DE DE69615680T patent/DE69615680T2/de not_active Expired - Fee Related
- 1996-04-26 MX MX9708728A patent/MX9708728A/es not_active IP Right Cessation
- 1996-04-26 WO PCT/US1996/005830 patent/WO1996038434A1/en not_active Ceased
- 1996-04-26 ES ES96913185T patent/ES2165496T3/es not_active Expired - Lifetime
- 1996-05-31 ZA ZA964508A patent/ZA964508B/xx unknown

Also Published As

Publication number	Publication date
WO1996038434A1 (en)	1996-12-05
ES2165496T3 (es)	2002-03-16
EP0828726A1 (en)	1998-03-18
ATE206416T1 (de)	2001-10-15
ZA964508B (en)	1996-12-09
EP0828726B1 (en)	2001-10-04
JPH11506097A (ja)	1999-06-02
KR19990022171A (ko)	1999-03-25
AU5577796A (en)	1996-12-18
DE69615680D1 (de)	2001-11-08
MX9708728A (es)	1997-12-31
CA2220040A1 (en)	1996-12-05
DE69615680T2 (de)	2002-07-11
AU717570B2 (en)	2000-03-30
PT828726E (pt)	2002-03-28

Publication	Publication Date	Title
IL123901A (en)	2003-06-24	Sulfonamide inhibitors of matrix metalloproteinases and pharmaceutical compositions comprising them
ATE214368T1 (de)	2002-03-15	Aromatische keto-säure und ihre derivate als inhibitoren der matrix metalloproteinase
NZ509439A (en)	2002-10-25	Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases
ATE277929T1 (de)	2004-10-15	Immunsuppressive wirkungen von pteridinderivaten
BG107537A (bg)	2003-09-30	Инхибиране на човешка tnf алфа активност
FR16C1001I1 (fr)	2016-07-01	"Dérivé de 2-oxo-1-pyrrolidine et ses applications pharmaceutique"
ES2165496T3 (es)	2002-03-16	Inhibidores triciclicos de metaloproteinasas matriciales.
HN1997000052A (es)	1997-06-26	Nuevas 4(3h)--quinazolinas 2,3-disustituidas
FI953139A0 (fi)	1995-06-22	Atovakonia käsittäviä farmaseuttisia koostumuksia
DK0642351T3 (da)	2002-07-15	Nye farmaceutiske anvendelser af krillenzymer
ES2072163T3 (es)	1995-07-01	Compuestos de inclusion de acido 5,10-metilenotetrahidrofolico y ciclodextrina.
BR9503572A (pt)	1996-04-30	Composto composiçao farmaceutica e método de tratamento ou prevençao de uma doença
NO20000771D0 (no)	2000-02-16	Anvendelse av fankinon for behandling av Alzheimers sykdom
DE69907720D1 (de)	2003-06-12	Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten
EA199700451A1 (ru)	1998-08-27	Мономерные 4,4-(дизамещенные) циклогексан-1-олы и родственные соединения
CA2233560A1 (en)	1997-05-29	Sulfonamide inhibitors of matrix metalloproteinases